{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T08:12:12Z","timestamp":1782029532521,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bbrep.2020.100852","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T23:37:53Z","timestamp":1605137873000},"page":"100852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Exopolysaccharide-peptide complex from oyster mushroom (Pleurotus ostreatus) protects against hepatotoxicity in rats"],"prefix":"10.1016","volume":"24","author":[{"given":"Nihad M.","family":"Abdel-Monem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"El-Saadani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman S.","family":"Daba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar R.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-8213","authenticated-orcid":false,"given":"Eiman","family":"Aleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2020.100852_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2174\/1871520611313050005","article-title":"\u03b2-Glucans and their applications in cancer therapy: focus on human studies","volume":"13","author":"Aleem","year":"2013","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.bbrep.2020.100852_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.foodchem.2004.12.018","article-title":"Chemical and analytical screening of some edible mushrooms","volume":"95","author":"Mallavadhani","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrep.2020.100852_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4489\/MYCO.2011.39.1.045","article-title":"Hypolipidemic activities of dietary Pleurotus ostreatus in hypercholesterolemic rats","volume":"39","author":"Alam","year":"2011","journal-title":"MYCOBIOLOGY"},{"key":"10.1016\/j.bbrep.2020.100852_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0899-9007(97)00471-1","article-title":"Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats","volume":"14","author":"Bobek","year":"1998","journal-title":"Nutrition"},{"key":"10.1016\/j.bbrep.2020.100852_bib5","first-page":"1307","article-title":"Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway","volume":"33","author":"Jedinak","year":"2008","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrep.2020.100852_bib6","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.biortech.2008.09.004","article-title":"Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus","volume":"100","author":"Tong","year":"2009","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.bbrep.2020.100852_bib7","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.fct.2006.06.025","article-title":"Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats","volume":"44","author":"Jayakumar","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrep.2020.100852_bib8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbi.2008.08.006","article-title":"Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain","volume":"176","author":"Jayakumar","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrep.2020.100852_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.exger.2006.10.006","article-title":"Protective effect of an extract of the oyster mushroom, Pleurotus ostreatus, on antioxidants of major organs of aged rats","volume":"42","author":"Jayakumar","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrep.2020.100852_bib10","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.peptides.2005.04.010","article-title":"Pleurostrin, an antifungal peptide from the oyster mushroom","volume":"26","author":"Chu","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.bbrep.2020.100852_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2019.03.043","article-title":"The hepatoprotective effect of polysaccharides from Pleurotus ostreatus on carbon tetrachloride-induced acute liver injury rats","volume":"131","author":"Zhu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbrep.2020.100852_bib12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/019262338901700304","article-title":"Protection of hepatotoxic and lethal effects of CCl4 by partial hepatectomy","volume":"17","author":"Kodavanti","year":"1989","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.bbrep.2020.100852_bib13","series-title":"Plan of Action for the Prevention, Care & Treatment of Viral Hepatitis","first-page":"1","author":"Population","year":"2018"},{"key":"10.1016\/j.bbrep.2020.100852_bib14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00253-007-0865-4","article-title":"A polysaccharide-peptide complex from abalone mushroom (Pleurotus abalonus) fruiting bodies increases activities and gene expression of antioxidant enzymes and reduces lipid peroxidation in senescence-accelerated mice","volume":"75","author":"Li","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbrep.2020.100852_bib15","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.fct.2011.03.013","article-title":"Hepatoprotective and antioxidant effects of porcine plasma protein hydrolysates on carbon tetrachloride-induced liver damage in rats","volume":"49","author":"Liu","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrep.2020.100852_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11010-005-9012-7","article-title":"Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine\/Phenobarbital-induced hepatocarcinogenesis in Wistar rats","volume":"284","author":"Sreepriya","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrep.2020.100852_bib17","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.fct.2008.01.003","article-title":"Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats","volume":"46","author":"Pari","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrep.2020.100852_bib18","series-title":"Hepatology: A Textbook of Liver Disease","first-page":"791","article-title":"Liver Function tests and the objective evaluation of the patient with liver disease","author":"Sj","year":"1996"},{"key":"10.1016\/j.bbrep.2020.100852_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2296-2-2","article-title":"High serum alkaline phosphatase levels, a study in 181 Thai adult hospitalized patients","volume":"2","author":"Wiwanitkit","year":"2001","journal-title":"BMC Fam. Pract."},{"key":"10.1016\/j.bbrep.2020.100852_bib20","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00432-012-1224-0","article-title":"Schizophyllan inhibits the development of mammary and hepatic carcinomas induced by 7,12 dimethylbenz(alpha)anthracene and decreases cell proliferation: comparison with tamoxifen","volume":"138","author":"Mansour","year":"2012","journal-title":"J. Canc. Res. Clin. Oncol."