{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:54:07Z","timestamp":1791237247311,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrep.2026.102749","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:56:43Z","timestamp":1786665403000},"page":"102749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The NtAN3 gene plays a key role in increasing tobacco leaf area"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5970-0485","authenticated-orcid":false,"given":"Shuxian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbrep.2026.102749_bib1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/jxb\/ery448","article-title":"Prospects for enhancing leaf photosynthetic capacity by manipulating mesophyll cell morphology","volume":"70","author":"Ren","year":"2019","journal-title":"J. Exp. Bot."},{"issue":"9","key":"10.1016\/j.bbrep.2026.102749_bib2","first-page":"36","article-title":"The effect of lower leaf harvesting time on the physiological and biochemical changes of upper leaves and post-curing quality","author":"Changrong","year":"2003","journal-title":"tobacco technology"},{"issue":"5","key":"10.1016\/j.bbrep.2026.102749_bib3","first-page":"41","article-title":"Research on improving the usability of upper leaves of cured tobacco using a combination of air drying and baking methods","author":"Zenghan","year":"2003","journal-title":"Zhejiang Agric. Sci."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102749_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-313X.2005.02429.x","article-title":"The transcription factor AtGRF5 and the transcription coactivator AN3 regulate cell proliferation in leaf primordia of Arabidopsis thaliana","volume":"43","author":"Horiguchi","year":"2005","journal-title":"Plant J."},{"issue":"12","key":"10.1016\/j.bbrep.2026.102749_bib5","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.jplph.2011.03.003","article-title":"Enhanced cytokinin degradation in leaf primordia of transgenic Arabidopsis plants reduces leaf size and shoot organ primordia formation","volume":"168","author":"Holst","year":"2011","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.bbrep.2026.102749_bib6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jplph.2018.09.011","article-title":"Effect of constitutive expression of Arabidopsis CLAVATA3 on cell growth and possible role of cytokinins in leaf size control in transgenic tobacco plants","volume":"231","author":"Kuluev","year":"2018","journal-title":"J. Plant Physiol."},{"issue":"14","key":"10.1016\/j.bbrep.2026.102749_bib7","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.3390\/ijms21145132","article-title":"Molecular and hormonal regulation of leaf morphogenesis in Arabidopsis","volume":"21","author":"Ali","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2026.102749_bib8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3389\/fpls.2019.00520","article-title":"Transcription coactivator ANGUSTIFOLIA3 (AN3) regulates leafy head formation in Chinese cabbage","volume":"10","author":"Yu","year":"2019","journal-title":"Front. Plant Sci."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102749_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2229-12-125","article-title":"Bioinformatic cis-element analyses performed in Arabidopsis and rice disclose bZIP-and MYB-related binding sites as potential AuxRE-coupling elements in auxin-mediated transcription","volume":"12","author":"Berendzen","year":"2012","journal-title":"BMC Plant Biol."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102749_bib10","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.2135\/cropsci2016.03.0183","article-title":"Pre\u2010and post\u2010silking carbohydrate concentrations in maize ear\u2010leaves and developing ears in response to nitrogen availability","volume":"56","author":"Peng","year":"2016","journal-title":"Crop Sci."},{"key":"10.1016\/j.bbrep.2026.102749_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fpls.2019.00095","article-title":"An overview of sucrose synthases in plants","volume":"10","author":"Stein","year":"2019","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.bbrep.2026.102749_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s004380050792","article-title":"Genetic evidence that the two isozymes of sucrose synthase present in developing maize endosperm are critical, one for cell wall integrity and the other for starch biosynthesis","volume":"259","author":"Chourey","year":"1998","journal-title":"Mol. Gen. Genet. MGG"},{"issue":"31","key":"10.1016\/j.bbrep.2026.102749_bib13","doi-asserted-by":"crossref","first-page":"13118","DOI":"10.1073\/pnas.0900188106","article-title":"Sucrose synthase affects carbon partitioning to increase cellulose production and altered cell wall ultrastructure","volume":"106","author":"Coleman","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"31","key":"10.1016\/j.bbrep.2026.102749_bib14","doi-asserted-by":"crossref","first-page":"13124","DOI":"10.1073\/pnas.0900689106","article-title":"Normal growth of Arabidopsis requires cytosolic invertase but not sucrose synthase","volume":"106","author":"Barratt","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.bbrep.2026.102749_bib15","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1093\/jxb\/erab033","article-title":"The F-box protein MIO1\/SLB1 regulates organ size and leaf movement in Medicago truncatula","volume":"72","author":"Zhou","year":"2021","journal-title":"J. Exp. Bot."