{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:56:01Z","timestamp":1791237361935,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024MS08043"],"award-info":[{"award-number":["2024MS08043"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrep.2026.102659","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:42:46Z","timestamp":1780746166000},"page":"102659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mitochondrial dynamics and T cells immunity in cancer"],"prefix":"10.1016","volume":"47","author":[{"given":"Xiaomei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cmet.2015.05.013","article-title":"Evolution of Mitochondria as signaling organelles","volume":"22","author":"Chandel","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrep.2026.102659_bib2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbrep.2026.102659_bib3","doi-asserted-by":"crossref","first-page":"217728","DOI":"10.1016\/j.canlet.2025.217728","article-title":"SENP1-Sirt3 axis promotes cholesterol biosynthesis in tumor-associated macrophages to suppress anti-tumor immunity","volume":"623","author":"Peng","year":"2025","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102659_bib4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.trecan.2025.04.002","article-title":"Mitochondrial transfer drives immune evasion in tumor microenvironment","volume":"11","author":"Cai","year":"2025","journal-title":"Trends Cancer"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets immunology: the cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"T\u00e1bara","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102659_bib7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","article-title":"Determinants and outcomes of mitochondrial dynamics","volume":"83","author":"Quintana-Cabrera","year":"2023","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"issue":"7170","key":"10.1016\/j.bbrep.2026.102659_bib63","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nature06322","article-title":"mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex","volume":"450","author":"Cunningham","year":"2007","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.bbrep.2026.102659_bib64","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1073\/pnas.0308686101","article-title":"The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis","volume":"101","author":"Schreiber","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"23","key":"10.1016\/j.bbrep.2026.102659_bib65","doi-asserted-by":"crossref","first-page":"10411","DOI":"10.1021\/acs.jmedchem.6b00669","article-title":"Development of therapeutics that induce mitochondrial biogenesis for the treatment of acute and chronic degenerative diseases","volume":"59","author":"Cameron","year":"2016","journal-title":"J. Med. Chem."},{"issue":"7896","key":"10.1016\/j.bbrep.2026.102659_bib66","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41586-021-04340-2","article-title":"Activation mechanism of PINK1","volume":"602","author":"Gan","year":"2022","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bbrep.2026.102659_bib67","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib68","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib69","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrm.2017.129","article-title":"Building and decoding ubiquitin chains for mitophagy","volume":"19","author":"Harper","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib70","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.molcel.2011.07.039","article-title":"Serine 403 phosphorylation of p62\/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins","volume":"44","author":"Matsumoto","year":"2011","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.bbrep.2026.102659_bib71","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.molcel.2009.01.020","article-title":"A role for NBR1 in autophagosomal degradation of ubiquitinated substrates","volume":"33","author":"Kirkin","year":"2009","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.bbrep.2026.102659_bib72","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ni.1800","article-title":"The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria","volume":"10","author":"Thurston","year":"2009","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib73","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/15548627.2015.1009792","article-title":"Temporal dynamics of PARK2\/parkin and OPTN\/optineurin recruitment during the mitophagy of damaged mitochondria","volume":"11","author":"Wong","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrep.2026.102659_bib74","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbamcr.2015.10.009","article-title":"Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex","volume":"1","author":"Huynen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.bbrep.2026.102659_bib75","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cmet.2015.04.006","article-title":"Mic10 oligomerizes to bend mitochondrial inner membranes at cristae junctions","volume":"21","author":"Barbot","year":"2015","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102659_bib76","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1083\/jcb.200811099","article-title":"Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e\/g","volume":"185","author":"Rabl","year":"2009","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib77","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion","volume":"126","author":"Frezza","year":"2006","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bbrep.2026.102659_bib78","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1073\/pnas.1816556116","article-title":"Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows","volume":"116","author":"Blum","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib79","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2008.06.001","article-title":"Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein","volume":"8","author":"Campanella","year":"2008","journal-title":"IF1. Cell Metab."