{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:31:13Z","timestamp":1793784673678,"version":"4.6.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,10,12]],"date-time":"2027-10-12T00:00:00Z","timestamp":1823299200000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H05683"],"award-info":[{"award-number":["JP20H05683"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 25H00923"],"award-info":[{"award-number":["JP 25H00923"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 25K09018"],"award-info":[{"award-number":["JP 25K09018"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbrc.2026.154724","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:51:14Z","timestamp":1791561074000},"page":"154724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Delphinidin induces the upregulation of miR-23a-3p expression in skeletal muscle and miR-23a-3p release from intestinal cells"],"prefix":"10.1016","volume":"839","author":[{"given":"Yuki","family":"Marugame","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riku","family":"Migihashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Morozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motofumi","family":"Kumazoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0798-0649","authenticated-orcid":false,"given":"Yoshinori","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154724_bib1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0031-9422(03)00438-2","article-title":"Analysis and biological activities of anthocyanins","volume":"64","author":"Kong","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bbrc.2026.154724_bib2","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1080\/10715760600758522","article-title":"Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities","volume":"40","author":"Prior","year":"2006","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbrc.2026.154724_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.62313\/ijpbp.2022.22","article-title":"Anthocyanins: Plant-based flavonoid pigments with diverse biological activities","volume":"2","author":"Patra","year":"2022","journal-title":"Int. J. Plant Based Pharma."},{"key":"10.1016\/j.bbrc.2026.154724_bib4","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.foodchem.2008.09.001","article-title":"Chemical studies of anthocyanins: a review","volume":"113","author":"Casta\u00f1eda-Ovando","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrc.2026.154724_bib5","doi-asserted-by":"crossref","first-page":"11288","DOI":"10.1021\/acs.jafc.9b05079","article-title":"The multifunctional benefits of naturally occurring delphinidin and its glycosides","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2026.154724_bib6","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1080\/09168451.2016.1184560","article-title":"Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression","volume":"80","author":"Murata","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.bbrc.2026.154724_bib7","article-title":"Delphinidin induces a fast-to-slow muscle fiber type shift through the AMPK signaling pathway in C2C12 myotubes","volume":"40","author":"Murata","year":"2024","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.bbrc.2026.154724_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154724_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s13105-010-0050-6","article-title":"Biological functions of microRNAs: a review","volume":"67","author":"Huang","year":"2011","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.bbrc.2026.154724_bib10","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.3390\/nu14091861","article-title":"miR-222 is involved in the amelioration effect of genistein on dexamethasone-induced skeletal muscle atrophy","volume":"14","author":"Gan","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2026.154724_bib11","article-title":"Green Tea epigallocatechin gallate inhibits preadipocyte growth via the microRNA-let-7a\/HMGA2 signaling pathway","volume":"67","author":"Chen","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbrc.2026.154724_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.12938\/bmfh.2022-056","article-title":"Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer","volume":"42","author":"Murata","year":"2023","journal-title":"Biosci. Microbiota Food Health"},{"key":"10.1016\/j.bbrc.2026.154724_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1021\/acs.jafc.6b03661","article-title":"Delphinidin prevents muscle atrophy and upregulates miR-23a expression","volume":"65","author":"Murata","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2026.154724_bib14","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"Del Rio","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbrc.2026.154724_bib15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154724_bib16","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","article-title":"Secretory mechanisms and intercellular transfer of microRNAs in living cells","volume":"285","author":"Kosaka","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154724_bib17","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbagen.2012.03.017","article-title":"Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials","volume":"1820","author":"Vlassov","year":"2012","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbrc.2026.154724_bib18","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/1878-0261.12144","article-title":"Cell-to-cell communication: MicroRNAs as hormones","volume":"11","author":"Bayraktar","year":"2017","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bbrc.2026.154724_bib19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2026.154724_bib20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41419-024-06791-7","article-title":"The miR-29 family facilitates the activation of NK-cell immune responses by targeting the B7-H3 immune checkpoint in neuroblastoma","volume":"15","author":"Pathania","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2026.154724_bib21","doi-asserted-by":"crossref","first-page":"446","DOI":"10.62347\/BXFG4038","article-title":"miR-143 