{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:08:38Z","timestamp":1792685318658,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370738"],"award-info":[{"award-number":["32370738"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbrep.2025.101924","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T19:29:31Z","timestamp":1737228571000},"page":"101924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hepatic HSD17B6 is dispensable for diet-induced fatty liver disease in mice"],"prefix":"10.1016","volume":"41","author":[{"given":"Delong","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.101924_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cld.2017.08.007","article-title":"Pathophysiology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"22","author":"Manne","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.bbrep.2025.101924_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jsbmb.2010.12.013","article-title":"17\u03b2-Hydroxysteroid dehydrogenases (17\u03b2-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development","volume":"125","author":"Marchais-Oberwinkler","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrep.2025.101924_bib3","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1210\/endo.140.11.7137","article-title":"Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta\/3alpha-hydroxysteroid\/retinoid short chain dehydrogenase\/reductase","volume":"140","author":"Su","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrep.2025.101924_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155631","article-title":"HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation","volume":"145","author":"Wei","year":"2023","journal-title":"Metab., Clin. Exp."},{"key":"10.1016\/j.bbrep.2025.101924_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12935-020-01298-5","article-title":"Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma","volume":"20","author":"Lv","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbrep.2025.101924_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100611","article-title":"Acute gene inactivation in the adult mouse liver using the CRISPR-Cas9 technology","volume":"2","author":"Wang","year":"2021","journal-title":"STAR Protoc"},{"key":"10.1016\/j.bbrep.2025.101924_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2020.05.007","article-title":"Acetyl-CoA derived from hepatic peroxisomal \u03b2-oxidation inhibits autophagy and promotes steatosis via mTORC1 activation","author":"He","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrep.2025.101924_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbrc.2023.08.010","article-title":"Autophagy modulates the stability of Wee1 and cell cycle G2\/M transition","volume":"677","author":"Han","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrep.2025.101924_bib9","doi-asserted-by":"crossref","first-page":"D313","DOI":"10.1093\/nar\/gkv1104","article-title":"BioGPS: building your own mash-up of gene annotations and expression profiles","volume":"44","author":"Wu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2025.101924_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11050320","article-title":"Role of steroid hormones in the pathogenesis of nonalcoholic fatty liver disease","volume":"11","author":"Yang","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.bbrep.2025.101924_bib11","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000419","article-title":"Liver-specific mitochondrial amidoxime-reducing component 1 (Mtarc1) knockdown protects the liver from diet-induced MASH in multiple mouse models","volume":"8","author":"Guo","year":"2024","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbrep.2025.101924_bib12","article-title":"Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression","author":"Ju\u00e1rez-Fern\u00e1ndez","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrep.2025.101924_bib13","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000319","article-title":"Tyrosine kinase receptor B (TrkB) attenuates liver fibrosis via inhibiting TGF-\u03b2\/SMAD signaling","author":"Song","year":"2023","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"10.1016\/j.bbrep.2025.101924_bib14","first-page":"S10","article-title":"Pathogenesis of MASLD and MASH - role of insulin resistance and lipotoxicity","volume":"59","author":"Bansal","year":"2024","journal-title":"Aliment Pharmacol. Therapeut."},{"issue":"Pt 2","key":"10.1016\/j.bbrep.2025.101924_bib15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/bj3110437","article-title":"Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV","volume":"311","author":"Adamski","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrep.2025.101924_bib16","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1091\/mbc.e11-07-0592","article-title":"The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse","volume":"22","author":"Larimore","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrep.2025.101924_bib17","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cell.2007.04.035","article-title":"HEF1-dependent Aurora A activation induces disassembly of the primary cilium","volume":"129","author":"Pugacheva","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2025.101924_bib18","doi-asserted-by":"crossref","first-page":"38179","DOI":"10.1074\/jbc.M202601200","article-title":"Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine","volume":"277","author":"Gotoh","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2025.101924_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021109","article-title":"The role of SCAP\/SREBP as central regulators of lipid metabolism in hepatic steatosis","volume":"25","author":"Chandrasekaran","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2025.101924_bib20","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s12276-020-0430-0","article-title":"The cellular function of SCAP in metabolic signaling","volume":"52","author":"Lee","year":"2020","journal-title":"Exp. Mol. Med."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825000111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825000111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:07:02Z","timestamp":1773864422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825000111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":20,"alternative-id":["S2405580825000111"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.101924","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic HSD17B6 is dispensable for diet-induced fatty liver disease in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.101924","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101924"}}