{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:54:39Z","timestamp":1781740479765,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K15360"],"award-info":[{"award-number":["22K15360"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbrep.2026.102585","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:56:09Z","timestamp":1775800569000},"page":"102585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Oxysterol-binding protein-related protein 6 regulates neuronal morphology and migration of cerebellar granule cells during cerebellar development in vivo"],"prefix":"10.1016","volume":"46","author":[{"given":"Shinya","family":"Mochizuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8068-1277","authenticated-orcid":false,"given":"Wataru","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiji","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harukata","family":"Miki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2026.102585_bib1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1083\/jcb.201401126","article-title":"Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics","volume":"205","author":"Prinz","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrep.2026.102585_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.664788","article-title":"Functions of oxysterol-binding proteins at membrane contact sites and their control by phosphoinositide metabolism","volume":"9","author":"Nakatsu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrep.2026.102585_bib3","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/ATVBAHA.116.307282","article-title":"miRNA targeting of oxysterol-binding protein-like 6 regulates cholesterol trafficking and efflux","volume":"36","author":"Ouimet","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrep.2026.102585_bib4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.yexcr.2018.07.025","article-title":"Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons","volume":"370","author":"Mochizuki","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrep.2026.102585_bib5","article-title":"The involvement of oxysterol-binding protein related protein (ORP) 6 in the counter-transport of phosphatidylinositol-4-phosphate (PI4P) and phosphatidylserine (PS) in neurons","volume":"30","author":"Mochizuki","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.bbrep.2026.102585_bib6","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1523\/JNEUROSCI.15-02-00981.1995","article-title":"Motility and cytoskeletal organization of migrating cerebellar granule neurons","volume":"15","author":"Rivas","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102585_bib7","article-title":"Origins, development, and compartmentation of the granule cells of the cerebellum","volume":"14","author":"Consalez","year":"2020","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.bbrep.2026.102585_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/dneu.22236","article-title":"Deficits in cerebellar granule cell development and social interactions in CD47 knockout mice","volume":"75","author":"Hsieh","year":"2015","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbrep.2026.102585_bib9","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1523\/JNEUROSCI.5157-07.2008","article-title":"Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cells","volume":"28","author":"Espinosa","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102585_bib10","first-page":"1","article-title":"Signaling pathways in cerebellar granule cells development","volume":"8","author":"Wang","year":"2019","journal-title":"Am J Stem Cells"},{"key":"10.1016\/j.bbrep.2026.102585_bib11","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0468-20.2021","article-title":"Notch signaling between cerebellar granule cell progenitors","volume":"8","author":"Adachi","year":"2021","journal-title":"eNeuro"},{"key":"10.1016\/j.bbrep.2026.102585_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14484","article-title":"Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection","volume":"8","author":"Trivedi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2026.102585_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00441-003-0817-y","article-title":"Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7","volume":"315","author":"Lehto","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbrep.2026.102585_bib14","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbrep.2026.102585_bib15","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/2211-5463.13628","article-title":"Diacylglycerol kinase \u03b6 interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions","volume":"13","author":"Furuta","year":"2023","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bbrep.2026.102585_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2009.05.073","article-title":"Effect of transitory glucose deprivation on mitochondrial structure and functions in cultured cerebellar granule neurons","volume":"461","author":"Stelmashook","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrep.2026.102585_bib17","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1523\/JNEUROSCI.2722-13.2014","article-title":"Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons","volume":"34","author":"Yamada","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102585_bib18","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1523\/JNEUROSCI.0086-19.2019","article-title":"Sensorimotor coding of vermal granule neurons in the developing mammalian cerebellum","volume":"39","author":"Markwalter","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102585_bib19","article-title":"Utilizing in vivo postnatal electroporation to study cerebellar granule neuron morphology and synapse development","author":"Chan","year":"2021","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbrep.2026.102585_bib20","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.cellsig.2009.01.036","article-title":"Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells","volume":"21","author":"Wu","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrep.2026.102585_bib21","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1471-4159.2004.02770.x","article-title":"Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells","volume":"91","author":"Lee","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrep.2026.102585_bib22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.chemphyslip.2011.03.002","article-title":"Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?","volume":"164","author":"Vihervaara","year":"2011","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbrep.2026.102585_bib23","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1007\/s12035-015-9540-4","article-title":"MicroRNA124 regulated neurite elongation by targeting OSBP","volume":"53","author":"Gu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrep.2026.102585_bib24","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00018-020-03604-w","article-title":"ORP\/osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs","volume":"78","author":"Weber-Boyvat","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrep.2026.102585_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(02)00364-5","article-title":"The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling","volume":"1631","author":"Lehto","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrep.2026.102585_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032591","article-title":"Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection","volume":"7","author":"Shenoy","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2026.102585_bib27","doi-asserted-by":"crossref","first-page":"33617","DOI":"10.1074\/jbc.C300296200","article-title":"Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate","volume":"278","author":"Campbell","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2026.102585_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193257","article-title":"PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules","volume":"13","author":"Kath","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2026.102585_bib29","article-title":"F-BAR proteins CIP4 and FBP17 function in cortical neuron radial migration and process outgrowth","author":"English","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbrep.2026.102585_bib30","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.neuroscience.2010.10.022","article-title":"Neuronal soma migration is determined by neurite tension","volume":"172","author":"Hanein","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrep.2026.102585_bib31","doi-asserted-by":"crossref","first-page":"12138","DOI":"10.1073\/pnas.0604911103","article-title":"Cellular scaling rules for rodent brains","volume":"103","author":"Herculano-Houzel","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.bbrep.2026.102585_bib32","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/cells11040726","article-title":"Transit amplifying progenitors in the cerebellum: similarities to and differences from transit amplifying cells in other brain regions and between species","volume":"11","author":"Miyashita","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbrep.2026.102585_bib33","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1523\/JNEUROSCI.23-14-06132.2003","article-title":"Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation","volume":"23","author":"Patten","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102585_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000090754","article-title":"Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia","volume":"28","author":"Weller","year":"2006","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102585_bib35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neulet.2018.05.013","article-title":"Insights into cerebellar development and connectivity","volume":"688","author":"Beckinghausen","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrep.2026.102585_bib36","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1242\/dev.01891","article-title":"PTEN deletion in bergmann glia leads to premature differentiation and affects laminar organization","volume":"132","author":"Yue","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.bbrep.2026.102585_bib37","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1073\/pnas.0408612101","article-title":"Notch-1 activation and dendritic atrophy in prion disease","volume":"102","author":"Ishikura","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:35:42Z","timestamp":1781739342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826001457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S2405580826001457"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102585","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxysterol-binding protein-related protein 6 regulates neuronal morphology and migration of cerebellar granule cells during cerebellar development in vivo","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102585","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102585"}}