{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:28:33Z","timestamp":1793975313733,"version":"4.8.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031153","name":"Ministry of Higher Education, Science and Innovations of the Republic of Uzbekistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bbrep.2026.102796","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:05:39Z","timestamp":1789419939000},"page":"102796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Inorganic polyphosphate chelates Ca2+ but cannot substitute for ATP as an energy source for SERCA"],"prefix":"10.1016","volume":"48","author":[{"given":"F.A.","family":"Khasanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7754-7325","authenticated-orcid":false,"given":"F.R.","family":"Rustamova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.P.","family":"Semernya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.","family":"Akhmadkhojaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Nebesnaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.R.","family":"Rustamov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-5059","authenticated-orcid":false,"given":"A.Y.","family":"Baev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2026.102796_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molcel.2015.02.010","article-title":"Protein polyphosphorylation of lysine residues by inorganic polyphosphate","volume":"58","author":"Azevedo","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.bbrep.2026.102796_bib2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2014.01.012","article-title":"Polyphosphate is a primordial chaperone","volume":"53","author":"Gray","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.bbrep.2026.102796_bib3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.molcel.2016.07.016","article-title":"Polyphosphate: a conserved modifier of amyloidogenic processes","volume":"63","author":"Cremers","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/j.bbrep.2026.102796_bib4","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.jmb.2018.08.016","article-title":"Polyphosphate stabilizes protein unfolding intermediates as soluble amyloid-like oligomers","volume":"430","author":"Yoo","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrep.2026.102796_bib5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bpj.2019.07.028","article-title":"Polyphosphate initiates tau aggregation through Intra- and intermolecular scaffolding","volume":"117","author":"Wickramasinghe","year":"2019","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrep.2026.102796_bib6","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1073\/pnas.0507195103","article-title":"Polyphosphate modulates blood coagulation and fibrinolysis","volume":"103","author":"Smith","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2026.102796_bib7","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/jth.12295","article-title":"Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates","volume":"11","author":"Puy","year":"2013","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.bbrep.2026.102796_bib8","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1182\/blood-2012-03-306605","article-title":"Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation","volume":"119","author":"Morrissey","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbrep.2026.102796_bib9","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/ncomms2364","article-title":"Signalling properties of inorganic polyphosphate in the mammalian brain","volume":"4","author":"Holmstrom","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2026.102796_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1042\/BST20150223","article-title":"Role of inorganic polyphosphate in mammalian cells: from signal transduction and mitochondrial metabolism to cell death","volume":"44","author":"Angelova","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrep.2026.102796_bib11","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/glia.23466","article-title":"Signal transduction in astrocytes: localization and release of inorganic polyphosphate","volume":"66","author":"Angelova","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.bbrep.2026.102796_bib12","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1523\/JNEUROSCI.0314-19.2019","article-title":"Inorganic polyphosphate regulates AMPA and NMDA receptors and protects against glutamate excitotoxicity via activation of P2Y receptors","volume":"39","author":"Maiolino","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrep.2026.102796_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2025.110555","article-title":"The molecular mechanism of P2Y1 receptor activation by inorganic polyphosphates","volume":"772","author":"Rustamov","year":"2025","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrep.2026.102796_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2023.130523","article-title":"Inorganic polyphosphate regulates functions of thymocytes via activation of P2X purinoreceptors","volume":"1868","author":"Nebesnaya","year":"2024","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbrep.2026.102796_bib15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1182\/blood-2013-09-529602","article-title":"Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor","volume":"123","author":"Dinarvand","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbrep.2026.102796_bib16","doi-asserted-by":"crossref","first-page":"18091","DOI":"10.1073\/pnas.0708959104","article-title":"Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death","volume":"104","author":"Abramov","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2026.102796_bib17","doi-asserted-by":"crossref","first-page":"9420","DOI":"10.1074\/jbc.M109.013011","article-title":"Inorganic polyphosphate and energy metabolism in mammalian cells","volume":"285","author":"Pavlov","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2026.102796_bib18","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1042\/BCJ20200042","article-title":"Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria","volume":"477","author":"Baev","year":"2020","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrep.2026.102796_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111413","article-title":"The inositol pyrophosphate 5-InsP(7) regulates mitochondrial polyphosphate synthesis and bioenergetic function","volume":"302","author":"Ladke","year":"2026","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2026.102796_bib20","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1042\/BCJ20200975","article-title":"Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis","volume":"478","author":"Solesio","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrep.2026.102796_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11040685","article-title":"Enzymatic