{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:30:26Z","timestamp":1793784626054,"version":"4.6.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Secretariat of Science Humanities Technology and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbrc.2026.154710","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:10:49Z","timestamp":1791501049000},"page":"154710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["In silico discovery and cellular validation of PBM-342: a novel PPAR-\u03b2\/\u03b4 modulator for skeletal muscle differentiation"],"prefix":"10.1016","volume":"839","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8386-5238","authenticated-orcid":false,"given":"Manuel","family":"Guti\u00e9rrez-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7114-1404","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Hern\u00e1ndez-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-073X","authenticated-orcid":false,"given":"Rodolfo Daniel","family":"\u00c1vila-Avil\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magally","family":"Ram\u00edrez-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7624-9986","authenticated-orcid":false,"given":"J. Manuel","family":"Hern\u00e1ndez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/apha.12532","article-title":"Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise","volume":"216","author":"Brook","year":"2016","journal-title":"Acta Physiol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s11658-024-00618-1","article-title":"Epigenetic control of skeletal muscle atrophy","volume":"29","author":"Liang","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bbrc.2026.154710_bib3","series-title":"Biology and Engineering of Stem Cell Niches","first-page":"145","article-title":"The satellite cell niche in skeletal muscle","author":"Brun","year":"2017"},{"key":"10.1016\/j.bbrc.2026.154710_bib4","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-0716-3036-5","article-title":"Skeletal muscle stem cells: methods and protocols","author":"Asakura Ed","year":"2023"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154710_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","article-title":"Skeletal muscle: a brief review of structure and function","volume":"96","author":"Frontera","year":"2015","journal-title":"Calcif. Tissue Int."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154710_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jcp.25477","article-title":"The effects of acute and chronic exercise on skeletal muscle proteome","volume":"232","author":"Petriz","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/864140","article-title":"Regulation of glial cell functions by PPAR\u2010\u03b3 natural and synthetic agonists","volume":"2008","author":"Bernardo","year":"2008","journal-title":"PPAR Res."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154710_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1097-2765(00)80467-0","article-title":"Molecular recognition of fatty acids by Peroxisome proliferator\u2013activated receptors","volume":"3","author":"Xu","year":"1999","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154710_bib9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbalip.2007.01.007","article-title":"Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators","volume":"1771","author":"Zoete","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbrc.2026.154710_bib10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.plipres.2016.09.001","article-title":"Transcriptional control of physiological and pathological processes by the nuclear receptor PPAR\u03b2\/\u03b4","volume":"64","author":"Tan","year":"2016","journal-title":"Prog. Lipid Res."},{"issue":"6698","key":"10.1016\/j.bbrc.2026.154710_bib11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/25931","article-title":"Ligand binding and Co-Activator assembly of the Peroxisome proliferator-activated Receptor-\u03b3","volume":"395","author":"Nolte","year":"1998","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154710_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/jm990554g","article-title":"The PPARs: from orphan receptors to drug discovery","volume":"43","author":"Willson","year":"2000","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/13813455.2013.829105","article-title":"PPAR\u03b4 activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference","volume":"120","author":"Feng","year":"2014","journal-title":"Arch. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154710_bib14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","article-title":"A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154710_bib15","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.bbrc.2007.01.092","article-title":"PPAR\u03b4, but not PPAR\u03b1, activates PGC-1\u03b1 gene transcription in muscle","volume":"354","author":"Hondares","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154710_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/4779199","article-title":"PPAR\u03b2\/\u03b4 agonism with GW501516 increases Myotube PGC-1\u03b1 content and reduces BCAA media content independent of changes in BCAA catabolic enzyme expression","volume":"2023","author":"Rivera","year":"2023","journal-title":"PPAR Res."