{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:54:35Z","timestamp":1791237275821,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI22\/01498"],"award-info":[{"award-number":["PI22\/01498"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI18\/00892"],"award-info":[{"award-number":["PI18\/00892"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI16\/01937"],"award-info":[{"award-number":["PI16\/01937"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009674","name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrep.2026.102726","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:43:38Z","timestamp":1785800618000},"page":"102726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Systems biology integration of miR\u2013mRNA profiles identifies steroid refractoriness mechanisms and biomarker candidates in ulcerative colitis"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-9939","authenticated-orcid":false,"given":"Iris","family":"Gin\u00e9s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Suau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Enrique","family":"Naves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7378-7340","authenticated-orcid":false,"given":"Carla","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Clua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Lor\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Pluvinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diandra","family":"Monfort-Ferr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"L\u00f3pez Balastegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"S\u00e1nchez Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Seg\u00fa-Verg\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Aransay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Buschbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00edriam","family":"Ma\u00f1osa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauro","family":"Sumoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Serena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeni","family":"Dom\u00e8nech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Many\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2026.102726_bib1","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2016.10.020","article-title":"Understanding and preventing the global increase of inflammatory bowel disease","volume":"152","author":"Kaplan","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrep.2026.102726_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/ecco-jcc\/jjab178","article-title":"ECCO guidelines on therapeutics in ulcerative colitis: medical treatment","volume":"16","author":"Raine","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.bbrep.2026.102726_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S2468-1253(23)00313-8","article-title":"Acute severe ulcerative colitis management: unanswered questions and latest insights","volume":"9","author":"Rivi\u00e8re","year":"2024","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrep.2026.102726_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5009\/gnl220017","article-title":"Acute severe ulcerative colitis: optimal strategies for drug therapy","volume":"17","author":"Nakase","year":"2023","journal-title":"Gut Liver"},{"key":"10.1016\/j.bbrep.2026.102726_bib5","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.14309\/ajg.0000000000002635","article-title":"Tofacitinib in acute severe ulcerative colitis (TACOS): a randomized controlled trial","volume":"119","author":"Singh","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.bbrep.2026.102726_bib6","doi-asserted-by":"crossref","DOI":"10.1080\/17474124.2019.1604219","article-title":"A current overview of corticosteroid use in active ulcerative colitis","volume":"13","author":"Salice","year":"2019","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrep.2026.102726_bib7","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1128\/MCB.01151-12","article-title":"Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements","volume":"33","author":"Ramamoorthy","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrep.2026.102726_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2024.100741","article-title":"Selective modulation of the human glucocorticoid receptor compromises GR chromatin occupancy and recruitment of p300\/CBP and the mediator complex","volume":"23","author":"Van Moortel","year":"2024","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbrep.2026.102726_bib9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/ecco-jcc\/jjy171","article-title":"ANP32E, a protein involved in steroid-refractoriness in ulcerative colitis, identified by a systems biology approach","volume":"13","author":"Lor\u00e9n","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.bbrep.2026.102726_bib11","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ymeth.2012.09.015","article-title":"Assessing sample and miR profile quality in serum and plasma or other biofluids","volume":"59","author":"Blondal","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.bbrep.2026.102726_bib12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3390\/genes14020448","article-title":"DraculR: a web-based application for in Silico haemolysis detection in high-throughput microRNA sequencing data","volume":"14","author":"Smith","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bbrep.2026.102726_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228926","article-title":"In-silico simulated prototype-patients using TPMS technology to study a potential adverse effect of sacubitril and valsartan","volume":"15","author":"Jorba","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2026.102726_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12602-016-9239-5","article-title":"Comparative effect of the I3.1 probiotic formula in two animal models of colitis","volume":"9","author":"Lor\u00e9n","year":"2017","journal-title":"Probiotics Antimicrob. Proteins"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102726_bib15","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1038\/s41598-022-12955-2","article-title":"Data mining analyses for precision medicine in acromegaly: a proof of concept","volume":"12","author":"Gil","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102726_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910329","article-title":"In silico modeling of fabry disease pathophysiology for the identification of early cellular damage biomarker candidates","volume":"25","author":"Gervas-Arruga","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2026.102726_bib35","unstructured":"Kenji Kira LAR. The Feature Selection Problem: Traditional Methods and a New Algorithm n.d."