{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:20:20Z","timestamp":1773919220868,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1595"],"award-info":[{"award-number":["2022NSFSC1595"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2023QN088"],"award-info":[{"award-number":["2023QN088"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2025243"],"award-info":[{"award-number":["2025243"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbrep.2026.102469","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:37:29Z","timestamp":1769269049000},"page":"102469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chidamide and Anlotinib act synergistically in Jurkat cells by inhibiting the Hippo signaling pathway"],"prefix":"10.1016","volume":"45","author":[{"given":"Tao","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuqin","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbrep.2026.102469_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11864-020-00757-5","article-title":"Biology and treatment paradigms in T cell acute lymphoblastic leukemia in older adolescents and adults","volume":"21","author":"Patel","year":"2020","journal-title":"Curr. Treat. Options Oncol."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102469_bib2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/bjh.20007","article-title":"Outcomes and prognostic factors associated with relapse after haploidentical stem cell transplantation for paediatric T-cell acute lymphoblastic leukaemia","volume":"206","author":"Zhao","year":"2025","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102469_bib3","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1016\/S2352-3026(22)00036-9","article-title":"In-vivo T-cell depleted reduced-intensity conditioned allogeneic haematopoietic stem-cell transplantation for patients with acute lymphoblastic leukaemia in first remission: results from the prospective, single-arm evaluation of the UKALL14 trial","volume":"9","author":"Marks","year":"2022","journal-title":"Lancet Haematol."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102469_bib4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/wsbm.123","article-title":"Quantitative analysis of phosphorylation-based protein signaling networks in the immune system by mass spectrometry","volume":"3","author":"Nita-Lazar","year":"2011","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.bbrep.2026.102469_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116696","article-title":"Overview of class I HDAC modulators: inhibitors and degraders","volume":"276","author":"Huang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102469_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001696","article-title":"Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma","volume":"9","author":"Que","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102469_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s43556-022-00110-2","article-title":"Targeting the PI3K\/AKT\/mTOR and RAF\/MEK\/ERK pathways for cancer therapy","volume":"3","author":"Li","year":"2022","journal-title":"Mol. Biomed."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102469_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41419-020-2414-3","article-title":"Chidamide epigenetically represses autophagy and exerts cooperative antimyeloma activity with bortezomib","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102469_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s43440-025-00700-1","article-title":"Off-label use of anlotinib in malignancies' treatment: efficacy and management of adverse reactions","volume":"77","author":"Wang","year":"2025","journal-title":"Pharmacol. Rep."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102469_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41419-020-02749-7","article-title":"Anlotinib suppresses tumor progression via blocking the VEGFR2\/PI3K\/AKT cascade in intrahepatic cholangiocarcinoma","volume":"11","author":"Song","year":"2020","journal-title":"Cell Death Dis."},{"issue":"17","key":"10.1016\/j.bbrep.2026.102469_bib11","doi-asserted-by":"crossref","first-page":"9459","DOI":"10.1073\/pnas.96.17.9459","article-title":"Cation-pi interactions in structural biology","volume":"96","author":"Gallivan","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102469_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41419-024-06693-8","article-title":"Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress","volume":"15","author":"Takchi","year":"2024","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102469_bib13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s42255-020-0174-0","article-title":"Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities","volume":"2","author":"Huang","year":"2020","journal-title":"Nat. Metab."