{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:18:37Z","timestamp":1783135117776,"version":"3.54.6"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbrep.2026.102623","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:07:58Z","timestamp":1778285278000},"page":"102623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["SGK1 inhibition exerts atheroprotective effects in vascular endothelial cells"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-6172","authenticated-orcid":false,"given":"Hiroyasu","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayu","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanako","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2026.102623_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11906-018-0812-z","article-title":"The global epidemic of the metabolic syndrome","volume":"20","author":"Saklayen","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.bbrep.2026.102623_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/nu14214519","article-title":"Diet, exercise, and the metabolic syndrome: enrollment of the mitochondrial machinery","volume":"14","author":"Silvestri","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrep.2026.102623_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S2213-8587(19)30084-1","article-title":"Atherosclerosis, O. International chair on cardiometabolic Risk Working Group on Visceral, Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement","volume":"7","author":"Neeland","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.bbrep.2026.102623_bib4","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bbrep.2026.102623_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1161\/CIRCRESAHA.116.301313","article-title":"Inflammation and immunity in diseases of the arterial tree: players and layers","volume":"116","author":"Libby","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrep.2026.102623_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000480652","article-title":"The role of the mineralocorticoid receptor in inflammation: focus on kidney and vasculature","volume":"46","author":"Belden","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.bbrep.2026.102623_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/FJC.0000000000001316","article-title":"Esaxerenone blocks vascular endothelial inflammation through SGK1","volume":"80","author":"Yamamoto","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102623_bib8","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1152\/physrev.00050.2005","article-title":"(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms","volume":"86","author":"Lang","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrep.2026.102623_bib9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/01.HYP.0000030153.19366.26","article-title":"Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure","volume":"40","author":"Busjahn","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrep.2026.102623_bib10","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/HJH.0b013e3283455117","article-title":"Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke","volume":"29","author":"Dahlberg","year":"2011","journal-title":"J. Hypertens."},{"key":"10.1016\/j.bbrep.2026.102623_bib11","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/01.RES.0000210539.54861.27","article-title":"The serum- and glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary vascular remodeling: role in redox-sensitive regulation of tissue factor by thrombin","volume":"98","author":"BelAiba","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrep.2026.102623_bib12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/ATVBAHA.114.304454","article-title":"Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis","volume":"35","author":"Borst","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrep.2026.102623_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bbrc.2016.01.023","article-title":"E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion","volume":"470","author":"Yamamoto","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrep.2026.102623_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155831","article-title":"Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening","volume":"154","author":"Zhang","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrep.2026.102623_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.bbrep.2026.102623_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory mechanisms linking obesity and metabolic disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrep.2026.102623_bib17","doi-asserted-by":"crossref","DOI":"10.1530\/JME-23-0066","article-title":"Vascular endothelial mineralocorticoid receptors and epithelial sodium channels in metabolic syndrome and related cardiovascular disease","volume":"71","author":"Jia","year":"2023","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbrep.2026.102623_bib18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1476-5381.2012.02194.x","article-title":"Aldosterone affects blood flow and vascular tone regulated by endothelium-derived NO: therapeutic implications","volume":"168","author":"Toda","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102623_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/01.HYP.0000083298.23119.16","article-title":"Rapid nongenomic effects of aldosterone on human forearm vasculature","volume":"42","author":"Schmidt","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrep.2026.102623_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/HYPERTENSIONAHA.107.088955","article-title":"Influence of acute and chronic mineralocorticoid excess on endothelial function in healthy men","volume":"50","author":"Nietlispach","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrep.2026.102623_bib21","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1161\/01.CIR.0000093188.53554.44","article-title":"Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation","volume":"108","author":"Liu","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.bbrep.2026.102623_bib22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/01.RES.0000106135.02935.E1","article-title":"Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone","volume":"93","author":"Uhrenholt","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrep.2026.102623_bib23","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1291\/hypres.31.1811","article-title":"Aldosterone enhances ligand-stimulated nitric oxide production in endothelial cells","volume":"31","author":"Mutoh","year":"2008","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bbrep.2026.102623_bib24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/FJC.0b013e3181bfb00d","article-title":"Nitric oxide-mediated dilation of arterioles to intraluminal administration of aldosterone","volume":"54","author":"Heylen","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102623_bib25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.CIR.101.6.594","article-title":"Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I\/angiotensin II conversion in patients with chronic heart failure","volume":"101","author":"Farquharson","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bbrep.2026.102623_bib26","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1089\/ars.2005.7.1294","article-title":"Eplerenone reduces oxidative stress and enhances eNOS in SHR: vascular functional and structural