{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:15:34Z","timestamp":1791062134980,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.bcmd.2005.12.006","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T07:21:15Z","timestamp":1140074475000},"page":"283-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development"],"prefix":"10.1016","volume":"36","author":[{"given":"Sophia R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manik C.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Ollivierre-Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing","family":"Hang Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey A.","family":"Rouault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2005.12.006_bib1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.283.5402.676","article-title":"Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC","volume":"283","author":"Wu","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2005.12.006_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/plac.2002.0885","article-title":"Identification of multiple differentially expressed messenger RNAs in normal and pathological trophoblast","volume":"24","author":"Durand","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.bcmd.2005.12.006_bib3","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/oxfordjournals.humrep.a019195","article-title":"Alleviation of the \u20182-cell block\u2019 and development to the blastocyst of CF1 mouse embryos: role of amino acids, EDTA and physical parameters","volume":"11","author":"Gardner","year":"1996","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.bcmd.2005.12.006_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/B:BIOM.0000027693.60932.26","article-title":"Lactoferrin: role in iron homeostasis and host defense against microbial infection","volume":"17","author":"Ward","year":"2004","journal-title":"Biometals"},{"key":"10.1016\/j.bcmd.2005.12.006_bib5","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1210\/endo.140.4.6671","article-title":"Restricted spatiotemporal expression of lactoferrin during murine embryonic development","volume":"140","author":"Ward","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcmd.2005.12.006_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1023\/B:BIOM.0000027709.42733.e4","article-title":"Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse","volume":"17","author":"Suzuki","year":"2004","journal-title":"BioMetals"},{"key":"10.1016\/j.bcmd.2005.12.006_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0143-4004(05)80199-7","article-title":"Transferrin receptor expression in early postimplantation mouse trophoblast and associated tissues","volume":"11","author":"Drake","year":"1990","journal-title":"Placenta"},{"key":"10.1016\/j.bcmd.2005.12.006_bib8","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1600-0854.2004.00221.x","article-title":"Endocytic and transcytotic processes in villous syncytiotrophoblast: role in nutrient transport to the human fetus","volume":"5","author":"Fuchs","year":"2004","journal-title":"Traffic"},{"key":"10.1016\/j.bcmd.2005.12.006_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/7727","article-title":"Transferrin receptor is necessary for development of erythrocytes and the nervous system","volume":"21","author":"Levy","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2005.12.006_bib10","doi-asserted-by":"crossref","first-page":"20826","DOI":"10.1074\/jbc.274.30.20826","article-title":"Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family","volume":"274","author":"Kawabata","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2005.12.006_bib11","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1242\/dev.01540","article-title":"The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1","volume":"131","author":"Wingert","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.bcmd.2005.12.006_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1306.001","article-title":"Iron metabolism and the IRE\/IRP regulatory system: an update","volume":"1012","author":"Pantopoulos","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bcmd.2005.12.006_bib13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.emboj.7600041","article-title":"Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis","volume":"23","author":"Meyron-Holtz","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bcmd.2005.12.006_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/84859","article-title":"Targeted deletion of iron regulatory protein 2 causes misregulation of iron metabolism and neurodegenerative disease in mice","volume":"27","author":"LaVaute","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2005.12.006_bib15","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1182\/blood-2004-12-4703","article-title":"Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2","volume":"106","author":"Cooperman","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.12.006_bib16","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1126\/science.1103786","article-title":"Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo","volume":"306","author":"Meyron-Holtz","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2005.12.006_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2137(97)80001-5","article-title":"Regulation of iron metabolism in eukaryotes","volume":"35","author":"Rouault","year":"1997","journal-title":"Curr. Top. Cell. Regul."},{"key":"10.1016\/j.bcmd.2005.12.006_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1196\/annals.1306.006","article-title":"Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies","volume":"1012","author":"Smith","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bcmd.2005.12.006_bib19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/BF02215719","article-title":"Optimization of superovulation in the reproductively mature mouse","volume":"11","author":"Legge","year":"1994","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.bcmd.2005.12.006_bib20","series-title":"Recovery and In Vitro Culture of Pre-Implantation-Stage Embryos","first-page":"201","year":"2003"},{"key":"10.1016\/j.bcmd.2005.12.006_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/mrd.1090","article-title":"Expression of retinol-binding protein messenger RNA and retinoic acid receptors in preattachment bovine embryos","volume":"60","author":"Mohan","year":"2001","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.bcmd.2005.12.006_bib22","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M000713200","article-title":"A novel mammalian iron-regulated protein involved in intracellular iron metabolism","volume":"275","author":"Abboud","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2005.12.006_bib23","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1182\/blood-2005-04-1365","article-title":"Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)","volume":"106","author":"Galy","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.12.006_bib24","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1261\/rna.7220704","article-title":"Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo","volume":"10","author":"Galy","year":"2004","journal-title":"RNA"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979605002196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979605002196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:23:54Z","timestamp":1761049434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979605002196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1079979605002196"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2005.12.006","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2005.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}