{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:26:37Z","timestamp":1778703997186,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["140007205816"],"award-info":[{"award-number":["140007205816"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bbrep.2025.102336","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:55:57Z","timestamp":1761947757000},"page":"102336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Cardiac, reproductive, and brain toxicity of zinc oxide nanoparticles in male rats: Focus on morphological alterations and oxidative stress markers"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-9461","authenticated-orcid":false,"given":"Fatemeh","family":"Mirzaei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Soleimani Asl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.102336_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124360","article-title":"Cardiovascular toxic effects of nanoparticles and corresponding molecular mechanisms","volume":"356","author":"Huang","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.bbrep.2025.102336_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.lfs.2016.09.017","article-title":"Cardiotoxicity of nano-particles","volume":"165","author":"Bostan","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrep.2025.102336_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142993","article-title":"Toxicity of zinc oxide nanoparticles: cellular and behavioural effects","volume":"363","author":"Fern\u00e1ndez-Bert\u00f3lez","year":"2024","journal-title":"Chemosphere."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102336_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s10238-024-01302-6","article-title":"Role of zinc in health and disease","volume":"24","author":"Stiles","year":"2024","journal-title":"Clin. Exp. Med."},{"issue":"5","key":"10.1016\/j.bbrep.2025.102336_bib5","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00204-020-02702-9","article-title":"Recent aspects of the effects of zinc on human health","volume":"94","author":"Chasapis","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"8","key":"10.1016\/j.bbrep.2025.102336_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087152","article-title":"Zinc in cardiovascular functions and diseases: epidemiology and molecular mechanisms for therapeutic development","volume":"24","author":"Hara","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102336_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.61186\/JCT.15.3.231","article-title":"The effects of different doses of nano zinc oxide on the level of oxidative stress and histopathological changes in the kidneys of rats","volume":"15","author":"Mirzaei","year":"2024","journal-title":"Cell. Tissue. J."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102336_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12011-024-04108-5","article-title":"Toxicity and hepatoprotective effects of ZnO nanoparticles on normal and high-fat diet-fed rat livers: mechanism of action","volume":"203","author":"Mirzaei","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbrep.2025.102336_bib9","article-title":"Zinc oxide nanoparticles induced testicular toxicity through inflammation and reducing testosterone and cell viability in adult Male rats","author":"Ahmed","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbrep.2025.102336_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1127460","article-title":"Insights into nanoparticles-induced neurotoxicity and cope up strategies","volume":"17","author":"Zia","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrep.2025.102336_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122950","article-title":"Zinc oxide nanoparticles induce acute lung injury via oxidative stress-mediated mitochondrial damage and NLRP3 inflammasome activation: in vitro and in vivo studies","volume":"341","author":"Zhuo","year":"2024","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.bbrep.2025.102336_bib12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/1061186X.2024.2316785","article-title":"Nanoparticles toxicity: an overview of its mechanism and plausible mitigation strategies","volume":"32","author":"Sharma","year":"2024","journal-title":"J. Drug Target."},{"issue":"11","key":"10.1016\/j.bbrep.2025.102336_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11112925","article-title":"Oxidative stress in health and disease","volume":"11","author":"Reddy","year":"2023","journal-title":"Biomedicines."},{"key":"10.1016\/j.bbrep.2025.102336_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121620","article-title":"Antioxidant, anti-inflammatory, and wound healing effects of topical silver-doped zinc oxide and silver oxide nanocomposites","volume":"617","author":"Borges Rosa de Moura","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"21","key":"10.1016\/j.bbrep.2025.102336_bib15","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.2217\/nnm-2018-0202","article-title":"Effects of ZnO nanoparticles on intestinal function and structure in normal\/high fat diet-fed rats and Caco-2 cells","volume":"13","author":"Abbasi-Oshaghi","year":"2018","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.bbrep.2025.102336_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/1874104502014010035","article-title":"Alleviates sperm Damagd by Limitlng Oxidative Stress and Insulin Resistance in rDiabetic Rats","volume":"14","author":"Abbasi-Oshaghi","year":"2020","journal-title":"Open Med. Chem. J."