promotes cell proliferation, invasion and migration via directly binding to BRD2 in lens epithelial cells","volume":"16","author":"Chen","year":"2024","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbrc.2026.154724_bib22","first-page":"19","article-title":"(\u2212)-Epigallocatechin-3-O-gallate upregulates the expression levels of miR-6757-3p, a suppressor of fibrosis-related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells, Biomed","volume":"18","author":"Murata","year":"2023","journal-title":"Rep"},{"key":"10.1016\/j.bbrc.2026.154724_bib23","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.1007\/s11033-022-07918-9","article-title":"Circulating miRNA profiles in mice plasma following flavonoid intake","volume":"49","author":"Murata","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbrc.2026.154724_bib24","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Bodine","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2026.154724_bib25","doi-asserted-by":"crossref","first-page":"38456","DOI":"10.1074\/jbc.M111.271270","article-title":"Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy","volume":"286","author":"Wada","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154724_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112810","article-title":"Intestinal epithelial cell-derived exosomes package microRNA-23a-3p alleviate gut damage after ischemia\/reperfusion via targeting MAP4K4","volume":"149","author":"Yang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2026.154724_bib27","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1021\/acsfoodscitech.5c00322","article-title":"Regulatory effect of oolonghomobisflavan B on the expression of miRNAs secreted by intestinal cells","volume":"5","author":"Marugame","year":"2025","journal-title":"ACS Food Sci. Technol."},{"key":"10.1016\/j.bbrc.2026.154724_bib28","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2026.154724_bib29","doi-asserted-by":"crossref","first-page":"12103","DOI":"10.1073\/pnas.0811371106","article-title":"miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy","volume":"106","author":"Lin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.bbrc.2026.154724_bib30","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbagrm.2014.07.009","article-title":"Identification of regulatory elements directing miR-23a\u2013miR-27a\u2013miR-24-2 transcriptional regulation in response to muscle hypertrophic stimuli","volume":"1839","author":"Hernandez-Torres","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2026.154724_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110875","article-title":"Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells","volume":"39","author":"Matsui","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2026.154724_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12935-019-0927-6","article-title":"NEAT1\/miR-23a-3p\/KLF3: a novel regulatory axis in melanoma cancer progression","volume":"19","author":"Ding","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbrc.2026.154724_bib33","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s11626-021-00606-1","article-title":"miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1","volume":"57","author":"Sheng","year":"2021","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.bbrc.2026.154724_bib34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.prp.2018.12.021","article-title":"miR-23a-3p suppresses cell proliferation in oral squamous cell carcinomas by targeting FGF2 and correlates with a better prognosis: miR-23a-3p inhibits OSCC growth by targeting FGF2","volume":"215","author":"Chen","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bbrc.2026.154724_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12033-023-00746-7","article-title":"The role of microRNA-23a-3p in the progression of human aging process by targeting FOXO3a","volume":"66","author":"Wang","year":"2024","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.bbrc.2026.154724_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1083\/jcb.201212113","article-title":"Exosomes: looking back three decades and into the future","volume":"200","author":"Harding","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2026.154724_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nature14626","article-title":"Diagnosis by extracellular vesicles","volume":"523","author":"Th\u00e9ry","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2026.154724_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-64924-6","article-title":"Hyaluronidase inhibitor delphinidin inhibits cancer metastasis","volume":"14","author":"McGuire","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2026.154724_bib39","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.18632\/aging.102956","article-title":"Delphinidin attenuates pathological cardiac hypertrophy via the AMPK\/NOX\/MAPK signaling pathway","volume":"12","author":"Chen","year":"2020","journal-title":"Aging (albany NY)"},{"key":"10.1016\/j.bbrc.2026.154724_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41531-025-01244-0","article-title":"Delphinidin modulates neuroinflammation and behavioral deficits in a Parkinson's disease mouse model","volume":"12","author":"Grotemeyer","year":"2026","journal-title":"npj Parkinson's Dis."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26014907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:05:24Z","timestamp":1793783124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26014907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":40,"alternative-id":["S0006291X26014907"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154724","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delphinidin induces the upregulation of miR-23a-3p expression in skeletal muscle and miR-23a-3p release from intestinal cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154724"}}