{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:16:10Z","timestamp":1773350170075,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504403"],"award-info":[{"award-number":["2022YFC2504403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009812","name":"Chinese Society of Clinical Oncology","doi-asserted-by":"publisher","award":["MS-0101"],"award-info":[{"award-number":["MS-0101"]}],"id":[{"id":"10.13039\/501100009812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bbrep.2025.102348","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T19:39:16Z","timestamp":1762717156000},"page":"102348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["HECTD1-mediated SFTPB overexpression in fibrotic lung induced by silica"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-4496","authenticated-orcid":false,"given":"Mengling","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4223-5428","authenticated-orcid":false,"given":"Shencun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbrep.2025.102348_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1172\/JCI74942","article-title":"PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis","volume":"125","author":"Bueno","year":"2015","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102348_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121246","article-title":"Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis","volume":"10","author":"Patel","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bbrep.2025.102348_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1474-9726.2007.00312.x","article-title":"Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms","volume":"6","author":"Lambert","year":"2007","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102348_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/rcmb.2007-0004RC","article-title":"Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants","volume":"37","author":"Reddy","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"11","key":"10.1016\/j.bbrep.2025.102348_bib5","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1096\/fj.03-1127fje","article-title":"The transcription factor NRF2 protects against pulmonary fibrosis","volume":"18","author":"Cho","year":"2004","journal-title":"FASEB J."},{"issue":"3 Suppl","key":"10.1016\/j.bbrep.2025.102348_bib6","doi-asserted-by":"crossref","first-page":"20S","DOI":"10.1378\/chest.121.3_suppl.20S","article-title":"Mutations in the surfactant protein C gene associated with interstitial lung disease","volume":"121","author":"Nogee","year":"2002","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102348_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ajhg.2008.11.010","article-title":"Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer","volume":"84","author":"Wang","year":"2009","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102348_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2350\/09-01-0586.1","article-title":"Genetic disorders of surfactant dysfunction","volume":"12","author":"Wert","year":"2009","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.bbrep.2025.102348_bib9","article-title":"Gene therapy potential for genetic disorders of surfactant dysfunction","volume":"3","author":"Cooney","year":"2021","journal-title":"Front. Genome."},{"issue":"6","key":"10.1016\/j.bbrep.2025.102348_bib10","article-title":"An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis","volume":"4","author":"Katzen","year":"2019","journal-title":"JCI Insight"},{"issue":"14","key":"10.1016\/j.bbrep.2025.102348_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.142501","article-title":"Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease","volume":"6","author":"Sitaraman","year":"2021","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.bbrep.2025.102348_bib12","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1172\/JCI99287","article-title":"Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis","volume":"128","author":"Nureki","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"7","key":"10.1016\/j.bbrep.2025.102348_bib13","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1096\/fj.201701059R","article-title":"Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown","volume":"32","author":"Bi","year":"2018","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.bbrep.2025.102348_bib14","doi-asserted-by":"crossref","first-page":"14804","DOI":"10.1002\/jcb.28741","article-title":"Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbrep.2025.102348_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.med.60.041807.123500","article-title":"Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease","volume":"61","author":"Whitsett","year":"2010","journal-title":"Annu. Rev. Med."},{"issue":"9","key":"10.1016\/j.bbrep.2025.102348_bib16","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1128\/MCB.00723-10","article-title":"Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis","volume":"31","author":"Chen","year":"2011","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102348_bib17","doi-asserted-by":"crossref","first-page":"L74","DOI":"10.1152\/ajplung.00103.2006","article-title":"Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression","volume":"292","author":"Das","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbrep.2025.102348_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.gep.2019.119064","article-title":"Hectd1 is essential for embryogenesis in mice","volume":"34","author":"D'Alonzo","year":"2019","journal-title":"Gene Expr. Patterns"},{"issue":"7","key":"10.1016\/j.bbrep.2025.102348_bib19","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.stem.2021.02.008","article-title":"HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis","volume":"28","author":"Lv","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.bbrep.2025.102348_bib20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.celrep.2017.12.096","article-title":"The E3 ubiquitin ligase HectD1 suppresses EMT and metastasis by targeting the +TIP ACF7 for degradation","volume":"22","author":"Duhamel","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrep.2025.102348_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110545","article-title":"AT2 cell-derived IgA trapped by the extracellular matrix in silica-induced pulmonary fibrosis","volume":"122","author":"Chen","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102348_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13578-022-00761-2","article-title":"A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation","volume":"12","author":"Yin","year":"2022","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.bbrep.2025.102348_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1165\/rcmb.2009-0058OC","article-title":"Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C","volume":"42","author":"Conkright","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102348_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41419-018-0432-1","article-title":"circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1","volume":"9","author":"Fang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.bbrep.2025.102348_bib25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.7150\/thno.21648","article-title":"circRNA