{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:36:34Z","timestamp":1791221794818,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017531","name":"Gandhi Institute of Technology and Management","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014825","name":"Biotechnology Industry Research Assistance Council","doi-asserted-by":"publisher","award":["BT\/AIR01566\/PACE-27\/22"],"award-info":[{"award-number":["BT\/AIR01566\/PACE-27\/22"]}],"id":[{"id":"10.13039\/501100014825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrep.2025.102074","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T15:00:37Z","timestamp":1749135637000},"page":"102074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Novel and efficient synthesis of 5-chloro-6-methoxy-3-(2-((1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzo[d]isoxazole derivatives as new \u03b1-glucosidase inhibitors"],"prefix":"10.1016","volume":"43","author":[{"given":"Ram Reddy","family":"Mudireddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rambabu","family":"Gundla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Prakash","family":"Koraboina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vani Madhuri","family":"Velavalapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Veernjaneya","family":"Sarma Dhulipalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowri Sankararao","family":"Burle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekantha B.","family":"Jonnalagadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-8528","authenticated-orcid":false,"given":"Naresh Kumar","family":"Katari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.102074_bib1","article-title":"Diabetes mellitus \u2013 a challenging metabolic disorder of the modern world","volume":"8","author":"Nabeela","year":"2019","journal-title":"Pure Appl. Biol."},{"key":"10.1016\/j.bbrep.2025.102074_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.807548","article-title":"Trends in antidiabetic drug discovery: FDA approved drugs, new drugs in clinical trials and global sales","volume":"12","author":"Dahl\u00e9n","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrep.2025.102074_bib3","first-page":"1","article-title":"Josep Julve, Overview on chronic complications of diabetes mellitus","author":"Vlacho","year":"2024","journal-title":"Elsevier EBooks"},{"key":"10.1016\/j.bbrep.2025.102074_bib4","first-page":"1","article-title":"Diabetic vascular diseases: molecular mechanisms and therapeutic strategiesSignal Transduct. Target","volume":"8","author":"Li","year":"2023","journal-title":"Ther"},{"key":"10.1016\/j.bbrep.2025.102074_bib5","series-title":"Chronic Complications of Diabetes Mellitus","author":"Mauricio","year":"2024"},{"key":"10.1016\/j.bbrep.2025.102074_bib6","first-page":"S4","article-title":"Summary of revisions: standards of medical care in diabetes\u20142022","volume":"45","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrep.2025.102074_bib7","first-page":"S46","article-title":"Comprehensive medical evaluation and assessment of comorbidities: standards of medical care in diabetes\u20142022","volume":"45","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrep.2025.102074_bib8","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas","volume":"vol. 157","author":"Saeedi","year":"2019"},{"key":"10.1016\/j.bbrep.2025.102074_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115119","article-title":"Synthetic \u03b1-glucosidase inhibitors as promising anti-diabetic agents: recent developments and future challenges","volume":"249","author":"Mushtaq","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib10","article-title":"A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes","volume":"21","author":"Dirir","year":"2021","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.bbrep.2025.102074_bib11","article-title":"Alpha-glucosidase inhibitory peptides: sources, preparations, identifications, and action mechanisms","volume":"15","author":"Han","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrep.2025.102074_bib12","first-page":"2722","article-title":"Recent updates on phytoconstituent alpha-glucosidase inhibitors: an approach towards the treatment of type two diabetes","volume":"11","author":"Kashtoh","year":"2022","journal-title":"Plants (Basel, Switzerland)"},{"key":"10.1016\/j.bbrep.2025.102074_bib13","doi-asserted-by":"crossref","DOI":"10.2174\/0113894501313365240722100902","article-title":"Recent advances in the development of alpha-glucosidase and alpha-amylase inhibitors in type 2 diabetes management: insights from in silico to in vitro studies","volume":"25","author":"Khan","year":"2024","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbrep.2025.102074_bib14","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/cmdc.202100370","article-title":"A patent review on the current developments of benzoxazoles in drug discovery","volume":"16","author":"Wong","year":"2021","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bbrep.2025.102074_bib15","article-title":"The benzoxazole heterocycle: a comprehensive review of the most recent medicinal chemistry developments of antiproliferative, brain-penetrant, and