{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:37:23Z","timestamp":1792874243244,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbrc.2026.154703","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:43:07Z","timestamp":1791416587000},"page":"154703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Stage-dependent antitumor effects of Icaritin in AOM\/DSS-induced colon cancer: association with CPEB1 restoration and suppression of CSC-associated Wnt\/\u03b2-Catenin and Notch Signaling pathways"],"prefix":"10.1016","volume":"839","author":[{"given":"Zhenhai","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaik Althaf","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2125-4197","authenticated-orcid":false,"given":"Tiantian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrc.2026.154703_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13010040","article-title":"Colorectal cancer: current updates and future perspectives","volume":"13","author":"Marcellinaro","year":"2023","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154703_bib2","first-page":"89","article-title":"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Przegl\u0105d Gastroenterol."},{"issue":"19","key":"10.1016\/j.bbrc.2026.154703_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/nu14193954","article-title":"The link between food environment and colorectal cancer: a systematic review","volume":"14","author":"Masdor","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154703_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3748\/wjg.v30.i3.211","article-title":"Why is early detection of colon cancer still not possible in 2023?","volume":"30","author":"Tonini","year":"2024","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154703_bib5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-024-01851-y","article-title":"Cancer stem cells: advances in knowledge and implications for cancer therapy","volume":"9","author":"Chu","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154703_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14040976","article-title":"Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence","volume":"14","author":"Aramini","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154703_bib7","first-page":"7653","article-title":"Therapeutic strategies against cancer stem cells in human colorectal cancer","volume":"14","author":"Szarynska","year":"2017","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154703_bib8","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.21037\/jgo-22-561","article-title":"Low CPEB1 levels may predict the benefit of 5-fluorouracil treatment in patients with colon or stomach adenocarcinoma","volume":"13","author":"Cao","year":"2022","journal-title":"J. Gastrointest. Oncol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154703_bib9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41467-022-28612-1","article-title":"CPEB1 directs muscle stem cell activation by reprogramming the translational landscape","volume":"13","author":"Zeng","year":"2022","journal-title":"Nat. Commun."},{"issue":"45","key":"10.1016\/j.bbrc.2026.154703_bib10","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.18632\/oncotarget.27806","article-title":"CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells","volume":"11","author":"Rajabi","year":"2020","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154703_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41392-025-02360-2","article-title":"Cancer stem cells: landscape, challenges and emerging therapeutic innovations","volume":"10","author":"Lee","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bbrc.2026.154703_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2147\/CMAR.S411168","article-title":"Wnt\/beta-Catenin signaling pathway in the development and progression of colorectal cancer","volume":"15","author":"He","year":"2023","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.bbrc.2026.154703_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1231416","article-title":"Notch receptor\/ligand diversity: contribution to colorectal cancer stem cell heterogeneity","volume":"11","author":"Brisset","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154703_bib14","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2020.11744","article-title":"Wnt\/beta-catenin signaling: causes and treatment targets of drug resistance in colorectal cancer","volume":"23","author":"Zhu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2026.154703_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113054","article-title":"Targeting cancer signaling pathways by natural products: exploring promising anti-cancer agents","volume":"150","author":"Hashem","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154703_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/ddr.22175","article-title":"New insights into the anticancer therapeutic potential of icaritin and its synthetic derivatives","volume":"85","author":"Reyes-Hernandez","year":"2024","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bbrc.2026.154703_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113991","article-title":"Icariin as an emerging candidate drug for anticancer treatment: current status and perspective","volume":"157","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154703_bib18","article-title":"Icaritin: a novel natural candidate for hematological malignancies therapy","volume":"2019","author":"Yang","year":"2019","journal-title":"Biomed Res. Int."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154703_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1248\/bpb.b23-00668","article-title":"Icariin regulates EMT and stem cell-like character in breast cancer through modulating lncRNA NEAT1\/TGFbeta\/SMAD2 signaling pathway","volume":"47","author":"Song","year":"2024","journal-title":"Biol. