{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:52:41Z","timestamp":1791237161758,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 23K15862"],"award-info":[{"award-number":["JP 23K15862"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrep.2026.102715","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:38:01Z","timestamp":1784230681000},"page":"102715","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Vestibular functional assessment using the caloric test in mice with arsanilic acid\u2013induced vestibular dysfunction"],"prefix":"10.1016","volume":"47","author":[{"given":"Shotaro","family":"Harada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-0716","authenticated-orcid":false,"given":"Yoshihisa","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-6787","authenticated-orcid":false,"given":"Takao","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Inohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-1069","authenticated-orcid":false,"given":"Shoichi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2026.102715_bib1","first-page":"251","article-title":"Neuronal events paralleling functional recovery (compensation) following peripheral vestibular lesions","volume":"1","author":"Precht","year":"1985","journal-title":"Rev. Oculomot. Res."},{"key":"10.1016\/j.bbrep.2026.102715_bib2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1749-6632.2008.03731.x","article-title":"Tell me your vestibular deficit, and i'll tell you how you'll compensate","volume":"1164","author":"Lacour","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrep.2026.102715_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167198","article-title":"A mouse model of autoimmune inner ear disease without endolymphatic hydrops","volume":"1870","author":"Harada","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.bbrep.2026.102715_bib4","doi-asserted-by":"crossref","first-page":"29790","DOI":"10.1038\/s41598-025-14302-7","article-title":"Efficacy of the silicon based agent for age related decline in vestibular function","volume":"15","author":"Harada","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102715_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/MAO.0b013e31819bda13","article-title":"Vestibular evoked myogenic potentials in normal mice and Phex mice with spontaneous endolymphatic hydrops","volume":"30","author":"Sheykholeslami","year":"2009","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.bbrep.2026.102715_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0378-5955(99)00090-8","article-title":"Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL\/6JEi-het mice","volume":"135","author":"Jones","year":"1999","journal-title":"Hear. Res."},{"key":"10.1016\/j.bbrep.2026.102715_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/00016487509124705","article-title":"Directional preponderance, 1942-1974. A review","volume":"79","author":"Hallpike","year":"1975","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.bbrep.2026.102715_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci9110329","article-title":"Vestibular compensation after vestibular dysfunction induced by Arsanilic acid in mice","volume":"9","author":"Ito","year":"2019","journal-title":"Brain Sci."},{"key":"10.1016\/j.bbrep.2026.102715_bib9","doi-asserted-by":"crossref","first-page":"17191","DOI":"10.1038\/s41598-021-96596-x","article-title":"Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex","volume":"11","author":"Harada","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102715_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106194","article-title":"Quantitative analysis and correlative evaluation of video-oculography, micro-computed tomography, and histopathology in Pendrin-null mice","volume":"183","author":"Watanabe","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrep.2026.102715_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00029330-200701020-00009","article-title":"Effects of caloric vestibular stimulation on serotoninergic system in the media vestibular nuclei of Guinea pigs","volume":"120","author":"Ma","year":"2007","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.bbrep.2026.102715_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152307","article-title":"High-speed video-oculography for measuring three-dimensional rotation vectors of eye movements in mice","volume":"11","author":"Imai","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2026.102715_bib13","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/0042-6989(94)00257-M","article-title":"Mathematics of three-dimensional eye rotations","volume":"35","author":"Haslwanter","year":"1995","journal-title":"Vis. Res."},{"key":"10.1016\/j.bbrep.2026.102715_bib14","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1109\/10.35304","article-title":"A fuzzy set theoretical approach to automatic analysis of nystagmic eye movements","volume":"36","author":"Arzi","year":"1989","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.bbrep.2026.102715_bib15","article-title":"Three-dimensional eye movement simulator extracting instantaneous eye movement rotation axes, the plane formed by rotation axes, and innervations for eye muscles","volume":"86","author":"Naoi","year":"2003","journal-title":"IEICE Trans. Inf. Syst."