{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:15:04Z","timestamp":1778883304800,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ICMR 2019\/905"],"award-info":[{"award-number":["ICMR 2019\/905"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.bbrep.2020.100774","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T07:45:10Z","timestamp":1593071110000},"page":"100774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Structural features and oligomeric nature of human podocin domain"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0237-9320","authenticated-orcid":false,"given":"Sandeep K.N.","family":"Mulukala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-6213","authenticated-orcid":false,"given":"Shivkumar S.","family":"Irukuvajjula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan","family":"Garai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pannuru","family":"Venkatesu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramakrishna","family":"Vadrevu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9467-7650","authenticated-orcid":false,"given":"Anil K.","family":"Pasupulati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2020.100774_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fendo.2014.00151","article-title":"Molecular and cellular events mediating glomerular podocyte dysfunction and depletion in diabetes mellitus","volume":"5","author":"Anil Kumar","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrep.2020.100774_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/07853890600978149","article-title":"Molecular basis of the glomerular filtration: nephrin and the emerging protein complex at the podocyte slit diaphragm","volume":"38","author":"Patari-Sampo","year":"2006","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbrep.2020.100774_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2017.00102","article-title":"Novel actions of growth hormone in podocytes: implications for diabetic nephropathy","volume":"4","author":"Mukhi","year":"2017","journal-title":"Front. Med."},{"key":"10.1016\/j.bbrep.2020.100774_bib4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1083\/jcb.60.2.423","article-title":"Porous substructure of the glomerular slit diaphragm in the rat and mouse","volume":"60","author":"Rodewald","year":"1974","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrep.2020.100774_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/iub.1515","article-title":"In silico Structural characterization of podocin and assessment of nephrotic syndrome-associated podocin mutants","volume":"68","author":"Mulukala","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbrep.2020.100774_bib6","doi-asserted-by":"crossref","first-page":"F689","DOI":"10.1152\/ajprenal.00298.2010","article-title":"TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology","volume":"299","author":"Dryer","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrep.2020.100774_bib7","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI200112849","article-title":"Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin","volume":"108","author":"Schwarz","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrep.2020.100774_bib8","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/S0002-9440(10)63080-5","article-title":"CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain","volume":"159","author":"Shih","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrep.2020.100774_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/08927022.2019.1570508","article-title":"Intrinsically disordered regions mediate macromolecular assembly of the Slit diaphragm proteins associated with Nephrotic syndrome","volume":"45","author":"Mulukala","year":"2019","journal-title":"Mol. Simulat."},{"key":"10.1016\/j.bbrep.2020.100774_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1097-2765(00)80057-X","article-title":"Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome","volume":"1","author":"Kestila","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrep.2020.100774_bib11","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s00467-010-1495-0","article-title":"Hereditary nephrotic syndrome: a systematic approach for genetic testing and a review of associated podocyte gene mutations","volume":"25","author":"Benoit","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbrep.2020.100774_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/74166","article-title":"NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome","volume":"24","author":"Boute","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrep.2020.100774_bib13","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1681\/ASN.2014050489","article-title":"A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome","volume":"26","author":"Sadowski","year":"2015","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.bbrep.2020.100774_bib14","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2215\/CJN.07830910","article-title":"TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype","volume":"6","author":"Gigante","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol. : CJASN"},{"key":"10.1016\/j.bbrep.2020.100774_bib15","first-page":"1858","volume":"vol 24","author":"Gigante","year":"2009"},{"key":"10.1016\/j.bbrep.2020.100774_bib16","doi-asserted-by":"crossref","first-page":"41543","DOI":"10.1074\/jbc.C100452200","article-title":"Interaction with podocin facilitates nephrin signaling","volume":"276","author":"Huber","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2020.100774_bib17","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1093\/hmg\/ddg360","article-title":"Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains","volume":"12","author":"Huber","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrep.2020.100774_bib18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/08927022.2019.1570508","article-title":"Intrinsically disordered regions mediate macromolecular assembly of the Slit diaphragm proteins associated with Nephrotic syndrome","volume":"45","author":"Mulukala Narasimha","year":"2019","journal-title":"Mol. Simulat."},{"key":"10.1016\/j.bbrep.2020.100774_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0002-9440(10)64357-X","article-title":"Podocin localizes in the kidney to the slit diaphragm area","volume":"160","author":"Roselli","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrep.2020.100774_bib20","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.bpj.2009.07.034","article-title":"Unusual thermal disassembly of the SPFH domain oligomer from Pyrococcus horikoshii","volume":"97","author":"Kuwahara","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrep.2020.100774_bib21","doi-asserted-by":"crossref","first-page":"17221","DOI":"10.1074\/jbc.273.27.17221","article-title":"Oligomeric nature of the integral membrane protein stomatin","volume":"273","author":"Snyers","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2020.100774_bib22","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jmb.2007.12.024","article-title":"Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold","volume":"376","author":"Yokoyama","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrep.2020.100774_bib23","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.bbadis.2018.04.008","article-title":"C-terminal oligomerization of podocin mediates interallelic interactions, Biochimica et biophysica acta","volume":"1864","author":"Straner","year":"2018","journal-title":"Mol. Basis Dis."},{"key":"10.1016\/j.bbrep.2020.100774_bib24","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1097\/01.ASN.0000019842.50870.41","article-title":"Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line","volume":"13","author":"Palmen","year":"2002","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.bbrep.2020.100774_bib25","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0006-3495(94)80799-4","article-title":"The use of fluorescence methods to monitor unfolding transitions in proteins","volume":"66","author":"Eftink","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrep.2020.100774_bib26","doi-asserted-by":"crossref","first-page":"17079","DOI":"10.1073\/pnas.0607465103","article-title":"Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels","volume":"103","author":"Huber","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2020.100774_bib27","series-title":"Characteristics of Cinnamaldehyde Nanoemulsion Prepared Using APV-High Pressure Homogenizer and Ultra turrax","first-page":"244","volume":"1614","author":"Asmawati","year":"2014"},{"key":"10.1016\/j.bbrep.2020.100774_bib28","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1038\/emboj.2012.203","article-title":"A stomatin dimer modulates the activity of acid-sensing ion channels","volume":"31","author":"Brand","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrep.2020.100774_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004277","article-title":"The hydrophobic temperature dependence of amino acids directly calculated from protein structures","volume":"11","author":"van Dijk","year":"2015","journal-title":"PLoS Comput. Biol."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580820300832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580820300832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:44:35Z","timestamp":1778881475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580820300832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":29,"alternative-id":["S2405580820300832"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2020.100774","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.21.108415","asserted-by":"object"}]},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural features and oligomeric nature of human podocin domain","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2020.100774","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100774"}}