{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:55:53Z","timestamp":1781740553419,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016067","name":"Shaanxi Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["SZY-KJCYC-2025-JC-004"],"award-info":[{"award-number":["SZY-KJCYC-2025-JC-004"]}],"id":[{"id":"10.13039\/100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012562","name":"Gansu University of Chinese Medicine","doi-asserted-by":"publisher","award":["L2024-QCY-ZYYJJQ-Y09"],"award-info":[{"award-number":["L2024-QCY-ZYYJJQ-Y09"]}],"id":[{"id":"10.13039\/501100012562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbrep.2026.102540","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:20:32Z","timestamp":1773091232000},"page":"102540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Quercetin alleviates CCl4-induced liver fibrosis via regulating gut microbiota and the AGE-RAGE\/PI3K\/Akt signaling axis"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7047-7528","authenticated-orcid":false,"given":"Yi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Han","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Tai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbrep.2026.102540_bib1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1053\/j.gastro.2023.05.053","article-title":"Prevalence of liver steatosis and fibrosis in the general population and various high-risk populations: a nationwide study with 5.7 million adults in China","volume":"165","author":"Man","year":"2023","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.bbrep.2026.102540_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S2468-1253(19)30349-8","article-title":"The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"5","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrep.2026.102540_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspect. Med."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102540_bib4","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.drudis.2021.12.012","article-title":"Therapeutic potential of targeting regulatory mechanisms of hepatic stellate cell activation in liver fibrosis","volume":"27","author":"Baghaei","year":"2022","journal-title":"Drug Discov. Today"},{"issue":"14","key":"10.1016\/j.bbrep.2026.102540_bib5","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.3390\/ijms25147873","article-title":"Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells","volume":"25","author":"Akk\u0131z","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102540_bib6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"issue":"Suppl 1","key":"10.1016\/j.bbrep.2026.102540_bib7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jhep.2020.11.042","article-title":"The global burden of cirrhosis: a review of disability-adjusted life-years lost and unmet needs","volume":"75","author":"Jepsen","year":"2021","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102540_bib8","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1002\/ptr.7001","article-title":"Role of ellagic acid for the prevention and treatment of liver diseases","volume":"35","author":"Aishwarya","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrep.2026.102540_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119298","article-title":"The advancement of targeted regulation of hepatic stellate cells using traditional Chinese medicine for the treatment of liver fibrosis","volume":"341","author":"Liang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102540_bib10","first-page":"1101","article-title":"Research progress on the mechanism of regulating hepatic stellate cell glycolysis against hepatic fibrosis and the prevention and treatment with traditional Chinese medicine","volume":"35","author":"Hao","year":"2024","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102540_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1485065","article-title":"Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities","volume":"15","author":"Liao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102540_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fphar.2018.00072","article-title":"The flavonoid quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102540_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1389179","article-title":"A detailed overview of quercetin: implications for cell death and liver fibrosis mechanisms","volume":"15","author":"Xiong","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"13","key":"10.1016\/j.bbrep.2026.102540_bib14","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.3390\/ijms20133177","article-title":"The anti-cancer effect of quercetin: molecular implications in cancer metabolism","volume":"20","author":"Reyes-Farias","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2026.102540_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.fct.2018.12.028","article-title":"Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy","volume":"125","author":"Zeng","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/nu13010206","article-title":"Curcumin, quercetin, catechins and metabolic diseases: the role of gut microbiota","volume":"13","author":"Shabbir","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrep.2026.102540_bib17","article-title":"Salidroside alleviates cholestasis-induced liver fibrosis by inhibiting hepatic stellate cells via activation of the PI3K\/AKT\/GSK-3\u03b2 signaling pathway and regulating intestinal flora distribution","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102540_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cels.2022.11.002","article-title":"Metabolic models of human gut microbiota: advances and challenges","volume":"14","author":"Rios Garza","year":"2023","journal-title":"Cell Syst."