{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:50:16Z","timestamp":1762501816434,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20fk0310112"],"award-info":[{"award-number":["JP20fk0310112"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bbrep.2020.100855","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T23:12:50Z","timestamp":1606345970000},"page":"100855","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Comprehensive gene expression profiling of human astrocytes treated with a hepatic encephalopathy-inducible factor, alpha 1-antichymotripsin"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0791-0870","authenticated-orcid":false,"given":"Kenji","family":"Kawaguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghyuk","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4914-0541","authenticated-orcid":false,"given":"Yoshihiro","family":"Mezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4133-3170","authenticated-orcid":false,"given":"Sae","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-3518","authenticated-orcid":false,"given":"Tomokazu","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2020.100855_bib1","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1056\/NEJMra1600561","article-title":"Hepatic encephalopathy","volume":"375","author":"Wijdicks","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrep.2020.100855_bib2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jhep.2017.11.005","article-title":"Hepatic encephalopathy: classification and treatment","volume":"68","author":"Bajaj","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrep.2020.100855_bib3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s11011-020-00549-8","article-title":"Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema","volume":"35","author":"Sepehrinezhad","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbrep.2020.100855_bib4","doi-asserted-by":"crossref","unstructured":"M.C.Papadopoulos, A.S. Verkman, Aquaporin water channels in the nervous system. Nat Rev Neurosci. 14 (2013) 265-277. https\/\/doi: 10.1038\/nrn3468. Epub 2013 Mar 13.","DOI":"10.1038\/nrn3468"},{"key":"10.1016\/j.bbrep.2020.100855_bib5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/72256","article-title":"Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke","volume":"6","author":"Manley","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrep.2020.100855_bib6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neulet.2014.10.040","article-title":"Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia","volume":"584","author":"Yao","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrep.2020.100855_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189346","article-title":"Alpha-1 antichymotrypsin is involved in astrocyte injury in concert with arginine-vasopressin during the development of acute hepatic encephalopathy","volume":"12","author":"Park","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2020.100855_bib8","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Going forward","volume":"43","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2020.100855_bib9","doi-asserted-by":"crossref","first-page":"D559","DOI":"10.1093\/nar\/gky973","article-title":"CORUM: the comprehensive resource of mammalian protein complexes-2019","volume":"47","author":"Giurgiu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2020.100855_bib10","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The reactome pathway knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2020.100855_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.sbi.2020.03.004","article-title":"Beyond structure: emerging approaches to study GPCR dynamics","volume":"63","author":"Gusach","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbrep.2020.100855_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2020.03.003","article-title":"Impact of GPCR structures on drug discovery","volume":"181","author":"Congreve","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2020.100855_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neulet.2018.06.025","article-title":"Astroglial cAMP signalling in space and time","volume":"689","author":"Horvat","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrep.2020.100855_bib14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/ijms20030779","article-title":"The astrocytic cAMP pathway in health and disease","volume":"20","author":"Zhou","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2020.100855_bib15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12864-016-2623-4","article-title":"Cyclic AMP signaling restricts activation and promotes maturation and antioxidant defenses in astrocytes","volume":"17","author":"Paco","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.bbrep.2020.100855_bib16","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2020.100855_bib17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12863-016-0466-2","article-title":"A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network","volume":"17","author":"Ignatieva","year":"2016","journal-title":"BMC Genet."},{"key":"10.1016\/j.bbrep.2020.100855_bib18","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1038\/sj.emboj.7600228","article-title":"Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor","volume":"23","author":"Liu","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrep.2020.100855_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2014.08.016","article-title":"Beneficial effects of deferoxamine against astrocyte death induced by modified oxygen glucose deprivation","volume":"1583","author":"Zhang","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrep.2020.100855_bib20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1471-4159.2005.03204.x","article-title":"Astrocyte- and hepatocyte-specific expression of genes from the distal serpin subcluster at 14q32.1 associates with tissue-specific chromatin structures","volume":"94","author":"Gopalan","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrep.2020.100855_bib21","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1093\/brain\/awl255","article-title":"Dickson, Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons","volume":"129","author":"Padmanabhan","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.bbrep.2020.100855_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003870","article-title":"Urinary