{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:43:00Z","timestamp":1784295780027,"version":"3.55.0"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biocatalysis and Agricultural Biotechnology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.bcab.2021.102056","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T02:05:42Z","timestamp":1623031542000},"page":"102056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Evidence-based traditional Siddha formulations for prophylaxis and management of respiratory symptoms in COVID-19 pandemic-a review"],"prefix":"10.1016","volume":"35","author":[{"given":"P.","family":"Prakash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-5294","authenticated-orcid":false,"given":"R.","family":"Meena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Stanley Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Sunkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Govindaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-0628","authenticated-orcid":false,"given":"Durgasruthi","family":"Pully","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony V.","family":"Samrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bcab.2021.102056_bib1","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.sjbs.2020.12.005","article-title":"Nano-formulation of herbo-mineral alternative medicine from linga chenduram and evaluation of antiviral efficacy","volume":"28","author":"Al-Ansari","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.fct.2007.09.085","article-title":"Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research","volume":"46","author":"Ali","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcab.2021.102056_bib3","series-title":"A Compendium of Siddha Doctrine","author":"Anaivarai","year":"2005"},{"key":"10.1016\/j.bcab.2021.102056_bib4","series-title":"Principles of Diagnosis in Siddha-Part 1","author":"Anaivarai","year":"2009"},{"key":"10.1016\/j.bcab.2021.102056_bib5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1995-7645(11)60201-0","article-title":"Antipyretic, anti-inflammatory and analgesic properties of Nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever","volume":"4","author":"Anbarasu","year":"2011","journal-title":"Asian Pac J Trop Med"},{"issue":"2","key":"10.1016\/j.bcab.2021.102056_bib6","first-page":"37","article-title":"Acute and sub acute toxicity studies of pavala parpam","volume":"14","author":"Anbu","year":"2018","journal-title":"J. dent. orofac. Res."},{"key":"10.1016\/j.bcab.2021.102056_bib7","first-page":"402","article-title":"In vitro antimicrobial activity of Sapindus mukorossi and Emblica officinalis against dental caries pathogens","volume":"14","author":"Aneja","year":"2010","journal-title":"Ethnobot Leaflets"},{"key":"10.1016\/j.bcab.2021.102056_bib8","article-title":"Potential of complementary and alternative medicine in preventive management of novel H1N1 Flu (Swine Flu) pandemic: thwarting potential disasters in the bud. Evid Based Complement","volume":"1\u201316","author":"Arora","year":"2011","journal-title":"Alternate Med"},{"key":"10.1016\/j.bcab.2021.102056_bib9","first-page":"194","article-title":"In vitro studies on the effect of glycyrrhizin from Indian glycyrrhlza glabra linn. on some RNA and DNA viruses","volume":"26","author":"Badam","year":"1994","journal-title":"Indian J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcab.2021.102056_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/1099-1573(200006)14:4<245::AID-PTR571>3.0.CO;2-O","article-title":"Protection of epithelial cells against influenza A virus by plant derived biological response modifier Ledretan-96","volume":"44","author":"Badmaev","year":"2000","journal-title":"Phytother Res."},{"issue":"10","key":"10.1016\/j.bcab.2021.102056_bib11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/10667857.2018.1494241","article-title":"Physicochemical characterisation and anti-inflammatory activity of Ayurvedic herbo-metallic Tamra Bhasma in acute and chronic models of inflammation","volume":"33","author":"Bafna","year":"2018","journal-title":"Mater. Technol."},{"key":"10.1016\/j.bcab.2021.102056_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/292369a0","article-title":"4',6-Dichloroflavan (BW 683C), a new anti-rhinovirus compound","volume":"292","author":"Bauer","year":"1976","journal-title":"Nature (London)"},{"key":"10.1016\/j.bcab.2021.102056_bib13","first-page":"467","article-title":"Preeti tiwari barua immunomodulatory effects of triphala","volume":"76","author":"belapurkar","year":"2014","journal-title":"Indian J. Pharmaceut. Sci."