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12934-020-01348-7","article-title":"Gut microbial dysbiosis in individuals with Sj\u00f6gren's syndrome","volume":"19","author":"Mendez","year":"2020","journal-title":"Microb. Cell Fact."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib20","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1038\/s41598-023-30582-3","article-title":"Mangiferin relieves CCl4-induced liver fibrosis in mice","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib21","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-\u03b21\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.bbrep.2026.102540_bib22","first-page":"7348","article-title":"Research progress on the effect and mechanism of quercetin and its derivatives against liver injury","volume":"52","author":"Zhang","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s10753-015-0227-9","article-title":"Quercetin protects mice from ConA-Induced hepatitis by inhibiting HMGB1-TLR expression and down-regulating the nuclear factor Kappa B pathway","volume":"39","author":"Li","year":"2016","journal-title":"Inflammation"},{"issue":"7783","key":"10.1016\/j.bbrep.2026.102540_bib24","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bbrep.2026.102540_bib25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3390\/metabo14110629","article-title":"The action of colchicine in patients with metabolic syndrome and obesity: perspectives and challenges","volume":"14","author":"Bulh\u00f5es","year":"2024","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib26","first-page":"65","article-title":"Shugan Huoxue Huayu Fang attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting transforming growth factor-\u03b21\/Smad signaling","volume":"42","author":"Lei","year":"2022","journal-title":"J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.semarthrit.2020.11.007","article-title":"A systematic review of the infectious complications of colchicine and the use of colchicine to treat infections","volume":"51","author":"McEwan","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.bbrep.2026.102540_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-294X.2009.04480.x","article-title":"Multiple marker parallel tag environmental DNA sequencing reveals a highly complex eukaryotic community in marine anoxic water","volume":"19","author":"Stoeck","year":"2010","journal-title":"Mol. Ecol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s43657-025-00232-x","article-title":"Impact of DNA extraction methods on gut microbiome profiles: a comparative metagenomic study","volume":"5","author":"Pu","year":"2025","journal-title":"Phenomics"},{"issue":"10","key":"10.1016\/j.bbrep.2026.102540_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00859-24","article-title":"A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities","volume":"9","author":"Dommann","year":"2024","journal-title":"mSystems"},{"key":"10.1016\/j.bbrep.2026.102540_bib31","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3389\/fmicb.2016.01297","article-title":"Evaluation of 16S rRNA gene primer pairs for monitoring microbial community structures showed high reproducibility within and low comparability between datasets generated with multiple archaeal and bacterial primer pairs","volume":"7","author":"Fischer","year":"2016","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49520-3","article-title":"Stool sampling and DNA isolation kits affect DNA quality and bacterial composition following 16S rRNA gene sequencing using MiSeq Illumina platform","volume":"9","author":"Videnska","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib33","doi-asserted-by":"crossref","first-page":"8268","DOI":"10.1038\/s41598-024-58753-w","article-title":"Bacterial biota associated with the invasive insect pest Tuta absoluta (Meyrick)","volume":"14","author":"Lateef","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102540_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195972","article-title":"Data quality of whole genome bisulfite sequencing on Illumina platforms","volume":"13","author":"Raine","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbrep.2026.102540_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22842","article-title":"Association between blood microbiome and type 2 diabetes mellitus: a nested case-control study","volume":"33","author":"Qiu","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"issue":"9","key":"10.1016\/j.bbrep.2026.102540_bib36","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00109-024-02464-2","article-title":"Molecular targets in bone cancer pain: a systematic review of inflammatory cytokines","volume":"102","author":"Ruivo","year":"2024","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"11","key":"10.1016\/j.bbrep.2026.102540_bib37","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.3390\/ijms21113858","article-title":"Relevance of SIRT1-NF-\u03baB axis as therapeutic target to ameliorate inflammation in liver disease","volume":"21","author":"de Gregorio","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40164-022-00329-3","article-title":"Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor","volume":"11","author":"Jabbar","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102540_bib39","first-page":"494","article-title":"Guidelines for integrative traditional Chinese and Western medicine diagnosis and treatment of hepatic fibrosis (2019 edition)","volume":"27","year":"2019","journal-title":"Chin. J. Hepatol."