{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:54:16Z","timestamp":1762502056155,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bbrep.2023.101442","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T07:21:37Z","timestamp":1677223297000},"page":"101442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Producing amyloid fibrils in vitro: A tool for studying AL amyloidosis"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-6010","authenticated-orcid":false,"given":"Daria V.","family":"Sizova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Raiker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deaneira","family":"Lakheram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwanatha","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Proffitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazen","family":"Jmeian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Voegtli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Batonick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"42","key":"10.1016\/j.bbrep.2023.101442_bib1","doi-asserted-by":"crossref","first-page":"14101","DOI":"10.1021\/bi991131j","article-title":"Thermodynamic instability of human lambda 6 light chains: correlation with fibrillogenicity","volume":"38","author":"Wall","year":"1999","journal-title":"Biochemistry"},{"issue":"12","key":"10.1016\/j.bbrep.2023.101442_bib2","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1016\/S0021-9258(18)93138-8","article-title":"Bence-Jones proteins and light chains of immunoglobulins. I. Formation and characterization of amino-terminal (variant) and carboxyl-terminal (constant) halves","volume":"244","author":"Solomon","year":"1969","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.bbrep.2023.101442_bib3","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1021\/acs.biochem.6b00090","article-title":"Recruitment of light chains by homologous and heterologous fibrils shows distinctive kinetic and conformational specificity","volume":"55","author":"Blancas-Mej\u00eda","year":"2016","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.bbrep.2023.101442_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/13506129.2021.1898365","article-title":"Incidence of light chain amyloidosis in Florence metropolitan area, Italy: a population-based study","volume":"28","author":"Zampieri","year":"2021","journal-title":"Amyloid"},{"issue":"10","key":"10.1016\/j.bbrep.2023.101442_bib5","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1182\/bloodadvances.2018016402","article-title":"Epidemiology of AL amyloidosis: a real-world study using US claims data","volume":"2","author":"Quock","year":"2018","journal-title":"Blood Adv"},{"issue":"1","key":"10.1016\/j.bbrep.2023.101442_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41572-018-0034-3","article-title":"Systemic immunoglobulin light chain amyloidosis","volume":"4","author":"Merlini","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"3","key":"10.1016\/j.bbrep.2023.101442_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/14728214.2020.1803829","article-title":"Emerging drugs for the treatment of light chain amyloidosis","volume":"25","author":"Chakraborty","year":"2020","journal-title":"Expet Opin. Emerg. Drugs"},{"issue":"4","key":"10.1016\/j.bbrep.2023.101442_bib8","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0006-291X(70)90186-5","article-title":"Human amyloid protein: diversity and uniformity","volume":"41","author":"Glenner","year":"1970","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"46","key":"10.1016\/j.bbrep.2023.101442_bib9","doi-asserted-by":"crossref","first-page":"E10839","DOI":"10.1073\/pnas.1805515115","article-title":"Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy","volume":"115","author":"Wall","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.bbrep.2023.101442_bib10","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1074\/jbc.M114.615401","article-title":"Differential effects on light chain amyloid formation depend on mutations and type of glycosaminoglycans","volume":"290","author":"Blancas-Mej\u00eda","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2023.101442_bib11","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0076-6879(99)09016-3","article-title":"In vitro immunoglobulin light chain fibrillogenesis","volume":"309","author":"Wall","year":"1999","journal-title":"Methods Enzymol."},{"issue":"95","key":"10.1016\/j.bbrep.2023.101442_bib12","doi-asserted-by":"crossref","DOI":"10.3791\/51537-v","article-title":"In vitro aggregation assays using hyperphosphorylated tau protein","author":"Sui","year":"2015","journal-title":"JoVE"},{"issue":"1","key":"10.1016\/j.bbrep.2023.101442_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/asheducation-2017.1.1","article-title":"AL amyloidosis: from molecular mechanisms to targeted therapies","volume":"2017","author":"Merlini","year":"2017","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"1","key":"10.1016\/j.bbrep.2023.101442_bib14","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/s41467-019-09032-0","article-title":"Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis","volume":"10","author":"Radamaker","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2023.101442_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fimmu.2018.00117","article-title":"Insights into the structural basis of antibody affinity maturation from next-generation sequencing","volume":"9","author":"Mishra","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrep.2023.101442_bib16","article-title":"Antibodies gone bad - the molecular mechanism of light chain amyloidosis","author":"Absmeier","year":"2022","journal-title":"FEBS J."