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154703_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/15384101.2018.1426413","article-title":"Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition","volume":"17","author":"Li","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbrc.2026.154703_bib21","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16159","article-title":"Murine models of colorectal cancer: the azoxymethane (AOM)\/dextran sulfate sodium (DSS) model of colitis-associated cancer","volume":"11","author":"Dzhalilova","year":"2023","journal-title":"PeerJ"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154703_bib22","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.21873\/anticanres.12616","article-title":"A novel modification of the AOM\/DSS model for inducing intestinal adenomas in mice","volume":"38","author":"Angelou","year":"2018","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154703_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s42826-021-00096-y","article-title":"Induction of colorectal carcinogenesis in the C57BL\/6J and A\/J mouse strains with a reduced DSS dose in the AOM\/DSS model","volume":"37","author":"Arnesen","year":"2021","journal-title":"Lab Anim Res"},{"issue":"20","key":"10.1016\/j.bbrc.2026.154703_bib24","article-title":"Icaritin represses autophagy to promote colorectal cancer cell apoptosis and sensitized low-temperature photothermal therapy via targeting HSP90-TXNDC9 interactions","volume":"12","author":"He","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154703_bib25","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s13277-015-4134-3","article-title":"Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells","volume":"37","author":"Zhou","year":"2016","journal-title":"Tumour Biol"},{"issue":"16","key":"10.1016\/j.bbrc.2026.154703_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e35989","article-title":"Blocking the WNT\/beta-catenin pathway in cancer treatment:pharmacological targets and drug therapeutic potential","volume":"10","author":"Zhao","year":"2024","journal-title":"Heliyon"},{"issue":"16","key":"10.1016\/j.bbrc.2026.154703_bib27","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.18632\/oncotarget.2250","article-title":"CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression","volume":"5","author":"Yin","year":"2014","journal-title":"Oncotarget"},{"issue":"22","key":"10.1016\/j.bbrc.2026.154703_bib28","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1038\/onc.2015.350","article-title":"CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis","volume":"35","author":"Nagaoka","year":"2016","journal-title":"Oncogene"},{"issue":"18","key":"10.1016\/j.bbrc.2026.154703_bib29","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2174\/0113816128291321240329050945","article-title":"Colorectal cancer stem cell biomarkers: biological traits and prognostic insights","volume":"30","author":"Soleimani","year":"2024","journal-title":"Curr. Pharm. Des."},{"issue":"13","key":"10.1016\/j.bbrc.2026.154703_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310910","article-title":"Unmasking the deceptive Nature of cancer stem cells: the role of CD133 in revealing their secrets","volume":"24","author":"Pospieszna","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154703_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13045-020-00901-6","article-title":"Emerging agents that target signaling pathways in cancer stem cells","volume":"13","author":"Yang","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154703_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25116188","article-title":"The crucial role of inflammation and the immune System in colorectal cancer carcinogenesis: a comprehensive perspective","volume":"25","author":"Burgos-Molina","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154703_bib33","article-title":"Correlation of the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha, inflammatory markers, and tumor markers with the diagnosis and prognosis of colorectal","volume":"13","author":"Florescu","year":"2023","journal-title":"Cancer. Life (Basel)"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154703_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154703_bib35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/wound.2019.1032","article-title":"The role of the anti-inflammatory cytokine Interleukin-10 in tissue fibrosis","volume":"9","author":"Steen","year":"2020","journal-title":"Adv. Wound Care"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154703_bib36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12885-021-08043-9","article-title":"Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma","volume":"21","author":"Li","year":"2021","journal-title":"BMC Cancer"},{"issue":"12","key":"10.1016\/j.bbrc.2026.154703_bib37","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.18632\/oncotarget.3399","article-title":"Icaritin suppresses multiple myeloma, by inhibiting IL-6\/JAK2\/STAT3","volume":"6","author":"Zhu","year":"2015","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154703_bib38","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.3892\/mmr.2014.3007","article-title":"Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells","volume":"11","author":"Sun","year":"2015","journal-title":"Mol. Med. Rep."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:54:59Z","timestamp":1792871699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26014695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":38,"alternative-id":["S0006291X26014695"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154703","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stage-dependent antitumor effects of Icaritin in AOM\/DSS-induced colon cancer: association with CPEB1 restoration and suppression of CSC-associated Wnt\/\u03b2-Catenin and Notch Signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154703"}}