{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:17:18Z","timestamp":1775557038091,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bbrep.2024.101647","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T09:02:59Z","timestamp":1705827779000},"page":"101647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Identification of novel potential drugs for the treatment and prevention of osteoarthritis"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1666-8405","authenticated-orcid":false,"given":"Xiaosong","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2024.101647_bib1","first-page":"169","article-title":"Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223\/NLRP3\/pyroptosis axis: toward a precision therapy","volume":"30","author":"Liu","year":"2023","journal-title":"Bioact. Mater."},{"issue":"10182","key":"10.1016\/j.bbrep.2024.101647_bib2","first-page":"1745","volume":"393","author":"Hunter","year":"2019","journal-title":"Osteoarthritis. Lancet"},{"issue":"11","key":"10.1016\/j.bbrep.2024.101647_bib3","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.joca.2014.07.015","article-title":"Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032","volume":"22","author":"Turkiewicz","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.bbrep.2024.101647_bib4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41584-021-00612-3","article-title":"Bone stresses out cartilage in OA","volume":"17","author":"Clarke","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbrep.2024.101647_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110724","article-title":"Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1","volume":"384","author":"Liu","year":"2023","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41413-022-00226-9","article-title":"Current understanding of osteoarthritis pathogenesis and relevant new approaches","volume":"10","author":"Tong","year":"2022","journal-title":"Bone Res"},{"issue":"10","key":"10.1016\/j.bbrep.2024.101647_bib7","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.joca.2023.05.015","article-title":"Recommendations for the management of hip and knee osteoarthritis: a systematic review of clinical practice guidelines","volume":"31","author":"Gibbs","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.bbrep.2024.101647_bib8","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.joca.2023.03.008","article-title":"Osteoarthritis year in review 2022: Epidemiology & therapy","volume":"31","author":"Foster","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.bbrep.2024.101647_bib9","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jhep.2023.05.031","article-title":"Identification and experimental validation of druggable epigenetic targets in hepatoblastoma","volume":"79","author":"Claveria-Cabello","year":"2023","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib10","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2219346","article-title":"Comparative analysis of whole genomes and transcriptomes of Microsporum canis from invasive dermatophytosis and tinea capitis","volume":"12","author":"Wang","year":"2023","journal-title":"Emerg Microbes Infect"},{"issue":"13","key":"10.1016\/j.bbrep.2024.101647_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14133284","article-title":"Novel drug candidate prediction for Intrahepatic Cholangiocarcinoma via hub gene network analysis and Connectivity Mapping","volume":"14","author":"Xiao","year":"2022","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.bbrep.2024.101647_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2174\/1381612827666211104154459","article-title":"Identifying the hub genes and immune cell infiltration in synovial tissue between osteoarthritic and Rheumatoid Arthritic patients by bioinformatic approach","volume":"28","author":"Wang","year":"2022","journal-title":"Curr Pharm Des"},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/21691401.2023.2185627","article-title":"Exploration of effective biomarkers and infiltrating Immune cells in Osteoarthritis based on bioinformatics analysis","volume":"51","author":"Cheng","year":"2023","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"10.1016\/j.bbrep.2024.101647_bib14","volume":"vol. 1","author":"Gentleman","year":"2005"},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1186\/s12885-021-08412-4","article-title":"Bioinformatics analysis of differentially expressed genes and pathways in the development of cervical cancer","volume":"21","author":"Wu","year":"2021","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.bbrep.2024.101647_bib16","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"issue":"11","key":"10.1016\/j.bbrep.2024.101647_bib17","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"W1","key":"10.1016\/j.bbrep.2024.101647_bib18","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"10.1016\/j.bbrep.2024.101647_bib19","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbrep.2024.101647_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122030","article-title":"MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy","volume":"295","author":"Liu","year":"2023","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.bbrep.2024.101647_bib21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/jbmr.3887","article-title":"Effects of estrogen replacement on bone Geometry and Microarchitecture in Adolescent and Young Adult Oligoamenorrheic Athletes: a Randomized trial","volume":"35","author":"Ackerman","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"17","key":"10.1016\/j.bbrep.2024.101647_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176033","article-title":"Identification of novel targets of knee osteoarthritis Shared by cartilage and synovial tissue","volume":"21","author":"Li","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 120","key":"10.1016\/j.bbrep.2024.101647_bib23","first-page":"31","article-title":"Public health interventions for osteoarthritis - updates on the osteoarthritis action Alliance's efforts to address the 2010 OA public health Agenda Recommendations","volume":"37","author":"Callahan","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"issue":"11","key":"10.1016\/j.bbrep.2024.101647_bib24","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1007\/s00256-022-04191-6","article-title":"Structural phenotypes of knee osteoarthritis: potential clinical and research relevance","volume":"52","author":"Roemer","year":"2023","journal-title":"Skeletal Radiol."