{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:21:10Z","timestamp":1773858070307,"version":"3.50.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016221","name":"Rowan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bbrep.2025.102354","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T06:25:00Z","timestamp":1763187900000},"page":"102354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Unlocking nature's potential: Soursop in the battle against resistant acute myeloid leukemia"],"prefix":"10.1016","volume":"44","author":[{"given":"Sabrina M.","family":"Paparo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca M.","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Jethi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash C.","family":"Jonnalagadda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulin","family":"Budak-Alpdogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Strair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj K.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.102354_bib1","series-title":"Acute Myeloid Leukemia (AML) in Adults","year":"2024"},{"issue":"22","key":"10.1016\/j.bbrep.2025.102354_bib2","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1182\/blood-2015-05-646240","article-title":"Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse","volume":"126","author":"Garg","year":"2015","journal-title":"Blood"},{"issue":"9550","key":"10.1016\/j.bbrep.2025.102354_bib3","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0140-6736(06)69780-8","article-title":"Acute myeloid leukaemia","volume":"368","author":"Estey","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bbrep.2025.102354_bib4","series-title":"Acute Myeloid Leukemia","article-title":"Harrison's principles of internal medicine","volume":"vol. 1","author":"Blum","year":"2022"},{"key":"10.1016\/j.bbrep.2025.102354_bib5","series-title":"Acute Myeloid Leukemia","author":"Vakiti","year":"2024"},{"issue":"2","key":"10.1016\/j.bbrep.2025.102354_bib6","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a005967","article-title":"Blood cancer health disparities in the United States Hispanic population","volume":"7","author":"Bencomo-Alvarez","year":"2021","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"key":"10.1016\/j.bbrep.2025.102354_bib7","unstructured":"Chang, C.-C.J. and A. Kuzu. What's New in AML Classification (WHO 2022 Vs International Consensus Classification)."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102354_bib8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ajh.26822","article-title":"Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Shimony","year":"2023","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib9","first-page":"12","article-title":"Acute myeloid leukemia: novel mutations and their clinical implications","volume":"13","author":"Makkar","year":"2023","journal-title":"Am J. Blood Res."},{"key":"10.1016\/j.bbrep.2025.102354_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103277","article-title":"Cell signaling pathways as molecular targets to eliminate AML stem cells","volume":"160","author":"Rodrigues","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bbrep.2025.102354_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.669363","article-title":"JAK-STAT in early hematopoiesis and leukemia","volume":"9","author":"Fasouli","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.bbrep.2025.102354_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9081051","article-title":"The ups and downs of STAT inhibition in acute myeloid leukemia","volume":"9","author":"Moser","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4161\/jkst.19316","article-title":"STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells","volume":"1","author":"Schepers","year":"2012","journal-title":"JAK-STAT"},{"issue":"3","key":"10.1016\/j.bbrep.2025.102354_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/bjc.2015.233","article-title":"The role of JAK\/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours","volume":"113","author":"Thomas","year":"2015","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.bbrep.2025.102354_bib15","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.27159","article-title":"STAT5 in hematopoietic stem cell biology and transplantation","volume":"2","author":"Wang","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1016\/j.bbrep.2025.102354_bib16","article-title":"STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity","author":"Patel","year":"2023","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.bbrep.2025.102354_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1158\/1078-0432.CCR-12-2087","article-title":"The role of JAK pathway dysregulation in the pathogenesis and treatment of acute myeloid leukemia","volume":"19","author":"Lee","year":"2013","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12964-023-01421-9","article-title":"The oncogenic mechanisms of the Janus kinase-signal transducer and activator of transcription