consequences","volume":"7","author":"Sanz-Rosa","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.bbrep.2026.102623_bib27","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/HYPERTENSIONAHA.118.12198","article-title":"Diet-Induced obesity promotes kidney endothelial stiffening and fibrosis dependent on the endothelial Mineralocorticoid receptor","volume":"73","author":"Aroor","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrep.2026.102623_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/01.HYP.0000226054.53527.bb","article-title":"Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity","volume":"48","author":"Nagata","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrep.2026.102623_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/HYPERTENSIONAHA.111.196832","article-title":"Aldosterone modulates endothelial permeability and endothelial nitric oxide synthase activity by rearrangement of the actin cytoskeleton","volume":"61","author":"Kirsch","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrep.2026.102623_bib30","doi-asserted-by":"crossref","first-page":"326","DOI":"10.5551\/jat.63382","article-title":"A selective mineralocorticoid receptor blocker, esaxerenone, attenuates vascular dysfunction in diabetic C57BL\/6 mice","volume":"30","author":"Munkhjargal","year":"2023","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.bbrep.2026.102623_bib31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2026.102623_bib32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(98)01705-0","article-title":"AMP-activated protein kinase phosphorylation of endothelial NO synthase","volume":"443","author":"Chen","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrep.2026.102623_bib33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0960-9822(99)80371-6","article-title":"The Akt kinase signals directly to endothelial nitric oxide synthase","volume":"9","author":"Michell","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrep.2026.102623_bib34","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1161\/01.ATV.0000221230.08596.98","article-title":"AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress","volume":"26","author":"Zhang","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrep.2026.102623_bib35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/bs.ctdb.2016.11.006","article-title":"SGK1: the dark side of PI3K signaling","volume":"123","author":"Di Cristofano","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbrep.2026.102623_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102946","article-title":"Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K\/Akt\/eNOS signaling pathway in diabetic tubulopathy","volume":"68","author":"Yao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrep.2026.102623_bib37","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1152\/ajpregu.00274.2021","article-title":"Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet-induced obese male mice","volume":"324","author":"Aroor","year":"2023","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbrep.2026.102623_bib38","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqz010","article-title":"Role of mineralocorticoid receptor in adipogenesis and obesity in Male mice","volume":"161","author":"Ferguson","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrep.2026.102623_bib39","doi-asserted-by":"crossref","first-page":"R253","DOI":"10.1152\/ajpregu.00316.2021","article-title":"Targeting mineralocorticoid receptors in diet-induced hepatic steatosis and insulin resistance","volume":"322","author":"Habibi","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbrep.2026.102623_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101225","article-title":"Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer","volume":"24","author":"Wang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrep.2026.102623_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109785","article-title":"Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase","volume":"37","author":"Zhou","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrep.2026.102623_bib42","doi-asserted-by":"crossref","first-page":"23371","DOI":"10.1074\/jbc.M413839200","article-title":"Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway","volume":"280","author":"Huddleson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2026.102623_bib43","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1042\/BST0371254","article-title":"ERK5 and the regulation of endothelial cell function","volume":"37","author":"Roberts","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrep.2026.102623_bib44","first-page":"37","article-title":"MEK5\/ERK5 pathway: the first fifteen years","volume":"1825","author":"Drew","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrep.2026.102623_bib45","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.1128\/MCB.25.14.5893-5903.2005","article-title":"Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases","volume":"25","author":"Kumar","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrep.2026.102623_bib46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/cvr\/cvu183","article-title":"Histone deacetylase 5 interacts with Kruppel-like factor 2 and inhibits its transcriptional activity in endothelium","volume":"104","author":"Kwon","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrep.2026.102623_bib47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbrc.2014.04.079","article-title":"Functional role of NF-kappaB in expression of human endothelial nitric oxide synthase","volume":"448","author":"Lee","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrep.2026.102623_bib48","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1074\/jbc.M309552200","article-title":"Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells","volume":"279","author":"Anderson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2026.102623_bib49","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1074\/jbc.M806928200","article-title":"Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase\/AKT-dependent activation of myocyte enhancer factor 2","volume":"284","author":"Sako","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2026.102623_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/cvr\/cvs283","article-title":"FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2","volume":"97","author":"Lee","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrep.2026.102623_bib51","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.bbadis.2019.04.009","article-title":"Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2","volume":"1865","author":"Tian","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.bbrep.2026.102623_bib52","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007134","article-title":"Suberanilohydroxamic acid as a pharmacological kruppel-like factor 2 activator that represses vascular inflammation and atherosclerosis","volume":"6","author":"Xu","year":"2017","journal-title":"J. Am. Heart Assoc."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826001834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:41:41Z","timestamp":1783132901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826001834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":52,"alternative-id":["S2405580826001834"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102623","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SGK1 inhibition exerts atheroprotective effects in vascular endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102623"}}