{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:16:04Z","timestamp":1791389764334,"version":"4.3.3"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019336","name":"Program for Education and Research in Biotechnology, California State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008134","name":"California State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5SC2GM126551"],"award-info":[{"award-number":["5SC2GM126551"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["4T34GM008253"],"award-info":[{"award-number":["4T34GM008253"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bbrep.2023.101513","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T17:21:35Z","timestamp":1689528095000},"page":"101513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The effect of histone deacetylase inhibitors on the efficiency of the CRISPR\/Cas9 system"],"prefix":"10.1016","volume":"35","author":[{"given":"Ymer","family":"Bj\u00f6rnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Codey Y.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaedyn L.","family":"Rollins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6385-8333","authenticated-orcid":false,"given":"Jennifer M.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6121","key":"10.1016\/j.bbrep.2023.101513_bib1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","article-title":"RNA-guided human genome engineering via Cas9","volume":"339","author":"Mali","year":"2013","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bbrep.2023.101513_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.stem.2014.05.018","article-title":"An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells","volume":"15","author":"Gonz\u00e1lez","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"7504","key":"10.1016\/j.bbrep.2023.101513_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature13420","article-title":"Targeted genome editing in human repopulating haematopoietic stem cells","volume":"510","author":"Genovese","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbrep.2023.101513_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.stem.2010.05.016","article-title":"A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal","volume":"7","author":"Milyavsky","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"12","key":"10.1016\/j.bbrep.2023.101513_bib5","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/nbt.3408","article-title":"Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors","volume":"33","author":"Wang","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"8943","key":"10.1016\/j.bbrep.2023.101513_bib6","article-title":"Small molecules enhance CRISPR\/Cas9-mediated homology-directed genome editing in primary cells","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbrep.2023.101513_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stem.2010.06.014","article-title":"Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis","volume":"7","author":"Mohrin","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.bbrep.2023.101513_bib8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nbt.3198","article-title":"Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells","volume":"33","author":"Chu","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.bbrep.2023.101513_bib9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.stem.2015.01.003","article-title":"Small molecules enhance CRISPR genome editing in pluripotent stem cells","volume":"16","author":"Yu","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.bbrep.2023.101513_bib10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nbt.3190","article-title":"Inhibition of non-homologous end joining increases the efficiency of CRISPR\/Cas9-mediated precise [TM: inserted] genome editing","volume":"33","author":"Maruyama","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"9","key":"10.1016\/j.bbrep.2023.101513_bib11","article-title":"Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells","volume":"4","author":"Riesenberg","year":"2018","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbrep.2023.101513_bib12","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1073\/pnas.0307708100","article-title":"Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1","volume":"101","author":"Gui","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6121","key":"10.1016\/j.bbrep.2023.101513_bib13","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.bbrep.2023.101513_bib14","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1093\/nar\/gku936","article-title":"Easy quantitative assessment of genome editing by sequence trace decomposition","volume":"42","author":"Brinkman","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2023.101513_bib15","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nbt1210-1248","article-title":"Towards a knowledge-based human protein atlas","volume":"28","author":"Uhlen","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"6472","key":"10.1016\/j.bbrep.2023.101513_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aax9198","article-title":"A genome-wide transcriptomic analysis of protein-coding genes in human blood cells","volume":"366","author":"Uhlen","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.bbrep.2023.101513_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2018.07.057","article-title":"Valproic acid as an adjunctive therapeutic agent for the treatment of breast T cancer","volume":"835","author":"Heers","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbrep.2023.101513_bib18","doi-asserted-by":"crossref","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.bbrep.2023.101513_bib19","first-page":"395","article-title":"Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells","volume":"17","author":"Biermann","year":"2011","journal-title":"Mol. Vis."},{"issue":"13","key":"10.1016\/j.bbrep.2023.101513_bib20","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1093\/emboj\/cdg315","article-title":"The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2","volume":"22","author":"Kr\u00e4mer","year":"2003","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bbrep.2023.101513_bib21","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12974-016-0765-6","article-title":"The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats","volume":"13","author":"Park","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbrep.2023.101513_bib22","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12864-018-4718-6","article-title":"A genome-wide survey of mutations in the Jurkat cell line","volume":"19","author":"Gioia","year":"2018","journal-title":"BMC Genom."},{"issue":"3","key":"10.1016\/j.bbrep.2023.101513_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1096\/fj.04-3062fje","article-title":"Cancer cell line identification by short tandem repeat profiling: power and limitations","volume":"19","author":"Parson","year":"2005","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrep.2023.101513_bib24","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrep.2023.101513_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1615\/CritRevOncog.2015012997","article-title":"Histone deacetylases and mechanisms of regulation of gene expression (histone deacetylases in cancer)","volume":"20","author":"Chen","year":"2015","journal-title":"Crit. Rev. Oncog."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580823000948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580823000948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:45:27Z","timestamp":1778881527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580823000948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":25,"alternative-id":["S2405580823000948"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2023.101513","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of histone deacetylase inhibitors on the efficiency of the CRISPR\/Cas9 system","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2023.101513","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101513"}}