},{"key":"10.1016\/j.bbrep.2026.102715_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093824","article-title":"The human semicircular canals orientation is more similar to the bonobos than to the chimpanzees","volume":"9","author":"El Khoury","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2026.102715_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10162-006-0031-1","article-title":"Planar relationships of the semicircular canals in two strains of mice","volume":"7","author":"Calabrese","year":"2006","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.bbrep.2026.102715_bib18","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1001\/archotol.1992.01880100069015","article-title":"Three-component analysis of caloric nystagmus in humans","volume":"118","author":"Yagi","year":"1992","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.bbrep.2026.102715_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0034-1396926","article-title":"Vestibular function measurement devices","volume":"36","author":"Miles","year":"2015","journal-title":"Semin. Hear."},{"key":"10.1016\/j.bbrep.2026.102715_bib20","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.3950\/jibiinkoka.96.1933","article-title":"[Relationship between external auditory canal temperature and caloric nystagmus--the problem with the ordinary cold-warm caloric test]","volume":"96","author":"Tsunoda","year":"1993","journal-title":"Nihon Jibiinkoka Gakkai Kaiho"},{"key":"10.1016\/j.bbrep.2026.102715_bib21","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1097\/00001756-199707280-00035","article-title":"Cellular basis of vestibular compensation: changes in intrinsic excitability of MVN neurones","volume":"8","author":"Cameron","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbrep.2026.102715_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3233\/VES-2009-0353","article-title":"Tonic and phasic contributions to the pathways mediating compensation and adaptation of the vestibulo-ocular reflex","volume":"19","author":"Minor","year":"2009","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.bbrep.2026.102715_bib23","first-page":"1","article-title":"Dynamic characteristics of vestibular nuclear neurons responses to vestibular and optokinetic stimulation during vestibular compensation in the rat","volume":"445","author":"Hamann","year":"1987","journal-title":"Acta Otolaryngol. Suppl."},{"issue":"Pt 2","key":"10.1016\/j.bbrep.2026.102715_bib24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1469-7793.2000.t01-1-00413.x","article-title":"Rapid compensatory changes in GABA receptor efficacy in rat vestibular neurones after unilateral labyrinthectomy","volume":"523 Pt 2","author":"Yamanaka","year":"2000","journal-title":"J Physiol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102715_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0306-4522(96)00374-0","article-title":"Role of the flocculus in the development of vestibular compensation: immunohistochemical studies with retrograde tracing and flocculectomy using Fos expression as a marker in the rat brainstem","volume":"76","author":"Kitahara","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrep.2026.102715_bib26","series-title":"The Vestibular System: a Sixth Sense","author":"Goldberg","year":"2012"},{"key":"10.1016\/j.bbrep.2026.102715_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.neuro.31.060407.125555","article-title":"Vestibular system: the many facets of a multimodal sense","volume":"31","author":"Angelaki","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102715_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/00016489850155143","article-title":"Neurotransmitters of vestibular commissural inhibition in the cat","volume":"118","author":"Furuya","year":"1998","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.bbrep.2026.102715_bib29","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archneur.1988.00520310043015","article-title":"A clinical sign of canal paresis","volume":"45","author":"Halmagyi","year":"1988","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrep.2026.102715_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neures.2025.104982","article-title":"A mouse model of bilateral acute inner-ear (labyrinthine) injury with vestibular involvement reveals functional, behavioral, and histological correlates of vestibular compensation","volume":"221","author":"Xie","year":"2025","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102715_bib31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0165-0173(89)90013-1","article-title":"Mechanisms of recovery following unilateral labyrinthectomy: a review","volume":"14","author":"Smith","year":"1989","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102715_bib32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/MOO.0b013e32833de71f","article-title":"Mechanisms of vestibular compensation: recent advances","volume":"18","author":"Dutia","year":"2010","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082600275X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082600275X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:00:09Z","timestamp":1791234009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240558082600275X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"alternative-id":["S240558082600275X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102715","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vestibular functional assessment using the caloric test in mice with arsanilic acid\u2013induced vestibular dysfunction","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102715","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102715"}}