{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:52:11Z","timestamp":1791237131876,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["140406185094"],"award-info":[{"award-number":["140406185094"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbrep.2026.102763","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:37:34Z","timestamp":1787791054000},"page":"102763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Complex interactions between miR-107 and PTEN gene expression, more specifically in viral and NASH cirrhosis"],"prefix":"10.1016","volume":"47","author":[{"given":"Sara","family":"Motiee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidar","family":"Tayebinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Jalilian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3916-3253","authenticated-orcid":false,"given":"Zahra","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Mohagheghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbrep.2026.102763_bib1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.bbrep.2026.102763_bib2","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.3390\/biomedicines12102229","article-title":"Liver fibrosis leading to cirrhosis: basic mechanisms and clinical perspectives","volume":"12","author":"Somnay","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrep.2026.102763_bib3","article-title":"An updated review on the epidemiology, pathophysiology, etiology and diagnosis of liver cirrhosis","author":"Geong","year":"2019","journal-title":"Preprints"},{"issue":"23","key":"10.1016\/j.bbrep.2026.102763_bib4","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.3748\/wjg.v20.i23.7312","article-title":"Pathogenesis of liver cirrhosis","volume":"20","author":"Zhou","year":"2014","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"3","key":"10.1016\/j.bbrep.2026.102763_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.7861\/clinmedicine.18-3-245","article-title":"Non-alcoholic fatty liver disease","volume":"18","author":"Maurice","year":"2018","journal-title":"Clin. Med."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102763_bib6","first-page":"76","article-title":"Non-alcoholic fatty liver disease: growing burden, adverse outcomes and associations","volume":"8","author":"Kumar","year":"2019","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102763_bib7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3390\/ijms17050774","article-title":"The natural course of non-alcoholic fatty liver disease","volume":"17","author":"Calzadilla Bertot","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2026.102763_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gene.2017.09.027","article-title":"Integrated analysis of microRNA and gene expression profiles reveals a functional regulatory module associated with liver fibrosis","volume":"636","author":"Chen","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.bbrep.2026.102763_bib9","article-title":"MicroRNA: role in macrophage polarization and the pathogenesis of the liver fibrosis","volume":"14","author":"Yu","year":"2023","journal-title":"Front. Immunol."},{"issue":"7353","key":"10.1016\/j.bbrep.2026.102763_bib10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature10112","article-title":"MicroRNAs 103 and 107 regulate insulin sensitivity","volume":"474","author":"Trajkovski","year":"2011","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbrep.2026.102763_bib11","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1194\/jlr.M082602","article-title":"miR-103\/107 promote ER stress-mediated apoptosis via targeting the Wnt3a\/\u03b2-catenin\/ATF6 pathway in preadipocytes","volume":"59","author":"Zhang","year":"2018","journal-title":"J. Lipid Res."},{"issue":"24","key":"10.1016\/j.bbrep.2026.102763_bib12","article-title":"MiR-103\/107 induces tumorigenicity in bladder cancer cell by suppressing PTEN","volume":"22","author":"Yu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bbrep.2026.102763_bib13","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.2147\/OTT.S225235","article-title":"The down-regulation of lncRNA PCAT18 promotes the progression of gastric cancer via MiR-107\/PTEN\/PI3K\/AKT signaling pathway","author":"Chen","year":"2019","journal-title":"OncoTargets Ther."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102763_bib14","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41419-021-03514-0","article-title":"Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN","volume":"12","author":"Tian","year":"2021","journal-title":"Cell Death Dis."},{"issue":"37","key":"10.1016\/j.bbrep.2026.102763_bib15","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.3748\/wjg.v16.i37.4627","article-title":"PTEN in liver diseases and cancer","volume":"16","author":"Peyrou","year":"2010","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102763_bib16","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/s41467-023-37142-3","article-title":"Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K\/AKT\/PDGF axis activation in male mice","volume":"14","author":"Ye","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bbrep.2026.102763_bib17","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3390\/cells8111337","article-title":"Akt1 and Akt2 isoforms play distinct roles in regulating the development of inflammation and fibrosis associated with alcoholic liver disease","volume":"8","author":"Reyes-Gordillo","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102763_bib18","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.1038\/ncomms8400","article-title":"PI3K-C2\u03b3 is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling","volume":"6","author":"Braccini","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbrep.2026.102763_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2011.06.002","article-title":"Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways","volume":"14","author":"Yecies","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrep.2026.102763_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.111044","article-title":"Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-\u03baB and Akt","volume":"135","author":"Kim","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.bbrep.2026.102763_bib21","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/hep.24400","article-title":"Hypoxia\u2010inducible transcription factor 2\u03b1 promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis","volume":"54","author":"Qu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrep.2026.102763_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1344971","article-title":"Hypoxia-inducible factor-2\u03b1 promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells","volume":"15","author":"Yan","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"23","key":"10.1016\/j.bbrep.2026.102763_bib23","article-title":"HIF-2\u03b1 upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway","volume":"11","author":"Chen","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10.1016\/j.bbrep.2026.102763_bib24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbagrm.2014.02.009","article-title":"miR-107 orchestrates ER stress induction and lipid accumulation by post-transcriptional regulation of fatty acid synthase in hepatocytes","volume":"1839","author":"Bhatia","year":"2014","journal-title":"Biochim. Biophys. Acta, Gene Regul. Mech."