{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:13:50Z","timestamp":1773666830563,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010876","name":"Shanghai University of TCM","doi-asserted-by":"publisher","award":["A1-U21-205-01010202"],"award-info":[{"award-number":["A1-U21-205-01010202"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bbrep.2023.101593","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T01:28:20Z","timestamp":1701307700000},"page":"101593","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Codonopsis pilosula polysaccharide alleviates rotenone-induced murine brain organoids death through downregulation of gene body DNA methylation modification in the ZIC4\/PGM5\/CAMTA1 axis"],"prefix":"10.1016","volume":"37","author":[{"given":"Haiyang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiling","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-4210","authenticated-orcid":false,"given":"Weidong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3976-3489","authenticated-orcid":false,"given":"Te","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2023.101593_bib1","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1021\/acs.est.1c00129","article-title":"Photochemical pathways of rotenone and deguelin degradation: implications for rotenoid attenuation and persistence in high-latitude lakes","volume":"55","author":"Redman","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.bbrep.2023.101593_bib2","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1021\/tx200366j","article-title":"Rotenone-mediated changes in intracellular coenzyme A thioester levels: implications for mitochondrial dysfunction","volume":"24","author":"Basu","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbrep.2023.101593_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5114\/fn.2019.89857","article-title":"Rotenone: from modelling to implication in Parkinson's disease","volume":"57","author":"Radad","year":"2019","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.bbrep.2023.101593_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128355","article-title":"Rotenone alters behavior and reproductive functions of freshwater catfish, Mystus cavasius, through deficits of dopaminergic neurons in the brain","volume":"263","author":"Badruzzaman","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbrep.2023.101593_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22605","article-title":"The protective effect of natural compounds against rotenone-induced neurotoxicity","volume":"34","author":"Yarmohammadi","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbrep.2023.101593_bib6","first-page":"315","article-title":"A review of the literature of rotenone, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-1-benzopyrano[3,5-b]furo[ 2,3-h][1]benzopyran-6(6h)-one","volume":"1","author":"Haley","year":"1978","journal-title":"J. Environ. Pathol. Toxicol."},{"key":"10.1016\/j.bbrep.2023.101593_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuro.2014.12.002","article-title":"An update on the rotenone models of Parkinson's disease: their ability to reproduce the features of clinical disease and model gene-environment interactions","volume":"46","author":"Johnson","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbrep.2023.101593_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.scitotenv.2015.04.059","article-title":"Using gamma distribution to determine half-life of rotenone, applied in freshwater","volume":"527\u2013528","author":"Rohan","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bbrep.2023.101593_bib9","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.7150\/ijms.74569","article-title":"Rotenone, an environmental toxin, causes abnormal methylation of the mouse brain organoid's genome and ferroptosis","volume":"19","author":"Huang","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.bbrep.2023.101593_bib10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/jnc.13172","article-title":"Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells","volume":"134","author":"Feng","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrep.2023.101593_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00128-013-1040-5","article-title":"Dissipation and residue of rotenone in cabbage and soil under field conditions","volume":"91","author":"Zhou","year":"2013","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.bbrep.2023.101593_bib12","article-title":"Codonopsis pilosula polysaccharide improved spleen deficiency in mice by modulating gut microbiota and energy related metabolisms","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrep.2023.101593_bib13","doi-asserted-by":"crossref","first-page":"13422","DOI":"10.18632\/aging.103445","article-title":"Codonopsis pilosula polysaccharide attenuates Abeta toxicity and cognitive defects in APP\/PS1 mice","volume":"12","author":"Wan","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbrep.2023.101593_bib14","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1177\/08853282211054333","article-title":"Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats","volume":"36","author":"Yang","year":"2022","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.bbrep.2023.101593_bib15","first-page":"208","article-title":"Codonopsis pilosula polysaccharides alleviate abeta (1-40)-induced PC12 cells energy dysmetabolism via CD38\/NAD+ signaling pathway","volume":"18","author":"Hu","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbrep.2023.101593_bib16","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.4014\/jmb.1601.01094","article-title":"Effects of selenizing Codonopsis pilosula polysaccharide on macrophage modulatory activities","volume":"26","author":"Qin","year":"2016","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbrep.2023.101593_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3389\/fnmol.2018.00437","article-title":"Codonopsis pilosula polysaccharide attenuates Tau hyperphosphorylation and cognitive impairments in hTau infected mice","volume":"11","author":"Zhang","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbrep.2023.101593_bib18","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1234852","article-title":"Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications","volume":"340","author":"Sato","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bbrep.2023.101593_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/science.1247125","article-title":"Organogenesis in a dish: modeling development and disease using organoid