},{"issue":"6","key":"10.1016\/j.bcab.2021.102056_bib14","first-page":"467","article-title":"Immunomodulatory effects of triphala and its individual constituents: a review","volume":"76","author":"Belapurkar","year":"2014","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib15","first-page":"1","article-title":"Haniya et al Role of tastes in treatment modalities of siddha science","volume":"1","author":"Bhavishya","year":"2016","journal-title":"Siddha papers"},{"issue":"3\u20134","key":"10.1016\/j.bcab.2021.102056_bib16","first-page":"203","article-title":"Evaluation of anti-diarrhoeal property and acute toxicity of triphala mashi, an ayurvedic formulation","volume":"7","author":"Biradar","year":"2007","journal-title":"J. Herb. Pharmacother."},{"key":"10.1016\/j.bcab.2021.102056_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2131\/jts.27.139","article-title":"Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl 4 intoxicated mature albino rats","volume":"27","author":"Bishayi","year":"2002","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib18","series-title":"Ministry of AYUSH, Government of India","author":"Booklet on Common Yoga Protocol","year":"2019"},{"key":"10.1016\/j.bcab.2021.102056_bib19","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12013-015-0524-9","article-title":"Promising anti-influenza properties of active constituent of Withania somnifera ayurvedic herb in targeting neuraminidase of H1N1 influenza","volume":"72","author":"Cai","year":"2015","journal-title":"Computational Study Cell Biochem Biophys"},{"key":"10.1016\/j.bcab.2021.102056_bib20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ptr.737","article-title":"Study of alkaloids from Adhatoda vasica Nees on their antiinflammatory activity","volume":"15","author":"Chakraborty","year":"2001","journal-title":"Phytother Res."},{"key":"10.1016\/j.bcab.2021.102056_bib21","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jep.2012.10.043","article-title":"Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines","volume":"145","author":"Chang","year":"2013","journal-title":"Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.bcab.2021.102056_bib22","first-page":"231","article-title":"In vitro inhibitory activity of Justicia adhatoda extracts against influenza virus infection and hemagglutination","volume":"25","author":"Chavan","year":"2014","journal-title":"Int. J. Pharmaceut. Sci. Rev. Res."},{"key":"10.1016\/j.bcab.2021.102056_bib23","first-page":"769","article-title":"Anti- viral activity of Indian medicinal plant Justicia adhatoda against herpes simplex virus: an in-vitro study","volume":"4","author":"Chavan","year":"2013","journal-title":"Int. J. Pharm. Biol. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib24","first-page":"1","article-title":"Toxicity evaluation of purna cantirotaya centuram a siddha medicine in wistar rats","volume":"10","author":"Chitra","year":"2015","journal-title":"Int Sch Res Notices"},{"key":"10.1016\/j.bcab.2021.102056_bib25","article-title":"An open clinical evaluation of selected siddha regimen in expediting the management of covid-19 -A randomized controlled study","author":"Chitra","year":"2021","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.bcab.2021.102056_bib26","first-page":"1656","article-title":"Protective effect of polyherbal siddha formulation-nilavembu kudineer against common viral fevers including dengue - a case-control approach","volume":"6","author":"Christian","year":"2015","journal-title":"Int. J. Pharma Sci. Res."},{"key":"10.1016\/j.bcab.2021.102056_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/thorax.2003.012658","article-title":"Role of lopinavir\/ritonavir in the treatment of SARS: initial virological and clinical findings","volume":"59","author":"Chu","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.bcab.2021.102056_bib28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/np50107a017","article-title":"Lorn. Isolation of antirhinoviral sesquiterpenes from ginger (Zingzber offcinale)","volume":"57","author":"Clive","year":"1994","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcab.2021.102056_bib29","first-page":"945","article-title":"Zinc regulates iNOS-derived nitric oxide formation in endothelial cells, Redox","volume":"2","author":"Cortese-krott","year":"2014","journal-title":"Biol."