{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:32:46Z","timestamp":1793251966705,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:00:00Z","timestamp":1792972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbrc.2026.154767","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:54:16Z","timestamp":1792684456000},"page":"154767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The transcriptional repressor Gfi1 is critical for the differentiation of pathogenic Th2 cells"],"prefix":"10.1016","volume":"840","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1029-1396","authenticated-orcid":false,"given":"Hiroki","family":"Tokiwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yabushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2026.154767_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nri.2017.118","article-title":"T(H)2 cell development and function","volume":"18","author":"Walker","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41423-025-01261-2","article-title":"Type 2 immunity in allergic diseases","volume":"22","author":"Ogulur","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib5","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0140-6736(22)02125-0","article-title":"Asthma","volume":"401","author":"Porsbjerg","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2026.154767_bib6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jaci.2012.06.034","article-title":"IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies","volume":"130","author":"Ingram","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.immuni.2015.01.016","article-title":"The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway","volume":"42","author":"Endo","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154767_bib8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jaci.2015.08.007","article-title":"Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function","volume":"137","author":"Mitson-Salazar","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam9171","article-title":"A phenotypically and functionally distinct human T(H)2 cell subpopulation is associated with allergic disorders","volume":"9","author":"Wambre","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2026.154767_bib10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4049\/jimmunol.1600397","article-title":"Transcriptional profiling of Th2 cells identifies pathogenic features associated with asthma","volume":"197","author":"Seumois","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib11","doi-asserted-by":"crossref","first-page":"18214","DOI":"10.1073\/pnas.0608981103","article-title":"Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion","volume":"103","author":"Zhu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2026.154767_bib12","doi-asserted-by":"crossref","first-page":"28216","DOI":"10.1074\/jbc.M804174200","article-title":"Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation","volume":"283","author":"Shinnakasu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154767_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061785","article-title":"A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus","volume":"8","author":"Suzuki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2026.154767_bib14","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/ni.2743","article-title":"Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1","volume":"14","author":"Spooner","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib15","article-title":"Developmental Gfi1 dynamics define hematopoietic emergence and adult hematopoietic stem cell potency","author":"Yabushita","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbrc.2026.154767_bib16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.immuni.2011.12.012","article-title":"Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells","volume":"36","author":"Miyao","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154767_bib17","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ni.2362","article-title":"The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-beta and suppresses T(H)2 differentiation","volume":"13","author":"Kuwahara","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbaexp.2005.01.012","article-title":"T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3","volume":"1728","author":"Hayakawa","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2026.154767_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/intimm\/dxag015","article-title":"Lipid metabolic regulation of pathogenic type 2 immunity in the airway","volume":"38","author":"Yagyu","year":"2026","journal-title":"Int. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib20","doi-asserted-by":"crossref","first-page":"48502","DOI":"10.1074\/jbc.M107836200","article-title":"GATA-3 has dual regulatory functions in human interleukin-5 transcription","volume":"276","author":"Schwenger","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154767_bib21","doi-asserted-by":"crossref","first-page":"42399","DOI":"10.1074\/jbc.M205876200","article-title":"Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus","volume":"277","author":"Yamashita","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2026.154767_bib22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1074-7613(03)00179-1","article-title":"Regulation of the Th2 cytokine locus by a locus control region","volume":"19","author":"Lee","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2026.154767_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ni1148","article-title":"Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions","volume":"6","author":"Lee","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2026.154767_bib24","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.immuni.2011.08.017","article-title":"Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3","volume":"35","author":"Endo","year":"2011","journal-title":"Immunity"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26015330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X26015330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:00:54Z","timestamp":1793250054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X26015330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":24,"alternative-id":["S0006291X26015330"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154767","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The transcriptional repressor Gfi1 is critical for the differentiation of pathogenic Th2 cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2026.154767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154767"}}