{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:30:50Z","timestamp":1793784650419,"version":"4.6.1"},"reference-count":244,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Anusandhan National Research Foundation","doi-asserted-by":"publisher","award":["EEQ\/2021\/000591"],"award-info":[{"award-number":["EEQ\/2021\/000591"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","award":["ANRF \/IRG\/2025\/001515\/LS"],"award-info":[{"award-number":["ANRF \/IRG\/2025\/001515\/LS"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbrc.2026.154717","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:06:33Z","timestamp":1791644793000},"page":"154717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting tau acetylation in Alzheimer's disease: Molecular mechanisms, pathological consequences, and therapeutic opportunities of dietary phytochemicals"],"prefix":"10.1016","volume":"839","author":[{"given":"K.C.","family":"Basavaraju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7449-5777","authenticated-orcid":false,"given":"Poornima","family":"Priyadarshini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4062\/biomolther.2022.116","article-title":"Phytochemicals that Act on synaptic plasticity as potential prophylaxis against stress-induced depressive disorder","volume":"31","author":"Yoon","year":"2023","journal-title":"Biomolecules & Therapeutics"},{"key":"10.1016\/j.bbrc.2026.154717_bib2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.sajb.2022.05.047","article-title":"Neuroprotective, lifespan, memory enhancing potential, and molecular docking studies of natural compound from Curculigo orchioides Gaertn.,: a study on Alzheimer's disease model of Appl-GAL4 Drosophila melanogaster","volume":"149","author":"Pratap","year":"2022","journal-title":"South Afr. J. Bot."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjpad.2024.100004","article-title":"Dietary supplementation and the role of phytochemicals against the Alzheimer's disease: focus on polyphenolic compounds","volume":"12","author":"Naik","year":"2025","journal-title":"The journal of prevention of Alzheimer's disease"},{"key":"10.1016\/j.bbrc.2026.154717_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175584","article-title":"Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway","volume":"944","author":"Xu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154717_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155369","article-title":"Gastrodin alleviates mitochondrial dysfunction by regulating SIRT3-mediated TFAM acetylation in vascular dementia","volume":"128","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2026.154717_bib6","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.3233\/JAD-230064","article-title":"Betaine mitigates Amyloid-\u03b2-Associated neuroinflammation by suppressing the NLRP3 and NF-\u03baB signaling pathways in microglial cells","volume":"94","author":"Zhang","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbrc.2026.154717_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.foodres.2018.07.019","article-title":"The effects of grape and red wine polyphenols on gut microbiota - a systematic review","volume":"113","author":"Nash","year":"2018","journal-title":"Food Res. Int."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/nu17040653","article-title":"The potential role of phytochemicals in Alzheimer's Disease","volume":"17","author":"Baranowska-W\u00f3jcik","year":"2025","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib9","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1471-4159.2009.06181.x","article-title":"The amyloid hypothesis for Alzheimer's disease: a critical reappraisal","volume":"110","author":"Hardy","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2026.154717_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2014.00071","article-title":"Possible modification of Alzheimer's disease by statins in nnidlife: interactions with genetic and non-genetic risk factors","volume":"6","author":"Shinohara","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/19336918.2021.1898727","article-title":"\u03b1-Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia","volume":"15","author":"Desale","year":"2021","journal-title":"Cell Adhes. Migrat."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exger.2009.10.010","article-title":"Total and phosphorylated tau protein as biological markers of Alzheimer's disease","volume":"45","author":"Hampel","year":"2010","journal-title":"Exp. Gerontol."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib14","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/jnc.13037","article-title":"Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD","volume":"133","author":"Tramutola","year":"2015","journal-title":"J. Neurochem."},{"issue":"33","key":"10.1016\/j.bbrc.2026.154717_bib15","doi-asserted-by":"crossref","first-page":"34873","DOI":"10.1074\/jbc.M405131200","article-title":"Promotion of hyperphosphorylation by frontotemporal dementia tau mutations","volume":"279","author":"Alonso","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib16","article-title":"Tau is a candidate gene for chromosome 17 frontotemporal dementia (vol 42, pg 815, 1998)","volume":"44","year":"1998","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","article-title":"Tau protein isoforms, phosphorylation and role in neurodegenerative disorders","volume":"33","author":"Bu\u00e9e","year":"2000","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.bbrc.2026.154717_bib18","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3233\/JAD-210297","article-title":"T217-Phosphorylation exacerbates tau pathologies and tau-induced cognitive impairment","volume":"81","author":"Wang","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-41672-1","article-title":"Acetylation discriminates disease-specific tau deposition","volume":"14","author":"Chakraborty","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154717_bib20","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1042\/BCJ20190042","article-title":"An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubulin polymerization","volume":"476","author":"Rane","year":"2019","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2026.154717_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1255","article-title":"The acetylation of tau inhibits its function and promotes pathological tau aggregation","volume":"2","author":"Cohen","year":"2011","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib22","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1080\/00207454.2022.2081165","article-title":"Tau acetylation at K280 regulates tau phosphorylation","volume":"133","author":"Kim","year":"2023","journal-title":"Int. J. Neurosci."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154717_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.str.2023.05.020","article-title":"Disease-associated patterns of acetylation stabilize tau fibril formation","volume":"31","author":"Li","year":"2023","journal-title":"Structure"},{"key":"10.1016\/j.bbrc.2026.154717_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/srep44102","article-title":"A dual pathogenic mechanism links tau acetylation to sporadic tauopathy","volume":"7","author":"Trzeciakiewicz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154717_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/srep22685","article-title":"Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo","volume":"6","author":"Gorsky","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3233\/JAD-200529","article-title":"Tau acetylation in entorhinal cortex induces its chronic hippocampal propagation and cognitive deficits in mice","volume":"77","author":"Wang","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbrc.2026.154717_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1255","article-title":"The acetylation of tau inhibits its function and promotes pathological tau aggregation","volume":"2","author":"Cohen","year":"2011","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154717_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158470","article-title":"Intrinsic tau acetylation is coupled to auto-proteolytic tau fragmentation","volume":"11","author":"Cohen","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1021\/acschemneuro.9b00455","article-title":"The acetyl mimicking mutation, K274Q in Tau, enhances the metal binding affinity of Tau and reduces the ability of Tau to protect DNA","volume":"11","author":"Rane","year":"2020","journal-title":"ACS Chem. Neurosci."