{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T17:58:17Z","timestamp":1766599097622,"version":"3.48.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bbrep.2025.102283","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:23:20Z","timestamp":1758788600000},"page":"102283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role of long intergenic non-protein coding RNA 312 in cancer: A bioinformatics and literature based study"],"prefix":"10.1016","volume":"44","author":[{"given":"Arash","family":"Safarzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setareh","family":"Ataei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-499X","authenticated-orcid":false,"given":"Soudeh","family":"Ghafouri-Fard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrep.2025.102283_bib1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41556-019-0311-8","article-title":"Cellular functions of long noncoding RNAs","volume":"21","author":"Yao","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102283_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/1389202923666220531105035","article-title":"Long non-coding RNAs: pivotal epigenetic regulators in diabetic retinopathy","volume":"23","author":"Song","year":"2022","journal-title":"Curr. Genom."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/1389202921666200210142840","article-title":"Novel approaches to profile functional long noncoding RNAs associated with stem cell pluripotency","volume":"21","author":"Zhu","year":"2020","journal-title":"Curr. Genom."},{"issue":"2\u20133","key":"10.1016\/j.bbrep.2025.102283_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10142-016-0524-x","article-title":"Long noncoding RNA (lincRNA), a new paradigm in gene expression control","volume":"17","author":"Deniz","year":"2017","journal-title":"Funct. Integr. Genom."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102283_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrm.2017.104","article-title":"The functions and unique features of long intergenic non-coding RNA","volume":"19","author":"Ransohoff","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41419-020-03302-2","article-title":"LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma","volume":"12","author":"Guo","year":"2021","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102283_bib7","first-page":"1296","article-title":"Long non-coding RNA LINC00312 regulates breast cancer progression through the miR-9\/CDH1 axis","volume":"21","author":"Chen","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"1.30","key":"10.1016\/j.bbrep.2025.102283_bib8","first-page":"31","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinformat."},{"key":"10.1016\/j.bbrep.2025.102283_bib9","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.7717\/peerj-cs.67","article-title":"OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs","volume":"2","author":"Anaya","year":"2016","journal-title":"PeerJ Comput. Sci."},{"issue":"5","key":"10.1016\/j.bbrep.2025.102283_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"issue":"D1","key":"10.1016\/j.bbrep.2025.102283_bib11","doi-asserted-by":"crossref","first-page":"D199","DOI":"10.1093\/nar\/gkac984","article-title":"LncTarD 2.0: an updated comprehensive database for experimentally-supported functional lncRNA\u2013target regulations in human diseases","volume":"51","author":"Zhao","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.bbrep.2025.102283_bib12","doi-asserted-by":"crossref","first-page":"D326","DOI":"10.1093\/nar\/gkab997","article-title":"RNAInter v4.0: RNA interactome repository with redefined confidence scoring system and improved accessibility","volume":"50","author":"Kang","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.bbrep.2025.102283_bib13","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"7","key":"10.1016\/j.bbrep.2025.102283_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003731","article-title":"iRegulon: from a gene list to a gene regulatory network using large motif and track collections","volume":"10","author":"Janky","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bbrep.2025.102283_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw100","article-title":"The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins","volume":"2016","author":"Rouillard","year":"2016","journal-title":"Database"},{"issue":"D1","key":"10.1016\/j.bbrep.2025.102283_bib16","doi-asserted-by":"crossref","first-page":"D919","DOI":"10.1093\/nar\/gkad1008","article-title":"LncSEA 2.0: an updated platform for long non-coding RNA related sets and enrichment analysis","volume":"52","author":"Zhang","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.bbrep.2025.102283_bib17","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.bbrep.2025.102283_bib18","doi-asserted-by":"crossref","first-page":"W319","DOI":"10.1093\/nar\/gkad392","article-title":"miEAA 2023: updates, new functional microRNA sets and improved enrichment visualizations","volume":"51","author":"Aparicio-Puerta","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2025.102283_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bat018","article-title":"MalaCards: an integrated compendium for diseases and their annotation","volume":"2013","author":"Rappaport","year":"2013","journal-title":"Database"},{"issue":"D1","key":"10.1016\/j.bbrep.2025.102283_bib20","doi-asserted-by":"crossref","first-page":"D1365","DOI":"10.1093\/nar\/gkad828","article-title":"LncRNADisease v3.0: an updated database of long non-coding RNA-associated diseases","volume":"52","author":"Lin","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.bbrep.2025.102283_bib21","doi-asserted-by":"crossref","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","article-title":"Comparative Toxicogenomics database (CTD): update 2023","volume":"51","author":"Davis","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2025.102283_bib22","article-title":"TLSEA: a tool for lncRNA set enrichment analysis based on multi-source heterogeneous information fusion","volume":"14","author":"Li","year":"2023","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12885-024-13393-1","article-title":"Diagnostic role of circulating long non-coding RNA LINC00312 in patients with non-small cell lung cancer: a retrospective study","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12572","article-title":"Identification of long noncoding RNAs downregulated specifically in ovarian high-grade serous carcinoma","volume":"23","author":"Hayashi-Okada","year":"2024","journal-title":"Reprod. Med. Biol."