{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:14:22Z","timestamp":1784693662427,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbrep.2024.101901","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T04:29:36Z","timestamp":1736310576000},"page":"101901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Computational identification of novel natural inhibitors against triple mutant DNA gyrase A in fluoroquinolone-resistant Salmonella Typhimurium"],"prefix":"10.1016","volume":"41","author":[{"given":"Sree","family":"Haryini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Priya","family":"Doss C","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2024.101901_bib1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/cid\/ciac035","article-title":"Invasive non-typhoidal Salmonella (iNTS) infections","volume":"75","author":"Fierer","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bbrep.2024.101901_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.18683\/germs.2021.1244","article-title":"Salmonella spp. infection - a continuous threat worldwide","volume":"11","author":"Popa","year":"2021","journal-title":"Germs"},{"key":"10.1016\/j.bbrep.2024.101901_bib4","article-title":"Outbreak of monophasic Salmonella Typhimurium Sequence Type 34 linked to chocolate products","volume":"82","author":"Lund","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"10.1016\/j.bbrep.2024.101901_bib5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11274-021-03146-8","article-title":"Prevalence and multidrug resistance in Salmonella enterica typhimurium: an overview in south East asia","volume":"37","author":"Patra","year":"2021","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbrep.2024.101901_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13099-020-00388-z","article-title":"A nineteen-year report of serotype and antimicrobial susceptibility of enteric non-typhoidal Salmonella from humans in Southern India: changing facades of taxonomy and resistance trend","volume":"12","author":"Jacob","year":"2020","journal-title":"Gut Pathog."},{"key":"10.1016\/j.bbrep.2024.101901_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3390\/antibiotics11040532","article-title":"Antibiotic resistance of Salmonella typhimurium monophasic variant 1,4,[5],12:i:-in China: a systematic review and meta-analysis","volume":"11","author":"Qin","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.bbrep.2024.101901_bib8","article-title":"Antibiotic resistance in Salmonella typhimurium isolates recovered from the food chain through national antimicrobial resistance monitoring system between 1996 and 2016","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbrep.2024.101901_bib9","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1039\/C9MD00120D","article-title":"Quinolone antibiotics","volume":"10","author":"Pham","year":"2019","journal-title":"Medchemcomm"},{"key":"10.1016\/j.bbrep.2024.101901_bib10","series-title":"Salmonella - A Re-emerging Pathogen","article-title":"Fluoroquinolone resistance in Salmonella: mechanisms, fitness, and virulence","author":"Li","year":"2018"},{"key":"10.1016\/j.bbrep.2024.101901_bib11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/jac\/32.3.367","article-title":"High-level fluoroquinolone resistance in a Salmonella typhimurium isolate due to alterations in both gyrA and gyrB genes","volume":"32","author":"Heisig","year":"1993","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bbrep.2024.101901_bib12","doi-asserted-by":"crossref","first-page":"a025320","DOI":"10.1101\/cshperspect.a025320","article-title":"Topoisomerase inhibitors: fluoroquinolone mechanisms of action and resistance","volume":"6","author":"Hooper","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.bbrep.2024.101901_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1751-7915.2008.00063.x","article-title":"Mechanism of action of and resistance to quinolones","volume":"2","author":"F\u00e0brega","year":"2009","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.bbrep.2024.101901_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jgar.2023.09.010","article-title":"Characterization of quinolone resistance in Salmonella enterica serovar Typhimurium and its monophasic variants from food and patients in China","volume":"35","author":"Yang","year":"2023","journal-title":"Journal of Global Antimicrobial Resistance"},{"key":"10.1016\/j.bbrep.2024.101901_bib15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.foodres.2011.01.031","article-title":"Mutations in gyrase and topoisomerase genes associated with fluoroquinolone resistance in Salmonella serovars from retail meats","volume":"45","author":"Yang","year":"2012","journal-title":"Food Res. Int."},{"key":"10.1016\/j.bbrep.2024.101901_bib16","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1128\/AAC.48.10.4012-4015.2004","article-title":"Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica","volume":"48","author":"Eaves","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrep.2024.101901_bib17","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/jac\/dkl391","article-title":"Molecular characterization of ciprofloxacin-resistant Salmonella enterica serovar Typhi and Paratyphi A causing enteric fever in India","volume":"58","author":"Gaind","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.bbrep.2024.101901_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bjid.2012.11.012","article-title":"Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica","volume":"17","author":"Rushdy","year":"2013","journal-title":"The Brazilian Journal of Infectious Diseases"},{"key":"10.1016\/j.bbrep.2024.101901_bib19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s12879-020-05203-3","article-title":"The