{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:59:47Z","timestamp":1787065187750,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.bcmd.2005.08.001","type":"journal-article","created":{"date-parts":[[2005,9,6]],"date-time":"2005-09-06T18:05:14Z","timestamp":1126029914000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8+ T lymphocyte numbers"],"prefix":"10.1016","volume":"35","author":[{"given":"M. Fatima","family":"Macedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a","family":"Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2005.08.001_bib1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis","volume":"13","author":"Feder","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2005.08.001_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0016-5085(98)70483-4","article-title":"Genotypic\/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria","volume":"114","author":"Adams","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcmd.2005.08.001_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/bcmd.1997.0129","article-title":"Genetic and clinical description of hemochromatosis probands and heterozygotes: evidence that multiple genes linked to the major histocompatibility complex are responsible for hemochromatosis","volume":"23","author":"Barton","year":"1997","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bcmd.2005.08.001_bib4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1034\/j.1600-0609.2001.t01-1-00481.x","article-title":"Clinical and genetic heterogeneity in hereditary haemochromatosis: association between lymphocyte counts and expression of iron overload","volume":"67","author":"Porto","year":"2001","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.7326\/0003-4819-127-2-199707150-00002","article-title":"Clinical features of genetic hemochromatosis in women compared with men","volume":"127","author":"Moirand","year":"1997","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bcmd.2005.08.001_bib6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0016-5085(98)70319-1","article-title":"Heterogeneity of hemochromatosis in Italy","volume":"114","author":"Piperno","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcmd.2005.08.001_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bcmd.2004.08.022","article-title":"HLA haplotype A*03\u2013B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overload","volume":"34","author":"Barton","year":"2005","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bcmd.2005.08.001_bib8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1600-0609.1994.tb00097.x","article-title":"Haemochromatosis as a window into the study of the immunological system: a novel correlation between CD8+ lymphocytes and iron overload","volume":"52","author":"Porto","year":"1994","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib9","first-page":"397","article-title":"Relative impact of HLA phenotype and CD4\u2013CD8 ratios on the clinical expression of hemochromatosis","volume":"25","author":"Porto","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.bcmd.2005.08.001_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1034\/j.1399-0039.2003.00065.x","article-title":"HFE, the MHC and hemochromatosis: paradigm for an extended function for MHC class I","volume":"61","author":"Cardoso","year":"2003","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.bcmd.2005.08.001_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1365-3083.1994.tb03396.x","article-title":"Decreased CD8-p56lck activity in peripheral blood T-lymphocytes from patients with hereditary haemochromatosis","volume":"39","author":"Arosa","year":"1994","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib12","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1046\/j.1365-2249.1997.d01-967.x","article-title":"Anomalies of the CD8+ T cell pool in haemochromatosis: HLA-A3-linked expansions of CD8+CD28-T cells","volume":"107","author":"Arosa","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0198-8859(01)00233-6","article-title":"T-cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects","volume":"62","author":"Cardoso","year":"2001","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0168-8278(02)00276-3","article-title":"Peripheral lymphocytes and intracellular cytokines in C282Y homozygous hemochromatosis patients","volume":"37","author":"Fabio","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI9635","article-title":"Genes that modify the hemochromatosis phenotype in mice","volume":"105","author":"Levy","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcmd.2005.08.001_bib16","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1182\/blood-2003-09-3300","article-title":"Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(\u2212\/\u2212) and beta2mRag1(\u2212\/\u2212) double knock-out mice","volume":"103","author":"Miranda","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.08.001_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.immunol.18.1.83","article-title":"Population biology of lymphocytes: the flight for survival","volume":"18","author":"Freitas","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0014-4827(72)90492-2","article-title":"Identification of transferrin as a lymphocyte growth promoter in human serum","volume":"74","author":"Tormey","year":"1972","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bcmd.2005.08.001_bib19","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1084\/jem.147.3.923","article-title":"Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes","volume":"147","author":"Iscove","year":"1978","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcmd.2005.08.001_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1196\/annals.1306.002","article-title":"The metabolism of neuronal iron and its pathogenic role in neurological disease","volume":"1012","author":"Moos","year":"2004","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bcmd.2005.08.001_bib21","series-title":"Iron in Immunity, Cancer and Inflammation","first-page":"81","article-title":"Iron and cells of the immune system","author":"Brock","year":"1989"},{"key":"10.1016\/j.bcmd.2005.08.001_bib22","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1002\/eji.1830241147","article-title":"Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody","volume":"24","author":"Brekelmans","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib23","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1182\/blood-2003-04-1086","article-title":"Transferrin