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154717_bib30","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/nsmb.2642","article-title":"Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation","volume":"20","author":"Delvecchio","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biocel.2008.08.035","article-title":"Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1","volume":"41","author":"Grimaldi","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154717_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115519","article-title":"Acetylation in pathogenesis: revealing emerging mechanisms and therapeutic prospects","volume":"167","author":"Jiang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib33","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1002\/jcb.27371","article-title":"Impact of curcumin on sirtuins: a review","volume":"119","author":"Zendedel","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2026.154717_bib34","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s11064-016-2110-y","article-title":"Sirtuins and their roles in brain aging and neurodegenerative disorders","volume":"42","author":"Jesko","year":"2017","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25041956","article-title":"Sirtuins as players in the signal transduction of citrus flavonoids","volume":"25","author":"Lombardo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154717_bib36","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1101\/gad.1467506","article-title":"Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction","volume":"20","author":"Haigis","year":"2006","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib37","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.molcel.2012.03.024","article-title":"USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for Mouse embryonic development","volume":"46","author":"Lin","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2026.154717_bib38","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1007\/s12035-020-02079-x","article-title":"AMPK ameliorates tau acetylation and memory impairment through Sirt1","volume":"57","author":"Wang","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2026.154717_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109035","article-title":"SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis","volume":"35","author":"Portillo","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.154717_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01225","article-title":"SIRT1 activation by natural phytochemicals: an overview","volume":"11","author":"Iside","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"16","key":"10.1016\/j.bbrc.2026.154717_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/nu15163578","article-title":"Natural phytochemicals as SIRT activators-focus on potential biochemical mechanisms","volume":"15","author":"Wicinski","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.154717_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149747","article-title":"Nobiletin enhances mitochondrial function by regulating SIRT1\/PGC-1\u03b1 signaling in porcine oocytes during in vitro maturation","volume":"706","author":"Lee","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154717_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.tifs.2021.05.005","article-title":"Protective effects of anthocyanins on neurodegenerative diseases","volume":"117","author":"Li","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.bbrc.2026.154717_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2025.105264","article-title":"Nanoencapsulated flavonoids for enhanced modulation of the microbiota-gut-brain axis and neurodegenerative add-on therapy","volume":"164","author":"Rosales","year":"2025","journal-title":"Trends Food Sci. Technol."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154717_bib45","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1093\/hmg\/ddp367","article-title":"Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing","volume":"18","author":"Wang","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib46","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1080\/00207454.2022.2081165","article-title":"Tau acetylation at K280 regulates tau phosphorylation","volume":"133","author":"Kim","year":"2023","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154717_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10225-0","article-title":"Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity","volume":"7","author":"Gorsky","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib48","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/pro.4257","article-title":"Three-repeat and four-repeat tau isoforms form different oligomers","volume":"31","author":"Shahpasand-Kroner","year":"2022","journal-title":"Protein Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/NEN.0b013e3181922348","article-title":"Sirtuin 1 reduction parallels the accumulation of Tau in alzheimer disease","volume":"68","author":"Julien","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000095638","article-title":"It may take inflammation, phosphorylation and ubiquitination to \"tangle' in Alzheimer's disease","volume":"3","author":"Arnaud","year":"2006","journal-title":"Neurodegener. Dis."},{"issue":"37","key":"10.1016\/j.bbrc.2026.154717_bib51","doi-asserted-by":"crossref","first-page":"15277","DOI":"10.1074\/jbc.M117.794602","article-title":"An acetylation-phosphorylation switch that regulates tau aggregation propensity and function","volume":"292","author":"Carlonnagno","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2022.130276","article-title":"Acetylation and phosphorylation processes modulate Tau's binding to microtubules: a molecular dynamics study","volume":"1867","author":"Castro","year":"2023","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"10.1016\/j.bbrc.2026.154717_bib53","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3906\/sag-1407-75","article-title":"Role of autophagy in the pathogenesis of Alzheimer disease","volume":"45","author":"Kizilarslanoglu","year":"2015","journal-title":"Turk. J. Med. Sci."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib54","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nsmb.2555","article-title":"The microtubule-associated tau protein has intrinsic acetyltransferase activity","volume":"20","author":"Cohen","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1134\/S1819712416010098","article-title":"The role of autophagy in neurodegenerative diseases","volume":"10","author":"Kochergin","year":"2016","journal-title":"Neurochemical Journal"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000301","article-title":"Proteome-wide analysis of chaperone-mediated autophagy targeting motifs","volume":"17","author":"Kirchner","year":"2019","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22501-9","article-title":"Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice","volume":"12","author":"Caballero","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2026.154717_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg3897","article-title":"TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy","volume":"7","author":"Alquezar","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2026.154717_bib59","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/978-981-15-0602-4_20","article-title":"Chaperone-Mediated autophagy","volume":"1206","author":"Yang","year":"2019","journal-title":"Autophagy: Biology And Diseases: Basic Science"},{"key":"10.1016\/j.bbrc.2026.154717_bib60","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-019-0354-0","article-title":"Promoting tau secretion and propagation by hyperactive p300\/CBP via autophagy-lysosomal pathway in tauopathy","volume":"15","author":"Chen","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109035","article-title":"SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis","volume":"35","author":"Portillo","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.154717_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00727","article-title":"USP14 as a therapeutic target against neurodegeneration: a rat brain perspective","volume":"8","author":"Banerjee","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030556","article-title":"Deubiquitinases in neurodegeneration","volume":"11","author":"Bello","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbagrm.2010.08.008","article-title":"Structure characterization of the 26S proteasome","volume":"1809","author":"Kim","year":"2011","journal-title":"BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib65","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/1389203053545453","article-title":"Chaperone activities of the 26S and 20S proteasome","volume":"6","author":"Yano","year":"2005","journal-title":"Curr. Protein Pept. Sci."