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102540_bib40","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3390\/foods13071124","article-title":"The probiotic Kluyveromyces lactis JSA 18 alleviates obesity and hyperlipidemia in high-fat diet C57BL\/6J mice","volume":"13","author":"Hong","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.bbrep.2026.102540_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.680241","article-title":"Broccoli florets supplementation improves insulin sensitivity and alters gut microbiome Population-A steatosis mice model induced by high-fat diet","volume":"8","author":"Zandani","year":"2021","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102540_bib42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13578-025-01382-1","article-title":"Special correlation between diet and MASLD: positive or negative?","volume":"15","author":"Liu","year":"2025","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102540_bib43","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/antiox11020358","article-title":"Quercetin regulates key components of the cellular microenvironment during early hepatocarcinogenesis","volume":"11","author":"Reyes-Avenda\u00f1o","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrep.2026.102540_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135802","article-title":"Alginate-inulin-chitosan based microspheres alter metabolic fate of encapsulated quercetin, promote short chain fatty acid production, and modulate pig gut microbiota","volume":"418","author":"Liu","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrep.2026.102540_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117520","article-title":"Ameliorative effects of modified Huangqi Chifeng decoctio n on podocyte injury via autophagy mediated by PI3K\/AKT\/mTOR and AMPK\/mTOR path ways","volume":"321","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"Pt A","key":"10.1016\/j.bbrep.2026.102540_bib46","article-title":"CD73 aggravates alcohol-related liver fibrosis by promoting autophagy mediated activation of hepatic stellate cells through AMPK\/AKT\/mTOR signaling pathway","volume":"113","author":"Wu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.bbrep.2026.102540_bib47","first-page":"1652","article-title":"Effect and mechanism of Fuzheng Huaxian recipe on regulating PI3K\/AKT\/BAD signaling pathway in mice with hepatic fibrosis","volume":"35","author":"Sun","year":"2024","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102540_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1389329","article-title":"The role of PI3k\/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review","volume":"11","author":"Shamsan","year":"2024","journal-title":"Front. Med."},{"issue":"Pt A","key":"10.1016\/j.bbrep.2026.102540_bib49","article-title":"Blocking P2X4 purinergic receptor attenuates alcohol-r elated liver fibrosis by inhibiting hepatic stellate cell activation through PI3K\/AKT signaling pathway","volume":"113","author":"Li","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102540_bib50","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/jgh.16538","article-title":"Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K\/Akt\/mTOR pathway","volume":"39","author":"Wang","year":"2024","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"Pt 2","key":"10.1016\/j.bbrep.2026.102540_bib51","article-title":"Bie Jia Jian pill ameliorates BDL-induced cholestatic hepatic fibrosis in rats by regulating intestinal microbial composition and TMAO-mediated PI3K\/AKT signaling pathway","volume":"337","author":"Cui","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrep.2026.102540_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107208","article-title":"Prediction and verification of target of helenalin against hepatic stellate cell activation based on miR-200a-mediated PI3K\/Akt and NF-\u03baB pathways","volume":"92","author":"Fang","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"23","key":"10.1016\/j.bbrep.2026.102540_bib53","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.3390\/molecules25235591","article-title":"The development of maillard reaction, and advanced G lycation end product (AGE)-receptor for AGE (RAGE) signaling inhibitors as novel ther apeutic strategies for patients with AGE-related diseases","volume":"25","author":"Shen","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbrep.2026.102540_bib54","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.metabol.2018.01.023","article-title":"Serum levels of advanced glycation end-products (AGEs) and the decoy soluble receptor for AGEs (sRAGE) can identify non-alcoholic fatty liver disease in age-, sex- and BMI-matched normo-glycemic adults","volume":"83","author":"Palma-Duran","year":"2018","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.bbrep.2026.102540_bib55","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/nu15030743","article-title":"Sulforaphane ameliorates nonalcoholic fatty liver disease induced by high-fat and high-fructose diet via LPS\/TLR4 in the gut-liver axis","volume":"15","author":"Xu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrep.2026.102540_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1385907","article-title":"Crosstalk between hypoxia-inducible factor-1\u03b1 and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery","volume":"15","author":"Xiao","year":"2024","journal-title":"Front. Immunol."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:45:32Z","timestamp":1781739932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826001007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":56,"alternative-id":["S2405580826001007"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102540","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin alleviates CCl4-induced liver fibrosis via regulating gut microbiota and the AGE-RAGE\/PI3K\/Akt signaling axis","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102540","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102540"}}