phenotypic and molecular characteristics of antimicrobial resistance of Salmonella enterica subsp. enterica serovar Typhimurium in Henan Province, China","volume":"20","author":"Dong","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.bbrep.2024.101901_bib20","doi-asserted-by":"crossref","first-page":"C21","DOI":"10.1016\/j.vaccine.2015.03.102","article-title":"Antimicrobial resistance and management of invasive Salmonella disease","volume":"33","author":"Kariuki","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrep.2024.101901_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrep.2024.101901_bib22","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/metabo13060716","article-title":"Plant secondary metabolites: the weapons for biotic stress management","volume":"13","author":"Al-Khayri","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.bbrep.2024.101901_bib23","unstructured":"Chemical Libraries. Complete List of ChemDiv's Compound Libraries, (n.d.). https:\/\/www.chemdiv.com\/catalog\/complete-list-of-compounds-libraries\/(accessed December 2, 2024)."},{"key":"10.1016\/j.bbrep.2024.101901_bib24","first-page":"D190","article-title":"The universal protein resource (UniProt)","volume":"36","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2024.101901_bib25","series-title":"Open Access Databases and Datasets for Drug Discovery","first-page":"39","article-title":"PubChem: a large-scale public chemical database for drug discovery","author":"Kim","year":"2024"},{"key":"10.1016\/j.bbrep.2024.101901_bib26","series-title":"Open Access Databases and Datasets for Drug Discovery","first-page":"175","article-title":"The SWISS-model repository of 3D protein structures and models","author":"Robin","year":"2024"},{"key":"10.1016\/j.bbrep.2024.101901_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2024.101901_bib28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2024.101901_bib29","series-title":"Advances in Protein Molecular and Structural Biology Methods","first-page":"373","article-title":"Chapter 23 - prediction, validation, and analysis of protein structures: a beginner's guide","author":"Sasidharan","year":"2022"},{"key":"10.1016\/j.bbrep.2024.101901_bib30","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrep.2024.101901_bib31","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1038\/s41598-020-65766-8","article-title":"Survey of drug resistance associated gene mutations in Mycobacterium tuberculosis, ESKAPE and other bacterial species","volume":"10","author":"Ghosh","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2024.101901_bib32","article-title":"Performing in silico mutagenesis using Pymol?","author":"Faiza","year":"2021","journal-title":"Bioinformatics Review"},{"key":"10.1016\/j.bbrep.2024.101901_bib33","doi-asserted-by":"crossref","first-page":"W122","DOI":"10.1093\/nar\/gkad472","article-title":"DDMut: predicting effects of mutations on protein stability using deep learning","volume":"51","author":"Zhou","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2024.101901_bib34","unstructured":"QikProp, Schr\u00f6dinger (n.d.). https:\/\/www.schrodinger.com\/platform\/products\/qikprop\/(accessed August 17, 2024)."},{"key":"10.1016\/j.bbrep.2024.101901_bib35","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gky473","article-title":"CASTp 3.0: computed atlas of surface topography of proteins","volume":"46","author":"Tian","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2024.101901_bib36","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for Protein\u2212Ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrep.2024.101901_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbrep.2024.101901_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.bbrep.2024.101901_bib39","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbrep.2024.101901_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.jctc.5b00935","article-title":"CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM\/OpenMM simulations using the CHARMM36 additive force field","volume":"12","author":"Lee","year":"2016","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.bbrep.2024.101901_bib41","series-title":"Protein Dynamics: Methods and Protocols","first-page":"193","article-title":"Principal component analysis: a method for determining the essential dynamics of proteins","author":"David","year":"2014"},{"key":"10.1016\/j.bbrep.2024.101901_bib42","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1016\/S0006-3495(03)74687-6","article-title":"Protein dynamics, thermal stability, and free-energy landscapes: a molecular dynamics investigation","volume":"85","author":"Tavernelli","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrep.2024.101901_bib43","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1006\/jmbi.1995.0514","article-title":"Fluctuation and cross-correlation analysis of protein motions observed in nanosecond molecular dynamics simulations","volume":"252","author":"H\u00fcnenberger","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrep.2024.101901_bib44","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/ci500020m","article-title":"g_mmpbsa\u2014a GROMACS tool for high-throughput MM-PBSA calculations","volume":"54","author":"Kumari","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bbrep.2024.101901_bib45","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.bbrep.2024.101901_bib46","first-page":"3","article-title":"Fluoroquinolone resistance in Salmonella serovars isolated from humans and food animals 1","volume":"26","author":"Piddock","year":"2002","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Rev."