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib66","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1073\/pnas.060025497","article-title":"Physical association of ubiqutin ligases and the 26S proteasome","volume":"97","author":"Xie","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.154717_bib67","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2013.03.001","article-title":"Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system","volume":"105","author":"Lee","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbrc.2026.154717_bib68","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.cell.2021.03.032","article-title":"Reducing acetylated tau is neuroprotective in brain injury","volume":"184","author":"Shin","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154717_bib69","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/02699050600664467","article-title":"Neurobehavioural deficits after severe traumatic brain injury (TBI)","volume":"20","author":"Lippert-Gr\u00fcner","year":"2006","journal-title":"Brain Inj."},{"key":"10.1016\/j.bbrc.2026.154717_bib70","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.neubiorev.2012.02.013","article-title":"Traumatic brain injury: a risk factor for Alzheimer's disease","volume":"36","author":"Sivanandam","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbrc.2026.154717_bib71","first-page":"303","article-title":"Traumatic brain injury and Alzheimer's disease: a review","volume":"161","author":"Van Den Heuvel","year":"2007","journal-title":"NEUROTRAUMA: NEW INSIGHTS INTO PATHOLOGY AND TREATMENT"},{"key":"10.1016\/j.bbrc.2026.154717_bib72","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.neubiorev.2020.10.020","article-title":"An update on the association between traumatic brain injury and Alzheimer's disease: focus on Tau pathology and synaptic dysfunction","volume":"120","author":"Li","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbrc.2026.154717_bib73","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"NATURE"},{"key":"10.1016\/j.bbrc.2026.154717_bib74","article-title":"Repair mechanisms and mutagenesis of oxidative DNA damage","volume":"197","author":"Fortini","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154717_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00015","article-title":"DNA damage, repair, and cancer metabolism","volume":"8","author":"Turgeon","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrc.2026.154717_bib76","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.dnarep.2013.04.015","article-title":"DNA repair mechanisms in dividing and non-dividing cells","volume":"12","author":"Iyama","year":"2013","journal-title":"DNA Repair"},{"key":"10.1016\/j.bbrc.2026.154717_bib77","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/aja.2012.88","article-title":"DNA damage, NF-\u03baB and accelerated aging","volume":"14","author":"Le Couteur","year":"2012","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.bbrc.2026.154717_bib78","article-title":"A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival","volume":"8","author":"Samra","year":"2017","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10120946","article-title":"Tau and DNA damage in neurodegeneration","volume":"10","author":"Colnaghi","year":"2020","journal-title":"Brain Sci."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154717_bib80","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1242\/jcs.02907","article-title":"Tau protein binds to pericentromeric DNA:: a putative role for nuclear tau in nucleolar organization","volume":"119","author":"Sj\u00f6berg","year":"2006","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib81","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1570-9639(02)00538-1","article-title":"Tau could protect DNA double helix structure","volume":"1645","author":"Hua","year":"2003","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"10.1016\/j.bbrc.2026.154717_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-018-0565-6","article-title":"The involvement of tau in nucleolar transcription and the stress response","volume":"6","author":"Maina","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.bbrc.2026.154717_bib83","first-page":"17","article-title":"Chapter Two - Bioenergetic impairment-induced Tau acetylation: converging pathways in Alzheimer's disease","volume":"187","author":"B","year":"2026"},{"key":"10.1016\/j.bbrc.2026.154717_bib84","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1016\/j.bbadis.2018.07.011","article-title":"Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling","volume":"1864","author":"Cieri","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154717_bib85","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2174\/1568026615666150827095102","article-title":"Relationships between mitochondria and neuroinflammation: implications for Alzheimer's Disease","volume":"16","author":"Wilkins","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bbrc.2026.154717_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-83910-w","article-title":"Pathologically phosphorylated tau at S396\/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged wild-type mice","volume":"11","author":"Torres","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154717_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102697","article-title":"Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis","volume":"62","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib88","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2174\/1570159X14666160414111821","article-title":"Mitochondria and synaptic plasticity in the mature and aging nervous System","volume":"15","author":"Todorova","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bbrc.2026.154717_bib89","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3233\/JAD-200529","article-title":"Tau acetylation in entorhinal cortex induces its chronic hippocampal propagation and cognitive deficits in mice","volume":"77","author":"Wang","year":"2020","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2010.11.013","article-title":"Acetylation of Tau Inhibits its Degradation and Contributes to Tauopathy (vol 67, pg 953, 2010)","volume":"68","author":"Min","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2026.154717_bib91","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nm.3951","article-title":"Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits","volume":"21","author":"Min","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2026.154717_bib92","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4635163","article-title":"Resveratrol mitigates Hippocampal Tau acetylation and cognitive deficit by activation SIRT1 in aged rats following Anesthesia and surgery","volume":"2020","author":"Yan","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2026.154717_bib93","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.mito.2008.02.001","article-title":"Nuclear receptors, mitochondria and lipid metabolism","volume":"8","author":"Alaynick","year":"2008","journal-title":"Mitochondrion"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib94","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12264-013-1410-3","article-title":"Lipid metabolism in Alzheimer's disease","volume":"30","author":"Liu","year":"2014","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbrc.2026.154717_bib95","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.12659\/MSM.913937","article-title":"Resveratrol reduced liver damage after liver resection in a rat model by upregulating Sirtuin 1 (SIRT1) and inhibiting the Acetylation of High Mobility Group box 1 (HMGB1)","volume":"25","author":"Yu","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib96","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1007\/s12035-020-02079-x","article-title":"AMPK