{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:51:55Z","timestamp":1791237115961,"version":"4.1.0"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFD1801800"],"award-info":[{"award-number":["2022YFD1801800"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrep.2026.102734","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:39:22Z","timestamp":1786340362000},"page":"102734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Virus-like particles vaccine of porcine epidemic diarrhea virus spike 1 protein induces protective immunity challenge in piglets"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7331-3735","authenticated-orcid":false,"given":"Zhiqiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahai","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2026.102734_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11262-012-0713-1","article-title":"Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines","volume":"44","author":"Song","year":"2012","journal-title":"Virus Genes"},{"key":"10.1016\/j.bbrep.2026.102734_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1023\/A:1011831902219","article-title":"Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence","volume":"23","author":"Kocherhans","year":"2001","journal-title":"Virus Genes"},{"key":"10.1016\/j.bbrep.2026.102734_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106280","article-title":"Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis","volume":"26","author":"Si","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.bbrep.2026.102734_bib4","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1080\/15548627.2023.2181615","article-title":"N protein of PEDV plays chess game with host proteins by selective autophagy","volume":"19","author":"Zhai","year":"2023","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.bbrep.2026.102734_bib5","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.3390\/v14081744","article-title":"PEDV: insights and advances into types, function, structure, and receptor recognition","volume":"14","author":"Lin","year":"2022","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102734_bib6","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1038\/s41467-022-32588-3","article-title":"In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM","volume":"13","author":"Huang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2026.102734_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104553","article-title":"Porcine epidemic diarrhea virus: molecular mechanisms of attenuation and vaccines","volume":"149","author":"Li","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbrep.2026.102734_bib8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1586\/14760584.2016.1167603","article-title":"Vaccines for the prevention against the threat of MERS-CoV","volume":"15","author":"Du","year":"2016","journal-title":"Expert Rev. Vaccine"},{"issue":"4","key":"10.1016\/j.bbrep.2026.102734_bib9","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.vaccine.2024.01.020","article-title":"Immunogenicity and protective efficacy of a trimeric full-length S protein subunit vaccine for porcine epidemic diarrhea virus","volume":"42","author":"Guo","year":"2024","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.bbrep.2026.102734_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144818","article-title":"A porcine epidemic diarrhea virus outbreak in one geographic region of the United States: descriptive epidemiology and investigation of the possibility of airborne virus spread","volume":"10","author":"Beam","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102734_bib11","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1038\/s41467-018-06056-w","article-title":"An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102734_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3201\/eid1801.111259","article-title":"Outbreak of porcine epidemic diarrhea in suckling piglets, China","volume":"18","author":"Sun","year":"2012","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102734_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13567-018-0505-2","article-title":"Evidence of porcine epidemic diarrhea virus (PEDV) shedding in semen from infected specific pathogen-free boars","volume":"49","author":"Gallien","year":"2018","journal-title":"Vet. Res."},{"key":"10.1016\/j.bbrep.2026.102734_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2024.110003","article-title":"Enhancing humoral and mucosal immune response of PED vaccine candidate by fusing S1 protein to nanoparticle multimerization","volume":"290","author":"Li","year":"2024","journal-title":"Vet. Microbiol."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826002943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826002943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:57:33Z","timestamp":1791233853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826002943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":14,"alternative-id":["S2405580826002943"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102734","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virus-like particles vaccine of porcine epidemic diarrhea virus spike 1 protein induces protective immunity challenge in piglets","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102734"}}