{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:40:10Z","timestamp":1749037210261,"version":"3.41.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005612","name":"Shionogi and Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbrep.2025.102061","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T14:43:08Z","timestamp":1748184188000},"page":"102061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multidirectional therapeutic effects of synthesized HMGB1 peptide on liver cirrhosis in mice"],"prefix":"10.1016","volume":"42","author":[{"given":"Masaki","family":"Mito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9279-5917","authenticated-orcid":false,"given":"Atsunori","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Tonouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaito","family":"Furuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Jinbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuto","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.102061_bib1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41575-023-00759-2","article-title":"Global epidemiology of cirrhosis - aetiology, trends and predictions","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrep.2025.102061_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41232-019-0107-z","article-title":"Mesenchymal stem cell therapies for liver cirrhosis: MSCs as \"conducting cells\" for improvement of liver fibrosis and regeneration","volume":"39","author":"Tsuchiya","year":"2019","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.bbrep.2025.102061_bib3","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMra2200923","article-title":"Liver transplantation","volume":"389","author":"Lucey","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrep.2025.102061_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41232-021-00177-4","article-title":"Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice","volume":"41","author":"Nojiri","year":"2021","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.bbrep.2025.102061_bib5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/hepr.13825","article-title":"Synthesized HMGB1 peptide prevents the progression of inflammation, steatosis, fibrosis, and tumor occurrence in a non-alcoholic steatohepatitis mouse model","volume":"52","author":"Ishii","year":"2022","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.bbrep.2025.102061_bib6","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1073\/pnas.1016753108","article-title":"PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","volume":"108","author":"Tamai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2025.102061_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/srep11008","article-title":"Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFRalpha(+) mesenchymal cells from bone marrow","volume":"5","author":"Aikawa","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2025.102061_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbrc.2023.06.032","article-title":"High-mobility group box-1 peptide ameliorates bronchopulmonary dysplasia by suppressing inflammation and fibrosis in a mouse model","volume":"671","author":"Hara","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.bbrep.2025.102061_bib9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s00535-024-02112-z","article-title":"High-mobility group box 1 fragment ameliorates chronic pancreatitis induced by caerulein in mice","volume":"59","author":"Hokkoku","year":"2024","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bbrep.2025.102061_bib10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s41232-023-00299-x","article-title":"Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis","volume":"43","author":"Takeda","year":"2023","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.bbrep.2025.102061_bib11","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jhep.2023.12.023","article-title":"Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver","volume":"80","author":"Andrews","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrep.2025.102061_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004757","article-title":"Spatially resolved proteomic profiling identifies tumor cell CD44 as a biomarker associated with sensitivity to PD-1 axis blockade in advanced non-small-cell lung cancer","volume":"10","author":"Moutafi","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbrep.2025.102061_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.08.003","article-title":"Spatially organized multicellular immune hubs in human colorectal cancer","volume":"184","author":"Pelka","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2025.102061_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41698-023-00474-w","article-title":"Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment","volume":"7","author":"Furuhashi","year":"2023","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.bbrep.2025.102061_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13174456","article-title":"Best practices for spatial profiling for breast cancer research with the GeoMx((R)) digital spatial profiler","volume":"13","author":"Bergholtz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrep.2025.102061_bib16","article-title":"Proteomics reveals defective peroxisomal fatty acid oxidation during the progression of acute kidney injury and repair","volume":"9","author":"Chen","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.bbrep.2025.102061_bib17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13046-018-0942-9","article-title":"Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma","volume":"37","author":"Yun","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbrep.2025.102061_bib18","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.apsb.2022.10.017","article-title":"Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism","volume":"13","author":"Gan","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbrep.2025.102061_bib19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.actbio.2018.01.036","article-title":"Delayed release of chemokine CCL25 with bioresorbable microparticles for mobilization of human mesenchymal stem cells","volume":"69","author":"Frohlich","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbrep.2025.102061_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20010052","article-title":"Dose-dependent effect of mesenchymal stromal cell recruiting chemokine CCL25 on porcine tissue-engineered healthy and osteoarthritic cartilage","volume":"20","author":"Luderitz","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2025.102061_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00774-020-01122-0","article-title":"SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1\/CXCR4 axis in bone defect","volume":"39","author":"Zhang","year":"2021","journal-title":"J. Bone Miner. Metabol."},{"key":"10.1016\/j.bbrep.2025.102061_bib22","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1007\/s10620-012-2239-8","article-title":"Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice","volume":"57","author":"Tsuchiya","year":"2012","journal-title":"Dig. Dis. Sci."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825001487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825001487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:22:17Z","timestamp":1749036137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825001487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":22,"alternative-id":["S2405580825001487"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102061","relation":{},"ISSN":["2405-5808"],"issn-type":[{"type":"print","value":"2405-5808"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multidirectional therapeutic effects of synthesized HMGB1 peptide on liver cirrhosis in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102061"}}