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154710_bib17","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1074\/jbc.274.7.4341","article-title":"Stress-activated protein Kinase-2\/P38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis","volume":"274","author":"Cuenda","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154710_bib18","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1074\/jbc.274.8.5193","article-title":"P38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation","volume":"274","author":"Zetser","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbrc.2016.01.012","article-title":"Peroxisome proliferator-activated receptor \u03b2\/\u03b4 (PPAR\u03b2\/\u03b4) activates promyogenic signaling pathways, thereby promoting myoblast differentiation","volume":"470","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154710_bib20","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ncb1101-1009","article-title":"Mediation of IGF-1-Induced skeletal myotube hypertrophy by PI(3)K\/Akt\/mTOR and PI(3)K\/Akt\/GSK3 pathways","volume":"3","author":"Rommel","year":"2001","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154710_bib21","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1073\/pnas.091021198","article-title":"A selective peroxisome proliferator-activated receptor \u03b4 agonist promotes reverse cholesterol transport","volume":"98","author":"Oliver","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154710_bib22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.semcdb.2012.01.003","article-title":"PPARs: fatty acid sensors controlling metabolism","volume":"23","author":"Poulsen","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154710_bib23","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.bbalip.2007.04.017","article-title":"Emerging roles of PPAR\u03b4 in metabolism","volume":"1771","author":"Seedorf","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"9","key":"10.1016\/j.bbrc.2026.154710_bib24","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/mc.23033","article-title":"Regulatory mechanisms mediated by Peroxisome Proliferator\u2010activated Receptor\u2010\u03b2\/\u03b4 in skin cancer","volume":"58","author":"Peters","year":"2019","journal-title":"Mol. Carcinog."},{"issue":"13","key":"10.1016\/j.bbrc.2026.154710_bib25","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1621513114","article-title":"Structural basis for specific ligation of the Peroxisome proliferator-activated receptor \u03b4","volume":"114","author":"Wu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154710_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/pro.70472","article-title":"Expanding the therapeutic landscape of PDE10A inhibition through alchemical absolute binding free energy calculations and In\u2010vitro evaluation","volume":"35","author":"Sharma","year":"2026","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbrc.2026.154710_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2025.110643","article-title":"Decoding ROCK1 inhibition: a comprehensive computational analysis of key binding determinants for rational design of novel neurotherapeutics","volume":"775","author":"Gupta","year":"2026","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154710_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbapap.2026.141151","article-title":"Structure-guided engineering of serratiopeptidase using Constant-pH molecular dynamics and site-directed mutagenesis to improve pH-Dependent functional resilience","volume":"1874","author":"Dhiman","year":"2026","journal-title":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154710_bib29","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1021\/acs.jcim.6b00174","article-title":"SwissSimilarity: a web tool for low to ultra high throughput ligand-based virtual screening","volume":"56","author":"Zoete","year":"2016","journal-title":"J. Chem. Inf. Model."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154710_bib30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3390\/ijms23020811","article-title":"The SwissSimilarity 2021 web tool: novel chemical libraries and additional methods for an enhanced ligand-based virtual screening experience","volume":"23","author":"Bragina","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154710_bib31","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1021\/ci3001277","article-title":"ZINC: a free tool to discover chemistry for biology","volume":"52","author":"Irwin","year":"2012","journal-title":"J. Chem. Inf. Model."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154710_bib32","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1021\/acs.jcim.0c00675","article-title":"ZINC20\u2014A free ultralarge-scale chemical database for ligand discovery","volume":"60","author":"Irwin","year":"2020","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminf."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154710_bib34","doi-asserted-by":"crossref","DOI":"10.1063\/5.0014475","article-title":"Scalable molecular dynamics on CPU and GPU architectures with NAMD","volume":"153","author":"Phillips","year":"2020","journal-title":"J. Chem. Phys."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154710_bib35","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154710_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"issue":"16","key":"10.1016\/j.bbrc.2026.154710_bib37","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154710_bib38","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154710_bib39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154710_bib40","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: multiple ligand\u2013protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"1\u20133","key":"10.1016\/j.bbrc.2026.154710_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/cc9800071","article-title":"Knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases","volume":"1","author":"Ghose","year":"1999","journal-title":"J. Comb. Chem."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154710_bib45","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154710_bib46","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/jm000292e","article-title":"Prediction of drug absorption using multivariate statistics","volume":"43","author":"Egan","year":"2000","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154710_bib47","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/jm015507e","article-title":"Simple selection criteria for drug-like chemical matter","volume":"44","author":"Muegge","year":"2001","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154710_bib48","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/jcc.21816","article-title":"SwissParam: a fast force field generation tool for small organic molecules","volume":"32","author":"Zoete","year":"2011","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbrc.2026.154710_bib49","series-title":"GROMACS 2021.1 Manual","author":"Lindahl","year":"2021"},{"key":"10.1016\/j.bbrc.2026.154710_bib50","series-title":"XMGRACE","year":"2005"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154710_bib51","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1021\/acs.jcim.7b00695","article-title":"BFEE: a user-friendly graphical interface facilitating absolute binding free-energy calculations","volume":"58","author":"Fu","year":"2018","journal-title":"J. Chem. Inf. Model."