{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:19:52Z","timestamp":1777900792633,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060430"],"award-info":[{"award-number":["82060430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003455","name":"Guangxi University of Science and Technology","doi-asserted-by":"publisher","award":["AD19245196"],"award-info":[{"award-number":["AD19245196"]}],"id":[{"id":"10.13039\/501100003455","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi","doi-asserted-by":"publisher","award":["1598011-4"],"award-info":[{"award-number":["1598011-4"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"publisher","award":["GXMUYSF202327"],"award-info":[{"award-number":["GXMUYSF202327"]}],"id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrep.2025.102164","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:41:16Z","timestamp":1752730876000},"page":"102164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Up-regulation of NGEF via the BRAFV600E \/ERK\/AP1 pathway enhances invasion and migration abilities of BRAFV600E-mutant thyroid cancer"],"prefix":"10.1016","volume":"43","author":[{"given":"Zhao","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.102164_bib1","first-page":"55","article-title":"Differentiated and anaplastic thyroid carcinoma: major changes in the American joint committee on cancer eighth edition cancer staging manual","volume":"68","author":"Perrier","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrep.2025.102164_bib2","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/S0140-6736(16)30172-6","article-title":"Thyroid cancer","volume":"388","author":"Cabanillas","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbrep.2025.102164_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","article-title":"Integrated genomic characterization of papillary thyroid carcinoma","volume":"159","author":"Agrawal","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2025.102164_bib4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1158\/2159-8290.CD-17-1226","article-title":"Combined BRAF, EGFR, and MEK inhibition in patients with BRAF(V600E)-Mutant colorectal cancer","volume":"8","author":"Corcoran","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrep.2025.102164_bib5","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1158\/2159-8290.CD-12-0531","article-title":"Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas","volume":"3","author":"Montero-Conde","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrep.2025.102164_bib6","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/bcp.12651","article-title":"Vemurafenib\/Dabrafenib and trametinib","volume":"80","author":"Rissmann","year":"2015","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bbrep.2025.102164_bib7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1152\/physrev.00045.2020","article-title":"Rho GTPase signaling in cancer progression and dissemination","volume":"102","author":"Crosas-Molist","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrep.2025.102164_bib8","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3390\/cells10071831","article-title":"The RHO family GTPases: mechanisms of regulation and signaling","volume":"10","author":"Mosaddeghzadeh","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrep.2025.102164_bib9","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1080\/15548627.2021.1886721","article-title":"Autophagy-dependent regulation of skeletal muscle regeneration and strength by a RHOGEF","volume":"17","author":"You","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrep.2025.102164_bib10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0968-0004(99)01429-2","article-title":"GEFs: structural basis for their activation of small GTP-Binding proteins","volume":"24","author":"Cherfils","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrep.2025.102164_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0092-8674(01)00314-2","article-title":"EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin","volume":"105","author":"Shamah","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2025.102164_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/geno.2000.6138","article-title":"Characterization of ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus","volume":"65","author":"Rodrigues","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.bbrep.2025.102164_bib13","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuron.2008.12.028","article-title":"A presynaptic homeostatic signaling system composed of the eph receptor, ephexin, Cdc42, and CaV21 calcium channels","volume":"61","author":"Frank","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.bbrep.2025.102164_bib14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neuron.2010.01.012","article-title":"Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction","volume":"65","author":"Shi","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.bbrep.2025.102164_bib15","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1523\/JNEUROSCI.2257-17.2018","article-title":"Ephexin1 is required for eph-mediated limb trajectory of spinal motor axons","volume":"38","author":"Chang","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2025.102164_bib16","doi-asserted-by":"crossref","first-page":"31103","DOI":"10.1074\/jbc.M704430200","article-title":"Regulation of ephexin1, a guanine nucleotide exchange factor of rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation","volume":"282","author":"Zhang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2025.102164_bib17","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1038\/sj.onc.1206364","article-title":"Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes","volume":"22","author":"Teramoto","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrep.2025.102164_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04984-6","article-title":"Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1","volume":"13","author":"Kim","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrep.2025.102164_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04332-0","article-title":"Akt-mediated Ephexin1\u2013Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation","volume":"12","author":"Kim","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrep.2025.102164_bib20","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.7150\/jca.51551","article-title":"Identification of potential BRAF inhibitor joint therapy targets in PTC based on WGCAN and DCGA","volume":"12","author":"Han","year":"2021","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbrep.2025.102164_bib21","first-page":"273","article-title":"Encorafenib plus cetuximab as a new standard of care for previously treated BRAF V600E\u2013Mutant metastatic colorectal cancer: updated survival results and subgroup analyses from the BEACON study","volume":"39","author":"Tabernero","year":"2021","journal-title":"J. Clin. Orthod."},{"key":"10.1016\/j.bbrep.2025.102164_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrm1587","article-title":"GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors","volume":"6","author":"Rossman","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrep.2025.102164_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fcell.2020.00201","article-title":"Targeting rac and Cdc42 GEFs in metastatic cancer","volume":"8","author":"Maldonado","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrep.2025.102164_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/dvdy.24505","article-title":"The role of small GTPases of the Rho\/Rac family in TGF-\u03b2-induced EMT and cell motility in cancer","volume":"247","author":"Ungefroren","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbrep.2025.102164_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz1534","article-title":"BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation","volume":"6","author":"Pan","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrep.2025.102164_bib26","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.7150\/thno.44419","article-title":"Hypoxia induced exosomal circRNA promotes metastasis of colorectal cancer via targeting GEF-H1\/RhoA axis","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrep.2025.102164_bib27","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1158\/1541-7786.MCR-16-0184","article-title":"ERK\/MAPK