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102763_bib25","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ijo.2015.225","article-title":"Inhibition of mitochondrial \u03b2-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo","volume":"40","author":"Bhatia","year":"2016","journal-title":"Int. J. Obes."},{"issue":"3","key":"10.1016\/j.bbrep.2026.102763_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1189\/jlb.0312160","article-title":"miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes","volume":"92","author":"Foley","year":"2012","journal-title":"J. Leukoc. Biol."},{"issue":"12","key":"10.1016\/j.bbrep.2026.102763_bib27","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.3390\/genes13122201","article-title":"Identification of liver fibrosis-related MicroRNAs in human primary hepatic stellate cells using high-throughput sequencing","volume":"13","author":"Liu","year":"2022","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.bbrep.2026.102763_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016081","article-title":"The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families","volume":"6","author":"Murakami","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbrep.2026.102763_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1665-2681(19)31848-4","article-title":"PTEN at the crossroad of metabolic diseases and cancer in the liver","volume":"7","author":"Vinciguerra","year":"2008","journal-title":"Ann. Hepatol."},{"issue":"6","key":"10.1016\/j.bbrep.2026.102763_bib30","first-page":"295","article-title":"Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling","volume":"12","author":"Ikeda","year":"2020","journal-title":"Biomed. Reports"},{"issue":"6","key":"10.1016\/j.bbrep.2026.102763_bib31","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3892\/ijmm.2012.1151","article-title":"Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal","volume":"30","author":"Zheng","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrep.2026.102763_bib32","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00535-009-0073-3","article-title":"The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation","volume":"44","author":"Takashima","year":"2009","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bbrep.2026.102763_bib33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.redox.2017.09.018","article-title":"Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver","volume":"14","author":"Zeng","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrep.2026.102763_bib34","article-title":"Signaling pathways that activate hepatic stellate cells during liver fibrosis","volume":"11","author":"Zhang","year":"2024","journal-title":"Front. Med."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102763_bib35","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1872-034X.2011.00786.x","article-title":"Hepatic Akt expression correlates with advanced fibrosis in patients with chronic hepatitis C infection","volume":"41","author":"Huang","year":"2011","journal-title":"Hepatol. Res."},{"issue":"41","key":"10.1016\/j.bbrep.2026.102763_bib36","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v20.i41.15087","article-title":"Hypoxia and fatty liver","volume":"20","author":"Suzuki","year":"2014","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"16","key":"10.1016\/j.bbrep.2026.102763_bib37","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1128\/MCB.00200-09","article-title":"Hypoxia-inducible factor 2 regulates hepatic lipid metabolism","volume":"29","author":"Rankin","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrep.2026.102763_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbrc.2021.01.002","article-title":"Hypoxia-inducible factor-2 promotes liver fibrosis in non-alcoholic steatohepatitis liver disease via the NF-\u03baB signalling pathway","volume":"540","author":"Cai","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102763_bib39","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1159\/000366348","article-title":"Hypoxia induces dysregulation of lipid metabolism in HepG2 cells via activation of HIF-2\u03b1","volume":"34","author":"Cao","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.bbrep.2026.102763_bib40","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.3390\/ijms24054710","article-title":"Structural characterization of hypoxia inducible factor \u03b1\u2014Prolyl hydroxylase domain 2 interaction through MD simulations","volume":"24","author":"Camagni","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5932","key":"10.1016\/j.bbrep.2026.102763_bib41","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.1169956","article-title":"Regulation of hypoxia-inducible factor 2\u03b1 signaling by the stress-responsive deacetylase sirtuin 1","volume":"324","author":"Dioum","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbrep.2026.102763_bib42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.freeradbiomed.2023.07.020","article-title":"Oxygen-independent stabilization of HIF-2\u03b1 in breast cancer through direct interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1","volume":"207","author":"Guillen-Quispe","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.bbrep.2026.102763_bib43","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.225698","article-title":"ERK1\/2 phosphorylates HIF-2\u03b1 and regulates its activity by controlling its CRM1-dependent nuclear shuttling","volume":"132","author":"Gkotinakou","year":"2019","journal-title":"J. Cell Sci."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826003237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826003237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:57:39Z","timestamp":1791233859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826003237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":43,"alternative-id":["S2405580826003237"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102763","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complex interactions between miR-107 and PTEN gene expression, more specifically in viral and NASH cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102763","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102763"}}