{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:10:10Z","timestamp":1778695810458,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405068"],"award-info":[{"award-number":["82405068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074234"],"award-info":[{"award-number":["82074234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004166"],"award-info":[{"award-number":["82004166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071756"],"award-info":[{"award-number":["82071756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073901"],"award-info":[{"award-number":["82073901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3506200"],"award-info":[{"award-number":["2024YFC3506200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFE0200900"],"award-info":[{"award-number":["2021YFE0200900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["ZD2021CY001"],"award-info":[{"award-number":["ZD2021CY001"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2021-2023)-0103"],"award-info":[{"award-number":["2021-2023)-0103"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbrep.2025.102038","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:38:08Z","timestamp":1746419888000},"page":"102038","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Therapeutic gene targets and epigenetic modifications in rheumatoid arthritis: Insights from MTX, JAK inhibitors, and LLDT-8"],"prefix":"10.1016","volume":"42","author":[{"given":"Jianan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8142-6092","authenticated-orcid":false,"given":"Yunshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runrun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.102038_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41584-022-00827-y","article-title":"Global epidemiology of rheumatoid arthritis","author":"Finckh","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbrep.2025.102038_bib2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/annrheumdis-2019-216243","article-title":"Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era","volume":"79","author":"Hsieh","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrep.2025.102038_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbrep.2025.102038_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.709178","article-title":"New insights from single-cell sequencing data: synovial fibroblasts and synovial macrophages in rheumatoid arthritis","volume":"12","author":"Cheng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrep.2025.102038_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.15212\/AMM-2024-0034","article-title":"Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis","volume":"4","author":"Luo","year":"2025","journal-title":"Acta Materia Medica"},{"key":"10.1016\/j.bbrep.2025.102038_bib6","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/acr.24596","article-title":"American college of rheumatology guideline for the treatment of rheumatoid arthritis","volume":"73","author":"Fraenkel","year":"2021","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.bbrep.2025.102038_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard-2022-223356","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update","volume":"82","author":"Smolen","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrep.2025.102038_bib8","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1017\/S1431927617012399","article-title":"Atomic force microscopy study of the anti-inflammatory effects of triptolide on rheumatoid arthritis fibroblast-like synoviocytes","volume":"23","author":"Su","year":"2017","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.bbrep.2025.102038_bib9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.4103\/1673-5374.249240","article-title":"(5R)-5-hydroxytriptolide inhibits the inflammatory cascade reaction in astrocytes","volume":"14","author":"Cui","year":"2019","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.bbrep.2025.102038_bib10","article-title":"Inflammatory fibroblast-like synoviocyte-derived exosomes aggravate osteoarthritis via enhancing macrophage glycolysis","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbrep.2025.102038_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/gm444","article-title":"An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype","volume":"5","author":"Whitaker","year":"2013","journal-title":"Genome Med."},{"key":"10.1016\/j.bbrep.2025.102038_bib12","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1038\/s41467-022-33785-w","article-title":"Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function","volume":"13","author":"Ainsworth","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2025.102038_bib13","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrep.2025.102038_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbrep.2025.102038_bib15","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbrep.2025.102038_bib16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrep.2025.102038_bib17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbrep.2025.102038_bib18","doi-asserted-by":"crossref","first-page":"D330","DOI":"10.1093\/nar\/gky1055","article-title":"The gene ontology resource: 20 years and still GOing strong","volume":"47","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2025.102038_bib19","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2025.102038_bib20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.bbrep.2025.102038_bib21","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41596-024-01020-z","article-title":"Using clusterProfiler to characterize multiomics data","volume":"19","author":"Xu","year":"2024","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrep.2025.102038_bib22","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.bbrep.2025.102038_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6026\/97320630002005","article-title":"A software package for soft clustering of microarray data","volume":"2","author":"Kumar","year":"2007","journal-title":"Bioinformation"},{"key":"10.1016\/j.bbrep.2025.102038_bib24","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1093\/bioinformatics\/btx513","article-title":"ChAMP: updated methylation analysis pipeline for illumina BeadChips","volume":"33","author":"Tian","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrep.2025.102038_bib25","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive bioconductor package for the analysis of infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrep.2025.102038_bib26","author":"Carlson"},{"key":"10.1016\/j.bbrep.2025.102038_bib27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis - common origins, divergent mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrep.2025.102038_bib28","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.bbrep.2025.102038_bib29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/ars.2010.3419","article-title":"The extending network of FOXO transcriptional target genes","volume":"14","author":"van der Vos","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrep.2025.102038_bib30","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1136\/annrheumdis-2013-203610","article-title":"JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"74","author":"Grabiec","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrep.2025.102038_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155109","article-title":"Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids","volume":"121","author":"Lin","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrep.2025.102038_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2023.102278","article-title":"PTEN-mediated FOXO signaling affects autophagy, migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes","volume":"86","author":"Chen","year":"2024","journal-title":"Tissue Cell"},{"key":"10.1016\/j.bbrep.2025.102038_bib33","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1007\/s10787-024-01565-1","article-title":"Conventional DMARDs therapy decreases