},{"key":"10.1016\/j.bcab.2021.102056_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bcab.2021.102056_bib31","article-title":"Did pangolins spread the China coronavirus to people?","author":"Cyranoski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bcab.2021.102056_bib32","first-page":"6372","article-title":"Evaluation of acute, sub acute toxicity and immunomodulatory activity of Urai mathirai-siddha herbal formulation","volume":"10","author":"Dayanand Reddy","year":"2019","journal-title":"Global Trends Pharm Sci"},{"key":"10.1016\/j.bcab.2021.102056_bib33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrd703","article-title":"Strategies in the design of antiviral drugs","volume":"1","author":"De Clercq","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcab.2021.102056_bib34","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/np50107a017","article-title":"Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber Offcinale)","volume":"57","author":"Denyer","year":"1994","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcab.2021.102056_bib35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0378-8741(99)00074-4","article-title":"Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals","volume":"67","author":"Dhuley","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcab.2021.102056_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/727304","article-title":"Antioxidant, and cytotoxic properties of vasicine acetate synthesized from vasicine isolated from adhatoda vasica L","author":"Duraipandiyan","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bcab.2021.102056_bib37","series-title":"Chennai","year":"1993"},{"issue":"3","key":"10.1016\/j.bcab.2021.102056_bib38","first-page":"531","article-title":"Safety evaluation of an antiviral polyherbal drug of Siddha Medicine in Wistar rats","volume":"18","author":"Ezhilarasan","year":"2019","journal-title":"INDIAN J TRADIT KNOW"},{"key":"10.1016\/j.bcab.2021.102056_bib39","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/pathogens9030231","article-title":"SARS-CoV-2 and coronavirus disease 2019: what we know so far","volume":"9","author":"Firas","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.bcab.2021.102056_bib40","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1128\/JVI.02232-10","article-title":"Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response","volume":"85","author":"Glowacka","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.bcab.2021.102056_bib41","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/ptr.1555","article-title":"Further studies on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma","volume":"18","author":"Govindan","year":"2004","journal-title":"Phytother Res."},{"key":"10.1016\/j.bcab.2021.102056_bib42","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2020.4031","article-title":"Critical care utilization for the covid-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response","author":"Grasselli","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bcab.2021.102056_bib44","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/JVI.02202-13","article-title":"TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein","volume":"88","author":"Heurich","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.bcab.2021.102056_bib45","first-page":"53","article-title":"Recent research on oriental medicinal plants","volume":"1","author":"Hikino","year":"1985","journal-title":"Economic and medicinal plant research"},{"key":"10.1016\/j.bcab.2021.102056_bib46","first-page":"32","article-title":"Standardization of in vitro assays to evaluate the activity of polyherbal siddha formulations against chikungunya virus infection","volume":"29","author":"Jain","year":"2017","journal-title":"Virus Dis"},{"key":"10.1016\/j.bcab.2021.102056_bib47","article-title":"AYUSH systems and COVID-19 epidemic","volume":"5","author":"James","year":"2020","journal-title":"FITM Policy Brief No"},{"key":"10.1016\/j.bcab.2021.102056_bib48","first-page":"111","article-title":"Antimicrobial properties and phytochemical analysis of Emblica officinalis","volume":"91","author":"Javale","year":"2010","journal-title":"Asian J Exp Biol Sci"},{"key":"10.1016\/j.bcab.2021.102056_bib49","first-page":"40","article-title":"Antibacterial activity of stem extracts of Tinospora cordifolia (Willd)","volume":"23","author":"Jeyachandran","year":"2003","journal-title":"Ancient