{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:28:18Z","timestamp":1793975298289,"version":"4.8.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Childhood Cancer Foundation","doi-asserted-by":"publisher","award":["PR2023-0033"],"award-info":[{"award-number":["PR2023-0033"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2024-03447"],"award-info":[{"award-number":["2024-03447"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["22 2391 S"],"award-info":[{"award-number":["22 2391 S"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 24 3485 Pj"],"award-info":[{"award-number":["CAN 24 3485 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemistry and Biophysics Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bbrep.2026.102818","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:22:18Z","timestamp":1790770938000},"page":"102818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development of a GPCR-binding ligand screening method using real-time interaction analysis on live cells"],"prefix":"10.1016","volume":"48","author":[{"given":"Hadis","family":"Westin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-0885","authenticated-orcid":false,"given":"Hanna","family":"Yushchyshyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Vorontsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-2568","authenticated-orcid":false,"given":"Saloni","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-4093","authenticated-orcid":false,"given":"Tianqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Bengtsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Begnini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Rosenstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Yngve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Nestor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3955-1320","authenticated-orcid":false,"given":"Jos","family":"Buijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrep.2026.102818_bib1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrm908","article-title":"Seven-transmembrane receptors","volume":"3","author":"Pierce","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrep.2026.102818_bib2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR drug discovery: new agents, targets and indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrep.2026.102818_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00726-006-0335-9","article-title":"The role of substance P in stress and anxiety responses","volume":"31","author":"Ebner","year":"2006","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbrep.2026.102818_bib4","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.2147\/OTT.S158570","article-title":"Evolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting","volume":"11","author":"Navari","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.bbrep.2026.102818_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/495704","article-title":"Biological and pharmacological aspects of the NK1-receptor","volume":"2015","author":"Garcia-Recio","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.bbrep.2026.102818_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1124\/pr.54.2.285","article-title":"The tachykinin peptide family","volume":"54","author":"Severini","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbrep.2026.102818_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41589-021-00890-8","article-title":"Selective G protein signaling driven by substance P-neurokinin receptor dynamics","volume":"18","author":"Harris","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrep.2026.102818_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0165-6147(97)90663-5","article-title":"The dual nature of the tachykinin NK1 receptor","volume":"18","author":"Maggi","year":"1997","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrep.2026.102818_bib9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/receptors1010004","article-title":"The Neurokinin-1 receptor: structure, dynamics and signaling","volume":"1","author":"Rodr\u00edguez","year":"2022","journal-title":"Receptors"},{"key":"10.1016\/j.bbrep.2026.102818_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk2872","article-title":"Structures of neurokinin 1 receptor in complex with Gq and Gs proteins reveal substance P binding mode and unique activation features","volume":"7","author":"Thom","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrep.2026.102818_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coemr.2020.09.002","article-title":"Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors","volume":"16","author":"Sulon","year":"2021","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"10.1016\/j.bbrep.2026.102818_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1091\/mbc.6.5.509","article-title":"Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor","volume":"6","author":"Grady","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrep.2026.102818_bib13","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.3390\/cancers14143539","article-title":"Involvement of the substance P\/Neurokinin-1 receptor system in cancer","volume":"14","author":"Cove\u00f1as","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrep.2026.102818_bib14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/cge.13750","article-title":"New insight into the role of substance P\/neurokinin-1 receptor system in breast cancer progression and its crosstalk with microRNAs","volume":"98","author":"Ebrahimi","year":"2020","journal-title":"Clin. Genet."