ameliorates tau acetylation and memory impairment through Sirt1","volume":"57","author":"Wang","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2026.154717_bib97","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1042\/BJ20111626","article-title":"Ceramide synthases at the centre of sphingolipid metabolism and biology","volume":"441","author":"Mullen","year":"2012","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib98","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.bbalip.2013.09.005","article-title":"Autophagy paradox and ceramide","volume":"1841","author":"Jiang","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"11","key":"10.1016\/j.bbrc.2026.154717_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113377","article-title":"Vitamin K2 as a New Modulator of the Ceramide De Novo Synthesis Pathway","volume":"26","author":"Kolakowski","year":"2021","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib100","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbalip.2013.02.001","article-title":"New insights on the role of ceramide 1-phosphate in inflammation","volume":"1831","author":"Gomez-Mu\u00f1oz","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib101","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1194\/jlr.M700480-JLR200","article-title":"Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins","volume":"49","author":"Stiban","year":"2008","journal-title":"JLR (J. Lipid Res.)"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154717_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10081956","article-title":"Diverse roles of ceramide in the progression and pathogenesis of Alzheimer's Disease","volume":"10","author":"Chowdhury","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib103","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0014-5793(93)80243-N","article-title":"The in-SITU degradation OF ceramide, a potential lipid MEDIATOR, IS not COMPLETELY impaired IN FARBER-DISease","volume":"329","author":"Levade","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2026.154717_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.04.011","article-title":"Amyloid \u03b2-induced ER stress is enhanced under mitochondrial dysfunction conditions","volume":"33","author":"Costa","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrc.2026.154717_bib105","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/cdd.2011.98","article-title":"mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway","volume":"19","author":"Kato","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2026.154717_bib106","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00232","article-title":"Interplay of energetics and ER stress exacerbates alzheimer's Amyloid-\u03b2 (A\u03b2) toxicity in yeast","volume":"10","author":"Chen","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154717_bib107","first-page":"6960","article-title":"ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bbrc.2026.154717_bib108","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1111\/j.1582-4934.2011.01374.x","article-title":"Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders","volume":"15","author":"Doyle","year":"2011","journal-title":"J. Cell Mol. Med."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154717_bib109","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.2174\/1570159X16666180416094646","article-title":"The role of IRE1 signaling in the central nervous System diseases","volume":"16","author":"Ni","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154717_bib110","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/00207454.2020.1715977","article-title":"Activating transcription factor 6 reduces A\u03b21-42 and restores memory in Alzheimer's disease model mice","volume":"130","author":"Du","year":"2020","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154717_bib111","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01799-4","article-title":"ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating \u03b3-secretase activity","volume":"8","author":"Zhu","year":"2017","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bbrc.2026.154717_bib112","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1007\/PL00000637","article-title":"Intracellular trafficking of AMPA receptors in synaptic plasticity","volume":"57","author":"Man","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib113","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.neuropharm.2010.12.028","article-title":"Ethanol modulation of synaptic plasticity","volume":"61","author":"McCool","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2026.154717_bib114","article-title":"From synaptic dynamics to cognitive decline: molecular insights into neuroplasticity","volume":"380","author":"Basavaraju","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib115","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"SCIENCE"},{"key":"10.1016\/j.bbrc.2026.154717_bib116","series-title":"Advances in Protein Chemistry and Structural Biology","article-title":"Understanding the impact of cytoskeleton disruption on synaptic plasticity in Alzheimer's disease","author":"Kc","year":"2025"},{"key":"10.1016\/j.bbrc.2026.154717_bib117","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basIS of cognitive alterations in alzheimers-dISease - synapse loss IS the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2026.154717_bib118","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1523\/JNEUROSCI.0225-08.2008","article-title":"Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone","volume":"28","author":"Chen","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154717_bib119","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0304-3940(91)90709-3","article-title":"The axonal origin of a subpopulation of dystrophic neurites in alzheimers-disease","volume":"129","author":"Tourtellotte","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2026.154717_bib120","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201600224","article-title":"Acetylated tau in Alzheimer's disease: an instigator of synaptic dysfunction underlying memory loss: increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy","volume":"39","author":"Tracy","year":"2017","journal-title":"Bioessays"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib121","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2016.03.005","article-title":"Acetylated Tau obstructs KIBRA-Mediated signaling in synaptic plasticity and promotes tauopathy-related memory loss","volume":"90","author":"Tracy","year":"2016","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib122","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuron.2010.08.044","article-title":"Acetylation of Tau inhibits its degradation and contributes to tauopathy","volume":"67","author":"Min","year":"2010","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib123","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96627-7","article-title":"Tau K321\/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation","volume":"11","author":"Xia","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib124","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13081","article-title":"Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models","volume":"19","author":"Choi","year":"2020","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.bbrc.2026.154717_bib125","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nm.3951","article-title":"Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits","volume":"21","author":"Min","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2026.154717_bib126","doi-asserted-by":"crossref","DOI":"10.1038\/srep44102","article-title":"A dual pathogenic mechanism links tau acetylation to sporadic tauopathy","volume":"7","author":"Trzeciakiewicz","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051360","article-title":"Acetylation disfavors tau phase separation","volume":"19","author":"Ferreon","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib128","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/hmg\/ddt402","article-title":"Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance","volume":"23","author":"Cook","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib129","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-41672-1","article-title":"Acetylation discriminates disease-specific tau deposition","volume":"14","author":"Chakraborty","year":"2023","journal-title":"Nat. Commun."