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102659_bib80","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102659_bib81","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause charcot-marie-tooth neuropathy type 2A","volume":"36","author":"Z\u00fcchner","year":"2004","journal-title":"Nat. Genet."},{"issue":"45","key":"10.1016\/j.bbrep.2026.102659_bib82","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"5","key":"10.1016\/j.bbrep.2026.102659_bib83","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.200704112","article-title":"Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage","volume":"178","author":"Griparic","year":"2007","journal-title":"J. Cell Biol."},{"issue":"41","key":"10.1016\/j.bbrep.2026.102659_bib14","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"10","key":"10.1016\/j.bbrep.2026.102659_bib84","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/sj.embor.7401062","article-title":"Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death","volume":"8","author":"Cribbs","year":"2007","journal-title":"EMBO Rep."},{"issue":"7631","key":"10.1016\/j.bbrep.2026.102659_bib85","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nature20555","article-title":"Multiple dynamin family members collaborate to drive mitochondrial division","volume":"540","author":"Lee","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib86","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11914-025-00918-1","article-title":"Mitochondrial distribution and osteocyte mechanosensitivity","volume":"23","author":"Jin","year":"2025","journal-title":"Curr. Osteoporos. Rep."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib87","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/0271678X241300223","article-title":"Molecular and cellular mechanisms of mitochondria transfer in models of central nervous system disease","volume":"46","author":"Nakano","year":"2026","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"21","key":"10.1016\/j.bbrep.2026.102659_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262110581","article-title":"Mechanisms of mitochondrial transfer through TNTs: from Organelle dynamics to cellular crosstalk","volume":"26","author":"Zamberlan","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/cancers12010019","article-title":"STING: a master regulator in the cancer-immunity cycle","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.bbrep.2026.102659_bib9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41423-020-0480-1","article-title":"The essential functions of mitochondrial dynamics in immune cells","volume":"17","author":"Xie","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102659_bib10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.immuni.2017.02.010","article-title":"Integrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation","volume":"46","author":"Tan","year":"2017","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.bbrep.2026.102659_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.celrep.2025.116412","article-title":"CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms","volume":"44","author":"Galloway","year":"2025","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2016.05.035","article-title":"Mitochondrial dynamics controls T cell fate through Metabolic programming","volume":"166","author":"Buck","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbrep.2026.102659_bib13","article-title":"Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression","volume":"6","author":"Mishra","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"11","key":"10.1016\/j.bbrep.2026.102659_bib15","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/j.celrep.2018.11.018","article-title":"Drp1 controls effective T cell immune-surveillance by regulating T cell migration, proliferation, and cMyc-Dependent metabolic reprogramming","volume":"25","author":"Simula","year":"2018","journal-title":"Cell Rep."},{"issue":"36","key":"10.1016\/j.bbrep.2026.102659_bib16","doi-asserted-by":"crossref","first-page":"14418","DOI":"10.1073\/pnas.0703126104","article-title":"T cell activation requires mitochondrial translocation to the immunological synapse","volume":"104","author":"Quintana","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"3","key":"10.1016\/j.bbrep.2026.102659_bib17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/JLB.2HI0520-191R","article-title":"Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse","volume":"109","author":"Ledderose","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41467-019-10226-9","article-title":"DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass","volume":"10","author":"Favaro","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102659_bib19","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/1878-0261.13578","article-title":"Mitochondrial fusion-fission dynamics and its involvement in colorectal cancer","volume":"18","author":"Wu","year":"2024","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4049\/jimmunol.0902872","article-title":"Mitochondria positioning controls local calcium influx in T