{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:35:00Z","timestamp":1792902900376,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Wroc\u0142aw Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbrc.2026.154637","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:59:39Z","timestamp":1790866779000},"page":"154637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Low-nanomolar chetomin in human skin cells: Preserved viability and wound closure, reduced basal IL-6 and IL-1\u03b2 release, and preliminary tolerability in Galleria mellonella"],"prefix":"10.1016","volume":"838","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-9989","authenticated-orcid":false,"given":"Dominika","family":"Kunachowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Szlasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Szwedowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Kalinin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kloc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Zar\u0119ba-Wdowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"B\u0119ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malwina","family":"Bro\u017cyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-7783","authenticated-orcid":false,"given":"Anna","family":"Choroma\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154637_bib1","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.2174\/0929867326666190916144709","article-title":"Bioactive secondary metabolites from endophytic fungi","volume":"27","author":"Ancheeva","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.154637_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/jof9020172","article-title":"Recent advances in search of bioactive secondary metabolites from fungi triggered by chemical epigenetic modifiers","volume":"9","author":"Xue","year":"2023","journal-title":"J. Fungi"},{"key":"10.1016\/j.bbrc.2026.154637_bib29","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3390\/jof7070570","article-title":"Structurally uncommon secondary metabolites derived from endophytic fungi","volume":"7","author":"Ortega","year":"2021","journal-title":"J. Fungi"},{"key":"10.1016\/j.bbrc.2026.154637_bib2","first-page":"105","article-title":"Cyclosporine in dermatology","volume":"14","author":"Kutlubay","year":"2016","journal-title":"Skinmed"},{"key":"10.1016\/j.bbrc.2026.154637_bib3","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.3390\/ijms23179573","article-title":"A comprehensive review of natural compounds for wound healing: targeting bioactivity perspective","volume":"23","author":"Trinh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154637_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/jb.48.5.527-530.1944","article-title":"Chaetomin, a new antibiotic substance produced by Chaetomium cochliodes: I. Formation and properties","volume":"48","author":"Waksman","year":"1944","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbrc.2026.154637_bib11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1099\/mic.0.27847-0","article-title":"The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis","volume":"151","author":"Gardiner","year":"2005","journal-title":"Microbiology"},{"key":"10.1016\/j.bbrc.2026.154637_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ccr.2004.06.009","article-title":"Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway","volume":"6","author":"Kung","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2026.154637_bib15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00018-022-04529-2","article-title":"Atypical induction of HIF-1\u03b1 expression by pericellular Notch1 signaling suffices for the malignancy of glioblastoma multiforme cells","volume":"79","author":"Lee","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2026.154637_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106701","article-title":"Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia","volume":"139","author":"Hu","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrc.2026.154637_bib16","doi-asserted-by":"crossref","first-page":"9835","DOI":"10.3390\/ijms26199835","article-title":"Antiproliferative and proapoptotic effects of chetomin in human melanoma cells","volume":"26","author":"Jonderko","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154637_bib17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.33549\/physiolres.935385","article-title":"Experimental lung transplantation related with HIF-1, VEGF, ROS. Assessment of HIF-1alpha, VEGF, and reactive oxygen species after competitive blockade of chetomin for lung transplantation in rats","volume":"73","author":"Bravo-Reyna","year":"2024","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bbrc.2026.154637_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1021\/np0302201","article-title":"Immunomodulatory constituents from an ascomycete, Chaetomium seminudum","volume":"67","author":"Fujimoto","year":"2004","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bbrc.2026.154637_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ja.2012.6","article-title":"Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines","volume":"65","author":"Takahashi","year":"2012","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.bbrc.2026.154637_bib7","article-title":"Evaluation of the chetomin effect on histopathological features in a murine acute spinal cord injury model","volume":"25","author":"Bravo-Reyna","year":"2025","journal-title":"World Neurosurg. X"},{"key":"10.1016\/j.bbrc.2026.154637_bib8","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1021\/acschembio.4c00131","article-title":"Chemical genetics in C. elegans identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis response","volume":"19","author":"Abraham","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bbrc.2026.154637_bib21","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1021\/acs.orglett.4c01274","article-title":"Reconstitution of the early stage of chetomin biosynthesis in Aspergillus fumigatus leads to the production of epipolythiodioxopiperazines","volume":"26","author":"Guo","year":"2024","journal-title":"Org. Lett."