},{"issue":"37","key":"10.1016\/j.bbrc.2026.154717_bib130","doi-asserted-by":"crossref","first-page":"15277","DOI":"10.1074\/jbc.M117.794602","article-title":"An acetylation\u2013phosphorylation switch that regulates tau aggregation propensity and function","volume":"292","author":"Carlomagno","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib131","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22501-9","article-title":"Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice","volume":"12","author":"Caballero","year":"2021","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154717_bib132","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70221","article-title":"Acetylation mimetic and null mutations within the filament core of P301L Tau have varied effects on susceptibility to seeding and aggregation","volume":"169","author":"Smith","year":"2025","journal-title":"J. Neurochem."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib133","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1158\/1535-7163.MCT-18-0511","article-title":"Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small-molecule inhibitor of p300\/CBP","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Cancer Therapeut."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2023.11.001","article-title":"Therapeutic targeting of EP300\/CBP by bromodomain inhibition in hematologic malignancies","volume":"41","author":"Nicosia","year":"2023","journal-title":"Cancer Cell"},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib135","article-title":"OPN-6602, a dual EP300\/CBP bromodomain inhibitor modulates androgen-driven transcription, including MYC, in mCRPC","volume":"22","author":"Matusow","year":"2023","journal-title":"Mol. Cancer Therapeut."},{"issue":"7","key":"10.1016\/j.bbrc.2026.154717_bib136","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1021\/acs.jmedchem.3c01789","article-title":"Discovery of CBPD-409 as a highly Potent, Selective, and Orally Efficacious CBP\/p300 PROTAC degrader for the treatment of advanced prostate cancer","volume":"67","author":"Chen","year":"2024","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib137","article-title":"Discovery of potent and selective EP300 degraders with anti-cancer activity","volume":"22","author":"Zimmerman","year":"2023","journal-title":"Mol. Cancer Therapeut."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib138","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000042","article-title":"Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers","volume":"2","author":"Venkatasubramanian","year":"2013","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib139","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/MIB.0000000000000597","article-title":"Assessing colonic exposure, safety, and clinical activity of SRT2104, a novel oral SIRT1 activator, in patients with mild to moderate ulcerative colitis","volume":"22","author":"Sands","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib140","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1302\/2046-3758.73.BJR-2017-0227.R1","article-title":"Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice","volume":"7","author":"Nishida","year":"2018","journal-title":"BONE & JOINT RESEARCH"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib141","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1039\/D3MD00489A","article-title":"Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying in vivo cardioprotective activities","volume":"15","author":"Bononi","year":"2024","journal-title":"RSC Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bbrc.2026.154717_bib142","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11010-012-1344-5","article-title":"Metformin interacts with AMPK through binding to \u03b3 subunit","volume":"368","author":"Zhang","year":"2012","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib143","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.celrep.2019.03.067","article-title":"Phenformin, but not metformin, delays development of T cell acute lymphoblastic Leukemia\/Lymphoma via cell-autonomous AMPK activation","volume":"27","author":"Vara-Ciruelos","year":"2019","journal-title":"Cell Rep."},{"issue":"28","key":"10.1016\/j.bbrc.2026.154717_bib144","doi-asserted-by":"crossref","first-page":"10281","DOI":"10.1080\/10408398.2023.2222404","article-title":"Targeting gut-brain axis by dietary flavonoids ameliorate aging-related cognition decline: evidences and mechanisms","volume":"64","author":"Chu","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbrc.2026.154717_bib145","article-title":"Potential implications of polyphenolic compounds in neurodegenerative diseases","author":"Shi","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib197","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2012.01.017","article-title":"Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases","volume":"148","author":"Park","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154717_bib198","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.2010.05842.x","article-title":"Bioavailability of resveratrol","volume":"1215","author":"Walle","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib178","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.lfs.2017.11.004","article-title":"Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration","volume":"193","author":"Singh","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib199","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.biopha.2018.07.079","article-title":"Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine","volume":"106","author":"Mehta","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib179","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbrc.2015.10.094","article-title":"Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells","volume":"467","author":"Kim","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154717_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107600","article-title":"Anti-inflammatory effects of curcumin in acute lung injury: in vivo and in vitro experimental model studies","volume":"96","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib201","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0300-483X(80)90122-5","article-title":"Absorption and tissue distribution of curcumin in rats","volume":"16","author":"Ravindranath","year":"1980","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154717_bib202","doi-asserted-by":"crossref","DOI":"10.1177\/1753425920933656","article-title":"Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1\/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats","volume":"26","author":"Yin","year":"2020","journal-title":"Innate Immun."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib203","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.18632\/aging.202566","article-title":"Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages","volume":"13","author":"Zheng","year":"2021","journal-title":"AGING-US"},{"issue":"11","key":"10.1016\/j.bbrc.2026.154717_bib204","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1007\/s00210-024-03199-0","article-title":"Research progress on pharmacological effects and bioavailability of berberine","volume":"397","author":"Cui","year":"2024","journal-title":"Naunyn-Schmiedebergs Archives Of Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154717_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104918","article-title":"Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling","volume":"89","author":"Alagal","year":"2022","journal-title":"J. Funct.Foods"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154717_bib206","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bdd.677","article-title":"Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats","volume":"30","author":"Barve","year":"2009","journal-title":"Biopharm. Drug Dispos."},{"issue":"10","key":"10.1016\/j.bbrc.2026.154717_bib207","doi-asserted-by":"crossref","first-page":"18192","DOI":"10.1002\/jcp.28452","article-title":"Quercetin attenuates oxidative stress-induced apoptosis via SIRT1\/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model","volume":"234","author":"Feng","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2026.154717_bib208","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.tifs.2021.11.032","article-title":"Recent advances on the improvement of quercetin bioavailability","volume":"119","author":"Kandemir","year":"2022","journal-title":"Trends Food Sci. Technol."