Sci. Life"},{"issue":"8","key":"10.1016\/j.bcab.2021.102056_bib50","doi-asserted-by":"crossref","first-page":"1004320","DOI":"10.1371\/journal.ppat.1004320","article-title":"The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis","volume":"10","author":"Jimenez-Guarde\u00f1o","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcab.2021.102056_bib51","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.phytochem.2015.06.001","article-title":"Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurations","volume":"117","author":"Jun-Jiang","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bcab.2021.102056_bib52","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0253-7613.42302","article-title":"Immunomodulatory effect of Tinospora cordifolia extract in human immuno-deficiency virus positive patients","volume":"40","author":"Kalikar","year":"2008","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.bcab.2021.102056_bib53","first-page":"159","article-title":"Anti-tussive principles of Glycyrrhiza radix, a main component of Kampo preparations Bakumondo-to","volume":"69","author":"Kamei","year":"2003","journal-title":"J. Pharm. (Lahore)"},{"issue":"2","key":"10.1016\/j.bcab.2021.102056_bib54","first-page":"92","article-title":"Ayurvedic preventive and curative protocol for Covid 19 - a proposal","volume":"5","author":"Kar","year":"2020","journal-title":"J. Ayurveda Integr. Med. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib55","first-page":"213","article-title":"Antibacterial activity of black pepper (Piper nigrum Linn.) with special reference to its mode of action on bacteria","volume":"1","author":"Karsha","year":"2010","journal-title":"Indian J Nat Prod Resour"},{"key":"10.1016\/j.bcab.2021.102056_bib56","first-page":"6509","article-title":"Zinc oxide nanoparticles suppress LPS induced NF- B activation by inducing A20 , a negative regulator of NF-KB, in RAW264.7 macrophages","volume":"15","author":"Kim","year":"2015","journal-title":"Nanosci. Nanotechnol."},{"key":"10.1016\/j.bcab.2021.102056_bib57","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.fct.2012.04.024","article-title":"Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C\/EBP and AP-1 signalling pathways in murine macrophages","volume":"50","author":"Kim","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcab.2021.102056_bib58","article-title":"In silico computational screening of Kabasura kudineer - official siddha formulation and JACOM against SARS-CoV-2 spike protein","author":"Kiran","year":"2020","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.bcab.2021.102056_bib59","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0006-2952(96)00469-8","article-title":"Influence of heat shock protein 70 and metallothionein induction by on the release of inflammatory mediators in a porcine model of recurrent endotoxemia","volume":"52","author":"Klostedudfen","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcab.2021.102056_bib61","first-page":"273","article-title":"Antibacterial activity of saponin isolated from the leaves of Solanum trilobatum Linn","volume":"2","author":"Krishnan","year":"2009","journal-title":"J. Pharma Res."},{"issue":"3","key":"10.1016\/j.bcab.2021.102056_bib62","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/medicina57030217","article-title":"Antiviral and immunomodulation effects of artemisia","volume":"57","author":"Kshirsagar","year":"2021","journal-title":"Medicina (Kaunas)."},{"key":"10.1016\/j.bcab.2021.102056_bib63","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa030781","article-title":"Novel coronavirus associated with severe acute respiratory syndrome","volume":"348","author":"Ksiazek","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcab.2021.102056_bib64","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nm1267","article-title":"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus\u2013induced lung injury","volume":"11","author":"Kuba","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcab.2021.102056_bib65","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4103\/0250-474X.57300","article-title":"Anti-inflammatory activity of piper longum fruit oil","volume":"71","author":"Kumar","year":"2009","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib66","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijtb.2017.05.005","article-title":"Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis","volume":"65","author":"Kumar","year":"2018","journal-title":"Indian J. Tubercul."