},{"key":"10.1016\/j.bbrep.2026.102726_bib36","unstructured":"Pattern Recognition - Sergios Theodoridis, Konstantinos Koutroumbas - Google Llibres n.d. (accessed May 21, 2025)."},{"key":"10.1016\/j.bbrep.2026.102726_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1214\/09-SS051","article-title":"Wilcoxon-Mann-Whitney or t-test? On assumptions for hypothesis tests and multiple interpretations of decision rules","volume":"4","author":"Fay","year":"2010","journal-title":"Stat. Surv."},{"key":"10.1016\/j.bbrep.2026.102726_bib38","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","article-title":"A method of comparing the areas under receiver operating characteristic curves derived from the same cases","volume":"148","author":"Hanley","year":"1983","journal-title":"Radiology"},{"key":"10.1016\/j.bbrep.2026.102726_bib17","doi-asserted-by":"crossref","first-page":"D147","DOI":"10.1093\/nar\/gkae1072","article-title":"miRTarBase 2025: updates to the collection of experimentally validated microRNA\u2013target interactions","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2026.102726_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt1266","article-title":"MiRTarBase update 2014: an information resource for experimentally validated miR-target interactions","volume":"42","author":"Hsu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrep.2026.102726_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076424","article-title":"Response variability to drug testing in two models of chemically induced colitis","volume":"24","author":"Suau","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2026.102726_bib20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbrep.2026.102726_bib21","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1128\/MCB.01151-12","article-title":"Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements","volume":"33","author":"Ramamoorthy","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrep.2026.102726_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00214","article-title":"A model of glucocorticoid receptor interaction with coregulators predicts transcriptional regulation of target genes","volume":"10","author":"Monczor","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrep.2026.102726_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2024.100741","article-title":"Selective modulation of the human glucocorticoid receptor compromises GR chromatin occupancy and recruitment of p300\/CBP and the mediator complex","volume":"23","author":"Van Moortel","year":"2024","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbrep.2026.102726_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-018-0832-x","article-title":"Interleukin-32: its role in asthma and potential as a therapeutic agent","volume":"19","author":"Xin","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbrep.2026.102726_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.3740","article-title":"ATG5: a central autophagy regulator implicated in various human diseases","volume":"40","author":"Changotra","year":"2022","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.bbrep.2026.102726_bib26","doi-asserted-by":"crossref","DOI":"10.2174\/1389450119666180219120534","article-title":"NF-\u03baB-IKK\u03b2 pathway as a target for drug development: realities, challenges and perspectives","volume":"19","author":"Freitas","year":"2018","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbrep.2026.102726_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/cei.13613","article-title":"Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling","volume":"205","author":"Qian","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbrep.2026.102726_bib28","article-title":"CBP (CREB binding protein) integrates NF-\u03baB (Nuclear Factor-\u03baB) and glucocorticoid receptor physical interactions and antagonism","volume":"14","author":"McKay","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbrep.2026.102726_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113114","article-title":"The NCOA1-CBP-NF-\u03baB transcriptional complex induces inflammation response and triggers endotoxin-induced myocardial dysfunction","volume":"415","author":"Peng","year":"2022","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102726_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-024-46728-4","article-title":"Aberrant non-canonical NF-\u03baB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma","volume":"15","author":"Ang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2026.102726_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116488","article-title":"Controllers of histone methylation-modifying enzymes in gastrointestinal cancers","volume":"174","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrep.2026.102726_bib32","doi-asserted-by":"crossref","first-page":"16275","DOI":"10.1073\/pnas.0904305106","article-title":"CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53","volume":"106","author":"Shi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2026.102726_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013247","article-title":"Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line","volume":"5","author":"Ohshima","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrep.2026.102726_bib34","doi-asserted-by":"crossref","first-page":"936","DOI":"10.7150\/ijms.8277","article-title":"Potential dual immunomodulatory role of VEGF in ulcerative colitis and colorectal carcinoma","volume":"11","author":"Zdravkovic","year":"2014","journal-title":"Int. J. Med. Sci."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826002864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826002864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:05:22Z","timestamp":1791234322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826002864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S2405580826002864"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102726","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systems biology integration of miR\u2013mRNA profiles identifies steroid refractoriness mechanisms and biomarker candidates in ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102726"}}