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib209","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1142\/S0192415X21500063","article-title":"Epigallocatechin gallate reduces homocysteine-caused oxidative damages through modulation SIRT1\/AMPK pathway in endothelial cells","volume":"49","author":"Pai","year":"2021","journal-title":"Am. J. Chin. Med."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154717_bib210","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1021\/jf000386x","article-title":"Identification of biliary metabolites of (\u2212)-Epigallocatechin gallate in rats","volume":"48","author":"Kida","year":"2000","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib211","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-025-10587-z","article-title":"Nobiletin potentially reduce lipid accumulation by up-regulating the SIRT1-AMPK signaling pathway in HepG2 hepatocarcinoma cells","volume":"52","author":"Shokri-Afra","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154717_bib212","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1002\/jps.22585","article-title":"Development of high-energy amorphous solid dispersion of Nanosized Nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability","volume":"100","author":"Onoue","year":"2011","journal-title":"J. Pharmaceut. Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153412","article-title":"Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-\/- mice: role of SIRT1","volume":"81","author":"Hua","year":"2021","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154717_bib214","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10071686","article-title":"Naringin and naringenin: their mechanisms of action and the potential anticancer activities","volume":"10","author":"Stabrauskiene","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2026.154717_bib215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.lfs.2018.10.066","article-title":"Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: an update","volume":"215","author":"Joshi","year":"2018","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154717_bib216","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1507\/endocrj.EJ20-0747","article-title":"Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose\/high fat-induced dysfunction in human umbilical vein endothelial cells","volume":"68","author":"Ye","year":"2021","journal-title":"Endocr. J."},{"issue":"21","key":"10.1016\/j.bbrc.2026.154717_bib217","doi-asserted-by":"crossref","DOI":"10.3390\/nu17213316","article-title":"Natural compounds targeting SIRT1 and beyond: promising nutraceutical strategies against atherosclerosis","volume":"17","author":"Domi","year":"2025","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib232","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jphs.2017.12.013","article-title":"Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes","volume":"136","author":"Sunagawa","year":"2018","journal-title":"J. Pharmacol. Sci."},{"issue":"41","key":"10.1016\/j.bbrc.2026.154717_bib233","doi-asserted-by":"crossref","first-page":"43806","DOI":"10.18632\/oncotarget.6245","article-title":"Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model","volume":"6","author":"Selvi","year":"2015","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib234","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9121271","article-title":"Inhibition of p300 by garcinol protects against cisplatin-induced acute kidney injury through suppression of oxidative stress, inflammation, and tubular cell death in mice","volume":"9","author":"Kim","year":"2020","journal-title":"Antioxidants"},{"issue":"21","key":"10.1016\/j.bbrc.2026.154717_bib235","doi-asserted-by":"crossref","first-page":"19134","DOI":"10.1074\/jbc.M301580200","article-title":"Small molecule modulators of histone acetyltransferase p300","volume":"278","author":"Balasubramanyam","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib220","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/cdd.2014.215","article-title":"Spermidine induces autophagy by inhibiting the acetyltransferase EP300","volume":"22","author":"Pietrocola","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2026.154717_bib236","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1042\/BJ20100980","article-title":"Procyanidin B3, an inhibitor of histone acetyltransferase, enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor","volume":"433","author":"Choi","year":"2011","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib237","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/jmf.2019.4670","article-title":"Plumbagin suppresses pulmonary fibrosis via inhibition of p300 histone acetyltransferase activity","volume":"23","author":"Lee","year":"2020","journal-title":"J. Med. Food"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154717_bib238","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022934","article-title":"Quercetin suppresses Cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling","volume":"6","author":"Xiao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.154717_bib239","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150061","article-title":"Apigenin suppresses epithelial-mesenchymal transition in high glucose-induced retinal pigment epithelial cell by inhibiting CBP\/p300-mediated histone acetylation","volume":"717","author":"Li","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2026.154717_bib146","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.freeradbiomed.2013.07.007","article-title":"SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury","volume":"65","author":"Yang","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bbrc.2026.154717_bib147","doi-asserted-by":"crossref","DOI":"10.1038\/srep38186","article-title":"Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation","volume":"6","author":"Hou","year":"2016","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.bbrc.2026.154717_bib148","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1074\/jbc.M501250200","article-title":"Mechanism of human SIRT1 activation by resveratrol","volume":"280","author":"Borra","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100929","article-title":"Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism","volume":"297","author":"Huang","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib150","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2026.154717_bib151","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1354809","article-title":"Nobiletin from citrus peel: a promising therapeutic agent for liver disease-pharmacological characteristics, mechanisms, and potential applications","volume":"15","author":"Cheng","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib152","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1007\/s10787-023-01292-z","article-title":"The citrus flavonoid \"Nobiletin\" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1\/FoxO3a mechanism","volume":"31","author":"El-Maraghy","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbrc.2026.154717_bib153","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s12276-019-0245-z","article-title":"Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1\/FOXO3a-mediated autophagy and mitochondrial biogenesis","volume":"51","author":"Dusabimana","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib154","article-title":"Extraction of Nobiletin and tangeretin from peels of Shekwasha and Ponkan using [C2mim][(MeO)(H)PO2] and centrifugation","volume":"14","author":"Mizuno","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.bbrc.2026.154717_bib155","doi-asserted-by":"crossref","DOI":"10.1186\/s13020-017-0127-z","article-title":"Chemical compositions, chromatographic fingerprints and antioxidant activities of Citri Exocarpium Rubrum (Juhong)","volume":"12","author":"Zhao","year":"2017","journal-title":"Chin. Med."