},{"key":"10.1016\/j.bcab.2021.102056_bib67","first-page":"1","article-title":"Coronavirus spike (S) glycoprotein (2019-ncov) targeted siddha medicines Kabasura kudineer and thonthasura kudineer \u2013in silico evidence for corona viral drug","volume":"11","author":"Kumar","year":"2019","journal-title":"Asian J. Pharmaceut. Res. Health Care"},{"issue":"5","key":"10.1016\/j.bcab.2021.102056_bib68","doi-asserted-by":"crossref","first-page":"104144","DOI":"10.1016\/j.jece.2020.104144","article-title":"COVID-19: environment concern and impact of Indian medicinal system","volume":"8","author":"Kumar","year":"2020","journal-title":"J Environ Chem Eng"},{"key":"10.1016\/j.bcab.2021.102056_bib70","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1073\/pnas.90.5.1839","article-title":"Three inhibitors of type 1 human immune deficiency virus long terminal repeat-directed gene expression and virus replication","volume":"90","author":"Li","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcab.2021.102056_bib72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1471-2180-13-187","article-title":"Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry","volume":"13","author":"Lin","year":"2013","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bcab.2021.102056_bib74","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1056\/NEJMp2002125","article-title":"Defining the epidemiology of Covid-19-studies needed","volume":"382","author":"Lipsitch","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcab.2021.102056_bib75","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/j.foodchem.2011.09.063","article-title":"Immunomodulatory and anticancer activities of phenolics from emblica fruit (Phyllanthus emblica L.)","volume":"131","author":"Liu","year":"2012","journal-title":"Food Chem."},{"issue":"13","key":"10.1016\/j.bcab.2021.102056_bib76","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.biomaterials.2014.01.054","article-title":"Inhibitory effect of silver nanomaterials on transmissible virus-induced host cell infections","volume":"35","author":"Lv","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcab.2021.102056_bib77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.sjbs.2014.09.009","article-title":"Indian ethnic medicinal plants against H1N","volume":"22","author":"Maria John","year":"2014","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1358\/mf.2000.22.5.796644","article-title":"In vitro antioxidant activity of piperine","volume":"22","author":"Mittal","year":"2002","journal-title":"Methods Find Exp. Clin. Pharmacol."},{"key":"10.1016\/j.bcab.2021.102056_bib79","series-title":"Siddha Materia Medica- Part 1","author":"Mudhaliyar","year":"2003"},{"key":"10.1016\/j.bcab.2021.102056_bib80","series-title":"Siddha Maruthuvam Podhu","author":"Mudhaliyar","year":"2004"},{"key":"10.1016\/j.bcab.2021.102056_bib81","series-title":"Siddha Vaithya Thirattu","author":"Mudhaliyar Kn","year":"1998"},{"key":"10.1016\/j.bcab.2021.102056_bib82","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3920\/BM2010.0033","article-title":"Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India","volume":"2","author":"Narayanan","year":"2011","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.bcab.2021.102056_bib83","first-page":"927","article-title":"Molecular and biochemical evidences for beneficial effects of zinc oxide nanoparticles in modulation of chlorpyrifos toxicity in human lymphocytes, Iran","volume":"17","author":"Navaei-nigjeh","year":"2018","journal-title":"J. Pharm. Res."},{"issue":"4","key":"10.1016\/j.bcab.2021.102056_bib84","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3923\/jpt.2009.173.177","article-title":"Antimicrobial activity of Curcuma longa aqueous extract","volume":"4","author":"Niamsaand","year":"2009","journal-title":"J. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.bcab.2021.102056_bib85","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1021\/nn3057005","article-title":"Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo","volume":"7","author":"Niikura","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.bcab.2021.102056_bib86","series-title":"Case-fatality Rate and Characteristics of Patients Dying in Relation to Covid-19 in Italy JAMA","author":"Onder","year":"2020"},{"key":"10.1016\/j.bcab.2021.102056_bib87","series-title":"Kannusami Parambarai Vaidhiyam","author":"Pillai K","year":"1948"},{"key":"10.1016\/j.bcab.2021.102056_bib88","series-title":"Pathartha Guna Villakkam (Moola Vargam)","author":"Pillai K","year":"2006"},{"issue":"7","key":"10.1016\/j.bcab.2021.102056_bib89","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/np50097a002","article-title":"Immunostimulant agents from Andrographis paniculate","volume":"56","author":"Puri","year":"1993","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcab.2021.102056_bib90","first-page":"267","article-title":"Screening of common siddha formulations for antimicrobial activity against respiratory pathogens","volume":"9","author":"Rajalakshmi","year":"2016","journal-title":"Asian J. Pharmaceut. Clin. Res."