{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:33:31Z","timestamp":1786116811317,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012562","name":"Gansu University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023YXKY020"],"award-info":[{"award-number":["2023YXKY020"]}],"id":[{"id":"10.13039\/501100012562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbrep.2026.102563","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:19:38Z","timestamp":1775135978000},"page":"102563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Network-based toxicological analysis of core targets and pathways of bisphenol A-driven hepatocellular carcinoma"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4652-8914","authenticated-orcid":false,"given":"Yanan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chujiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiucong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jceh.2024.102406","article-title":"Evolving global etiology of hepatocellular carcinoma (HCC): insights and trends for 2024","volume":"15","author":"Koshy","year":"2025","journal-title":"J. Clin. Exp. Hepatol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102563_bib2","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000627","article-title":"Environmental exposures and the risk of hepatocellular carcinoma","volume":"9","author":"Rayapati","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbrep.2026.102563_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1212301","article-title":"Association between air pollution and primary liver cancer in European and east Asian populations: a Mendelian randomization study","volume":"11","author":"Sun","year":"2023","journal-title":"Front. Public Health"},{"issue":"2","key":"10.1016\/j.bbrep.2026.102563_bib4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/a-2540-2861","article-title":"Environmental pollutants, occupational exposures, and liver disease","volume":"45","author":"Beier","year":"2025","journal-title":"Semin. Liver Dis."},{"issue":"9","key":"10.1016\/j.bbrep.2026.102563_bib5","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.3390\/ijms24098028","article-title":"Special issue \"molecular mechanisms of bisphenol A toxicity and effects of environmental levels on health\"","volume":"24","author":"Coppola","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.bbrep.2026.102563_bib6","doi-asserted-by":"crossref","first-page":"51217","DOI":"10.1007\/s11356-023-25924-7","article-title":"Association of urinary bisphenol A with cardiovascular and all-cause mortality: National Health and Nutrition Examination Survey (NHANES) 2003-2016","volume":"30","author":"Chen","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00005-022-00661-w","article-title":"Bisphenol A: potential factor of miscarriage in women in the context of the phenomenon of neutrophil extracellular traps","volume":"70","author":"Omeljaniuk","year":"2022","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102563_bib8","first-page":"836","article-title":"Relationship between daily exposure to bisphenol A and male sexual function-a study from the reproductive center","volume":"39","author":"Feng","year":"2018","journal-title":"Zhonghua Liuxingbingxue Zazhi"},{"issue":"6","key":"10.1016\/j.bbrep.2026.102563_bib9","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/biomedicines9060666","article-title":"The Role of the bisphenol A in diabetes and obesity","volume":"9","author":"P\u00e9rez-Bermejo","year":"2021","journal-title":"Biomedicines"},{"issue":"11","key":"10.1016\/j.bbrep.2026.102563_bib10","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.3390\/ijms25116229","article-title":"Bisphenol A-What do we know? A global or local approach at the public health risk level","volume":"25","author":"Charkiewicz","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.bbrep.2026.102563_bib11","doi-asserted-by":"crossref","first-page":"19643","DOI":"10.1007\/s11356-021-13071-w","article-title":"A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence","volume":"28","author":"Khan","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102563_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1515\/reveh-2019-0034","article-title":"A review on sources and health impacts of bisphenol A","volume":"35","author":"Abraham","year":"2020","journal-title":"Rev. Environ. Health"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biotechadv.2017.12.002","article-title":"Bisphenol A (BPA) and cell signaling pathways","volume":"36","author":"Murata","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.bbrep.2026.102563_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1592048","article-title":"Exploring the mechanisms and targets of proton pump inhibitors-induced osteoporosis through network toxicology, molecular docking, and molecular dynamics simulations","volume":"16","author":"Mu","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102563_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Nogales","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrep.2026.102563_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2025.125708","article-title":"Exploring the toxicological impact of bisphenol a exposure on psoriasis through network toxicology, machine learning, and multi-dimensional bioinformatics analysis","volume":"385","author":"Feng","year":"2025","journal-title":"J. Environ. Manag."},{"issue":"W1","key":"10.1016\/j.bbrep.2026.102563_bib17","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102563_bib18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2174\/1871530322666220928144043","article-title":"Bisphenol A-induced endocrine dysfunction and its associated metabolic disorders","volume":"23","author":"Maniradhan","year":"2023","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"},{"key":"10.1016\/j.bbrep.2026.102563_bib19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.etap.2016.09.014","article-title":"Bisphenol A and its analogs: do their metabolites have endocrine activity?","volume":"47","author":"Gramec Skledar","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"11","key":"10.1016\/j.bbrep.2026.102563_bib20","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41419-021-04328-w","article-title":"Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor-positive breast cancer cells","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1-2","key":"10.1016\/j.bbrep.2026.102563_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2013.05.023","article-title":"The