},{"key":"10.1016\/j.bbrc.2026.154717_bib156","article-title":"Role of the cAMP-PKA-CREB pathway in depression: mechanisms and therapeutic implications","volume":"1865","author":"Liu","year":"2025","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib157","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.intimp.2014.01.011","article-title":"Tangeretin exerts anti-neuroinflammatory effects via NF-\u03baB modulation in lipopolysaccharide-stimulated microglial cells","volume":"19","author":"Shu","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib158","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70516","article-title":"Tangeretin improves the memory of Swiss mice, suggesting potential molecular interventions through animal behavior assessments and in Silico studies","volume":"15","author":"Al Hasan","year":"2025","journal-title":"BRAIN AND BEHAVIOR"},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib159","article-title":"An update on the potential of tangeretin in the management of neuroinflammation-mediated neurodegenerative disorders","volume":"14","author":"Wani","year":"2024","journal-title":"LIFE-BASEL"},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib160","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s10787-023-01167-3","article-title":"Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats: targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis","volume":"31","author":"Sedik","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"7","key":"10.1016\/j.bbrc.2026.154717_bib161","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib162","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: from extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"issue":"17","key":"10.1016\/j.bbrc.2026.154717_bib163","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26178555","article-title":"Hormetic effects of curcumin in RPE cells: SIRT1 and Caspase-3 inactivation with implications for AMD","volume":"26","author":"Di Gregorio","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.bbrc.2026.154717_bib164","doi-asserted-by":"crossref","DOI":"10.3390\/nu17172884","article-title":"The neuroprotective role of curcumin: from molecular pathways to clinical Translation-A narrative review","volume":"17","author":"Lehoczki","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.154717_bib165","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8492780","article-title":"Quercetin isolated from Toona sinensis leaves attenuates hyperglycemia and protects hepatocytes in High-Carbohydrate\/High-Fat diet and alloxan induced experimental diabetic Mice","volume":"2016","author":"Zhang","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbrc.2026.154717_bib166","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.943321","article-title":"Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib167","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2020.9410","article-title":"Quercetin modulates AMPK\/SIRT1\/NF-\u03baB signaling to inhibit inflammatory\/oxidative stress responses in diabetic high fat diet-induced atherosclerosis in the rat carotid artery","volume":"20","author":"Zhang","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"13","key":"10.1016\/j.bbrc.2026.154717_bib168","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137461","article-title":"Quercetin modulates ferroptosis via the SIRT1\/Nrf-2\/HO-1 pathway and attenuates cartilage destruction in an Osteoarthritis Rat model","volume":"25","author":"Ruan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib169","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuro.2023.06.008","article-title":"Neuroprotective effect of quercetin and nano-quercetin against cyclophosphamide-induced oxidative stress in the rat brain: role of Nrf2\/HO-1\/Keap-1 signaling pathway","volume":"98","author":"AbdElrazek","year":"2023","journal-title":"Neurotoxicology"},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib170","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1023\/B:JOCI.0000040925.55682.a5","article-title":"Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte","volume":"24","author":"Muthian","year":"2004","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.bbrc.2026.154717_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104675","article-title":"Quercetin improves the impairment in memory function and attenuates hippocampal damage in cadmium chloride-intoxicated male rats by suppressing acetylcholinesterase and concomitant activation of SIRT1 signaling","volume":"86","author":"Alshammari","year":"2021","journal-title":"J. Funct.Foods"},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib172","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/ars.2012.4901","article-title":"Fisetin: a dietary antioxidant for health promotion","volume":"19","author":"Khan","year":"2013","journal-title":"Antioxid. Redox Signaling"},{"issue":"8","key":"10.1016\/j.bbrc.2026.154717_bib173","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.jnutbio.2013.01.003","article-title":"Fisetin regulates obesity by targeting mTORC1 signaling","volume":"24","author":"Jung","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2026.154717_bib174","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.lfs.2019.02.017","article-title":"Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy","volume":"221","author":"Althunibat","year":"2019","journal-title":"Life Sci."},{"issue":"31","key":"10.1016\/j.bbrc.2026.154717_bib175","doi-asserted-by":"crossref","first-page":"8291","DOI":"10.1021\/acs.jafc.8b02140","article-title":"Fisetin Attenuates metabolic dysfunction in mice challenged with a high-fructose diet","volume":"66","author":"Shi","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2026.154717_bib176","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejphar.2014.06.065","article-title":"Fisetin improves glucose homeostasis through the inhibition of gluconeogenic enzymes in hepatic tissues of streptozotocin induced diabetic rats","volume":"740","author":"Prasath","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154717_bib177","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9173436","article-title":"Fisetin confers cardioprotection against myocardial ischemia reperfusion injury by suppressing mitochondrial oxidative stress and mitochondrial dysfunction and inhibiting glycogen synthase kinase 3\u03b2 activity","volume":"2018","author":"Shanmugam","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"43","key":"10.1016\/j.bbrc.2026.154717_bib180","doi-asserted-by":"crossref","first-page":"10468","DOI":"10.1021\/jf502849j","article-title":"Fisetin Up-regulates the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-Deacetylase and peroxisome proliferator-activated receptors (PPARs)","volume":"62","author":"Jin","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.bbrc.2026.154717_bib181","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10571-019-00756-7","article-title":"Berberine attenuated the cytotoxicity induced by t-BHP via inhibiting oxidative stress and mitochondria dysfunction in PC-12 cells","volume":"40","author":"Li","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib182","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123903","article-title":"Combination of berberine with resveratrol improves the lipid-lowering efficacy","volume":"19","author":"Zhu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib183","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.biopha.2017.09.010","article-title":"Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0\/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways","volume":"95","author":"Li","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib184","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/1673-5374.344841","article-title":"Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease","volume":"18","author":"Wang","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"5","key":"10.1016\/j.bbrc.2026.154717_bib185","doi-asserted-by":"crossref","DOI":"10.3390\/cells11050796","article-title":"Therapeutic efficacies of berberine against neurological disorders: an update of pharmacological effects and mechanisms","volume":"11","author":"Shou","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2026.154717_bib186","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2147\/CMAR.S242329","article-title":"The anti-cancer mechanisms of berberine: a review","volume":"12","author":"Wang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.bbrc.2026.154717_bib187","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1689602","article-title":"Berberine Attenuates myocardial Ischemia\/Reperfusion Injury by reducing oxidative stress and inflammation response: role of silent information Regulator 1","volume":"2016","author":"Yu","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib188","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/aps.2015.136","article-title":"Berberine protects rat heart from ischemia\/reperfusion injury via activating JAK2\/STAT3 signaling and attenuating endoplasmic reticulum stress","volume":"37","author":"Zhao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2026.154717_bib189","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.fct.2017.11.025","article-title":"Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and alzheimer's-like disease in rats","volume":"111","author":"Hussien","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib190","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1101\/gad.265462.115","article-title":"Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol","volume":"29","author":"Cao","year":"2015","journal-title":"Genes Dev."