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102469_bib14","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3724\/abbs.2023035","article-title":"The Hippo signaling pathway: from multiple signals to the hallmarks of cancers","volume":"55","author":"Zhu","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102469_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V","volume":"184","author":"Vermes","year":"1995","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bbrep.2026.102469_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13059-016-0881-8","article-title":"A survey of best practices for RNA-seq data analysis","volume":"17","author":"Conesa","year":"2016","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102469_bib17","first-page":"29","article-title":"Expression of TGFBI in infantile hemangioma tissues and its effect on the biological characteristics of hemangioma endothelial cells","volume":"41","author":"Li","year":"2023","journal-title":"Hua xi kou qiang yi xue za zhi"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102469_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41413-025-00400-9","article-title":"CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.bbrep.2026.102469_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216970","article-title":"Anlotinib synergizes with venetoclax to induce mitotic catastrophe in acute myeloid leukemia","volume":"593","author":"Wang","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrep.2026.102469_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.34133\/research.0281","article-title":"Hepatic HDAC3 regulates systemic iron homeostasis and ferroptosis via the Hippo signaling pathway","volume":"6","author":"Meng","year":"2023","journal-title":"Research"},{"key":"10.1016\/j.bbrep.2026.102469_bib21","first-page":"46","article-title":"HDAC-driven mechanisms in anticancer resistance: epigenetics and beyond","volume":"7","author":"Minisini","year":"2024","journal-title":"Cancer Drug Resist."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102469_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13773","article-title":"The apoptotic and anti-proliferative effects of Neosetophomone B in T-cell acute lymphoblastic leukaemia via PI3K\/AKT\/mTOR pathway inhibition","volume":"58","author":"Kuttikrishnan","year":"2025","journal-title":"Cell Prolif."},{"issue":"9","key":"10.1016\/j.bbrep.2026.102469_bib23","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.cellsig.2014.05.016","article-title":"Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK\/Mcl-1 and p38 MAPK pathways","volume":"26","author":"Naci","year":"2014","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102469_bib24","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1038\/s41467-025-57697-7","article-title":"Targeting the disrupted Hippo signaling to prevent neoplastic renal epithelial cell immune evasion","volume":"16","author":"Lv","year":"2025","journal-title":"Nat. Commun."},{"issue":"728","key":"10.1016\/j.bbrep.2026.102469_bib25","doi-asserted-by":"crossref","first-page":"eadg3840","DOI":"10.1126\/scitranslmed.adg3840","article-title":"The extracellular matrix as hallmark of cancer and metastasis: from biomechanics to therapeutic targets","volume":"16","author":"Sleeboom","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102469_bib26","article-title":"Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.bbrep.2026.102469_bib27","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.3390\/ijms22094502","article-title":"The new therapeutic strategies in pediatric T-Cell acute lymphoblastic leukemia","volume":"22","author":"Lato","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bbrep.2026.102469_bib28","first-page":"1674","article-title":"Integrin signalling regulates YAP and TAZ to control skin homeostasis","volume":"143","author":"Elbediwy","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.bbrep.2026.102469_bib29","article-title":"Extracellular Matrix stiffness and TGF\u03b22 regulate YAP\/TAZ activity in human trabecular meshwork cells","volume":"10","author":"Li","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102469_bib30","first-page":"213","article-title":"Connective tissue growth factor (CCN2) inhibits TNF-\u03b1-induced apoptosis by enhancing autophagy through the Akt and Erk pathways in osteoblasts","volume":"75","author":"Ni","year":"2020","journal-title":"Pharmazie"},{"issue":"8","key":"10.1016\/j.bbrep.2026.102469_bib31","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1021\/acs.jmedchem.0c00193","article-title":"Design, synthesis, and biological evaluation of Quinazolin-4-one-Based hydroxamic acids as dual PI3K\/HDAC inhibitors","volume":"63","author":"Thakur","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrep.2026.102469_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115915","article-title":"Discovery of benzamide-based PI3K\/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells","volume":"262","author":"Deng","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.bbrep.2026.102469_bib33","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809443","article-title":"PDX models recapitulate the genetic and epigenetic landscape of pediatric T-cell leukemia","volume":"10","author":"Richter-Pecha\u0144ska","year":"2018","journal-title":"EMBO Mol. Med."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826000294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826000294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:28:47Z","timestamp":1773901727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826000294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"alternative-id":["S2405580826000294"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102469","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chidamide and Anlotinib act synergistically in Jurkat cells by inhibiting the Hippo signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102469"}}