nuclear localization signal is required for nuclear GPER translocation and function in breast cancer-associated fibroblasts (CAFs)","volume":"376","author":"Pupo","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102563_bib22","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3390\/ijms19020611","article-title":"The role of the estrogen pathway in the tumor microenvironment","volume":"19","author":"Rothenberger","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1-2","key":"10.1016\/j.bbrep.2026.102563_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2011.05.002","article-title":"Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects","volume":"127","author":"Rubin","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrep.2026.102563_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108630","article-title":"In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among girls in Mexico City","volume":"177","author":"Ashrap","year":"2019","journal-title":"Environ. Res."},{"issue":"11","key":"10.1016\/j.bbrep.2026.102563_bib25","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity-a review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"30","key":"10.1016\/j.bbrep.2026.102563_bib26","doi-asserted-by":"crossref","first-page":"75126","DOI":"10.1007\/s11356-023-27747-y","article-title":"Toxicity of bisphenol A (BPA) and its derivatives in divers biological models with the assessment of molecular mechanisms of toxicity","volume":"30","author":"Rybczy\u0144ska-Tkaczyk","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.bbrep.2026.102563_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143055","article-title":"BPA's transgenerational disturbance to transcription of ovarian steroidogenic genes in rare minnow gobiocypris rarus via DNA and histone methylation","volume":"762","author":"Zhu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bbrep.2026.102563_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phrs.2015.01.003","article-title":"Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors","volume":"94","author":"Roskoski","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"9","key":"10.1016\/j.bbrep.2026.102563_bib29","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1158\/0008-5472.CAN-11-3078","article-title":"p120RasGAP-mediated activation of c-Src is critical for oncogenic Ras to induce tumor invasion","volume":"72","author":"Chan","year":"2012","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/cancers16010032","article-title":"Role of c-Src in carcinogenesis and drug resistance","volume":"16","author":"Raji","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrep.2026.102563_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118711","article-title":"c-Src promotes the growth and tumorigenesis of hepatocellular carcinoma via the Hippo signaling pathway","volume":"264","author":"Yang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrep.2026.102563_bib32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.canlet.2021.11.005","article-title":"Inhibiting Src-mediated PARP1 tyrosine phosphorylation confers synthetic lethality to PARP1 inhibition in HCC","volume":"526","author":"Sun","year":"2022","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12885-024-11985-5","article-title":"PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil","volume":"24","author":"Sch\u00f6ckel","year":"2024","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.bbrep.2026.102563_bib34","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1172\/JCI90327","article-title":"Hepatocyte nuclear factor 1\u03b1 suppresses steatosis-associated liver cancer by inhibiting PPAR\u03b3 transcription","volume":"127","author":"Patitucci","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib35","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41467-022-29846-9","article-title":"USP22 regulates lipidome accumulation by stabilizing PPAR\u03b3 in hepatocellular carcinoma","volume":"13","author":"Ning","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.bbrep.2026.102563_bib36","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1007\/PL00012491","article-title":"Heat-shock protein 90, a chaperone for folding and regulation","volume":"59","author":"Picard","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2015.06.018","article-title":"Regulation and function of the human HSP90AA1 gene","volume":"570","author":"Zuehlke","year":"2015","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.bbrep.2026.102563_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.tips.2016.11.009","article-title":"Heat Shock Proteins and cancer","volume":"38","author":"Wu","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102563_bib39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12935-024-03455-6","article-title":"AFP-HSP90 mediated MYC\/MET activation promotes tumor progression in hepatocellular carcinoma and gastric cancers","volume":"24","author":"Lin","year":"2024","journal-title":"Cancer Cell Int."},{"issue":"11","key":"10.1016\/j.bbrep.2026.102563_bib40","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.tips.2019.09.005","article-title":"Comprehensive analysis of ERK1\/2 substrates for potential combination immunotherapies","volume":"40","author":"Yang","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"issue":"10","key":"10.1016\/j.bbrep.2026.102563_bib41","first-page":"6924","article-title":"Novel prognostic signature based on HRAS, MAPK3 and TFRC identified to be associated with ferroptosis and the immune microenvironment in hepatocellular carcinoma","volume":"14","author":"Sun","year":"2022","journal-title":"Am. J. Transl. Res."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102563_bib42","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/eci.12441","article-title":"The Ras\/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications","volume":"45","author":"Delire","year":"2015","journal-title":"Eur. J. Clin. Invest."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:24:52Z","timestamp":1786019092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826001238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"alternative-id":["S2405580826001238"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102563","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network-based toxicological analysis of core targets and pathways of bisphenol A-driven hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102563"}}