},{"issue":"23","key":"10.1016\/j.bbrc.2026.154717_bib191","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315105","article-title":"Resveratrol-like compounds as SIRT1 activators","volume":"23","author":"Ciccone","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bbrc.2026.154717_bib192","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5114\/bta.2023.127206","article-title":"Computational evaluation of bioactive compounds in Curcuma zanthorrhiza targeting SIRT1 and NF\u03baB","volume":"104","author":"Prasetyawan","year":"2023","journal-title":"Biotechnologia"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib193","article-title":"Quercetin 3,5,7,3\u2032,4\u2032-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1","volume":"4","author":"Zhang","year":"2021","journal-title":"Commun. Biol."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib194","doi-asserted-by":"crossref","DOI":"10.1007\/s11011-025-01567-0","article-title":"Effects of quercetin and derivatives on NAMPT\/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment","volume":"40","author":"John","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbrc.2026.154717_bib195","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.33263\/BRIAC126.76217632","article-title":"Identification of structurally similar phytochemicals to Quercetin with high SIRT1 binding affinity and improving diabetic wound healing by using in silico approaches","volume":"12","author":"Dubey","year":"2021","journal-title":"Biointerface Res. Appl. Chem."},{"key":"10.1016\/j.bbrc.2026.154717_bib196","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2026.149800","article-title":"Identification and evaluation of citrus peel-derived polymethoxyflavonoids as natural SIRT1 activators","volume":"520","author":"Ko","year":"2026","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib218","doi-asserted-by":"crossref","DOI":"10.3390\/ph10010031","article-title":"Anacardic acid constituents from Cashew Nut Shell Liquid: NMR characterization and the effect of unsaturation on its biological activities","volume":"10","author":"Morais","year":"2017","journal-title":"Pharmaceuticals"},{"issue":"10","key":"10.1016\/j.bbrc.2026.154717_bib219","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1182\/blood-2007-10-117994","volume":"111","author":"Sung","year":"2008","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib221","doi-asserted-by":"crossref","DOI":"10.3390\/ph14121338","article-title":"Pharmacological activity of Garcinia indica (Kokum): an updated review","volume":"14","author":"Lim","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"6","key":"10.1016\/j.bbrc.2026.154717_bib222","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062828","article-title":"Garcinol-A natural histone acetyltransferase inhibitor and new anti-cancer epigenetic drug","volume":"22","author":"Kopytko","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bbrc.2026.154717_bib223","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.7314\/APJCP.2014.15.12.5001","article-title":"Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17\u03b2-Estradiol","volume":"15","author":"Ye","year":"2014","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.bbrc.2026.154717_bib224","article-title":"Garcinol reduces streptozotocin-induced Alzheimer's like phenotypes and neuropathology in rats","volume":"142","author":"Paidi","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2026.154717_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111888","article-title":"Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential","volume":"141","author":"Fu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154717_bib226","article-title":"A natural p300-specific histone acetyltransferase inhibitor, curcumin, prevents the development heart failure in rats","volume":"21","author":"Morimoto","year":"2007","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"3","key":"10.1016\/j.bbrc.2026.154717_bib227","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1128\/AAC.02055-15","article-title":"C646, a novel p300\/CREB-Binding protein-specific inhibitor of Histone acetyltransferase, attenuates influenza A virus infection","volume":"60","author":"Zhao","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrc.2026.154717_bib228","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2020.107756","article-title":"Computational insights into the binding mode of curcumin analogues against EP300 HAT domain as potent acetyltransferase inhibitors","volume":"101","author":"Kandagalla","year":"2020","journal-title":"J. Mol. Graph. Model."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154717_bib229","doi-asserted-by":"crossref","DOI":"10.3390\/foods10081752","article-title":"Occurrence of polyamines in foods and the influence of cooking processes","volume":"10","author":"Mu\u00f1oz-Esparza","year":"2021","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.bbrc.2026.154717_bib230","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-026-11827-6","article-title":"Spermidine in the aging brain: mechanisms, preclinical evidence, and clinical perspectives","volume":"53","author":"Pandolfi","year":"2026","journal-title":"Mol. Biol. Rep."},{"issue":"9","key":"10.1016\/j.bbrc.2026.154717_bib231","doi-asserted-by":"crossref","DOI":"10.1038\/s41556-024-01468-x","article-title":"Spermidine is essential for fasting-mediated autophagy and longevity","volume":"26","author":"Hofer","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"7S_Part_5","key":"10.1016\/j.bbrc.2026.154717_bib240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2017.06.151","article-title":"[P1\u2013084]: long-term DRINKING INDUCES tau hyperphosphorylation and cognitive DEFICIT","volume":"13","author":"Fang","year":"2017","journal-title":"Alzheimer's Dement."},{"issue":"8","key":"10.1016\/j.bbrc.2026.154717_bib241","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084192","article-title":"Alzheimer's Disease and Tau Self-Assembly: in the search of the missing link","volume":"23","author":"Gonz\u00e1lez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2026.154717_bib242","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00163","article-title":"The Association of Tau with mitochondrial dysfunction in Alzheimer's Disease","volume":"12","author":"Cheng","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2026.154717_bib243","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2012.00014","article-title":"Microglia function in Alzheimer's disease","volume":"3","author":"Solito","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2026.154717_bib244","article-title":"Microglia in the neuroinflammatory pathogenesis of Alzheimer's Disease and related therapeutic targets","volume":"13","author":"Cai","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2601483X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2601483X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:02:48Z","timestamp":1793782968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2601483X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":244,"alternative-id":["S0006291X2601483X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154717","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting tau acetylation in Alzheimer's disease: Molecular mechanisms, pathological consequences, and therapeutic opportunities of dietary phytochemicals","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154717"}}