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102749_bib16","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/jxb\/eru438","article-title":"Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway","volume":"66","author":"Ahn","year":"2015","journal-title":"J. Exp. Bot."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102749_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00425-025-04662-9","article-title":"ABCB transporters: functionality extends to more than auxin transportation","volume":"261","author":"Devi","year":"2025","journal-title":"Planta"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102749_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/psb.5.1.10306","article-title":"ABP1: an auxin receptor for fast responses at the plasma membrane","volume":"5","author":"Dahlke","year":"2010","journal-title":"Plant Signal. Behav."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102749_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S0021859600071896","article-title":"Effects of plant density and fertilization on the yield and quality of flue-cured tobacco in the Kenana area of the Sudan","volume":"84","author":"Farah","year":"1975","journal-title":"J. Agric. Sci."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102749_bib20","first-page":"57","article-title":"The effect of different numbers of leaves retained on the growth and yield of the new flue-cured tobacco variety NC297","volume":"30","author":"Yanbin","year":"2009","journal-title":"China Tobacco Science"},{"key":"10.1016\/j.bbrep.2026.102749_bib21","series-title":"The Effect of Nitrogen Fertilizer Management and its Interaction with the Number of Leaves Retained on the Growth, Development, Yield, and Quality of White Ribbed Tobacco","author":"Debao","year":"2011"},{"issue":"7","key":"10.1016\/j.bbrep.2026.102749_bib22","doi-asserted-by":"crossref","DOI":"10.1242\/dev.159624","article-title":"Conserved functional control, but distinct regulation, of cell proliferation in rice and Arabidopsis leaves revealed by comparative analysis of GRF-INTERACTING FACTOR 1 orthologs","volume":"145","author":"Shimano","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.bbrep.2026.102749_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2024.1322223","article-title":"Precocious cell differentiation occurs in proliferating cells in leaf primordia in Arabidopsis angustifolia3 mutant","volume":"15","author":"Ezaki","year":"2024","journal-title":"Front. Plant Sci."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102749_bib24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jsfa.2740250707","article-title":"Changes in carbohydrates during growth and development of cheena (Panicum milaceum Linn.)","volume":"25","author":"Bhatia","year":"1974","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.bbrep.2026.102749_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scienta.2021.110377","article-title":"Dark inhibits leaf size by controlling carbohydrate and auxin catabolism in grape","volume":"288","author":"Gao","year":"2021","journal-title":"Sci. Hortic."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102749_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jplph.2012.01.005","article-title":"Stem sugar accumulation in sweet sorghum\u2013activity and expression of sucrose metabolizing enzymes and sucrose transporters","volume":"169","author":"Qazi","year":"2012","journal-title":"J. Plant Physiol."},{"issue":"12","key":"10.1016\/j.bbrep.2026.102749_bib27","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1093\/jxb\/erab066","article-title":"Sucrose transport and metabolism control carbon partitioning between stem and grain in rice","volume":"72","author":"Mathan","year":"2021","journal-title":"J. Exp. Bot."