mediates silica-induced macrophage activation via HECTD1\/ZC3H12A-Dependent ubiquitination","volume":"8","author":"Zhou","year":"2018","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.bbrep.2025.102348_bib26","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1074\/jbc.M109.039172","article-title":"Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene","volume":"285","author":"Cao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2025.102348_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pupt.2018.06.003","article-title":"Oropharyngeal administration of silica in Swiss mice: a robust and reproducible model of occupational pulmonary fibrosis","volume":"51","author":"Karkale","year":"2018","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bbrep.2025.102348_bib28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00204-015-1589-3","article-title":"Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents","volume":"90","author":"Dong","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbrep.2025.102348_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106387","article-title":"Comparing species-different responses in pulmonary fibrosis research: current understanding of in vitro lung cell models and nanomaterials","volume":"183","author":"Keshavan","year":"2023","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"6","key":"10.1016\/j.bbrep.2025.102348_bib30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1164\/rccm.202004-1274OC","article-title":"Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis","volume":"203","author":"Yao","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.bbrep.2025.102348_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072269","article-title":"Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis","volume":"21","author":"Parimon","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bbrep.2025.102348_bib32","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1172\/JCI139519","article-title":"Contributions of alveolar epithelial cell quality control to pulmonary fibrosis","volume":"130","author":"Katzen","year":"2020","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102348_bib33","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0041-008X(79)90372-7","article-title":"Pulmonary fibrosis--a possible mechanism","volume":"51","author":"Haschek","year":"1979","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrep.2025.102348_bib34","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.3389\/fimmu.2018.02256","article-title":"Genetic Association of pulmonary surfactant protein genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with cystic fibrosis","volume":"9","author":"Lin","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbrep.2025.102348_bib35","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00439-003-1015-4","article-title":"Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis","volume":"113","author":"Selman","year":"2003","journal-title":"Hum. Genet."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102348_bib36","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1183\/09031936.01.00043401","article-title":"Surfactant protein gene A, B, and D marker alleles in chronic obstructive pulmonary disease of a Mexican population","volume":"18","author":"Guo","year":"2001","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102348_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3899\/jrheum.140394","article-title":"Etiopathogenic role of surfactant protein d in the clinical and immunological expression of primary Sjogren syndrome","volume":"42","author":"Soto-Cardenas","year":"2015","journal-title":"J. Rheumatol."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102348_bib38","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.stem.2017.08.014","article-title":"Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells","volume":"21","author":"Jacob","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrep.2025.102348_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1173149","article-title":"Differentiation of human induced pluripotent stem cells into functional lung alveolar epithelial cells in 3D dynamic culture","volume":"11","author":"Alsobaie","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"36","key":"10.1016\/j.bbrep.2025.102348_bib40","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1200\/JCO.2013.50.6105","article-title":"Pro-surfactant protein B as a biomarker for lung cancer prediction","volume":"31","author":"Sin","year":"2013","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.bbrep.2025.102348_bib41","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1158\/1055-9965.EPI-13-0251","article-title":"Circulating pro-surfactant protein B as a risk biomarker for lung cancer","volume":"22","author":"Taguchi","year":"2013","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bbrep.2025.102348_bib42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.placenta.2015.12.002","article-title":"Abnormal labyrinthine zone in the Hectd1-null placenta","volume":"38","author":"Sarkar","year":"2016","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.bbrep.2025.102348_bib43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bbalip.2017.12.011","article-title":"The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages","volume":"1863","author":"Aleidi","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102348_bib44","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.1038\/s41598-020-66789-x","article-title":"Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1\/Rps3\/NF-kappaB pathway","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.bbrep.2025.102348_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168816","article-title":"Endocytic protein defects in the neural crest cell lineage and its pathway are associated with congenital heart defects","volume":"22","author":"Arrigo","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:45:32Z","timestamp":1773312332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825004352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":45,"alternative-id":["S2405580825004352"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102348","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HECTD1-mediated SFTPB overexpression in fibrotic lung induced by silica","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102348"}}