},{"key":"10.1016\/j.bbrep.2026.102818_bib15","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2174\/092986710790416308","article-title":"A new frontier in the treatment of cancer: NK-1 receptor antagonists","volume":"17","author":"Mu\u00f1oz","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrep.2026.102818_bib16","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1158\/1078-0432.CCR-05-2820","article-title":"Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance P","volume":"12","author":"Kneifel","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrep.2026.102818_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11060-010-0153-5","article-title":"Neoadjuvant targeting of glioblastoma multiforme with radiolabeled DOTAGA-substance P: results from a phase I study","volume":"100","author":"Cordier","year":"2010","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.bbrep.2026.102818_bib18","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00259-010-1385-5","article-title":"Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trial","volume":"37","author":"Cordier","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.bbrep.2026.102818_bib19","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1021\/acs.bioconjchem.8b00063","article-title":"Synthesis and evaluation of a novel ^64Cu- and ^67Ga-labeled neurokinin 1 receptor antagonist for in vivo targeting of NK1R-positive tumor xenografts","volume":"29","author":"Zhang","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bbrep.2026.102818_bib20","first-page":"108","article-title":"In vitro and in vivo studies of substance P receptor expression in rats with the new analog [indium-111-DTPA-Arg1]substance P","volume":"37","author":"Breeman","year":"1996","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bbrep.2026.102818_bib21","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3390\/ijms23031214","article-title":"Novel NK1R-targeted ^68Ga\/^177Lu-radioconjugates with potential application against glioblastoma multiforme: preliminary exploration of structure-activity relationships","volume":"23","author":"Matali\u0144ska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrep.2026.102818_bib22","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1016\/j.bmcl.2010.07.058","article-title":"Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor","volume":"20","author":"Morriello","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bbrep.2026.102818_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1054\/bjoc.1999.0946","article-title":"Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft","volume":"82","author":"Palma","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbrep.2026.102818_bib24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3390\/pharmaceutics11090443","article-title":"The significance of NK1 receptor ligands and their application in targeted radionuclide tumour therapy","volume":"11","author":"Majkowska-Pilip","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbrep.2026.102818_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2024.102479","article-title":"NK1 receptor blockade disrupts microtumor growth and aggregation in a three-dimensional murine breast cancer model","volume":"109","author":"Gutierrez","year":"2025","journal-title":"Neuropeptides"},{"key":"10.1016\/j.bbrep.2026.102818_bib26","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.3390\/molecules25163756","article-title":"Radiochemical synthesis and evaluation of novel radioconjugates of neurokinin 1 receptor antagonist aprepitant dedicated for NK1R-positive tumors","volume":"25","author":"Halik","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbrep.2026.102818_bib27","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.2967\/jnumed.108.054353","article-title":"Quantitative analysis of NK1 receptor in the human brain using PET with 18F-FE-SPA-RQ","volume":"49","author":"Okumura","year":"2008","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bbrep.2026.102818_bib28","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1021\/acs.bioconjchem.6b00374","article-title":"Design, synthesis, and evaluation of a neurokinin-1 receptor-targeted near-IR dye for fluorescence-guided surgery of neuroendocrine cancers","volume":"27","author":"Kanduluru","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bbrep.2026.102818_bib29","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrd.2016.123","article-title":"Biophysics in drug discovery: impact, challenges and opportunities","volume":"15","author":"Renaud","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrep.2026.102818_bib30","series-title":"Characterizing Biotherapeutics","article-title":"Target binding assays for biotherapeutics","author":"Janezic","year":"2025"},{"key":"10.1016\/j.bbrep.2026.102818_bib31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature22354","article-title":"Single-molecule analysis of ligand efficacy in \u03b22AR-G-protein activation","volume":"547","author":"Gregorio","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbrep.2026.102818_bib32","doi-asserted-by":"crossref","first-page":"14254","DOI":"10.1073\/pnas.1519626112","article-title":"Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor \u03b22AR","volume":"112","author":"Lamichhane","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrep.2026.102818_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jb\/mvae029","article-title":"Cryo-EM advances in GPCR structure determination","volume":"176","author":"Shihoya","year":"2024","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbrep.2026.102818_bib34","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jpcb.3c08349","article-title":"Probing activation and conformational dynamics of the vesicle-reconstituted \u03b22 adrenergic receptor at the single-molecule level","author":"Tutkus","year":"2024","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbrep.2026.102818_bib35","article-title":"SSTR2 receptor states and cellular metabolism modulate 177Lu-DOTATATE binding affinity","volume":"4","author":"Lundsten Salomonsson","year":"2026","journal-title":"EANM Innov."