{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:17:23Z","timestamp":1773307043737,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Heart and Stroke Foundation of Canada and Laurentian University","award":["#1092582"],"award-info":[{"award-number":["#1092582"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.bbrep.2015.11.012","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T23:12:33Z","timestamp":1448925153000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Thioredoxin 1 regulation of protein S -desulfhydration"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-1494","authenticated-orcid":false,"given":"Youngjun","family":"Ju","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangdong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2015.11.012_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrep.2015.11.012_bib2","doi-asserted-by":"crossref","first-page":"re2","DOI":"10.1126\/scisignal.268re2","article-title":"Signaling by gasotransmitters","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrep.2015.11.012_bib3","first-page":"e337","article-title":"Protein S-sulfhydration as a major source of H2S bioactivity","volume":"1","author":"Yang","year":"2014","journal-title":"Recept. Clin. Investig."},{"key":"10.1016\/j.bbrep.2015.11.012_bib4","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrep.2015.11.012_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/anie.201305876","article-title":"Detection of protein S-sulfhydration by a tag-switch technique","volume":"53","author":"Zhang","year":"2014","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bbrep.2015.11.012_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-kappaB mediates its antiapoptotic actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrep.2015.11.012_bib7","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrep.2015.11.012_bib8","doi-asserted-by":"crossref","first-page":"ra86","DOI":"10.1126\/scisignal.2002329","article-title":"H2S-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response","volume":"4","author":"Krishnan","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrep.2015.11.012_bib9","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1089\/ars.2013.5604","article-title":"Sulfhydration of p66Shc at cysteine59 mediates the anti-oxidant effect of Hydrogen Sulfide","volume":"21","author":"Xie","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.bbrep.2015.11.012_bib10","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbrep.2015.11.012_bib11","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nchembio.1018","article-title":"Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration","volume":"8","author":"Nishida","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrep.2015.11.012_bib12","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/embr.201338213","article-title":"S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair","volume":"15","author":"Zhao","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrep.2015.11.012_bib13","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1089\/ars.2014.6186","article-title":"Hydrogen sulfide maintains mitochondrial DNA replication via demethylation of TFAM","volume":"23","author":"Li","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbrep.2015.11.012_bib14","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbagen.2015.08.003","article-title":"H2S-induced of pyruvate carboxylase contributes to gluconeogenesis in liver cells","volume":"1850","author":"Ju","year":"2015","journal-title":"Biochem. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbrep.2015.11.012_bib15","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1126\/science.1158265","article-title":"Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins","volume":"320","author":"Benhar","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbrep.2015.11.012_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2005.03.012","article-title":"Src kinase regulation by phosphorylation and dephosphorylation","volume":"331","author":"Roskoski","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrep.2015.11.012_bib17","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1128\/MCB.20.6.2198-2208.2000","article-title":"Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin","volume":"20","author":"Liu","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrep.2015.11.012_bib18","doi-asserted-by":"crossref","first-page":"36160","DOI":"10.1074\/jbc.M109.057729","article-title":"Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation","volume":"284","author":"Forrester","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2015.11.012_bib19","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jmb.2004.11.004","article-title":"Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster","volume":"345","author":"Wahl","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrep.2015.11.012_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.stem.2014.03.005","article-title":"Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca(2+) Channel Sulfhydration","volume":"15","author":"Liu","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrep.2015.11.012_bib21","doi-asserted-by":"crossref","first-page":"ra87","DOI":"10.1126\/scisignal.2005478","article-title":"The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide","volume":"7","author":"Altaany","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrep.2015.11.012_bib22","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","article-title":"Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1","volume":"17","author":"Saitoh","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrep.2015.11.012_bib23","doi-asserted-by":"crossref","first-page":"11609","DOI":"10.1073\/pnas.0704898104","article-title":"Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells","volume":"104","author":"Mitchell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2015.11.012_bib24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bbagen.2011.08.012","article-title":"The role of thioredoxin in the regulation of cellular processes by S-nitrosylation","volume":"1820","author":"Sengupta","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrep.2015.11.012_bib25","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1074\/jbc.M113.503938","article-title":"Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor \u03baB (NF-\u03baB) activation","volume":"289","author":"Kelleher","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2015.11.012_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ymeth.2013.05.020","article-title":"S-sulfhydration\/desulfhydration and S-nitrosylation\/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO","volume":"62","author":"Lu","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.bbrep.2015.11.012_bib27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrm2764","article-title":"Protein denitrosylation: enzymatic mechanisms and cellular functions","volume":"10","author":"Benhar","year":"2009","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bbrep.2015.11.012_bib28","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/ncomms2623","article-title":"Sulfhydration mediates neuroprotective actions of parkin","volume":"4","author":"Vandiver","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2015.11.012_bib29","doi-asserted-by":"crossref","first-page":"e52788","DOI":"10.1371\/journal.pone.0052788","article-title":"N-methyl-d-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity","volume":"7","author":"Qu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2015.11.012_bib30","doi-asserted-by":"crossref","first-page":"22777","DOI":"10.1074\/jbc.M113.475467","article-title":"Mechanisms of nitrosylation and denitrosylation of cytoplasmic glyceraldehyde-3-phosphate dehydrogenase from Arabidopsis thaliana","volume":"288","author":"Zaffagnini","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2015.11.012_bib31","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.jprot.2011.06.001","article-title":"Distinction of thioredoxin transnitrosylation and denitrosylation target proteins by the ICAT quantitative approach","volume":"74","author":"Wu C","year":"2011","journal-title":"J. Proteom."},{"key":"10.1016\/j.bbrep.2015.11.012_bib32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00109-012-0878-z","article-title":"Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease","volume":"90","author":"Anand","year":"2012","journal-title":"J. Mol. Med. (Berl.)"}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580815001326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580815001326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T03:04:39Z","timestamp":1599879879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580815001326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":32,"alternative-id":["S2405580815001326"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2015.11.012","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thioredoxin 1 regulation of protein S-desulfhydration","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2015.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}