},{"key":"10.1016\/j.bbrep.2020.100852_bib21","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.intimp.2006.04.002","article-title":"Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans","volume":"6","author":"Sarangi","year":"2006","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrep.2020.100852_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2020.100852_bib23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbrep.2020.100852_bib24","series-title":"Proton and Carbon-13 NMR Spectroscopy:an Integrated Approach","author":"Abraham P","year":"1978"},{"key":"10.1016\/j.bbrep.2020.100852_bib25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.7150\/ijbs.5.549","article-title":"Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity","volume":"5","author":"Shaarawy","year":"2009","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrep.2020.100852_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrep.2020.100852_bib27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrep.2020.100852_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrep.2020.100852_bib29","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2020.100852_bib30","first-page":"11","article-title":"Animal models of hepatocellular carcinoma prevention","author":"Shankaraiah","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.bbrep.2020.100852_bib31","first-page":"14 30 11","article-title":"The DEN and CCl4 -induced mouse model of fibrosis and inflammation-associated hepatocellular carcinoma","volume":"66","author":"Uehara","year":"2014","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.bbrep.2020.100852_bib32","doi-asserted-by":"crossref","first-page":"982368","DOI":"10.1093\/ecam\/neq057","article-title":"Anti-cancer effects of protein extracts from calvatia lilacina, Pleurotus ostreatus and volvariella volvacea","volume":"2011","author":"Wu","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.bbrep.2020.100852_bib33","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.3892\/mmr.2015.3648","article-title":"Antitumor activity of polysaccharide extracted from Pleurotus ostreatus mycelia against gastric cancer in vitro and in vivo","volume":"12","author":"Cao","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrep.2020.100852_bib34","first-page":"1","article-title":"Effectiveness of different solvents extracts from edible mushrooms in inhibiting the growth of tumor cells","volume":"4","author":"Younis","year":"2014","journal-title":"Cancer Biology"},{"key":"10.1016\/j.bbrep.2020.100852_bib35","article-title":"Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K\/AKT signaling pathway","volume":"7","author":"Xu","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.bbrep.2020.100852_bib36","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1016\/j.fct.2010.08.019","article-title":"Mushroom insoluble polysaccharides prevent carbon tetrachloride-induced hepatotoxicity in rat","volume":"48","author":"Nada","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrep.2020.100852_bib37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2006.12.023","article-title":"Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats","volume":"560","author":"Pradeep","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrep.2020.100852_bib38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/antiox8030064","article-title":"Liver injury induced by carbon tetrachloride in mice is prevented by the antioxidant capacity of Anji white tea polyphenols","volume":"8","author":"Wang","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrep.2020.100852_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.synbio.2016.12.001","article-title":"Reactive oxygen species and antioxidant properties from mushrooms","volume":"2","author":"Sanchez","year":"2017","journal-title":"Synth Syst Biotechnol"},{"key":"10.1016\/j.bbrep.2020.100852_bib40","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.13005\/bpj\/1320","article-title":"Taurine and oyster mushroom (Pleurotus ostreatus) prevents oxidative damage in liver of mice induced by Paraquat","volume":"10","author":"Sutyarso","year":"2017","journal-title":"Biomedical and Pharmacology Journal"},{"key":"10.1016\/j.bbrep.2020.100852_bib41","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.fct.2010.11.039","article-title":"L-arginine and L-glutamine as immunonutrients and modulating agents for oxidative stress and toxicity induced by sodium nitrite in rats","volume":"49","author":"El-Sheikh","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrep.2020.100852_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16020274","article-title":"Toxic effect of acute cadmium and lead exposure in rat blood, liver, and kidney","volume":"16","author":"Andjelkovic","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.bbrep.2020.100852_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5897\/JMPR2018.6714","article-title":"Protective effects of Pleurotus ostreatus in ameliorating carbon tetrachloride (ccl4) induced liver injury in Wistar rats","volume":"13","author":"Ubhenin","year":"2019","journal-title":"Med. Plant Res."},{"key":"10.1016\/j.bbrep.2020.100852_bib44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BA20060105","article-title":"Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats","volume":"46","author":"Oluyemi","year":"2007","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.bbrep.2020.100852_bib45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fcell.2019.00165","article-title":"Modulation of NKG2D, KIR2DL and cytokine production by Pleurotus ostreatus glucan enhances natural killer cell cytotoxicity toward cancer cells","volume":"7","author":"El-Deeb","year":"2019","journal-title":"Front Cell Dev Biol"}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082030162X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082030162X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:44:09Z","timestamp":1762501449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240558082030162X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":45,"alternative-id":["S240558082030162X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2020.100852","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exopolysaccharide-peptide complex from oyster mushroom (Pleurotus ostreatus) protects against hepatotoxicity in rats","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2020.100852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100852"}}