cells","volume":"184","author":"Schwindling","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41467-021-24619-2","article-title":"Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development","volume":"12","author":"He","year":"2021","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102659_bib22","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/s41423-020-0365-3","article-title":"Enforced PGC-1\u03b1 expression promotes CD8 T cell fitness, memory formation and antitumor immunity","volume":"18","author":"Dumauthioz","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102659_bib23","first-page":"3706","article-title":"Autophagy is a critical regulator of memory CD8(+) T cell formation","volume":"11","author":"Puleston","year":"2014","journal-title":"eLife"},{"issue":"50","key":"10.1016\/j.bbrep.2026.102659_bib24","doi-asserted-by":"crossref","first-page":"38781","DOI":"10.1074\/jbc.M110.152173","article-title":"CCR7\/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1\/2 in primary T lymphocytes","volume":"285","author":"Shannon","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102659_bib25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.molcel.2015.01.002","article-title":"Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth","volume":"57","author":"Kashatus","year":"2015","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00262-023-03582-5","article-title":"Enhanced T cell immune activity mediated by Drp1 promotes the efficacy of PD-1 inhibitors in treating lung cancer","volume":"73","author":"Ma","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"issue":"13","key":"10.1016\/j.bbrep.2026.102659_bib27","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1084\/jem.20061877","article-title":"Orchestration of lymphocyte chemotaxis by mitochondrial dynamics","volume":"203","author":"Campello","year":"2006","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.bbrep.2026.102659_bib28","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1128\/MCB.01177-13","article-title":"Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity","volume":"34","author":"Morlino","year":"2014","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41467-024-46377-7","article-title":"Mitochondrial metabolism sustains CD8(+) T cell migration for an efficient infiltration into solid tumors","volume":"15","author":"Simula","year":"2024","journal-title":"Nat. Commun."},{"issue":"Pt A","key":"10.1016\/j.bbrep.2026.102659_bib30","first-page":"23","article-title":"Combination of oxymatrine (Om) and astragaloside IV (As) enhances the infiltration and function of TILs in triple-negative breast cancer (TNBC)","volume":"125","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"473","key":"10.1016\/j.bbrep.2026.102659_bib31","article-title":"Mitochondrial control and guidance of cellular activities of T cells","volume":"8","author":"Chao","year":"2017","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102659_bib32","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/emboj.2011.25","article-title":"The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse","volume":"30","author":"Baixauli","year":"2011","journal-title":"Embo J."},{"issue":"32","key":"10.1016\/j.bbrep.2026.102659_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/advs.202503095","article-title":"Mitochondrial regulation of CD8+ T cells: mechanisms and therapeutic modulation","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.immuni.2016.07.009","article-title":"The Tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell Metabolic insufficiency and dysfunction","volume":"45","author":"Scharping","year":"2016","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.bbrep.2026.102659_bib35","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1084\/jem.20171068","article-title":"4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses","volume":"215","author":"Menk","year":"2018","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102659_bib36","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1158\/2326-6066.CIR-17-0767","article-title":"Mitochondrial morphological and functional reprogramming following CD137 (4-1BB) costimulation","volume":"6","author":"Teijeira","year":"2018","journal-title":"Cancer Immunol. Res."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102659_bib37","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.celrep.2019.10.032","article-title":"NIX-Mediated mitophagy promotes effector memory Formation in antigen-specific CD8(+) T cells","volume":"29","author":"Gupta","year":"2019","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41590-020-00834-9","article-title":"Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion","volume":"22","author":"Scharping","year":"2021","journal-title":"Nat. Immunol."},{"issue":"8105","key":"10.1016\/j.bbrep.2026.102659_bib40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41586-025-09926-8","article-title":"The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction","volume":"651","author":"Cheng","year":"2026","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bbrep.2026.102659_bib41","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41590-020-0793-3","article-title":"Disturbed mitochondrial dynamics in CD8(+) TILs reinforce T cell exhaustion","volume":"21","author":"Yu","year":"2020","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.bbrep.2026.102659_bib42","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41590-020-0725-2","article-title":"Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen","volume":"21","author":"Vardhana","year":"2020","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/1878-0261.13103","article-title":"PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism","volume":"16","author":"Simula","year":"2022","journal-title":"Mol. Oncol."