disease activity and inflammation in newly diagnosed patients with rheumatoid arthritis by increasing FoxP3, sema-3A, and nrp-1 gene expression","volume":"32","author":"Soufivand","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbrep.2025.102038_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13075-022-02803-z","article-title":"Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis","volume":"24","author":"Sciacca","year":"2022","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrep.2025.102038_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13063-023-07176-5","volume":"24","author":"Shimizu","year":"2023","journal-title":"Trials"},{"key":"10.1016\/j.bbrep.2025.102038_bib36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2174\/1573397118666220401145710","article-title":"The relationship between FoxP3 and SOCs3 gene expressions and disease activity in rheumatoid arthritis","volume":"19","author":"Tawfeik","year":"2023","journal-title":"CRR"},{"key":"10.1016\/j.bbrep.2025.102038_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109997","article-title":"Identification and preliminary validation of synovial tissue-specific genes and their-mediated biological mechanisms in rheumatoid arthritis","volume":"117","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrep.2025.102038_bib38","article-title":"Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrep.2025.102038_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/ar2678","article-title":"Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis","volume":"11","author":"Badot","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbrep.2025.102038_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3899\/jrheum.2023-0588","article-title":"A call for gene expression analysis in whole blood of patients with rheumatoid arthritis (RA) as a biomarker for RA-associated interstitial lung disease","volume":"51","author":"Wierczeiko","year":"2024","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bbrep.2025.102038_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e35511","article-title":"Identification of diagnostic biomarkers of rheumatoid arthritis based on machine learning-assisted comprehensive bioinformatics and its correlation with immune cells","volume":"10","author":"Mu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bbrep.2025.102038_bib42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jbmr\/zjae015","article-title":"Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNF\u03b1-mediated osteoclastogenesis","volume":"39","author":"Yoshida","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrep.2025.102038_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13020-020-00339-5","article-title":"Identification of drug targets and potential molecular mechanisms for wantong jingu tablet extract in treatment of rheumatoid arthritis: bioinformatics analysis of fibroblast-like synoviocytes","volume":"15","author":"Li","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.bbrep.2025.102038_bib44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbrep.2025.102038_bib45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/acr2.11231","article-title":"Distinct DNA methylation patterns of rheumatoid arthritis peripheral blood and synovial tissue T cells","volume":"3","author":"Ai","year":"2021","journal-title":"ACR Open Rheumatol"},{"key":"10.1016\/j.bbrep.2025.102038_bib46","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/rheumatology\/kez411","article-title":"Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis","volume":"59","author":"Nair","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.bbrep.2025.102038_bib47","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/1878-0261.13347","article-title":"GALNT2 promotes invasiveness of colorectal cancer cells partly through AXL","volume":"17","author":"Liao","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bbrep.2025.102038_bib48","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bbagen.2007.09.010","article-title":"Mucin-type O-glycosylation and its potential use in drug and vaccine development","volume":"1780","author":"Tarp","year":"2008","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbrep.2025.102038_bib49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13148-023-01570-1","article-title":"Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas","volume":"15","author":"Gallardo-G\u00f3mez","year":"2023","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.bbrep.2025.102038_bib50","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/14397595.2016.1218595","article-title":"Genome-wide DNA methylation patterns in CD4+ T cells from Chinese han patients with rheumatoid arthritis","volume":"27","author":"Guo","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.bbrep.2025.102038_bib51","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1177\/10738584221120182","article-title":"Cyclin F, neurodegeneration, and the pathogenesis of ALS\/FTD","volume":"30","author":"Rayner","year":"2024","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbrep.2025.102038_bib52","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.molcel.2019.04.010","article-title":"Cyclin F controls cell-cycle transcriptional outputs by directing the degradation of the three activator E2Fs","volume":"74","author":"Clijsters","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrep.2025.102038_bib53","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1474-4422(17)30401-5","article-title":"Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications","volume":"17","author":"Chia","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbrep.2025.102038_bib54","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1007\/s12035-022-02934-z","article-title":"Recent updates on the genetics of amyotrophic lateral sclerosis and frontotemporal dementia","volume":"59","author":"Kirola","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrep.2025.102038_bib55","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.biocel.2017.06.011","article-title":"Cyclin F: a component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer","volume":"89","author":"Galper","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrep.2025.102038_bib56","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1038\/s41598-024-59437-1","article-title":"Overexpression of cyclin F\/CCNF as an independent prognostic factor for poor survival in clear cell renal cell carcinoma","volume":"14","author":"Kwiatkowski","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2025.102038_bib57","article-title":"Increased expression of cyclin F in liver cancer predicts poor prognosis: a study based on TCGA database","volume":"100","author":"Zelong","year":"2021","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.bbrep.2025.102038_bib58","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.7150\/jca.86597","article-title":"A comprehensive analysis of the prognostic, immunological and diagnostic role of CCNF in pan-cancer","volume":"14","author":"Gao","year":"2023","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbrep.2025.102038_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1109378","article-title":"CCNF is a potential pancancer biomarker and immunotherapy target","volume":"13","author":"Wei","year":"2023","journal-title":"Front. Oncol."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825001256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825001256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:34:45Z","timestamp":1762623285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825001256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":59,"alternative-id":["S2405580825001256"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102038","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic gene targets and epigenetic modifications in rheumatoid arthritis: Insights from MTX, JAK inhibitors, and LLDT-8","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102038"}}