{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:53:07Z","timestamp":1791237187533,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrep.2026.102670","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:45:37Z","timestamp":1781653537000},"page":"102670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Redox regulation of PDE6 and cGMP signaling in diabetic retinal neurodegeneration"],"prefix":"10.1016","volume":"47","author":[{"given":"Cinthia Jhovanna","family":"Perez-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidianys Maria","family":"Lewis-Luj\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alexis","family":"Cota-Arrayales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Emmanuel","family":"Guerrero-Maga\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judas Tadeo","family":"Vargas-Durazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim V.","family":"Trushin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail A.","family":"Osadchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette Pulcherie","family":"Iloki-Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Galvez-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-5881","authenticated-orcid":false,"given":"Simon Bernard","family":"Iloki-Assanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrep.2026.102670_bib1","article-title":"Diabetic retinopathy","volume":"2","author":"Wong","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"9735","key":"10.1016\/j.bbrep.2026.102670_bib2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","article-title":"Diabetic retinopathy","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.bbrep.2026.102670_bib3","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1007\/s00125-018-4692-1","article-title":"Neurodegeneration in diabetic retinopathy: does it really matter?","volume":"61","author":"Sim\u00f3","year":"2018","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.bbrep.2026.102670_bib4","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/cells10040794","article-title":"Does hyperglycemia cause oxidative stress in the diabetic rat retina?","volume":"10","author":"Ola","year":"2021","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.bbrep.2026.102670_bib5","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3390\/antiox14101204","article-title":"Oxidative stress in diabetic retinopathy: a comprehensive review of mechanisms, biomarkers, and therapeutic perspectives","volume":"14","author":"Mimura","year":"2025","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102670_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2007\/43603","article-title":"Oxidative stress and diabetic retinopathy","volume":"2007","author":"Kowluru","year":"2007","journal-title":"J. Diabetes Res."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102670_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.molcel.2020.09.013","article-title":"Structure of the visual signaling complex between transducin and phosphodiesterase 6","volume":"80","author":"Gao","year":"2020","journal-title":"Mol. Cell"},{"issue":"S1","key":"10.1016\/j.bbrep.2026.102670_bib8","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/sj.ijir.3901212","article-title":"Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5","volume":"16","author":"Cote","year":"2004","journal-title":"Int. J. Impot. Res."},{"issue":"31","key":"10.1016\/j.bbrep.2026.102670_bib9","doi-asserted-by":"crossref","first-page":"16282","DOI":"10.1074\/jbc.M116.737593","article-title":"Aryl hydrocarbon receptor-interacting protein-like 1 is an obligate chaperone of phosphodiesterase 6 and is assisted by the \u03b3-Subunit of its client","volume":"291","author":"Gopalakrishna","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102670_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101620","article-title":"Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1","volume":"298","author":"Yadav","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"42","key":"10.1016\/j.bbrep.2026.102670_bib11","doi-asserted-by":"crossref","first-page":"14402","DOI":"10.1074\/jbc.RA120.013873","article-title":"The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation","volume":"295","author":"Boehm","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102670_bib12","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.bbrep.2026.102670_bib13","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.bbadis.2015.08.001","article-title":"Oxidative stress, mitochondrial damage and diabetic retinopathy","volume":"1852","author":"Kowluru","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102670_bib14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jmb.2010.06.044","article-title":"Structural characterization of the rod cGMP phosphodiesterase 6","volume":"401","author":"Goc","year":"2010","journal-title":"J. Mol. Biol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102670_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00030.2010","article-title":"Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions","volume":"91","author":"Francis","year":"2011","journal-title":"Physiol. Rev."},{"issue":"2\u20133","key":"10.1016\/j.bbrep.2026.102670_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-2999(98)00346-X","article-title":"Effect of a cGMP-specific phosphodiesterase inhibitor on retinal function","volume":"352","author":"Estrade","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102670_bib17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.csbj.2019.03.004","article-title":"The molecular organization of human cGMP specific phosphodiesterase 6 (PDE6): structural implications of somatic mutations in cancer and retinitis pigmentosa","volume":"17","author":"Maryam","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.bbrep.2026.102670_bib18","series-title":"Guanylate Cyclase and Cyclic GMP","first-page":"51","article-title":"Enzyme assays for cGMP hydrolyzing phosphodiesterases","author":"Rybalkin","year":"2013"},{"key":"10.1016\/j.bbrep.2026.102670_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.07.005","article-title":"Cellular mechanisms of hereditary photoreceptor degeneration: focus on cGMP","volume":"74","author":"Power","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"issue":"29","key":"10.1016\/j.bbrep.2026.102670_bib20","doi-asserted-by":"crossref","first-page":"18397","DOI":"10.1074\/jbc.272.29.18397","article-title":"The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to \u03b3 subunit of the photoreceptor cGMP phosphodiesterase","volume":"272","author":"Lochhead","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"32","key":"10.1016\/j.bbrep.2026.102670_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1704782114","article-title":"Unique structural features of the AIPL1\u2013FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness","volume":"114","author":"Yadav","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"38","key":"10.1016\/j.bbrep.2026.102670_bib22","doi-asserted-by":"crossref","first-page":"24485","DOI":"10.1074\/jbc.273.38.24485","article-title":"Probing domain functions of chimeric PDE6\u03b1\u2032\/PDE5 cGMP-Phosphodiesterase","volume":"273","author":"Granovsky","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102670_bib23","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1038\/s41598-021-81482-3","article-title":"Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin","volume":"11","author":"Kida","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102670_bib24","article-title":"Risk of diabetic retinopathy and retinal neurodegeneration in individuals with type 2 diabetes: beichen eye study","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrep.2026.102670_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109650","article-title":"A correlation between oxidative stress and diabetic retinopathy: an updated review","volume":"236","author":"Hussain","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrep.2026.102670_bib26","article-title":"Targeting oxidative stress in diabetic retinopathy: mechanisms, pathology, and novel treatment approaches","volume":"16","author":"He","year":"2025","journal-title":"Front. Immunol."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082600230X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082600230X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:02:08Z","timestamp":1791234128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240558082600230X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"alternative-id":["S240558082600230X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102670","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox regulation of PDE6 and cGMP signaling in diabetic retinal neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102670","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102670"}}