},{"issue":"23","key":"10.1016\/j.bbrep.2023.101442_bib17","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1016\/j.jmb.2020.10.005","article-title":"Domain interactions determine the amyloidogenicity of antibody light chain mutants","volume":"432","author":"Weber","year":"2020","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2023.101442_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16953-7","article-title":"Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity","volume":"7","author":"Oberti","year":"2017","journal-title":"Sci. Rep."},{"issue":"50","key":"10.1016\/j.bbrep.2023.101442_bib19","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1021\/acs.biochem.7b00579","article-title":"Incomplete refolding of antibody light chains to non-native, protease-sensitive conformations leads to aggregation: a mechanism of amyloidogenesis in patients?","volume":"56","author":"Morgan","year":"2017","journal-title":"Biochemistry"},{"issue":"49","key":"10.1016\/j.bbrep.2023.101442_bib20","doi-asserted-by":"crossref","first-page":"16572","DOI":"10.1074\/jbc.RA120.013461","article-title":"Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis","volume":"295","author":"Lavatelli","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbrep.2023.101442_bib21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/path.2607","article-title":"Fibril protein fragmentation pattern in systemic AL-amyloidosis","volume":"219","author":"Enqvist","year":"2009","journal-title":"J. Pathol."},{"issue":"21","key":"10.1016\/j.bbrep.2023.101442_bib22","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1016\/j.jmb.2016.08.021","article-title":"The kinetic stability of a full-length antibody light chain dimer determines whether endoproteolysis can release amyloidogenic variable domains","volume":"428","author":"Morgan","year":"2016","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.bbrep.2023.101442_bib23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1073\/pnas.1817538116","article-title":"Role of domain interactions in the aggregation of full-length immunoglobulin light chains","volume":"116","author":"Rennella","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"22","key":"10.1016\/j.bbrep.2023.101442_bib24","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1073\/pnas.1522282113","article-title":"Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril","volume":"113","author":"Schmidt","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbrep.2023.101442_bib25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s42003-020-01641-6","article-title":"Breakdown of supersaturation barrier links protein folding to amyloid formation","volume":"4","author":"Noji","year":"2021","journal-title":"Commun Biol"},{"issue":"11","key":"10.1016\/j.bbrep.2023.101442_bib26","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1021\/bi061716v","article-title":"Structural characterization of the partially folded intermediates of an immunoglobulin light chain leading to amyloid fibrillation and amorphous aggregation","volume":"46","author":"Qin","year":"2007","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.bbrep.2023.101442_bib27","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.tibs.2021.05.003","article-title":"Protein amyloid cofactors: charged side-chain arrays meet their match?","volume":"46","author":"Lewkowicz","year":"2021","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.bbrep.2023.101442_bib28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/PL00000706","article-title":"Immunoglobulin light chains, glycosaminoglycans, and amyloid","volume":"57","author":"Stevens","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"issue":"48","key":"10.1016\/j.bbrep.2023.101442_bib29","doi-asserted-by":"crossref","first-page":"37672","DOI":"10.1074\/jbc.M110.149575","article-title":"Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils","volume":"285","author":"Ren","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bbrep.2023.101442_bib30","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1110\/ps.051997606","article-title":"The effects of sodium sulfate, glycosaminoglycans, and Congo red on the structure, stability, and amyloid formation of an immunoglobulin light-chain protein","volume":"15","author":"McLaughlin","year":"2006","journal-title":"Protein Sci."},{"issue":"5","key":"10.1016\/j.bbrep.2023.101442_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25051195","article-title":"Structure and aggregation mechanisms in amyloids","volume":"25","author":"Almeida","year":"2020","journal-title":"Molecules"}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580823000237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580823000237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:50:14Z","timestamp":1762501814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580823000237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":31,"alternative-id":["S2405580823000237"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2023.101442","relation":{},"ISSN":["2405-5808"],"issn-type":[{"type":"print","value":"2405-5808"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Producing amyloid fibrils in vitro: A tool for studying AL amyloidosis","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2023.101442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101442"}}