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102749_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/ppl.13673","article-title":"Genome\u2010wide identification of invertases in Fabaceae, focusing on transcriptional regulation of pisum sativum invertases in seed subjected to drought","volume":"174","author":"Morin","year":"2022","journal-title":"Physiol. Plantarum"},{"issue":"18","key":"10.1016\/j.bbrep.2026.102749_bib29","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1242\/dev.150573","article-title":"Metabolism in time and space\u2013exploring the frontier of developmental biology","volume":"144","author":"Krejci","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.bbrep.2026.102749_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev-cellbio-010521-015047","article-title":"Dynamic nutrient signaling networks in plants","volume":"37","author":"Li","year":"2021","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"21","key":"10.1016\/j.bbrep.2026.102749_bib31","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0960-9822(02)01260-5","article-title":"Galactose biosynthesis in arabidopsis: genetic evidence for substrate channeling from UDP-D-galactose into cell wall polymers","volume":"12","author":"Seifert","year":"2002","journal-title":"Curr. Biol."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102749_bib32","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/mp\/ssq044","article-title":"Sugar input, metabolism, and signaling mediated by invertase: roles in development, yield potential, and response to drought and heat","volume":"3","author":"Ruan","year":"2010","journal-title":"Mol. Plant"},{"issue":"2","key":"10.1016\/j.bbrep.2026.102749_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004502","article-title":"Glucose and auxin signaling interaction in controlling Arabidopsis thaliana seedlings root growth and development","volume":"4","author":"Mishra","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102749_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15060","article-title":"Cell-size dependent progression of the cell cycle creates homeostasis and flexibility of plant cell size","volume":"8","author":"Jones A","year":"2017","journal-title":"Nat. Commun."},{"issue":"7929","key":"10.1016\/j.bbrep.2026.102749_bib35","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/s41586-022-05171-5","article-title":"Glucose-driven TOR\u2013FIE\u2013PRC2 signalling controls plant development","volume":"609","author":"Ye","year":"2022","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbrep.2026.102749_bib36","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1104\/pp.19.01214","article-title":"Target of rapamycin signaling in plant stress responses","volume":"182","author":"Fu","year":"2020","journal-title":"Plant Physiol."},{"issue":"5391","key":"10.1016\/j.bbrep.2026.102749_bib37","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1126\/science.282.5391.1114","article-title":"Auxin-dependent cell expansion mediated by overexpressed auxin-binding protein 1","volume":"282","author":"Jones","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbrep.2026.102749_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.plantsci.2023.111625","article-title":"A mutation in CsABCB19 encoding an ATP-binding cassette auxin transporter leads to erect and compact leaf architecture in cucumber (Cucumis sativus L.)","volume":"329","author":"Cheng","year":"2023","journal-title":"Plant Sci."},{"key":"10.1016\/j.bbrep.2026.102749_bib39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12041-016-0614-5","article-title":"Genomewide analysis of ABCB s with a focus on ABCB1 and ABCB19 in Malus domestica","volume":"95","author":"Ma","year":"2016","journal-title":"J. Genet."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102749_bib40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/tpj.13095","article-title":"ABCB 19\u2010mediated polar auxin transport modulates Arabidopsis hypocotyl elongation and the endoreplication variant of the cell cycle","volume":"85","author":"Wu","year":"2016","journal-title":"Plant J."},{"issue":"25","key":"10.1016\/j.bbrep.2026.102749_bib41","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1016\/j.cell.2023.10.017","article-title":"ABLs and TMKs are co-receptors for extracellular auxin","volume":"186","author":"Yu","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102749_bib42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12041-016-0614-5","article-title":"Genomewide analysis of ABCB s with a focus on ABCB1 and ABCB19 in Malus domestica","volume":"95","author":"Ma","year":"2016","journal-title":"J. Genet."},{"issue":"4","key":"10.1016\/j.bbrep.2026.102749_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"methods."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826003092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826003092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:02:37Z","timestamp":1791234157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826003092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":43,"alternative-id":["S2405580826003092"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102749","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The NtAN3 gene plays a key role in increasing tobacco leaf area","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102749"}}