},{"key":"10.1016\/j.bcab.2021.102056_bib91","first-page":"189","article-title":"A systematic comprehensive review on therapeutic potential of Andrographis paniculate (Burm. F.) Wall","volume":"5","author":"Rajasekaran","year":"2016","journal-title":"Ex Nees Pharmacogn Phytochem"},{"key":"10.1016\/j.bcab.2021.102056_bib92","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4103\/0974-8490.60581","article-title":"Solanum trilobatum in the management of atopy: through inhibition of mast cell degranulation and moderation of release of interleukins","volume":"2","author":"Ranjith","year":"2010","journal-title":"Phcog Res"},{"issue":"12","key":"10.1016\/j.bcab.2021.102056_bib93","first-page":"1603","article-title":"Acute and subacute toxicity study of linga kattu \u2013 an unique siddha herbomineral formulation","volume":"6","author":"Ravichandran","year":"2017","journal-title":"World J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.bcab.2021.102056_bib94","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jaut.2020.102433","article-title":"The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak","volume":"109","author":"Rothan","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.bcab.2021.102056_bib60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S2222-1808(14)60424-2","article-title":"Evaluation of in vitro antiviral activity of vitex negundo L., hyptis suaveolens (L) poit., decalepis hamiltonii wight & arn., to chikungunya virus","volume":"4","author":"Sangeetha","year":"2014","journal-title":"Asian Pac J Trop Dis"},{"issue":"4","key":"10.1016\/j.bcab.2021.102056_bib95","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/acs.jnatprod.0c01324","article-title":"Anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component andrographolide in human lung epithelial cells and cytotoxicity evaluation in major organ cell representatives","volume":"84","author":"Sa-Ngiamsuntorn","year":"2021","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bcab.2021.102056_bib96","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s15010-020-01409-4","article-title":"Successful containment of covid-19: the who-report on the covid-19 outbreak in China","volume":"48","author":"Salzberger","year":"2020","journal-title":"Infection"},{"key":"10.1016\/j.bcab.2021.102056_bib97","first-page":"848","article-title":"Screening of antibacterial activity of Emblica officinalis fruits","volume":"3","author":"Saradha Jyothi","year":"2011","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.bcab.2021.102056_bib98","first-page":"9992","article-title":"Anti-inflammatory, antipyretic and antibacterial study of Kabasura kudineer choornam","volume":"7","author":"Saravanan","year":"2018","journal-title":"Int. J. Curr. Adv. Res."},{"key":"10.1016\/j.bcab.2021.102056_bib99","first-page":"1","article-title":"Ayurvedic metal nanoparticles could be novel antiviral agents against SARS-CoV-2","author":"Sarkar","year":"2021","journal-title":"Int. Nano Lett."},{"issue":"1","key":"10.1016\/j.bcab.2021.102056_bib100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12985-019-1182-0","article-title":"Coronavirus envelope protein: current knowledge","volume":"16","author":"Schoeman","year":"2019","journal-title":"Virol. J."},{"key":"10.1016\/j.bcab.2021.102056_bib101","first-page":"5","article-title":"Review of diagnosing disease by using Envagai Thervugal in Siddha aspect","volume":"3","author":"Selvam","year":"2018","journal-title":"Int. J. Curr. Res. Biol. Med."},{"issue":"9","key":"10.1016\/j.bcab.2021.102056_bib102","first-page":"119","article-title":"Toxicological screening of \u201cgowri chinthamani chendooram\u201d A siddha metallic preparation","volume":"2","author":"Shanmugapriya","year":"2014","journal-title":"Pharma"},{"issue":"8","key":"10.1016\/j.bcab.2021.102056_bib103","first-page":"767","article-title":"Effects of petroleum ether extract of Anacyclus pyrethrum DC on sexual behaviour in male rats","volume":"8","author":"Sharma","year":"2010","journal-title":"Phytother Res."},{"key":"10.1016\/j.bcab.2021.102056_bib104","first-page":"9","article-title":"Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses","volume":"3653","author":"Sheahan","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.bcab.2021.102056_bib105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.5958\/0974-360X.2019.00042.8","article-title":"Physiochemical and acute toxicity analysis of a siddha herbo-mineral formulation \u2013 pachai karpoora vadagam (PKV)","volume":"12","author":"Shunmugaram","year":"2019","journal-title":"Res. J. Pharm. Technol."