{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:33:43Z","timestamp":1787164423357,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.bcmd.2003.10.004","type":"journal-article","created":{"date-parts":[[2003,11,20]],"date-time":"2003-11-20T07:59:49Z","timestamp":1069315189000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells"],"prefix":"10.1016","volume":"32","author":[{"given":"Asit","family":"Nandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Karp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2003.10.004_BIB1","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/S0959-8049(99)00292-0","article-title":"Control of the cell cycle and apoptosis","volume":"35","author":"Lundberg","year":"1999","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bcmd.2003.10.004_BIB2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2003.10.004_BIB3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","article-title":"Proliferation, cell cycle and apoptosis in cancer","volume":"411","author":"Evan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2003.10.004_BIB4","doi-asserted-by":"crossref","first-page":"11617","DOI":"10.1074\/jbc.R100063200","article-title":"Signaling networks that link cell proliferation and cell fate","volume":"277","author":"Sears","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/sj.leu.2402460","article-title":"The Raf\/MEK\/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia","volume":"16","author":"Lee","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.bcmd.2003.10.004_BIB6","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"14","author":"Druker","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB7","first-page":"518a","article-title":"Identification of differentially expressed genes in a human Burkitt's lymphoma cell line using differential mRNA display","volume":"94","author":"Rapoport","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2003.10.004_BIB8","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1073\/pnas.090102397","article-title":"Characterization of PDZ-binding kinase, a mitotic kinase","volume":"97","author":"Gaudet","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB9","doi-asserted-by":"crossref","first-page":"21525","DOI":"10.1074\/jbc.M909629199","article-title":"Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells","volume":"275","author":"Abe","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/bcmd.2001.0452","article-title":"PBK\/TOPK is a novel mitotic kinase which is up-regulated in Burkitt's lymphoma and other highly proliferative malignant cells","volume":"27","author":"Simons-Evelyn","year":"2001","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jcb.1141","article-title":"Inhibition of p38 MAP kinase potentiates the JNK\/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells","volume":"82","author":"Wang","year":"2001","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bcmd.2003.10.004_BIB12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1128\/MCB.17.3.1459","article-title":"Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins","volume":"17","author":"Spotts","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB13","doi-asserted-by":"crossref","first-page":"35450","DOI":"10.1074\/jbc.M204458200","article-title":"A novel Myc target gene mina53, that is involved in cell proliferation","volume":"277","author":"Tsuneoka","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/cyto.2002.1988","article-title":"Regulation of growth-related genes by interleukin-6 in murine myeloma cells","volume":"20","author":"Cote","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.bcmd.2003.10.004_BIB15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0888-7543(02)00008-3","article-title":"Novel Raf kinase protein\u2013protein interactions found by an exhaustive yeast two-hybrid analysis","volume":"81","author":"Yuryev","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.bcmd.2003.10.004_BIB16","doi-asserted-by":"crossref","first-page":"31808","DOI":"10.1074\/jbc.M203964200","article-title":"Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation","volume":"277","author":"Pruitt","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB17","doi-asserted-by":"crossref","first-page":"38973","DOI":"10.1074\/jbc.M002856200","article-title":"The p38 pathway provides negative feedback for Ras proliferating signaling","volume":"275","author":"Chen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2003.10.004_BIB18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0959-437X(01)00270-2","article-title":"p38 and chK1 kinases: different conductors for the G2\/M checkpoint symphony","volume":"12","author":"Bulavin","year":"2002","journal-title":"Curr. Opin. Genet. Dev."}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979603002481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979603002481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:21:44Z","timestamp":1761049304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979603002481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S1079979603002481"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2003.10.004","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2003.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}