anti-inflammatory agents","volume":"382","author":"Martino","year":"2024","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112979","article-title":"Synthesis of some new benzoxazole derivatives and investigation of their anticancer activities","volume":"210","author":"Osmaniye","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202103559","article-title":"Synthesis, biological evaluation and in silico studies of some 2\u2010substituted benzoxazole derivatives as potential anticancer agents to breast cancer","volume":"7","author":"Kuzu","year":"2022","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bbrep.2025.102074_bib18","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.3390\/molecules27238375","article-title":"Design, synthesis, and anti-fungal evaluation of heterocyclic benzoxazole derivatives","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbrep.2025.102074_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.137965","article-title":"Synthesis and antibacterial activities of novel hybrid molecules based on benzothiazole, benzimidazole, benzoxazole, and pyrimidine derivatives, each connected to N-arylacetamide and benzoate groups","author":"Elwahy","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bbrep.2025.102074_bib20","doi-asserted-by":"crossref","DOI":"10.2174\/1570180819666220408133643","article-title":"Synthesis, antimicrobial activity, and molecular modeling studies of some benzoxazole derivatives","volume":"19","author":"Muhammed","year":"2022","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.bbrep.2025.102074_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2022.104242","article-title":"The anti-HIV potential of imidazole, oxazole and thiazole hybrids: a mini-review","volume":"15","author":"Deng","year":"2022","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.116777","article-title":"Identification of nitrofuranylchalcone tethered benzoxazole-2-amines as potent inhibitors of drug resistant Mycobacterium tuberculosis demonstrating bactericidal efficacy","volume":"64","author":"Kumar Sahoo","year":"2022","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib23","article-title":"Biomedical applications of selective metal complexes of indole, benzimidazole, benzothiazole and benzoxazole: a review (From 2015 to 2022)","volume":"31","author":"Abdullah","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.bbrep.2025.102074_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202201145","article-title":"Synthesis and anti\u2010inflammatory activity evaluation of benzoxazole derivatives as new myeloid differentiation protein 2 inhibitors","volume":"20","author":"Bai","year":"2023","journal-title":"Chem. Biodiversity"},{"key":"10.1016\/j.bbrep.2025.102074_bib25","article-title":"Current development of 1,2,3-triazole derived potential antimalarial scaffolds: structure- activity relationship (SAR) and bioactive compounds","volume":"259","author":"Rahman","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/ph16020179","article-title":"An overview of 1,2,3-triazole-Containing hybrids and their potential anticholinesterase activities","volume":"16","author":"Khan","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbrep.2025.102074_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202401109","article-title":"Recent developments in 1,2,3\u2010triazole based \u03b1\u2010glucosidase inhibitors: design strategies, structure\u2010activity relationship and mechanistic insights","author":"Singh","year":"2024","journal-title":"Chem. Biodiversity"},{"key":"10.1016\/j.bbrep.2025.102074_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202301612","article-title":"A comprehensive review of the diverse spectrum activity of 1,2,3\u2010Triazole\u2010linked isatin hybrids","author":"Rohila","year":"2024","journal-title":"Chem. Biodiversity"},{"key":"10.1016\/j.bbrep.2025.102074_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28227593","article-title":"Molecular hybridization of alkaloids using 1,2,3-triazole-based click chemistry","volume":"28","author":"Buchanan","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bbrep.2025.102074_bib30","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2174\/1568026616666160824104655","article-title":"Heterocyclic compounds: effective \u03b1-amylase and \u03b1-glucosidase inhibitors","volume":"17","author":"Saeedi","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib31","first-page":"161","article-title":"Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents","volume":"83","author":"Saeedi","year":"2019","journal-title":"In vitro \u03b1-glucosidase inhibition, kinetic, and docking study"},{"key":"10.1016\/j.bbrep.2025.102074_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115148","article-title":"Design, synthesis, in vitro, and in silico studies of novel diarylimidazole-1,2,3-triazole hybrids as potent \u03b1-glucosidase inhibitors","volume":"27","author":"Saeedi","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103206","article-title":"Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: design, synthesis, in vitro \u03b1-glucosidase inhibition, kinetic, and docking