technologies","volume":"345","author":"Lancaster","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbrep.2023.101593_bib20","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1242\/dev.118570","article-title":"Modeling mouse and human development using organoid cultures","volume":"142","author":"Huch","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.bbrep.2023.101593_bib21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nm.2695","article-title":"Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5(+) stem cell","volume":"18","author":"Yui","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrep.2023.101593_bib22","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.stem.2013.09.015","article-title":"Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury","volume":"13","author":"Fordham","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrep.2023.101593_bib23","first-page":"146","article-title":"Brain organoids: advances, applications and challenges","author":"Qian","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.bbrep.2023.101593_bib24","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1038\/emboj.2013.204","article-title":"Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5\/R-spondin axis","volume":"32","author":"Huch","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrep.2023.101593_bib25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature12271","article-title":"Vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"499","author":"Takebe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2023.101593_bib26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature09691","article-title":"Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro","volume":"470","author":"Spence","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2023.101593_bib27","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrep.2023.101593_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/ncb2894","article-title":"Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney","volume":"16","author":"Takasato","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrep.2023.101593_bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cell.2014.08.017","article-title":"Identification of multipotent luminal progenitor cells in human prostate organoid cultures","volume":"159","author":"Karthaus","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2023.101593_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature09941","article-title":"Self-organizing optic-cup morphogenesis in three-dimensional culture","volume":"472","author":"Eiraku","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2023.101593_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/mds.25740","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"29","author":"Hattori","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbrep.2023.101593_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2023.101593_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrg.2017.80","article-title":"The DNA methyltransferase family: a versatile toolkit for epigenetic regulation","volume":"19","author":"Lyko","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrep.2023.101593_bib34","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.jmb.2017.02.008","article-title":"Dynamics and context-dependent roles of DNA methylation","volume":"429","author":"Ambrosi","year":"2017","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrep.2023.101593_bib35","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1080\/15476286.2016.1191737","article-title":"Mechanism and biological role of Dnmt2 in nucleic acid methylation","volume":"14","author":"Jeltsch","year":"2017","journal-title":"RNA Biol."},{"key":"10.1016\/j.bbrep.2023.101593_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13072-020-00338-8","article-title":"The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure","volume":"13","author":"Freeman","year":"2020","journal-title":"Epigenet. Chromatin"},{"key":"10.1016\/j.bbrep.2023.101593_bib37","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1007\/s00213-014-3565-7","article-title":"Lithium reduces the effects of rotenone-induced complex I dysfunction on DNA methylation and hydroxymethylation in rat cortical primary neurons","volume":"231","author":"Scola","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbrep.2023.101593_bib38","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/nprot.2014.158","article-title":"Generation of cerebral organoids from human pluripotent stem cells","volume":"9","author":"Lancaster","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrep.2023.101593_bib39","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.celrep.2018.03.105","article-title":"Glioblastoma model using human cerebral organoids","volume":"23","author":"Ogawa","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrep.2023.101593_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.113083","article-title":"siRNA@superparamagnetic iron oxide nanoparticles attenuate physiological toxicity of DEHP by suppressing autophagy pathway activities in Caenorhabditis elegans","volume":"229","author":"Huang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bbrep.2023.101593_bib41","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1166\/jbn.2020.2991","article-title":"Superparamagnetic iron oxide nanoparticles induce ferroptosis of human ovarian cancer stem cells by weakening cellular autophagy","volume":"16","author":"Huang","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.bbrep.2023.101593_bib42","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrep.2023.101593_bib43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41571-018-0004-4","article-title":"Analysis of DNA methylation in cancer: location revisited","volume":"15","author":"Koch","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbrep.2023.101593_bib44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat. Rev. Genet."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580823001747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580823001747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:49:45Z","timestamp":1762501785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580823001747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"alternative-id":["S2405580823001747"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2023.101593","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Codonopsis pilosula polysaccharide alleviates rotenone-induced murine brain organoids death through downregulation of gene body DNA methylation modification in the ZIC4\/PGM5\/CAMTA1 axis","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2023.101593","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101593"}}