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102336_bib17","first-page":"148","article-title":"The association of mitochondrial translocator protein and voltage-dependent anion Channel-1 in granulosa cells with estradiol levels and presence of immature follicles in polycystic ovary syndrome","volume":"23","author":"Mazloomi","year":"2022","journal-title":"J. Reprod. Infertil."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102336_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.327","article-title":"Nanoparticles-induced potential toxicity on human health: applications, toxicity mechanisms, and evaluation models","volume":"4","author":"Xuan","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.bbrep.2025.102336_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112682","article-title":"Toxic effects of zinc oxide nanoparticles as a food additive in goat mammary epithelial cells","volume":"167","author":"Wang","year":"2023","journal-title":"Food Res. Int."},{"issue":"10","key":"10.1016\/j.bbrep.2025.102336_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jbt.21812","article-title":"Querectin alleviates zinc oxide nanoreprotoxicity in Male albino rats","volume":"30","author":"Hussein","year":"2016","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"8","key":"10.1016\/j.bbrep.2025.102336_bib21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/0748233718774220","article-title":"Enhanced steroidogenic and altered antioxidant response by ZnO nanoparticles in mouse testis Leydig cells","volume":"34","author":"Bara","year":"2018","journal-title":"Toxicol. Ind. Health"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102336_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00108-w","article-title":"Ameliorative effect of curcumin and zinc oxide nanoparticles on multiple mechanisms in obese rats with induced type 2 diabetes","volume":"11","author":"Abdulmalek","year":"2021","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.bbrep.2025.102336_bib23","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.3390\/w14172669","article-title":"Single and combined toxicity effects of zinc oxide nanoparticles: uptake and accumulation in marine microalgae, toxicity mechanisms, and their fate in the marine environment","volume":"14","author":"Hazeem","year":"2022","journal-title":"Water."},{"key":"10.1016\/j.bbrep.2025.102336_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.toxrep.2023.04.012","article-title":"Zinc oxide nanoparticles trigger autophagy-mediated cell death through activating lysosomal TRPML1 in normal kidney cells","volume":"10","author":"Kim","year":"2023","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102336_bib25","first-page":"1","article-title":"Mechanism of oxidative stress involved in the toxicity of ZnO nanoparticles against eukaryotic cells","volume":"3","author":"Saliani","year":"2016","journal-title":"Nanomedicine J."},{"key":"10.1016\/j.bbrep.2025.102336_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.fct.2016.02.002","article-title":"Zinc oxide nanoparticles induce renal toxicity through reactive oxygen species","volume":"90","author":"Xiao","year":"2016","journal-title":"Food Chem. Toxicol."},{"issue":"13","key":"10.1016\/j.bbrep.2025.102336_bib27","doi-asserted-by":"crossref","first-page":"751","DOI":"10.21037\/atm-22-3047","article-title":"Exposure to zinc oxide nanoparticles affects testicular structure, reproductive development and spermatogenesis in parental and offspring male rats","volume":"10","author":"Hong","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"5","key":"10.1016\/j.bbrep.2025.102336_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051081","article-title":"In vitro cytotoxicity effects of zinc oxide nanoparticles on spermatogonia cells","volume":"9","author":"Pinho","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102336_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-91226-y","article-title":"Zinc oxide nanoparticles improve testicular steroidogenesis machinery dysfunction in benzo[\u03b1]pyrene-challenged rats","volume":"11","author":"Daoud","year":"2021","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.bbrep.2025.102336_bib30","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1007\/s12011-023-04043-x","article-title":"Examining the influence of zinc oxide nanoparticles and bulk zinc oxide on rat brain functions: a comprehensive neurobehavioral, antioxidant, gene expression, and histopathological investigation","volume":"202","author":"Goma","year":"2024","journal-title":"Biol. Trace Elem. Res."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:04:20Z","timestamp":1773821060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825004236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":30,"alternative-id":["S2405580825004236"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102336","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac, reproductive, and brain toxicity of zinc oxide nanoparticles in male rats: Focus on morphological alterations and oxidative stress markers","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102336","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102336"}}