pathway in digestive tract tumors","volume":"22","author":"Zhao","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"3","key":"10.1016\/j.bbrep.2025.102354_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1586\/ehm.11.30","article-title":"The bone marrow microenvironment and leukemia: biology and therapeutic targeting","volume":"4","author":"Sison","year":"2011","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.bbrep.2025.102354_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.896426","article-title":"Drug resistance mechanisms of acute Myeloid Leukemia stem cells","volume":"12","author":"Niu","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/leu.2016.160","article-title":"Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)","volume":"31","author":"Sun","year":"2017","journal-title":"Leukemia"},{"issue":"25","key":"10.1016\/j.bbrep.2025.102354_bib23","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMoa1005143","article-title":"DNMT3A mutations in acute myeloid leukemia","volume":"363","author":"Ley","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.bbrep.2025.102354_bib24","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1038\/leu.2016.237","article-title":"Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia","volume":"30","author":"Madan","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrep.2025.102354_bib25","series-title":"Acute Myeloid Leukemia Treatment","year":"2024"},{"key":"10.1016\/j.bbrep.2025.102354_bib26","series-title":"Typical Treatment of Acute Myeloid Leukemia (Except APL)","year":"2023"},{"issue":"9","key":"10.1016\/j.bbrep.2025.102354_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26092741","article-title":"Medicinal plants with anti-leukemic effects: a review","volume":"26","author":"Maher","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bbrep.2025.102354_bib44","series-title":"Chemotherapy for Acute Myeloid Leukemia (AML)","year":"2024"},{"issue":"6","key":"10.1016\/j.bbrep.2025.102354_bib45","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1182\/blood-2005-08-3351","article-title":"Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial","volume":"107","author":"Sampath","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-15520-z","article-title":"Cytarabine-induced differentiation of AML cells depends on Chk1 activation and shares the mechanism with inhibitors of DHODH and pyrimidine synthesis","volume":"12","author":"Tomic","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bbrep.2025.102354_bib47","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1177\/1078155219898747","article-title":"Acute cerebellar toxicity induced by high dose of cytarabine (HiDAC): a case report","volume":"26","author":"Rahmani","year":"2020","journal-title":"J. Oncol. Pharm. Pract."},{"key":"10.1016\/j.bbrep.2025.102354_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114265","article-title":"Exposure to cytarabine causes side effects on adult development and physiology and induces intestinal damage via apoptosis in Drosophila","volume":"159","author":"Han","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrep.2025.102354_bib49","series-title":"Side Effects of Drugs Annual","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/bs.seda.2015.08.009","article-title":"Chapter 44 - cytostatic agents","author":"Keshishyan","year":"2015"},{"issue":"4","key":"10.1016\/j.bbrep.2025.102354_bib50","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1182\/blood.V98.4.913","article-title":"Signaling pathways activated by daunorubicin","volume":"98","author":"Laurent","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbrep.2025.102354_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117312","article-title":"Anthracycline-induced cardiotoxicity: an overview from cellular structural perspective","volume":"179","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrep.2025.102354_bib52","series-title":"Modern Surgical Pathology","first-page":"517","article-title":"Chapter 18 - heart and blood vessels","author":"Burke","year":"2009"},{"key":"10.1016\/j.bbrep.2025.102354_bib53","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.2147\/DDDT.S207425","article-title":"Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis","volume":"13","author":"Zhou","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"issue":"5","key":"10.1016\/j.bbrep.2025.102354_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103312","article-title":"Treatment of autoimmunity: the impact of disease-modifying therapies in multiple sclerosis and comorbid autoimmune disorders","volume":"22","author":"Konen","year":"2023","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10.1016\/j.bbrep.2025.102354_bib55","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.7150\/ijms.41793","article-title":"Cladribine induces ATF4 mediated apoptosis and synergizes with SAHA in diffuse large B-Cell lymphoma cells","volume":"17","author":"Xu","year":"2020","journal-title":"Int. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib56","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1586\/17469899.3.1.97","article-title":"Ocular toxicity of fludarabine: a purine analog","volume":"3","author":"Ding","year":"2008","journal-title":"Expet Rev. Ophthalmol."},{"key":"10.1016\/j.bbrep.2025.102354_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113218","article-title":"FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: synthesis and clinical application","volume":"214","author":"Wang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"17","key":"10.1016\/j.bbrep.2025.102354_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713126","article-title":"A clinically relevant dosage of mitoxantrone disrupts the glutathione and lipid Metabolic pathways of the CD-1 mice brain: a metabolomics study","volume":"24","author":"Dias-Carvalho","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2025.102354_bib59","series-title":"Cancer Immunotherapy","first-page":"101","article-title":"Chapter 7 - cytotoxic chemotherapy in clinical treatment of cancer","author":"Thirumaran","year":"2007"},{"key":"10.1016\/j.bbrep.2025.102354_bib60","series-title":"Complications of Urologic Surgery","first-page":"117","article-title":"Chapter 10 - toxicities of chemotherapy for genitourinary malignancies","author":"Montgomery","year":"2010"},{"issue":"7","key":"10.1016\/j.bbrep.2025.102354_bib61","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/FPC.0b013e32832e0e7f","article-title":"Etoposide pathway","volume":"19","author":"Yang","year":"2009","journal-title":"Pharmacogenet. Genom."},{"key":"10.1016\/j.bbrep.2025.102354_bib62","series-title":"Statpearls Publishing Copyright \u00a9 2024","article-title":"Hydroxyurea Toxicity, in StatPearls","author":"Jinna","year":"2024"},{"key":"10.1016\/j.bbrep.2025.102354_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7753857","article-title":"Mechanisms of hydroxyurea-induced cellular senescence: an oxidative stress connection?","volume":"2021","author":"Kapor","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrep.2025.102354_bib64","series-title":"Statpearls Publishing Copyright \u00a9 2024","article-title":"Corticosteroid adverse effects, in StatPearls","author":"Yasir","year":"2024"},{"key":"10.1016\/j.bbrep.2025.102354_bib65","doi-asserted-by":"crossref","first-page":"S364","DOI":"10.21037\/tlcr.2019.06.06","article-title":"Impact of baseline steroids on efficacy of programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) blockade in patients with advanced non-small cell lung cancer","author":"Jove","year":"2019","journal-title":"Transl. Lung Cancer Res."},{"issue":"9","key":"10.1016\/j.bbrep.2025.102354_bib66","article-title":"Overview of methotrexate toxicity: a comprehensive literature review","volume":"14","author":"Hamed","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.bbrep.2025.102354_bib67","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbacli.2015.01.006","article-title":"Cancer metabolism and oxidative stress: insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate","volume":"3","author":"Hess","year":"2015","journal-title":"BBA Clin."},{"key":"10.1016\/j.bbrep.2025.102354_bib68","series-title":"16 - Conventional Chemotherapy","first-page":"127","author":"Sprangers","year":"2020"},{"key":"10.1016\/j.bbrep.2025.102354_bib69","series-title":"Hematology","first-page":"849","article-title":"Chapter 57 - pharmacology and molecular mechanisms of antineoplastic agents for hematologic malignancies","author":"Gerson","year":"2018"},{"key":"10.1016\/j.bbrep.2025.102354_bib70","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2147\/CMAR.S4721","article-title":"The role of azacitidine in the management of myelodysplastic syndromes (MDS)","volume":"1","author":"G\u00f6tze","year":"2009","journal-title":"Cancer Manag. Res."},{"issue":"11","key":"10.1016\/j.bbrep.2025.102354_bib71","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/cncr.23463","article-title":"Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies","volume":"112","author":"Jabbour","year":"2008","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.bbrep.2025.102354_bib72","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jcph.1742","article-title":"Evaluation of the relationship of Glasdegib exposure and safety end points in patients with refractory solid tumors and hematologic malignancies","volume":"61","author":"Ruiz-Garcia","year":"2021","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bbrep.2025.102354_bib73","series-title":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury","year":"2012"},{"issue":"18","key":"10.1016\/j.bbrep.2025.102354_bib74","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1158\/1078-0432.CCR-17-3761","article-title":"Comprehensive safety analysis of venetoclax monotherapy for patients with relapsed\/refractory chronic lymphocytic leukemia","volume":"24","author":"Davids","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrep.2025.102354_bib75","article-title":"Mechanisms of venetoclax