alpha1-antichymotrypsin: a biomarker of prion infection","volume":"3","author":"Miele","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2020.100855_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064283","article-title":"Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV\/viral hepatitis coinfected patients","volume":"8","author":"Peters","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2020.100855_bib24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2014.01.014","article-title":"The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc","volume":"35","author":"Hascall","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbrep.2020.100855_bib25","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jhep.2019.06.020","article-title":"O-GlcNAcylation-dependent upregulation of HO1 triggers ammonia-induced oxidative stress and senescence in hepatic encephalopathy","volume":"71","author":"G\u00f6rg","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrep.2020.100855_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2010.11.067","article-title":"Heme oxygenase-1 comes back to endoplasmic reticulum","volume":"404","author":"Kim","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrep.2020.100855_bib27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ceca.2016.01.002","article-title":"Adrenergic stimulation of single rat astrocytes results in distinct temporal changes in intracellular Ca(2+) and cAMP-dependent PKA responses","volume":"59","author":"Horvat","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbrep.2020.100855_bib28","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/j.1476-5381.2010.01153.x","article-title":"Role of \u03b2-adrenoceptors in glucose uptake in astrocytes using \u03b2-adrenoceptor knockout mice","volume":"162","author":"Catus","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrep.2020.100855_bib29","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1038\/sj.emboj.7600228","article-title":"Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor","volume":"23","author":"Liu","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrep.2020.100855_bib30","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/glia.20724","article-title":"Actin cytoskeleton remodeling governs aquaporin-4 localization in astrocytes","volume":"56","author":"Nicchia","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.bbrep.2020.100855_bib31","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s00018-016-2405-9","article-title":"Gaq proteins: molecular pharmacology and therapeutic potential","volume":"74","author":"Kamato","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrep.2020.100855_bib32","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1073\/pnas.0308250100","article-title":"Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approach","volume":"101","author":"Gupte","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2020.100855_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.12659\/MSM.906002","article-title":"Elevated adenylyl cyclase 9 expression is a potential prognostic biomarker for patients with colon cancer","volume":"24","author":"Yi","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bbrep.2020.100855_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0896-6273(00)80358-X","article-title":"cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits","volume":"19","author":"Gao","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.bbrep.2020.100855_bib35","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/glia.22981","article-title":"Adrenergic activation attenuates astrocyte swelling induced by hypotonicity and neurotrauma","volume":"64","author":"Vardjan","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.bbrep.2020.100855_bib36","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1471-4159.2009.06541.x","article-title":"Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells","volume":"112","author":"Wurm","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrep.2020.100855_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jhep.2010.02.020","article-title":"Role of aquaporin-4 in the development of brain oedema in liver failure","volume":"53","author":"Wright","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrep.2020.100855_bib38","doi-asserted-by":"crossref","first-page":"20306","DOI":"10.1074\/jbc.M113.466797","article-title":"Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C","volume":"288","author":"Mamenko","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2020.100855_bib39","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/glia.22485","article-title":"Regulation of AQP4 surface expression via vesicle mobility in astrocytes","volume":"61","author":"Potokar","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.bbrep.2020.100855_bib40","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/glia.22626","article-title":"Dynamics of \u03b2-adrenergic\/cAMP signaling and morphological changes in cultured astrocytes","volume":"62","author":"Vardjan","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.bbrep.2020.100855_bib41","article-title":"Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling","volume":"7","author":"Song","year":"2012","journal-title":"PLoS One"}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580820301655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580820301655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:47:28Z","timestamp":1762501648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580820301655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":41,"alternative-id":["S2405580820301655"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2020.100855","relation":{},"ISSN":["2405-5808"],"issn-type":[{"type":"print","value":"2405-5808"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive gene expression profiling of human astrocytes treated with a hepatic encephalopathy-inducible factor, alpha 1-antichymotripsin","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2020.100855","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100855"}}