depletion of mitochondrial inorganic polyphosphate (polyP) increases the generation of Reactive Oxygen Species (ROS) and the activity of the Pentose Phosphate Pathway (PPP) in Mammalian cells","volume":"11","author":"Hambardikar","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrep.2026.102796_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14289","article-title":"Short-term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence","volume":"23","author":"Tagliafico","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrep.2026.102796_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.102077","article-title":"Mammalian mitochondrial inorganic polyphosphate (polyP) and cell signaling: crosstalk between polyP and the activity of AMPK","volume":"91","author":"Da Costa","year":"2025","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.bbrep.2026.102796_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-031-01237-2_1","article-title":"Inorganic polyphosphate and F0F1-ATP synthase of Mammalian mitochondria","volume":"61","author":"Baev","year":"2022","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"10.1016\/j.bbrep.2026.102796_bib25","doi-asserted-by":"crossref","first-page":"12337","DOI":"10.1021\/acs.chemrev.9b00460","article-title":"Inorganic polyphosphates as storage for and generator of Metabolic energy in the extracellular matrix","volume":"119","author":"Muller","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbrep.2026.102796_bib26","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0014-5793(97)00863-6","article-title":"Novel components and enzymatic activities of the human erythrocyte plasma membrane calcium pump","volume":"412","author":"Reusch","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrep.2026.102796_bib27","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/ncomms2262","article-title":"Identification and characterization of a human mitochondrial NAD kinase","volume":"3","author":"Ohashi","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2026.102796_bib28","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1038\/srep02632","article-title":"Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase","volume":"3","author":"Nakamichi","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102796_bib29","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1242\/jcs.170605","article-title":"Amorphous Ca(2)(+) polyphosphate nanoparticles regulate the ATP level in bone-like SaOS-2 cells","volume":"128","author":"Muller","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrep.2026.102796_bib30","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1242\/jcs.204941","article-title":"Polyphosphate as a donor of high-energy phosphate for the synthesis of ADP and ATP","volume":"130","author":"Muller","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrep.2026.102796_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110004","article-title":"Polyphosphate degradation by Nudt3-Zn(2+) mediates oxidative stress response","volume":"37","author":"Samper-Martin","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrep.2026.102796_bib32","first-page":"583","volume":"vol. 596","author":"Jumper","year":"2021"},{"key":"10.1016\/j.bbrep.2026.102796_bib33","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/nature06418","article-title":"The structural basis of calcium transport by the calcium pump","volume":"450","author":"Olesen","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2026.102796_bib34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature11899","article-title":"Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state","volume":"495","author":"Toyoshima","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2026.102796_bib35","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1073\/pnas.1017659108","article-title":"Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca2+-ATPase in the absence of Ca2+","volume":"108","author":"Toyoshima","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrep.2026.102796_bib36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.abb.2009.08.014","article-title":"Effects of monovalent cations on Ca2+ uptake by skeletal and cardiac muscle sarcoplasmic reticulum","volume":"490","author":"Beca","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrep.2026.102796_bib37","article-title":"Evaluation of AlphaFold2 structures as docking targets","volume":"32","author":"Holcomb","year":"2023"},{"key":"10.1016\/j.bbrep.2026.102796_bib38","series-title":"ICLR 2024 Workshop on Generative and Experimental Perspectives for Biomolecular Design","article-title":"Towards structure-based drug design with protein flexibility","author":"Schneuing","year":"2024"},{"key":"10.1016\/j.bbrep.2026.102796_bib39","article-title":"MSA clustering enhances AF-Multimer's ability to predict conformational landscapes of protein-protein interactions","volume":"5","author":"Rustamov","year":"2025","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.bbrep.2026.102796_bib40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13395-021-00280-7","article-title":"The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies","volume":"11","author":"Xu","year":"2021","journal-title":"Skeletal Muscle"},{"key":"10.1016\/j.bbrep.2026.102796_bib41","doi-asserted-by":"crossref","first-page":"44250","DOI":"10.1074\/jbc.M406261200","article-title":"Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes","volume":"279","author":"Ruiz","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrep.2026.102796_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2026.119578","article-title":"Prevention of NMDA receptor sensitization by neurotoxic beta-amyloid through polyphosphate coacervation","volume":"200","author":"Muller","year":"2026","journal-title":"Biomed. Pharmacother."}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826003560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405580826003560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:11:07Z","timestamp":1793974267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405580826003560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":42,"alternative-id":["S2405580826003560"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102796","relation":{},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inorganic polyphosphate chelates Ca2+ but cannot substitute for ATP as an energy source for SERCA","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102796","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102796"}}