},{"key":"10.1016\/j.bbrc.2026.154637_bib22","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1007\/s00253-022-11925-y","article-title":"Investigation of chetomin as a lead compound and its biosynthetic pathway","volume":"106","author":"Zhao","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbrc.2026.154637_bib20","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1021\/acs.jnatprod.4c00215","article-title":"UPLC-Q-TOF-MS\/MS-based targeted discovery of chetomin analogues from Chaetomium cochliodes","volume":"87","author":"Liu","year":"2024","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bbrc.2026.154637_bib32","article-title":"Peptide RL-QN15 regulates functions of epidermal stem cells to accelerate skin wound regeneration via the FZD8\/\u03b2-catenin axis","volume":"6","author":"Li","year":"2026","journal-title":"Exploration (Beijing)"},{"key":"10.1016\/j.bbrc.2026.154637_bib33","doi-asserted-by":"crossref","first-page":"19503","DOI":"10.1021\/acs.jmedchem.5c01734","article-title":"Cyclic heptapeptide FZ1 acts as an integrin \u03b1v\u03b23 agonist to facilitate diabetic skin wound healing by enhancing angiogenesis","volume":"68","author":"Wang","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.154637_bib34","first-page":"1187","article-title":"Ultra-short cyclic peptide Cy-RL-QN15 acts as a TLR4 antagonist to expedite oral ulcer healing","volume":"46","author":"Ru","year":"2025","journal-title":"Zool. Res."},{"key":"10.1016\/j.bbrc.2026.154637_bib31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.24272\/j.issn.2095-8137.2026.076","article-title":"Amphibian-derived peptides as novel therapeutics for skin wound healing: mechanisms, applications, and challenges","volume":"47","author":"Deng","year":"2026","journal-title":"Zool. Res."},{"key":"10.1016\/j.bbrc.2026.154637_bib12","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3390\/antibiotics10121545","article-title":"Galleria mellonella: the versatile host for drug discovery, in vivo toxicity testing and characterising host-pathogen interactions","volume":"10","author":"Piatek","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.bbrc.2026.154637_bib30","article-title":"Galleria mellonella as an antimicrobial screening model","volume":"212","author":"Barton","year":"2024","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbrc.2026.154637_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1191\/0960327102ht217oa","article-title":"Defining hormesis","volume":"21","author":"Calabrese","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.bbrc.2026.154637_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106393","article-title":"Hormesis: wound healing and keratinocytes","volume":"183","author":"Calabrese","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2026.154637_bib24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/10408440591034502","article-title":"Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses","volume":"35","author":"Calabrese","year":"2005","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.bbrc.2026.154637_bib26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/biof.1699","article-title":"Luteolin as a modulator of skin aging and inflammation","volume":"47","author":"Gendrisch","year":"2021","journal-title":"Biofactors"},{"key":"10.1016\/j.bbrc.2026.154637_bib27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.bbrc.2020.01.162","article-title":"A wheat germ-derived peptide YDWPGGRN facilitates skin wound-healing processes","volume":"524","author":"Sui","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154637_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5507\/bp.2016.063","article-title":"Models for the study of skin wound healing. The role of Nrf2 and NF-\u03baB","volume":"161","author":"Ambrozova","year":"2017","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.bbrc.2026.154637_bib28","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.freeradbiomed.2011.08.027","article-title":"Regulation of skin inflammation and angiogenesis by EC-SOD via HIF-1\u03b1 and NF-\u03baB pathways","volume":"51","author":"Kim","year":"2011","journal-title":"Free Radic. Biol. Med."}],"updated-by":[{"DOI":"10.1016\/j.bbrc.2026.154781","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:00:00Z","timestamp":1792886400000}}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:49:23Z","timestamp":1792813763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26014038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":32,"alternative-id":["S0006291X26014038"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154637","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-nanomolar chetomin in human skin cells: Preserved viability and wound closure, reduced basal IL-6 and IL-1\u03b2 release, and preliminary tolerability in Galleria mellonella","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154637"}}