{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:13:01Z","timestamp":1778883181800,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA 022414-01"],"award-info":[{"award-number":["AA 022414-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["537144118537144118"],"award-info":[{"award-number":["537144118537144118"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1423"],"award-info":[{"award-number":["CRC1423"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["NE2706\/2-1"],"award-info":[{"award-number":["NE2706\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["421152132"],"award-info":[{"award-number":["421152132"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AB393 \/9-1"],"award-info":[{"award-number":["AB393 \/9-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["09150172110002"],"award-info":[{"award-number":["09150172110002"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["PNRR-MR1-2022-12376412"],"award-info":[{"award-number":["PNRR-MR1-2022-12376412"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004038","name":"Jung Foundation for Science and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008678","name":"Universit\u00e4t Leipzig","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008678","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbrep.2025.102375","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:49:04Z","timestamp":1764334144000},"page":"102375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Single nucleotide variants in UNC13C associated with neurodevelopmental disorders affect ethanol sensitivity in Drosophila"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8465-8269","authenticated-orcid":false,"given":"Franz","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-8791","authenticated-orcid":false,"given":"Sonja","family":"Neuser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-0183","authenticated-orcid":false,"given":"Netra P.","family":"Neupane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina J.","family":"G\u00f6tze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6895-8819","authenticated-orcid":false,"given":"Nicola","family":"Brunetti-Pierri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Terrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Reymond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen L.","family":"van Gassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Brilstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Steindl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anais","family":"Begemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9237-8929","authenticated-orcid":false,"given":"Jonathan","family":"Rips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duha","family":"Fahham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahsin Stefan","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-1540","authenticated-orcid":false,"given":"Olivier","family":"Patat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-1961","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Mortreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-1938","authenticated-orcid":false,"given":"Matthew Hoi Kin","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-7987","authenticated-orcid":false,"given":"Jill A.","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-8502","authenticated-orcid":false,"given":"Elizabeth","family":"Mizerik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-4151","authenticated-orcid":false,"given":"Swati","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-2318","authenticated-orcid":false,"given":"Xi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-0296","authenticated-orcid":false,"given":"Anne-Kristin","family":"Dahse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-8451","authenticated-orcid":false,"given":"Nicole","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-5804","authenticated-orcid":false,"given":"Joydip","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-4699","authenticated-orcid":false,"given":"Gregg","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-3809","authenticated-orcid":false,"given":"Tobias","family":"Langenhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Abou Jamra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-164X","authenticated-orcid":false,"given":"Achmed","family":"Mrestani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-5374","authenticated-orcid":false,"given":"Dmitrij","family":"Ljaschenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2025.102375_bib1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/14764","article-title":"Drosophila UNC-13 is essential for synaptic transmission","volume":"2","author":"Aravamudan","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrep.2025.102375_bib2","doi-asserted-by":"crossref","first-page":"25273","DOI":"10.1074\/jbc.270.42.25273","article-title":"Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins","volume":"270","author":"Brose","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2025.102375_bib3","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1073\/pnas.88.13.5729","article-title":"A phorbol ester\/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans","volume":"88","author":"Maruyama","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrep.2025.102375_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-3-031-34229-5_8","article-title":"Functional roles of UNC-13\/Munc13 and UNC-18\/Munc18 in neurotransmission","volume":"33","author":"Meunier","year":"2023","journal-title":"Advances in neurobiology"},{"key":"10.1016\/j.bbrep.2025.102375_bib5","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nsmb1001","article-title":"A minimal domain responsible for Munc13 activity","volume":"12","author":"Basu","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrep.2025.102375_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/biomethods\/bpac003","article-title":"Improving one-step scarless genome editing in Drosophila melanogaster by combining ovoD co-CRISPR selection with sgRNA target site masking","volume":"7","author":"G\u00f6tze","year":"2022","journal-title":"Biology methods & protocols"},{"key":"10.1016\/j.bbrep.2025.102375_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050198","article-title":"Open syntaxin docks synaptic vesicles","volume":"5","author":"Hammarlund","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbrep.2025.102375_bib7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/35085583","article-title":"An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming","volume":"412","author":"Richmond","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2025.102375_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2012.06.012","article-title":"The presynaptic active zone","volume":"75","author":"S\u00fcdhof","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbrep.2025.102375_bib9","doi-asserted-by":"crossref","first-page":"8040","DOI":"10.1523\/JNEUROSCI.2350-06.2006","article-title":"UNC-13 and UNC-10\/rim localize synaptic vesicles to specific membrane domains","volume":"26","author":"Weimer","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2025.102375_bib10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.neuron.2017.07.015","article-title":"A C1-C2 module in Munc13 inhibits calcium-dependent neurotransmitter release","volume":"95","author":"Michelassi","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.bbrep.2025.102375_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22567","article-title":"Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN","volume":"6","author":"Xu","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.bbrep.2025.102375_bib12","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nn.4364","article-title":"Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling","volume":"19","author":"B\u00f6hme","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrep.2025.102375_bib13","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.neuron.2017.08.016","article-title":"Stable positioning of Unc13 restricts synaptic vesicle fusion to defined release sites to promote synchronous neurotransmission","volume":"95","author":"Reddy-Alla","year":"2017","journal-title":"Neuron"},{"issue":"630","key":"10.1016\/j.bbrep.2025.102375_bib14","first-page":"e3","article-title":"UNC13A