},{"issue":"12","key":"10.1016\/j.bbrep.2026.102659_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/jci.insight.93411","article-title":"Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma","volume":"2","author":"Siska","year":"2017","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102659_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40425-019-0628-7","article-title":"PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8(+) T lymphocytes","volume":"7","author":"Ogando","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib46","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.immuni.2016.07.008","article-title":"Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion","volume":"45","author":"Bengsch","year":"2016","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.bbrep.2026.102659_bib47","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.immuni.2024.08.003","article-title":"PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8(+) T cell ferroptosis","volume":"57","author":"Ping","year":"2024","journal-title":"Immunity"},{"issue":"599","key":"10.1016\/j.bbrep.2026.102659_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aav3334","article-title":"Tumor-derived TGF-\u03b2 inhibits mitochondrial respiration to suppress IFN-\u03b3 production by human CD4(+) T cells","volume":"12","author":"Dimeloe","year":"2019","journal-title":"Sci. Signal."},{"issue":"22","key":"10.1016\/j.bbrep.2026.102659_bib49","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.148438","article-title":"The TGF-\u03b2\/HDAC7 axis suppresses TCA cycle metabolism in renal cancer","volume":"6","author":"Nam","year":"2021","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.bbrep.2026.102659_bib50","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.immuni.2024.07.003","article-title":"The cytokine meteorin-like inhibits anti-tumor CD8(+) T cell responses by disrupting mitochondrial function","volume":"57","author":"Jackson","year":"2024","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.bbrep.2026.102659_bib51","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.immuni.2016.10.017","article-title":"Constitutive glycolytic metabolism supports CD8(+) T cell effector memory differentiation during viral infection","volume":"45","author":"Phan","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.bbrep.2026.102659_bib52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-94-024-1170-6_2","article-title":"Metabolic regulation of T cell immunity","volume":"1011","author":"Vignali","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1906","key":"10.1016\/j.bbrep.2026.102659_bib53","article-title":"Hypoxia induces mitochondrial defect that promotes T cell exhaustion in tumor microenvironment through MYC-Regulated pathways","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.bbrep.2026.102659_bib54","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","article-title":"Inhibitory effect of tumor cell-derived lactic acid on human T cells","volume":"109","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrep.2026.102659_bib55","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2022.01.006","article-title":"Remodeling metabolic fitness: strategies for improving the efficacy of chimeric antigen receptor T cell therapy","volume":"529","author":"Shen","year":"2022","journal-title":"Cancer Lett."},{"issue":"222","key":"10.1016\/j.bbrep.2026.102659_bib56","article-title":"Molecular mechanisms for cAMP-Mediated immunoregulation in T cells - role of anchored protein kinase A signaling units","volume":"7","author":"Wehbi","year":"2016","journal-title":"Front. Immunol."},{"issue":"28","key":"10.1016\/j.bbrep.2026.102659_bib57","first-page":"17","article-title":"Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment","volume":"5","author":"Scarf\u00f2","year":"2017","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbrep.2026.102659_bib58","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.canlet.2021.02.013","article-title":"The tumor microenvironment shapes the molecular characteristics of exhausted CD8(+) T cells","volume":"506","author":"Cheng","year":"2021","journal-title":"Cancer Lett."},{"issue":"8","key":"10.1016\/j.bbrep.2026.102659_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14081008","article-title":"Mitochondrial transfer between cancer and T cells: implications for immune evasion","volume":"14","author":"Chun","year":"2025","journal-title":"Antioxidants"},{"issue":"8049","key":"10.1016\/j.bbrep.2026.102659_bib60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41586-024-08439-0","article-title":"Immune evasion through mitochondrial transfer in the tumour microenvironment","volume":"638","author":"Ikeda","year":"2025","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbrep.2026.102659_bib61","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.cmet.2025.12.014","article-title":"Mitochondrial transfer from immune to tumor cells enables lymph node metastasis","volume":"38","author":"Terasaki","year":"2026","journal-title":"Cell Metab."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826002190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826002190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:13:29Z","timestamp":1791234809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826002190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":88,"alternative-id":["S2405580826002190"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102659","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial dynamics and T cells immunity in cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102659"}}