{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:21Z","timestamp":1790744541948,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T00:00:00Z","timestamp":1565395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009033","name":"Center of Innovation Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009037","name":"Science and Technology Research Partnership for Sustainable Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bbrep.2019.100678","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T05:36:02Z","timestamp":1565933762000},"page":"100678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Antifibrotic effect of methylated quercetin derivatives on TGF\u03b2-induced hepatic stellate cells"],"prefix":"10.1016","volume":"20","author":[{"given":"Munkhzul","family":"Ganbold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shimamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Ferdousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Isoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2019.100678_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrep.2019.100678_bib2","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/j.2040-4603.2013.tb00529.x","article-title":"Hepatic stellate cells and liver fibrosis","volume":"3","author":"Puche","year":"2013","journal-title":"Comp. Physiol."},{"key":"10.1016\/j.bbrep.2019.100678_bib3","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrep.2019.100678_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols\u202f: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrep.2019.100678_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/bj20021972","article-title":"Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites","volume":"372","author":"Spencer","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrep.2019.100678_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.taap.2013.10.026","article-title":"Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes","volume":"274","author":"Yang","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrep.2019.100678_bib7","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.3892\/mmr.2015.4269","article-title":"Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen-activated protein kinase kinase signaling pathways","volume":"12","author":"Hu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrep.2019.100678_bib8","first-page":"368658","article-title":"Antiobesity effects of an edible halophyte Nitraria retusa Forssk in 3T3-L1 preadipocyte differentiation and in C57B6J\/L mice fed a high fat diet-induced obesity, Evidence-Based Complement","volume":"2013","author":"Zar Kalai","year":"2013","journal-title":"Altern. Med."},{"key":"10.1016\/j.bbrep.2019.100678_bib9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fct.2014.07.029","article-title":"Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db\/db mice model \u201cBKS.Cg-Dock7m+\/+ Leprdb\/J\u201d through the modulation of lipogenesis-lipolysis balance","volume":"72","author":"Zar Kalai","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrep.2019.100678_bib10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejphar.2016.04.042","article-title":"Isorhamnetin attenuates liver fibrosis by inhibiting TGF-\u03b2\/Smad signaling and relieving oxidative stress","volume":"783","author":"Yang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrep.2019.100678_bib11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fitote.2011.10.012","article-title":"Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method","volume":"83","author":"Li","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bbrep.2019.100678_bib12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejmech.2012.04.044","article-title":"Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors","volume":"54","author":"Shi","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrep.2019.100678_bib13","first-page":"1513","article-title":"Bioactive phenolics from launaea intybacea","volume":"34","author":"Parveen","year":"2012","journal-title":"J. Chem. Soc. Pak."},{"key":"10.1016\/j.bbrep.2019.100678_bib14","doi-asserted-by":"crossref","first-page":"10423","DOI":"10.1002\/chem.201701812","article-title":"Natural and synthetic flavonoids as potent Mycobacterium tuberculosis UGM inhibitors","volume":"23","author":"Villaume","year":"2017","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.bbrep.2019.100678_bib15","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1016\/j.bmc.2014.04.053","article-title":"Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK","volume":"22","author":"Yamauchi","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrep.2019.100678_bib16","doi-asserted-by":"crossref","first-page":"E334","DOI":"10.3390\/molecules23020334","article-title":"Mexican propolis: a source of antioxidants and anti-inflammatory compounds, and isolation of a novel chalcone and \u03b5-caprolactone derivative","volume":"23","author":"Guzm\u00e1n-Guti\u00e9rrez","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bbrep.2019.100678_bib17","first-page":"d793","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbrep.2019.100678_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmed.2015.00059","article-title":"Signaling in fibrosis: TGF-\u03b2, WNT, and YAP\/TAZ converge","volume":"2","author":"Piersma","year":"2015","journal-title":"Front. Med."},{"key":"10.1016\/j.bbrep.2019.100678_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.intimp.2016.01.013","article-title":"Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL","volume":"32","author":"Xu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrep.2019.100678_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.hbpd.2018.04.003","article-title":"Hepatic fibrosis: it is time to go with hepatic stellate cell-specific therapeutic targets","volume":"17","author":"Ezhilarasan","year":"2018","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.bbrep.2019.100678_bib21","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/febs.13665","article-title":"TGF-\u03b2 signalling and liver disease","volume":"283","author":"Fabregat","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrep.2019.100678_bib22","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/hep.510270512","article-title":"Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and kupffer cells","volume":"27","author":"Kawada","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrep.2019.100678_bib23","doi-asserted-by":"crossref","first-page":"648308","DOI":"10.1155\/2014\/648308","article-title":"Herbal medicines for the treatment of nonalcoholic steatohepatitis: current scenario and future prospects","volume":"2014","author":"Jadeja","year":"2014","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.bbrep.2019.100678_bib24","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.7314\/APJCP.2015.16.7.3035","article-title":"Anti-proliferation effects of isorhamnetin on lung cancer cells in vitro and in vivo","volume":"16","author":"Li","year":"2015","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.bbrep.2019.100678_bib25","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-\u03b21\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580819301712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580819301712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:41:39Z","timestamp":1762501299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580819301712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":25,"alternative-id":["S2405580819301712"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2019.100678","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antifibrotic effect of methylated quercetin derivatives on TGF\u03b2-induced hepatic stellate cells","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2019.100678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100678"}}