is a modifier of survival in amyotrophic lateral sclerosis","volume":"33","author":"Diekstra","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbrep.2025.102375_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1172\/JCI90259","article-title":"Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder","volume":"127","author":"Lipstein","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrep.2025.102375_bib16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/npr2.12027","article-title":"De novo UNC13B mutation identified in a bipolar disorder patient increases a rare exon-skipping variant","volume":"38","author":"Nakamura","year":"2018","journal-title":"Neuropsychopharmacology Reports"},{"key":"10.1016\/j.bbrep.2025.102375_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-022-04436-3","article-title":"TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A","volume":"603","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2025.102375_bib18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-022-04424-7","article-title":"TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A","volume":"603","author":"Ma","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2025.102375_bib19","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1212\/WNL.0000000000004606","article-title":"Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials","volume":"89","author":"van Eijk","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.bbrep.2025.102375_bib20","article-title":"Homozygous UNC13A variant in an infant with congenital encephalopathy and severe neuromuscular phenotype: a case report with detailed central nervous system neuropathologic findings","volume":"14","author":"Mullins","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.bbrep.2025.102375_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American college of medical genetics and genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med. : official journal of the American College of Medical Genetics"},{"key":"10.1016\/j.bbrep.2025.102375_bib22","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/humu.22844","article-title":"GeneMatcher: a matching tool for connecting investigators with an interest in the same gene","volume":"36","author":"Sobreira","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbrep.2025.102375_bib24","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1534\/genetics.113.160713","article-title":"Highly specific and efficient CRISPR\/Cas9-catalyzed homology-directed repair in drosophila","volume":"196","author":"Gratz","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.bbrep.2025.102375_bib25","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1534\/genetics.113.152710","article-title":"Genome engineering of Drosophila with the CRISPR RNA-Guided Cas9 nuclease","volume":"194","author":"Gratz","year":"2013","journal-title":"Genetics"},{"issue":"8","key":"10.1016\/j.bbrep.2025.102375_bib26","first-page":"2749","article-title":"ovoD Co-selection: a method for enriching CRISPR\/Cas9","volume":"G3","author":"Ewen-Campen","year":"2018","journal-title":"Alleles in Drosophila"},{"key":"10.1016\/j.bbrep.2025.102375_bib27","doi-asserted-by":"crossref","DOI":"10.3791\/50442-v","article-title":"The FlyBar: administering alcohol to flies","author":"van der Linde","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbrep.2025.102375_bib28","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/acer.14363","article-title":"Effect of ethanol on Munc13-1 C1 in membrane: a molecular dynamics simulation study","volume":"44","author":"You","year":"2020","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbrep.2025.102375_bib29","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/humu.23270","article-title":"CSNK2B splice site mutations in patients cause intellectual disability with or without myoclonic epilepsy","volume":"38","author":"Poirier","year":"2017","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbrep.2025.102375_bib30","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1111\/epi.16931","article-title":"CSNK2B: a broad spectrum of neurodevelopmental disability and epilepsy severity","volume":"62","author":"Ernst","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.bbrep.2025.102375_bib31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41586-023-06045-0","article-title":"A genomic mutational constraint map using variation in 76,156 human genomes","volume":"625","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2025.102375_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(01)00635-3","article-title":"Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs","volume":"108","author":"Rhee","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2025.102375_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1074304","article-title":"Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation","volume":"16","author":"Dannh\u00e4user","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbrep.2025.102375_bib34","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1038\/s41467-021-22180-6","article-title":"Unc13A and Unc13B contribute to the decoding of distinct sensory information in drosophila","volume":"12","author":"Pooryasin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2025.102375_bib35","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.celrep.2015.04.008","article-title":"The adhesion GPCR latrophilin\/CIRL shapes mechanosensation","volume":"11","author":"Scholz","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrep.2025.102375_bib36","series-title":"The \u201cDrunken\u201d Synapse. Studies of Alcohol-Related Disorders","author":"Liu","year":"1999"},{"key":"10.1016\/j.bbrep.2025.102375_bib37","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0125-18.2018","article-title":"Ethanol regulates presynaptic activity and sedation through presynaptic Unc13 proteins in drosophila","volume":"5","author":"Xu","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.bbrep.2025.102375_bib38","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/jnc.12315","article-title":"The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration in drosophila","volume":"126","author":"Das","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrep.2025.102375_bib39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1476-5381.1989.tb11777.x","article-title":"Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site","volume":"96","author":"Alifimoff","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrep.2025.102375_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.128re7","article-title":"Ethanol's molecular targets","volume":"1","author":"Harris","year":"2008","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrep.2025.102375_bib41","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1097\/01.alc.0000183232.56788.62","article-title":"The slowpoke gene is necessary for rapid ethanol tolerance in drosophila","volume":"29","author":"Cowmeadow","year":"2005","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bbrep.2025.102375_bib42","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.bpj.2011.02.032","article-title":"Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor","volume":"100","author":"Murail","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrep.2025.102375_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002710","article-title":"Molecular mechanism for the dual alcohol modulation of Cys-loop receptors","volume":"8","author":"Murail","year":"2012","journal-title":"PLoS Comput. Biol."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580825004625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:46:46Z","timestamp":1778881606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580825004625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":43,"alternative-id":["S2405580825004625"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102375","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single nucleotide variants in UNC13C associated with neurodevelopmental disorders affect ethanol sensitivity in Drosophila","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2025.102375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102375"}}