},{"issue":"9","key":"10.1016\/j.bcab.2021.102056_bib106","first-page":"793","article-title":"Acute and subacute toxicity study of a herbomineral siddha formulation thuthuvalayathy chooranam","volume":"3","author":"Sofia","year":"2014","journal-title":"World J. Pharmaceut. Res."},{"key":"10.1016\/j.bcab.2021.102056_bib107","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1179\/135100002125000370","article-title":"Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage","volume":"7","author":"Subramanian","year":"2002","journal-title":"Redox Rep."},{"key":"10.1016\/j.bcab.2021.102056_bib108","first-page":"1","article-title":"COVID-19: epidemiology, evolution, and cross-disciplinary perspectives","volume":"1550","author":"Sun","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bcab.2021.102056_bib109","first-page":"228","article-title":"Screening of antibacterial potentials of some medicinal plants from Melghat forest in India","volume":"6","author":"Tambekar","year":"2009","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.bcab.2021.102056_bib69","article-title":"Screening of Antibacterial and Phytochemical activity of Acalypha indica Linn against isolated respiratory pathogens","volume":"2","author":"Thenmozhi","year":"2012","journal-title":"Res. Plant Biol."},{"key":"10.1016\/j.bcab.2021.102056_bib110","first-page":"376","article-title":"A review on \u201cKapa Sura Kudineer\u201d-a Siddha formulary prediction for swine flu","volume":"7","author":"Thillaivanan","year":"2015","journal-title":"Int. J. Pharmaceut. Sci. Drug Res."},{"key":"10.1016\/j.bcab.2021.102056_bib111","series-title":"Gunapadam Thathu Seeva Vaguppu-Part 2","author":"Thiyagarajan","year":"1981"},{"key":"10.1016\/j.bcab.2021.102056_bib112","first-page":"302","article-title":"Rubia. 5 din, a new antioxidant from rubia cordifolia","volume":"34","author":"Tripathi","year":"1997","journal-title":"Indian J. Biochem. Biophys."},{"issue":"11","key":"10.1016\/j.bcab.2021.102056_bib113","first-page":"454","article-title":"Evaluation of toxicity profiles of siddha metallic preparation of \u2018Aya chendooram\u2019 in laboratory animals","volume":"6","author":"Velmurugan","year":"2017","journal-title":"Scholars Acad. J. Pharm."},{"key":"10.1016\/j.bcab.2021.102056_bib114","first-page":"7","article-title":"Molecular docking studies on the anti-viral effects of compounds from Kabasura kudineer on SARSCoV-2 3CLpro","author":"Vincent","year":"2020","journal-title":"Frontiers in molecular biosciences"},{"key":"10.1016\/j.bcab.2021.102056_bib115","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1078\/09447110260571616","article-title":"Immunological studies of Revitonil: a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract","volume":"9","author":"Wagner","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcab.2021.102056_bib116","first-page":"1935","article-title":"Mohammadi, et al Evaluation of antiviral activities of curcumin derivatives against HSV-1 in Verocellline","volume":"5","author":"Zandi","year":"2010","journal-title":"Nat. Prod. Commun"},{"key":"10.1016\/j.bcab.2021.102056_bib117","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.antiviral.2015.06.004","article-title":"Broad range of inhibiting action of novel camphor-based compound with anti-hemagglutinin activity against influenza viruses in vitro and in vivo","volume":"120","author":"Zarubaev","year":"2015","journal-title":"Antivir. Res."}],"container-title":["Biocatalysis and Agricultural Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878818121001523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878818121001523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:51:28Z","timestamp":1761810688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878818121001523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":114,"alternative-id":["S1878818121001523"],"URL":"https:\/\/doi.org\/10.1016\/j.bcab.2021.102056","relation":{},"ISSN":["1878-8181"],"issn-type":[{"value":"1878-8181","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence-based traditional Siddha formulations for prophylaxis and management of respiratory symptoms in COVID-19 pandemic-a review","name":"articletitle","label":"Article Title"},{"value":"Biocatalysis and Agricultural Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcab.2021.102056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102056"}}