},{"key":"10.1016\/j.bbrep.2024.101901_bib47","series-title":"The Quinolones","first-page":"303","article-title":"Chapter 10 - use of the quinolones for treatment and prophylaxis of bacterial gastrointestinal infections","author":"Hamer","year":"2000"},{"key":"10.1016\/j.bbrep.2024.101901_bib48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/antibiotics10121455","article-title":"Mutational diversity in the quinolone resistance-determining regions of type-II topoisomerases of Salmonella serovars","volume":"10","author":"Shaheen","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.bbrep.2024.101901_bib49","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.1007\/s00203-021-02577-z","article-title":"Ciprofloxacin induced antibiotic resistance in Salmonella Typhimurium mutants and genome analysis","volume":"203","author":"Kakatkar","year":"2021","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.bbrep.2024.101901_bib50","unstructured":"Integration of target discovery, drug discovery and drug delivery: A review on computational strategies - Duarte - 2019 - WIREs Nanomedicine and Nanobiotechnology - Wiley Online Library, (n.d.). https:\/\/wires.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/wnan.1554 (accessed December 2, 2024)."},{"key":"10.1016\/j.bbrep.2024.101901_bib51","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3390\/molecules25061375","article-title":"A review on applications of computational methods in drug screening and design","volume":"25","author":"Lin","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbrep.2024.101901_bib52","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ipha.2024.01.010","article-title":"The importance of in-silico studies in drug discovery","volume":"2","author":"Roney","year":"2024","journal-title":"Intelligent Pharmacy"},{"key":"10.1016\/j.bbrep.2024.101901_bib53","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1021\/acs.jmedchem.3c02169","article-title":"Model-based virtual PK\/PD exploration and machine learning approach to define PK drivers in early drug discovery","volume":"67","author":"Chen","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrep.2024.101901_bib54","article-title":"Predicting pharmacodynamic effects through early drug discovery with artificial intelligence-physiologically based pharmacokinetic (AI-PBPK) modelling","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrep.2024.101901_bib55","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1039\/D3CP03492E","article-title":"Elucidation of protein\u2013ligand interactions by multiple trajectory analysis methods","volume":"26","author":"Wu","year":"2024","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bbrep.2024.101901_bib56","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1021\/acs.jcim.2c01444","article-title":"Analysis of protein folding simulation with moving Root mean square deviation","volume":"63","author":"Maruyama","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bbrep.2024.101901_bib57","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1021\/acs.jmedchem.5b01684","article-title":"Role of molecular dynamics and related methods in drug discovery","volume":"59","author":"De Vivo","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrep.2024.101901_bib58","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1134\/S0026893308040195","article-title":"Radius of gyration as an indicator of protein structure compactness","volume":"42","author":"Lobanov","year":"2008","journal-title":"Mol. Biol."},{"key":"10.1016\/j.bbrep.2024.101901_bib59","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.str.2011.03.010","article-title":"Relative solvent accessible surface area predicts protein conformational changes upon binding","volume":"19","author":"Marsh","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.bbrep.2024.101901_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1501240","article-title":"Regulation of protein-ligand binding affinity by hydrogen bond pairing","volume":"2","author":"Chen","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrep.2024.101901_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43586-022-00184-w","article-title":"Principal component analysis","volume":"2","author":"Greenacre","year":"2022","journal-title":"Nat Rev Methods Primers"},{"key":"10.1016\/j.bbrep.2024.101901_bib62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/prot.340110305","article-title":"Collective motions in proteins: a covariance analysis of atomic fluctuations in molecular dynamics and normal mode simulations","volume":"11","author":"Ichiye","year":"1991","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"10.1016\/j.bbrep.2024.101901_bib63","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/jcc.24467","article-title":"Calculating protein-ligand binding affinities with MMPBSA: method and error analysis","volume":"37","author":"Wang","year":"2016","journal-title":"J. Comput. Chem."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580824002656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580824002656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:15:06Z","timestamp":1773864906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580824002656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":62,"alternative-id":["S2405580824002656"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2024.101901","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational identification of novel natural inhibitors against triple mutant DNA gyrase A in fluoroquinolone-resistant Salmonella Typhimurium","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2024.101901","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101901"}}