},{"issue":"6","key":"10.1016\/j.bbrep.2025.102283_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cells12060873","article-title":"Molecular signature of long non-coding RNA associated with areca nut-induced head and neck cancer","volume":"12","author":"Huang","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbrc.2017.07.045","article-title":"Long noncoding RNA linc00346 promotes the malignant phenotypes of bladder cancer","volume":"491","author":"Ye","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12943-018-0920-z","article-title":"The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1","volume":"17","author":"Peng","year":"2018","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.bbrep.2025.102283_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14020439","article-title":"A signature of 14 long non-coding RNAs (lncRNAs) as a step towards precision diagnosis for NSCLC","volume":"14","author":"Sulewska","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"31","key":"10.1016\/j.bbrep.2025.102283_bib29","doi-asserted-by":"crossref","first-page":"51703","DOI":"10.18632\/oncotarget.18512","article-title":"Identification of dysregulated long non-coding RNAs\/microRNAs\/mRNAs in TNM I stage lung adenocarcinoma","volume":"8","author":"Tian","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrep.2025.102283_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6707821","article-title":"Linc00312 single nucleotide polymorphism as biomarker for chemoradiotherapy induced hematotoxicity in nasopharyngeal carcinoma patients","volume":"2022","author":"Guo","year":"2022","journal-title":"Dis. Markers"},{"issue":"6","key":"10.1016\/j.bbrep.2025.102283_bib31","first-page":"4991","article-title":"Network analysis of differentially expressed smoking-associated mRNAs, lncRNAs and miRNAs reveals key regulators in smoking-associated lung cancer","volume":"16","author":"Chen","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbrep.2025.102283_bib32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.future.2024.05.030","article-title":"Identification of ferroptosis-related lncRNAs for predicting prognosis and immunotherapy response in non-small cell lung cancer","volume":"159","author":"Yuan","year":"2024","journal-title":"Future Gener. Comput. Syst."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102283_bib33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5582\/bst.2018.01052","article-title":"Long non-coding RNA Linc00312 modulates the sensitivity of ovarian cancer to cisplatin via the Bcl-2\/Caspase-3 signaling pathway","volume":"12","author":"Zhang","year":"2018","journal-title":"Biosci Trends"},{"issue":"11","key":"10.1016\/j.bbrep.2025.102283_bib34","doi-asserted-by":"crossref","first-page":"14553","DOI":"10.1007\/s13277-016-5303-8","article-title":"LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p","volume":"37","author":"Wang","year":"2016","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1016\/j.bbrep.2025.102283_bib35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1615\/CritRevEukaryotGeneExpr.2022044042","article-title":"LINC00312 inhibits lung cancer progression through the miR-3175\/SEMA6A Axis","volume":"33","author":"Zhang","year":"2023","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"issue":"9","key":"10.1016\/j.bbrep.2025.102283_bib36","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1111\/jcmm.13142","article-title":"Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer","volume":"21","author":"Zhu","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102283_bib37","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.3892\/mmr.2017.7196","article-title":"Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues","volume":"16","author":"Tan","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102283_bib38","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/JTO.0000000000000470","article-title":"Identification and validation of long noncoding RNA biomarkers in human non\u2013small-cell lung carcinomas","volume":"10","author":"Yu","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"8","key":"10.1016\/j.bbrep.2025.102283_bib39","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.7150\/jca.94187","article-title":"Impact of LINC00312 gene polymorphism coupled with habitual risks on buccal mucosa cancer","volume":"15","author":"Hsu","year":"2024","journal-title":"J. Cancer"},{"issue":"5","key":"10.1016\/j.bbrep.2025.102283_bib40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10735-013-9503-x","article-title":"Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma","volume":"44","author":"Zhang","year":"2013","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.bbrep.2025.102283_bib41","article-title":"Genetic polymorphisms of long non-coding RNA Linc00312 are associated with susceptibility and predict poor survival of nasopharyngeal carcinoma","volume":"9","author":"Guo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbrc.2018.02.049","article-title":"Long non-coding RNA 00312 downregulates cyclin B1 and inhibits hepatocellular carcinoma cell proliferation in vitro and in vivo","volume":"497","author":"Wu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.bbrep.2025.102283_bib43","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1111\/jcmm.13830","article-title":"LINC00312 represses proliferation and metastasis of colorectal cancer cells by regulation of miR-21","volume":"22","author":"Li","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrep.2025.102283_bib44","first-page":"852","article-title":"Effect of long intergenic non-coding RNA 00312 on regulating biological behaviors of glioma cells by targeting microRNA-21-3p","volume":"14","author":"Lei","year":"2021","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"11","key":"10.1016\/j.bbrep.2025.102283_bib45","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1166\/jbn.2023.3699","article-title":"Long intergenic non-protein coding RNA 312 regulates FRABIN to inhibit the occurrence and development of pancreatic cancer","volume":"19","author":"Bai","year":"2023","journal-title":"J. Biomed. Nanotechnol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102283_bib46","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12935-021-01986-w","article-title":"Long non-coding RNAs in Epstein-Barr virus-related cancer","volume":"21","author":"Liu","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbrep.2025.102283_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111339","article-title":"miR-135b-5p promotes gastric carcinogenesis by targeting CLIP4-mediated JAK2\/STAT3 signal pathway","volume":"122","author":"Peng","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrep.2025.102283_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.985897","article-title":"A comprehensive review on miR-153: mechanistic and controversial roles of miR-153 in tumorigenicity of cancer cells","volume":"12","author":"Yousefnia","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrep.2025.102283_bib49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12935-019-0984-x","article-title":"miR-190-5p in human diseases","volume":"19","author":"Yu","year":"2019","journal-title":"Cancer Cell Int."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082500370X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082500370X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T17:54:20Z","timestamp":1766598860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240558082500370X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":49,"alternative-id":["S240558082500370X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102283","relation":{},"ISSN":["2405-5808"],"issn-type":[{"type":"print","value":"2405-5808"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of long intergenic non-protein coding RNA 312 in cancer: A bioinformatics and literature based study","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102283"}}