resistance and solutions","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12943-016-0571-x","article-title":"Targeting acute myeloid leukemia stem cell signaling by natural products","volume":"16","author":"Siveen","year":"2017","journal-title":"Mol. Cancer"},{"issue":"11","key":"10.1016\/j.bbrep.2025.102354_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biom9110679","article-title":"Natural products and synthetic analogs as a source of antitumor drugs","volume":"9","author":"Sharifi-Rad","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbrep.2025.102354_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.867318","article-title":"Research advances on matrine","volume":"10","author":"Sun","year":"2022","journal-title":"Front. Chem."},{"issue":"1","key":"10.1016\/j.bbrep.2025.102354_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4149\/neo_210802N1083","article-title":"Matrine exerted an anti-tumor effect on acute myeloid leukemia via the lncRNA LINC01116\/miR-592-mediated JAK\/STAT pathway inactivation","volume":"69","author":"Zhang","year":"2022","journal-title":"Neoplasma"},{"issue":"6","key":"10.1016\/j.bbrep.2025.102354_bib32","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/jcmm.13049","article-title":"Matrine induces Akt\/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells","volume":"21","author":"Wu","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102354_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27041201","article-title":"Pharmacological activities of soursop (Annona muricata Lin.)","volume":"27","author":"Mutakin","year":"2022","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.bbrep.2025.102354_bib39","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/1354750X.2020.1836025","article-title":"In vitro evaluation of Annona muricata L. (Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells","volume":"25","author":"Naik","year":"2020","journal-title":"Biomarkers"},{"issue":"7","key":"10.1016\/j.bbrep.2025.102354_bib33","doi-asserted-by":"crossref","first-page":"15625","DOI":"10.3390\/ijms160715625","article-title":"Annona muricata (Annonaceae): a review of its traditional uses, isolated acetogenins and biological activities","volume":"16","author":"Moghadamtousi","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bbrep.2025.102354_bib38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/carcin\/bgy024","article-title":"Emerging therapeutic potential of graviola and its constituents in cancers","volume":"39","author":"Qazi","year":"2018","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrep.2025.102354_bib41","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1186\/1472-6882-14-516","article-title":"Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells","volume":"14","author":"Pieme","year":"2014","journal-title":"BMC Compl. Alternative Med."},{"issue":"11","key":"10.1016\/j.bbrep.2025.102354_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27113462","article-title":"Traditional uses, phytochemistry and pharmacological activities of annonacae","volume":"27","author":"Al Kazman","year":"2022","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.bbrep.2025.102354_bib36","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.apjtm.2017.08.009","article-title":"Annona muricata: is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects","volume":"10","author":"Gavamukulya","year":"2017","journal-title":"Asian Pac. J. Tropical Med."},{"key":"10.1016\/j.bbrep.2025.102354_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1826170","article-title":"Anticancer Properties of Graviola (Annona muricata): a comprehensive mechanistic review","volume":"2018","author":"Rady","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"18","key":"10.1016\/j.bbrep.2025.102354_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14184539","article-title":"A review on Annona muricata and its anticancer activity","volume":"14","author":"Ilango","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrep.2025.102354_bib42","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3389\/fphar.2019.00783","article-title":"Selective acetogenins and their potential as anticancer agents","volume":"10","author":"Jacobo-Herrera","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrep.2025.102354_bib43","first-page":"7","article-title":"Induction of apoptosis in myelogenous leukemic K562 cells by ethanolic leaf extract of Annona muricata","volume":"2","author":"Ezirim","year":"2013","journal-title":"Indian J. Drug Dis."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:29:42Z","timestamp":1773833382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825004418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":75,"alternative-id":["S2405580825004418"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102354","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unlocking nature's potential: Soursop in the battle against resistant acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102354"}}