},{"key":"10.1016\/j.bbrep.2026.102818_bib36","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0165-6147(97)01091-2","article-title":"Endocytosis and recycling of G protein-coupled receptors","volume":"18","author":"Koenig","year":"1997","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrep.2026.102818_bib37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/1087057112464776","article-title":"Dual-point competition association assay: a fast and high-throughput kinetic screening method for assessing ligand-receptor binding kinetics","volume":"18","author":"Guo","year":"2013","journal-title":"J. Biomol. Screen"},{"key":"10.1016\/j.bbrep.2026.102818_bib38","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1038\/s41467-023-43601-8","article-title":"Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrep.2026.102818_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-47891-2","article-title":"Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy","volume":"13","author":"Mortensen","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102818_bib40","article-title":"Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy","volume":"144\u2013145","author":"Mortensen","year":"2025","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.bbrep.2026.102818_bib41","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/bab.1033","article-title":"Selection and in vitro characterization of human CD44v6-binding antibody fragments","volume":"59","author":"Nilvebrant","year":"2012","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.bbrep.2026.102818_bib42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ejmech.2014.09.082","article-title":"Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with 188Re","volume":"87","author":"Altai","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrep.2026.102818_bib43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13550-016-0249-9","article-title":"New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics","volume":"7","author":"Zeilinger","year":"2017","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.bbrep.2026.102818_bib44","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.3390\/cancers15092638","article-title":"Design and biological evaluation of small-molecule PET-tracers for imaging of programmed death ligand 1","volume":"15","author":"Krutzek","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrep.2026.102818_bib45","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1021\/acs.molpharmaceut.2c01047","article-title":"Live cells versus fixated cells: kinetic measurements of biomolecular interactions with the LigandTracer method and surface plasmon resonance microscopy","volume":"20","author":"Dong","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbrep.2026.102818_bib46","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ccell.2015.09.003","article-title":"Targeting human cancer by a glycosaminoglycan binding malaria protein","volume":"28","author":"Salanti","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrep.2026.102818_bib47","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1016\/j.celrep.2019.11.086","article-title":"Dectin-1 binding to annexins on apoptotic cells induces peripheral immune tolerance via NADPH oxidase-2","volume":"29","author":"Bode","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrep.2026.102818_bib48","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1038\/s41551-025-01415-7","article-title":"PET-based tracking of CAR T cells and viral gene transfer using a cell surface reporter that binds to lanthanide complexes","volume":"9","author":"Morath","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bbrep.2026.102818_bib49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/antib13020036","article-title":"Balancing the affinity and tumor cell binding of a two-in-one antibody simultaneously targeting EGFR and PD-L1","volume":"13","author":"Harwardt","year":"2024","journal-title":"Antibodies"},{"key":"10.1016\/j.bbrep.2026.102818_bib50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1023\/A:1006755103374","article-title":"Optimization of iodination of [125I]-N-succinimidyl-para-iodobenzoate using chloramine-T for labeling of proteins","volume":"246","author":"Tolmachev","year":"2000","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1016\/j.bbrep.2026.102818_bib51","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bbrc.2013.10.149","article-title":"Detecting ligand interactions with G protein-coupled receptors in real-time on living cells","volume":"441","author":"Xu","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrep.2026.102818_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-37015-1","article-title":"Modelling ligand depletion for simultaneous affinity and binding site quantification on cells and tissue","volume":"13","author":"Weber","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrep.2026.102818_bib53","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0028-3908(99)00172-0","article-title":"The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets","volume":"39","author":"Tattersall","year":"2000","journal-title":"Neuropharmacology"}],"container-title":["Biochemistry and Biophysics Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082600378X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240558082600378X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:01:27Z","timestamp":1793973687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240558082600378X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":53,"alternative-id":["S240558082600378X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102818","relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.177452855.54796920\/v1","asserted-by":"object"}]},"ISSN":["2405-5808"],"issn-type":[{"value":"2405-5808","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a GPCR-binding ligand screening method using real-time interaction analysis on live cells","name":"articletitle","label":"Article Title"},{"value":"Biochemistry and Biophysics Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrep.2026.102818","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102818"}}