signaling drives overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-mutant melanoma","volume":"14","author":"Ryan","year":"2016","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbrep.2025.102164_bib28","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nrc.2017.79","article-title":"New perspectives for targeting RAF kinase in human cancer","volume":"17","author":"Karoulia","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrep.2025.102164_bib29","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1210\/jc.2003-030838","article-title":"BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas","volume":"88","author":"Nikiforova","year":"2003","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.bbrep.2025.102164_bib30","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1210\/er.2007-0007","article-title":"BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications","volume":"28","author":"Xing","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrep.2025.102164_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12943-018-0786-0","article-title":"Novel targeted therapies and immunotherapy for advanced thyroid cancers","volume":"17","author":"Naoum","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrep.2025.102164_bib32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1530\/ERC-14-0531","article-title":"BRAFV600E mutation in papillary thyroid microcarcinoma: a meta-analysis","volume":"22","author":"Li","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bbrep.2025.102164_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/SLA.0000000000001420","article-title":"Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer","volume":"262","author":"Yip","year":"2015","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbrep.2025.102164_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-4939-9220-1_15","article-title":"Synthesis of gold nanoparticles for gene silencing","author":"Tortiglione","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrep.2025.102164_bib35","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1158\/2159-8290.CD-12-0429","article-title":"First-in-Humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement","volume":"3","author":"Tabernero","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrep.2025.102164_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jconrel.2009.12.006","article-title":"The forthcoming applications of gold nanoparticles in drug and gene delivery systems","volume":"149","author":"Pissuwan","year":"2011","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bbrep.2025.102164_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.addr.2012.10.002","article-title":"The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo","volume":"65","author":"Maeda","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrep.2025.102164_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.addr.2010.03.011","article-title":"Tumor delivery of macromolecular drugs based on the EPR effect","volume":"63","author":"Torchilin","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrep.2025.102164_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/thy.2018.0424","article-title":"Lysyl oxidase is a key player in BRAF\/MAPK pathway-driven thyroid cancer aggressiveness","volume":"29","author":"Boufraqech","year":"2019","journal-title":"Thyroid"},{"key":"10.1016\/j.bbrep.2025.102164_bib40","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/apm.12505","article-title":"Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation","volume":"124","author":"Bartolome","year":"2016","journal-title":"APMIS"},{"key":"10.1016\/j.bbrep.2025.102164_bib41","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1159\/000493296","article-title":"S100A4 knockout sensitizes anaplastic thyroid carcinoma cells harboring BRAFV600E\/Mt to vemurafenib","volume":"49","author":"Jiao","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbrep.2025.102164_bib42","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/jcmm.16279","article-title":"Bisphenol A at a human exposed level can promote epithelial\u2010mesenchymal transition in papillary thyroid carcinoma harbouring BRAF V600E mutation","volume":"25","author":"Li","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrep.2025.102164_bib43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41392-020-00231-6","article-title":"CYP2S1 is a synthetic lethal target in BRAFV600E-driven thyroid cancers","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrep.2025.102164_bib44","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1089\/ars.2015.6616","article-title":"NADPH oxidase NOX4 is a critical mediator of BRAFV600E-Induced downregulation of the sodium\/iodide symporter in papillary thyroid carcinomas","volume":"26","author":"Azouzi","year":"2017","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrep.2025.102164_bib45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-015-0321-5","article-title":"Apoptosis, autophagy, necroptosis, and cancer metastasis","volume":"14","author":"Su","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrep.2025.102164_bib46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1476-4598-10-118","article-title":"BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study","volume":"10","author":"Makrodouli","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrep.2025.102164_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.onc.1209759","article-title":"Transcription factors control invasion: AP-1 the first among equals","volume":"26","author":"Ozanne","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrep.2025.102164_bib48","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1038\/sj.onc.1206570","article-title":"Role of the Fos family members, c-Fos, Fra-1 and Fra-2, in the regulation of cell motility","volume":"22","author":"Tkach","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrep.2025.102164_bib49","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1038\/sj.onc.1205590","article-title":"The ability of Fos family members to produce phenotypic changes in epithelioid cells is not directly linked to their transactivation potentials","volume":"21","author":"Andersen","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrep.2025.102164_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1158\/1541-7786.MCR-05-0004","article-title":"Fos-related antigen 1 modulates malignant features of glioma cells","volume":"3","author":"Debinski","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbrep.2025.102164_bib51","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/onc.2011.336","article-title":"Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL","volume":"31","author":"Sayan","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrep.2025.102164_bib52","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1158\/0008-5472.CAN-17-0988","article-title":"Keratin 19 expression in hepatocellular carcinoma is regulated by fibroblast-derived HGF via a MET-ERK1\/2-AP1 and SP1 axis","volume":"78","author":"Rhee","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrep.2025.102164_bib53","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.31557\/APJCP.2020.21.8.2415","article-title":"TFAP2B, AP-1 and JAZF1 expression in tissues of papillary thyroid carcinoma patients; clinical, pathological and prognostic values","volume":"21","author":"A Abuderman","year":"2020","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.bbrep.2025.102164_bib54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12967-021-02932-0","article-title":"Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1\/Egr1\/IL-4 axis","volume":"19","author":"Wang","year":"2021","journal-title":"J. Transl. Med."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825002511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825002511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:41:37Z","timestamp":1777632097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825002511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":54,"alternative-id":["S2405580825002511"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102164","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Up-regulation of NGEF via the BRAFV600E \/ERK\/AP1 pathway enhances invasion and migration abilities of BRAFV600E-mutant thyroid cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102164"}}