},{"issue":"5639","key":"10.1016\/j.bbrc.2026.154710_bib52","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/270725a0","article-title":"Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle","volume":"270","author":"Yaffe","year":"1977","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154710_bib53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/mus.22056","article-title":"A quick, simple and unbiased method to quantify C2C12 myogenic differentiation","volume":"44","author":"Veli\u00e7a","year":"2011","journal-title":"Muscle Nerve"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154710_bib54","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154710_bib55","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbrc.2026.154710_bib56","series-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ygeno.2005.08.009","article-title":"Identification of novel pathway regulation during myogenic differentiation","volume":"87","author":"Szustakowski","year":"2006","journal-title":"Genomics"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154710_bib59","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0959-437X(97)80005-6","article-title":"Cell cycle exit upon myogenic differentiation","volume":"7","author":"Walsh","year":"1997","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154710_bib60","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/15384101.2015.1120925","article-title":"Coordinating cell proliferation and differentiation: antagonism between cell cycle regulators and cell type-specific gene expression","volume":"15","author":"Ruijtenberg","year":"2016","journal-title":"Cell Cycle"},{"issue":"10","key":"10.1016\/j.bbrc.2026.154710_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0020294","article-title":"Regulation of muscle fiber type and running endurance by PPAR\u03b4","volume":"2","author":"Wang","year":"2004","journal-title":"PLoS Biol."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154710_bib62","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.cmet.2017.04.006","article-title":"PPAR\u03b4 promotes running endurance by preserving glucose","volume":"25","author":"Fan","year":"2017","journal-title":"Cell Metab."},{"issue":"7305","key":"10.1016\/j.bbrc.2026.154710_bib63","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature09291","article-title":"Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR\u03b3 by Cdk5","volume":"466","author":"Choi","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib64","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev-biophys-070816-033654","article-title":"Predicting binding free energies: frontiers and benchmarks","volume":"46","author":"Mobley","year":"2017","journal-title":"Annu. Rev. Biophys."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154710_bib65","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.sbi.2011.01.011","article-title":"Alchemical free energy methods for drug discovery: progress and challenges","volume":"21","author":"Chodera","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154710_bib66","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1021\/ja0771033","article-title":"Role of the active-site solvent in the thermodynamics of factor Xa ligand binding","volume":"130","author":"Abel","year":"2008","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.bbrc.2026.154710_bib68","series-title":"Developing Solid Oral Dosage Forms","first-page":"455","article-title":"Oral formulations for preclinical studies","author":"Gao","year":"2017"},{"issue":"21","key":"10.1016\/j.bbrc.2026.154710_bib69","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1007\/s00018-013-1330-4","article-title":"Skeletal muscle hypertrophy and regeneration: interplay between the myogenic regulatory factors (MRFs) and insulin-like growth factors (IGFs) pathways","volume":"70","author":"Zanou","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154710_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/195065","article-title":"Multiple interactions between peroxisome proliferators\u2010activated receptors and the ubiquitin\u2010proteasome system and implications for cancer pathogenesis","volume":"2008","author":"Genini","year":"2008","journal-title":"PPAR Res."},{"issue":"16","key":"10.1016\/j.bbrc.2026.154710_bib71","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1101\/gad.12.16.2499","article-title":"A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type","volume":"12","author":"Chin","year":"1998","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154710_bib72","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cmet.2017.04.029","article-title":"PPAR\u03b2 is essential for maintaining normal levels of PGC-1\u03b1 and Mitochondria and for the increase in muscle Mitochondria induced by exercise","volume":"25","author":"Koh","year":"2017","journal-title":"Cell Metab."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:00:15Z","timestamp":1793782815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26014762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":71,"alternative-id":["S0006291X26014762"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154710","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico discovery and cellular validation of PBM-342: a novel PPAR-\u03b2\/\u03b4 modulator for skeletal muscle differentiation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154710"}}