},{"issue":"10","key":"10.1016\/j.bbrep.2024.101647_bib25","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.joca.2023.06.006","article-title":"Reflections from the OARSI 2022 clinical trials symposium: the pain of OA-Deconstruction of pain and patient-reported outcome measures for the benefit of patients and clinical trial design","volume":"31","author":"Karsdal","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.joca.2019.09.009","article-title":"Dual roles of misshapen\/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFbeta signaling","volume":"28","author":"Yu","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbrep.2024.101647_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115707","article-title":"Targeting regulated chondrocyte death in osteoarthritis therapy","volume":"215","author":"Zhu","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrep.2024.101647_bib28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbi.2015.07.020","article-title":"Proinflammatory receptor switch from Galphas to Galphai signaling by beta-arrestin-mediated PDE4 recruitment in mixed RA synovial cells","volume":"50","author":"Jenei-Lanzl","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"12","key":"10.1016\/j.bbrep.2024.101647_bib29","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00011-020-01404-3","article-title":"Roflumilast prevents lymphotoxin alpha (TNF-beta)-induced inflammation activation and degradation of type 2 collagen in chondrocytes","volume":"69","author":"Zhao","year":"2020","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.bbrep.2024.101647_bib30","first-page":"281","article-title":"[Effect of acupotomy intervention on the morphology and ultrastructure of rectus femoris muscle in rabbits with knee osteoarthritis]","volume":"35","author":"Liu","year":"2022","journal-title":"Zhong Guo Gu Shang"},{"issue":"4","key":"10.1016\/j.bbrep.2024.101647_bib31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/annrheumdis-2018-214200","article-title":"Wnt16 attenuates osteoarthritis progression through a PCP\/JNK-mTORC1-PTHrP cascade","volume":"78","author":"Tong","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib32","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/annrheumdis-2015-208577","article-title":"WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis","volume":"76","author":"Nalesso","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.bbrep.2024.101647_bib33","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4252\/wjsc.v15.i6.548","article-title":"Factors affecting osteogenesis and chondrogenic differentiation of mesenchymal stem cells in osteoarthritis","volume":"15","author":"Peng","year":"2023","journal-title":"World J Stem Cells"},{"key":"10.1016\/j.bbrep.2024.101647_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.913118","article-title":"Estradiol inhibits ER stress-induced apoptosis in chondrocytes and contributes to a reduced osteoarthritic cartilage degeneration in female mice","volume":"10","author":"Dreier","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.bbrep.2024.101647_bib35","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.joca.2016.04.008","article-title":"Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men","volume":"24","author":"Hussain","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.bbrep.2024.101647_bib36","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chemosphere.2010.01.040","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis of articular chondrocytes in culture","volume":"79","author":"Yang","year":"2010","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.bbrep.2024.101647_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040927","article-title":"Noggin inhibits IL-1beta and BMP-2 expression, and attenuates cartilage degeneration and subchondral bone Destruction in experimental osteoarthritis","volume":"9","author":"Chien","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12079-020-00600-4","article-title":"Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1","volume":"15","author":"Elseoudi","year":"2021","journal-title":"J Cell Commun Signal"},{"issue":"7","key":"10.1016\/j.bbrep.2024.101647_bib39","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/art.37965","article-title":"Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation","volume":"65","author":"Culley","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrep.2024.101647_bib40","article-title":"Identification of SCRG1 as a potential therapeutic target for human synovial inflammation","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrep.2024.101647_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.633315","article-title":"Valproic acid protects chondrocytes from LPS-Stimulated damage via regulating miR-302d-3p\/ITGB4 Axis and mediating the PI3K-AKT signaling pathway","volume":"8","author":"Sun","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"6","key":"10.1016\/j.bbrep.2024.101647_bib42","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/ane.13325","article-title":"Intravenous sodium valproate for acute migraine in the emergency department: a meta-analysis","volume":"142","author":"Wang","year":"2020","journal-title":"Acta Neurol. Scand."},{"issue":"6","key":"10.1016\/j.bbrep.2024.101647_bib43","doi-asserted-by":"crossref","first-page":"832","DOI":"10.2174\/1874467214666211013122528","article-title":"Pharmacotherapy for SARS-CoV-2 and Seizures for drug Repurposing Presumed on Mechanistic targets","volume":"15","author":"Goel","year":"2022","journal-title":"Curr. Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/febs.16194","article-title":"Neutrophil elastase and its inhibitors-overlooked players in osteoarthritis","volume":"289","author":"Kaneva","year":"2022","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/febs.16127","article-title":"Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis","volume":"289","author":"Wilkinson","year":"2022","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.bbrep.2024.101647_bib46","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001801R","article-title":"Alpha-1-antitrypsin reduces inflammation and exerts chondroprotection in arthritis","volume":"35","author":"Kaneva","year":"2021","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.bbrep.2024.101647_bib47","doi-asserted-by":"crossref","first-page":"9300","DOI":"10.1038\/s41598-020-66251-y","article-title":"An anticonvulsive drug, valproic acid (valproate), has effects on the biosynthesis of fatty acids and polyketides in microorganisms","volume":"10","author":"Poolchanuan","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbrep.2024.101647_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdnut.2023.100049","article-title":"An exploratory Case-Control study on the associations of Bacterially-derived Vitamin K Forms with the Intestinal Microbiome and Obesity-related osteoarthritis","volume":"7","author":"Liu","year":"2023","journal-title":"Curr. Dev. Nutr."},{"issue":"11","key":"10.1016\/j.bbrep.2024.101647_bib49","article-title":"The gut-joint Axis in osteoarthritis","volume":"15","author":"Jeyaraman","year":"2023","journal-title":"Cureus"}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580824000116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580824000116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:54:00Z","timestamp":1762502040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580824000116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":49,"alternative-id":["S2405580824000116"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2024.101647","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel potential drugs for the treatment and prevention of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2024.101647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101647"}}