{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:13:20Z","timestamp":1793121200654,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["992318"],"award-info":[{"award-number":["992318"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbrep.2026.102617","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:08:30Z","timestamp":1779343710000},"page":"102617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Drug repositioning in metastatic prostate cancer based on protein- protein interaction network: Computational and in vitro analysis"],"prefix":"10.1016","volume":"46","author":[{"given":"Zakie","family":"Saadat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mahdi","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad","family":"Bazyari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-7837","authenticated-orcid":false,"given":"Seyed Hamid","family":"Aghaee-Bakhtiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbrep.2026.102617_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"13","key":"10.1016\/j.bbrep.2026.102617_bib2","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S1470-2045(14)71113-1","article-title":"RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1","volume":"15","author":"Prensner","year":"2014","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102617_bib3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12920-022-01410-w","article-title":"LncRNA weighted gene co-expression network analysis reveals novel biomarkers related to prostate cancer metastasis","volume":"15","author":"Liu","year":"2022","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.bbrep.2026.102617_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.urology.2015.11.029","article-title":"Intravesical prostatic protrusion: a potential marker of alpha-blocker treatment success in patients with benign prostatic enlargement","volume":"88","author":"Kalkanli","year":"2016","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.bbrep.2026.102617_bib5","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1093\/bib\/bbaa027","article-title":"Drug repositioning by prediction of drug's anatomical therapeutic chemical code via network-based inference approaches","volume":"22","author":"Peng","year":"2021","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.bbrep.2026.102617_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcp.2025.102053","article-title":"Exploiting network-based drug repositioning to target metastasis in colorectal cancer: in-silico prediction and in-vitro evidence","author":"Bazyari","year":"2025","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.bbrep.2026.102617_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102617_bib8","article-title":"Onco\u2010multi\u2010OMICS approach: a new frontier in cancer research","volume":"2018","author":"Chakraborty","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrep.2026.102617_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2024.108329","article-title":"Drug repositioning in castration-resistant prostate cancer using systems biology and computational drug design techniques","volume":"115","author":"Rafiee","year":"2025","journal-title":"Comput. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102617_bib10","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1038\/s41598-022-06934-w","article-title":"Weighted correlation network analysis revealed novel long non-coding RNAs for colorectal cancer","volume":"12","author":"Chodary","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102617_bib11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3389\/fonc.2019.00661","article-title":"Screening of drug repositioning candidates for castration resistant prostate cancer","volume":"9","author":"Kim","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrep.2026.102617_bib12","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fphys.2018.00500","article-title":"Drug repositioning for effective prostate cancer treatment","volume":"9","author":"Turanli","year":"2018","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102617_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41597-020-00696-8","article-title":"Manually curated and harmonised transcriptomics datasets of psoriasis and atopic dermatitis patients","volume":"7","author":"Federico","year":"2020","journal-title":"Sci. Data"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102617_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrep.2026.102617_bib15","series-title":"Seminars in Oncology","article-title":"Current therapeutic options in metastatic castration-resistant prostate cancer","year":"2018"},{"issue":"6","key":"10.1016\/j.bbrep.2026.102617_bib16","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a030635","article-title":"Treatment of advanced prostate cancer\u2014A review of current therapies and future promise","volume":"8","author":"Sumanasuriya","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102617_bib17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00280-017-3251-7","article-title":"Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives","volume":"79","author":"Bhaw-Luximon","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102617_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.789284","article-title":"Artesunate inhibits the growth behavior of docetaxel-resistant prostate cancer cells","volume":"12","author":"Vakhrusheva","year":"2022","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102617_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neo.2017.02.002","article-title":"Targeting NF-kappa B signaling by artesunate restores sensitivity of castrate-resistant prostate cancer cells to antiandrogens","volume":"19","author":"Nunes","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbrep.2026.102617_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-020-01686-x","article-title":"Inhibition of cancer cell-derived exosomal microRNA-183 suppresses cell growth and metastasis in prostate cancer by upregulating TPM1","volume":"21","author":"Dai","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102617_bib21","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1159\/000529947","article-title":"LINC01002 targets miR-650\/FLNA pathway to suppress prostate cancer progression","volume":"107","author":"Qian","year":"2023","journal-title":"Urol. Int."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102617_bib22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s12672-022-00508-y","article-title":"Identification of hub genes predicting the development of prostate cancer from benign prostate hyperplasia and analyzing their clinical value in prostate cancer by bioinformatic analysis","volume":"13","author":"Chen","year":"2022","journal-title":"Discov. Oncol."},{"issue":"12","key":"10.1016\/j.bbrep.2026.102617_bib23","first-page":"4417","article-title":"First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers","volume":"31","author":"Jansen","year":"2011","journal-title":"Anticancer Res."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102617_bib24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2174\/1871520620666200120100252","article-title":"Therapeutic potentials and mechanisms of artemisinin and its derivatives for tumorigenesis and metastasis","volume":"20","author":"Li","year":"2020","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102617_bib25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1039\/B816679J","article-title":"Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents","volume":"39","author":"Chaturvedi","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bbrep.2026.102617_bib26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/physrev.2001.81.2.807","article-title":"Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation","volume":"81","author":"Kyriakis","year":"2001","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102617_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0092-8674(03)00278-2","article-title":"Actin dynamics control SRF activity by regulation of its coactivator MAL","volume":"113","author":"Miralles","year":"2003","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.bbrep.2026.102617_bib28","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102617_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bbrep.2026.102617_bib30","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"5865","key":"10.1016\/j.bbrep.2026.102617_bib31","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention","volume":"319","author":"Balch","year":"2008","journal-title":"Science"}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:57:11Z","timestamp":1783097831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826001779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"alternative-id":["S2405580826001779"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102617","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug repositioning in metastatic prostate cancer based on protein- protein interaction network: Computational and in vitro analysis","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102617","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102617"}}