studies","volume":"92","author":"Asgari","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103482","article-title":"Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential \u03b1-glucosidase inhibitors","volume":"95","author":"Asemanipoor","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104869","article-title":"Synthesis, in vitro evaluation, and molecular docking studies of novel hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives as potential \u03b1-glucosidase inhibitors","volume":"111","author":"Shareghi-Boroujeni","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib36","first-page":"1382","article-title":"Structural analysis of the \u00ce\u00b1-glucosidase HaG provides new insights into substrate specificity and catalytic mechanism","volume":"D71","author":"Shen","year":"2015","journal-title":"Acta Crystallogr."},{"key":"10.1016\/j.bbrep.2025.102074_bib37","article-title":"In silico co-crystal design: assessment of the latest advances","volume":"28","author":"von Essen","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bbrep.2025.102074_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.addr.2017.05.014","article-title":"Molecular properties associated with transporter-mediated drug disposition","volume":"116","author":"Varma","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrep.2025.102074_bib39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrep.2025.102074_bib40","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrep.2025.102074_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2025.102074_bib42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-2269-7_19","article-title":"Small-molecule library screening by docking with PyRx","volume":"1263","author":"Dallakyan","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrep.2025.102074_bib43","first-page":"303","volume":"vol. 18","author":"Bischoff","year":"1995"},{"key":"10.1016\/j.bbrep.2025.102074_bib44","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1093\/nar\/gkg563","article-title":"ExPASy: the proteomics server for in-depth protein knowledge and analysis","volume":"31","author":"Gasteiger","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2025.102074_bib45","series-title":"Marvin, Chemaxon.Com","year":"2024"},{"key":"10.1016\/j.bbrep.2025.102074_bib46","first-page":"135","volume":"vol. 14","author":"Jejurikar","year":"2021"},{"key":"10.1016\/j.bbrep.2025.102074_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2025.102074_bib48","doi-asserted-by":"crossref","first-page":"8773","DOI":"10.1016\/S0040-4020(01)00877-8","article-title":"A preparation and screening strategy for glycosidase inhibitors","volume":"57","author":"Pistia-Brueggeman","year":"2001","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bbrep.2025.102074_bib49","article-title":"In vitro evaluation of the \u03b1-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants","volume":"19","author":"Bhatia","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.bbrep.2025.102074_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijid.2003.03.002","article-title":"Well diffusion for antifungal susceptibility testing","volume":"8","author":"Magaldi","year":"2004","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.bbrep.2025.102074_bib51","first-page":"67","article-title":"Antibacterial activity of Terminalia chebula fruit by agar well diffusion method, journal of chemistry","volume":"1","author":"Ahuja","year":"2015","journal-title":"Environ. Sci. Appl."},{"key":"10.1016\/j.bbrep.2025.102074_bib52","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/0045-6535(89)90512-2","article-title":"The usefulness of the agar-well diffusion method for assessing chemical toxicity to bacteria and fungi","volume":"19","author":"Devillers","year":"1989","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbrep.2025.102074_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.125501","article-title":"Novel hybrid structures based on 4-Chlorobenzenesulfonyl and 1, 2, 3-triazoles: synthesis, in vitro biological activities and in silico studies","volume":"409","author":"\u00c7e\u015fme","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bbrep.2025.102074_bib54","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1080\/07391102.2023.2222833","article-title":"New sulfonamide derivatives based on 1, 2, 3-triazoles: synthesis, in vitro biological activities and in silico studies","volume":"42","author":"\u015eahin","year":"2024","journal-title":"J. Biomol. Struct. Dyn."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082500161X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082500161X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:32:01Z","timestamp":1767191521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240558082500161X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":54,"alternative-id":["S240558082500161X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102074","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel and efficient synthesis of 5-chloro-6-methoxy-3-(2-((1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzo[d]isoxazole derivatives as new \u03b1-glucosidase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102074"}}