receptor 1 is differentially required in lymphocyte development","volume":"102","author":"Ned","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.08.001_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2567.2004.01915.x","article-title":"Transferrin is required for early T-cell differentiation","volume":"112","author":"Macedo","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.bcmd.2005.08.001_bib25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1046\/j.1365-2141.2001.02949.x","article-title":"HFE mutations, iron deficiency and overload in 10,500 blood donors","volume":"114","author":"Jackson","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib26","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1182\/blood-2003-10-3564","article-title":"Hemochromatosis mutations in the general population: iron overload progression rate","volume":"103","author":"Andersen","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.08.001_bib27","series-title":"Iron in Biochemistry and Medicine","first-page":"29","article-title":"Transferrin and Transferrin Iron","author":"Morgan","year":"1974"},{"key":"10.1016\/j.bcmd.2005.08.001_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1399-0039.2004.00245.x","article-title":"Involvement of the MHC region in the genetic regulation of circulating CD8+T cell numbers in humans","volume":"64","author":"Cruz","year":"2004","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.bcmd.2005.08.001_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0140-6736(02)07447-0","article-title":"Penetrance of 845G\u2192A (C282Y) HFE hereditary haemochromatosis mutation in the USA","volume":"359","author":"Beutler","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bcmd.2005.08.001_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0140-6736(02)09581-8","article-title":"Clinical haemochromatosis in HFE mutation carriers","volume":"360","author":"Poullis","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bcmd.2005.08.001_bib31","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0140-6736(02)09583-1","article-title":"Clinical haemochromatosis in HFE mutation carriers","volume":"360","author":"Allen","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bcmd.2005.08.001_bib32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(02)09582-X","article-title":"Clinical haemochromatosis in HFE mutation carriers","volume":"360","author":"Cox","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.bcmd.2005.08.001_bib33","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1182\/blood-2002-05-1565","article-title":"Increased hepatic iron in mice lacking classical MHC class I molecules","volume":"100","author":"Cardoso","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.08.001_bib34","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1182\/blood-2004-12-4640","article-title":"HFE crosstalks with the MHC class I antigen presentation pathway","volume":"106","author":"De Almeida","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.08.001_bib35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/BF00345966","article-title":"Genetic control of T-cell subset representation in inbred mice","volume":"18","author":"Kraal","year":"1983","journal-title":"Immunogenetics"},{"key":"10.1016\/j.bcmd.2005.08.001_bib36","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.4049\/jimmunol.160.8.3649","article-title":"Thymic lineage commitment rather than selection causes genetic variations in size of CD4 and CD8 compartments","volume":"160","author":"van Meerwijk","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib37","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0960-9822(98)70276-3","article-title":"Thymic skewing of the CD4\/CD8 ratio maps with the T-cell receptor alpha-chain locus","volume":"8","author":"Sim","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib38","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.4049\/jimmunol.163.6.2983","article-title":"A dominant role for the thymus and MHC genes in determining the peripheral CD4\/CD8 T cell ratio in the rat","volume":"163","author":"Damoiseaux","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib39","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm1295-1279","article-title":"Genetic control of the CD4\/CD8 T-cell ratio in humans","volume":"1","author":"Amadori","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcmd.2005.08.001_bib40","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1086\/340090","article-title":"Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations","volume":"70","author":"Hall","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bcmd.2005.08.001_bib41","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.gene.6364126","article-title":"A major quantitative trait locus for CD4\u2013CD8 ratio is located on chromosome 11","volume":"5","author":"Evans","year":"2004","journal-title":"Genes Immun."},{"key":"10.1016\/j.bcmd.2005.08.001_bib42","first-page":"165","article-title":"Microenvironment to a lymphoid cell is nothing more than interaction with its neighbours","volume":"66","author":"de Sousa","year":"1976","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bcmd.2005.08.001_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/10623320009072208","article-title":"Characterization of iron uptake from transferrin by murine endothelial cells","volume":"7","author":"Hallmann","year":"2000","journal-title":"Endothelium"},{"key":"10.1016\/j.bcmd.2005.08.001_bib44","first-page":"393","article-title":"Lymphoid cell positioning: a new proposal for the mechanism of control of lymphoid cell migration","volume":"32","author":"De Sousa","year":"1978","journal-title":"Symp. Soc. Exp. Biol."}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997960500118X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107997960500118X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:22:17Z","timestamp":1761049337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107997960500118X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S107997960500118X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2005.08.001","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8+ T lymphocyte numbers","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2005.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}