{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:05:02Z","timestamp":1768622702755,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009029","name":"Adaptable and Seamless Technology Transfer Program through Target-Driven R and D","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["3407"],"award-info":[{"award-number":["3407"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bbrep.2017.07.004","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T16:30:23Z","timestamp":1499272223000},"page":"84-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Modulation of host HIF-1\u03b1 activity and the tryptophan pathway contributes to the anti-Toxoplasma gondii potential of nanoparticles"],"prefix":"10.1016","volume":"11","author":[{"given":"Oluyomi Stephen","family":"Adeyemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuho","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Sugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2017.07.004_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijpara.2008.10.001","article-title":"Molecular approaches to diversity of populations of apicomplexan parasites","volume":"39","author":"Beck","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbrep.2017.07.004_bib2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.actatropica.2016.12.006","article-title":"Pravastatin and simvastatin inhibit the adhesion, replication and proliferation of Toxoplasma gondii (RH strain) in HeLa cells","volume":"167","author":"Sanfelice","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.bbrep.2017.07.004_bib3","doi-asserted-by":"crossref","unstructured":"M.W. Black, J.C. Boothroyd, Lytic cycle of Toxoplasma gondii. Microbiol. Mol. Biol. Rev. 64 (200), pp. 607\u2013623.","DOI":"10.1128\/MMBR.64.3.607-623.2000"},{"key":"10.1016\/j.bbrep.2017.07.004_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1079\/AHR2005100","article-title":"Biology and epidemiology of Toxoplasma gondii in man and animals","volume":"6","author":"Hill","year":"2005","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.bbrep.2017.07.004_bib5","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/AAC.00868-12","article-title":"A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii","volume":"56","author":"Kamau","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrep.2017.07.004_bib6","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2147\/IJN.S122178","article-title":"Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential","volume":"12","author":"Adeyemi","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrep.2017.07.004_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40199-015-0125-6","article-title":"Nanoparticles as potential new generation broad spectrum antimicrobial agents","volume":"23","author":"Yah","year":"2015","journal-title":"DARU"},{"key":"10.1016\/j.bbrep.2017.07.004_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.taap.2013.03.028","article-title":"Hypoxia inducible factor-1 (HIF-1)-flavin containing monooxygenase-2 (FMO-2) signaling acts in silver nanoparticles and silver ion toxicity in the nematode, Caenorhabditis elegans","volume":"270","author":"Eom","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrep.2017.07.004_bib9","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.tiv.2015.02.010","article-title":"Gold nanoparticles do not induce myotube cytotoxicity but increase the susceptibility to cell death","volume":"29","author":"Leite","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.bbrep.2017.07.004_bib10","first-page":"554","article-title":"Silver nanoparticles inhibit hypoxia inducible factor function and cancer cell growth","volume":"12","author":"Yang","year":"2016","journal-title":"Nanomed.: Nanotechnol. Biol. Med."},{"key":"10.1016\/j.bbrep.2017.07.004_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-0463.2009.02453.x","article-title":"Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion and virulence","volume":"111","author":"Blader","year":"2009","journal-title":"APMIS"},{"key":"10.1016\/j.bbrep.2017.07.004_bib12","article-title":"Hypoxia-inducible factor 1 (HIF-1) pathway","volume":"407","author":"Semenza","year":"2007","journal-title":"Sci. STKE"},{"key":"10.1016\/j.bbrep.2017.07.004_bib13","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00109-007-0282-2","article-title":"Hypoxia-inducible factor (HIF) function in innate immunity and infection","volume":"85","author":"Zinkernagel","year":"2007","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bbrep.2017.07.004_bib14","doi-asserted-by":"crossref","first-page":"26852","DOI":"10.1074\/jbc.M110.147041","article-title":"Toxoplasma gondii activates hypoxia-inducible factor (HIF) by Stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling","volume":"285","author":"Mandi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2017.07.004_bib15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1462-5822.2005.00628.x","article-title":"The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels","volume":"8","author":"Spear","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.bbrep.2017.07.004_bib16","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/EC.00081-14","article-title":"Toxoplasma gondii development of its replicative niche: in its host cell and beyond","volume":"13","author":"Blader","year":"2014","journal-title":"Eukaryot. Cell."},{"key":"10.1016\/j.bbrep.2017.07.004_bib17","doi-asserted-by":"crossref","first-page":"e63301","DOI":"10.1371\/journal.pone.0063301","article-title":"Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions","volume":"8","author":"Schmidt","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2017.07.004_bib18","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1073\/pnas.81.3.908","article-title":"Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan","volume":"81","author":"Pfefferkorn","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrep.2017.07.004_bib19","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1007\/s00436-013-3608-8","article-title":"Effects of dextran sulfates on the acute infection and growth stages of Toxoplasma gondii","volume":"112","author":"Ishiwa","year":"2013","journal-title":"Par. Res."},{"key":"10.1016\/j.bbrep.2017.07.004_bib20","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2005-03-0979","article-title":"A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation","volume":"106","author":"Braun","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbrep.2017.07.004_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/CBI20090419","article-title":"Effects of YC-1 targeting hypoxia-inducible factor 1 alpha in oesophageal squamous carcinoma cell line Eca109 cells","volume":"35","author":"Feng","year":"2010","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrep.2017.07.004_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrep.2017.07.004_bib23","first-page":"2899","article-title":"Induction and testing of hypoxia in cell culture","volume":"54","author":"Wu","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbrep.2017.07.004_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1152\/physiolgenomics.00011.2005","article-title":"Influence of IFN-\u03b3on gene expression in normal human bronchial epithelial cells: modulation of IFN-\u03b3 effects by dexamethasone","volume":"23","author":"Pawliczak","year":"2005","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.bbrep.2017.07.004_bib25","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.4049\/jimmunol.170.9.4833","article-title":"Inhibition of IFN-gamma signaling by glucocorticoids","volume":"170","author":"Hu","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrep.2017.07.004_bib26","doi-asserted-by":"crossref","first-page":"73793","DOI":"10.1039\/C5RA13206A","article-title":"Silver and gold nanoparticles from Sargentodoxa cuneata: synthesis, characterization and antileishmanial activity","volume":"5","author":"Ahmad","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.bbrep.2017.07.004_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.exppara.2015.11.004","article-title":"Evidence of reactive oxygen species (ROS) mediated apoptosis in Setaria cervi induced by green silver nanoparticles from Acacia auriculiformis at a very low dose","volume":"I60","author":"Saini","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bbrep.2017.07.004_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1139\/jpn.0902","article-title":"Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder","volume":"34","author":"Anisman","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.bbrep.2017.07.004_bib29","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1471-4159.2005.03070.x","article-title":"Tryptophan metabolism and oxidative stress in patients with Huntington's disease","volume":"93","author":"Stoy","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrep.2017.07.004_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/143720","article-title":"Metal-based nanoparticles and the immune system: activation, inflammation, and potential applications","volume":"2015","author":"Luo","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.bbrep.2017.07.004_bib31","doi-asserted-by":"crossref","first-page":"24223","DOI":"10.1074\/jbc.M100951200","article-title":"Microarray analysis reveals previously unknown changes in Toxoplasma gondii\u2013infected human cells","volume":"276","author":"Blader","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580817301267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580817301267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:39:57Z","timestamp":1762501197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580817301267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":31,"alternative-id":["S2405580817301267"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2017.07.004","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of host HIF-1\u03b1 activity and the tryptophan pathway contributes to the anti-Toxoplasma gondii potential of nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2017.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}