{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:21:26Z","timestamp":1790043686775,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.bcmd.2005.12.029","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T09:28:24Z","timestamp":1142328504000},"page":"298-307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dendritic cells in patients with type I Gaucher disease are decreased in number but functionally normal"],"prefix":"10.1016","volume":"36","author":[{"given":"I.","family":"Micheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Marinakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Repa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kouraklis-Symeonidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vlacha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Anagnostopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zoumbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Symeonidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2005.12.029_bib1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1023\/A:1012496514170","article-title":"Gaucher disease: understanding the molecular pathogenesis of sphingolipidoses","volume":"24","author":"Cox","year":"2001","journal-title":"J. Inherited Metab. Dis."},{"key":"10.1016\/j.bcmd.2005.12.029_bib2","first-page":"3635","article-title":"Gaucher disease","volume":"vol. III","author":"Beutler","year":"2001"},{"key":"10.1016\/j.bcmd.2005.12.029_bib3","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1182\/blood.V86.12.4645.bloodjournal86124645","article-title":"Impaired microbicidal capacity of mononuclear phagocytes from patients with type I Gaucher disease: partial correction by enzyme replacement therapy","volume":"86","author":"Marodi","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.12.029_bib4","first-page":"388","article-title":"Gaucher's disease: a disease with chronic stimulation of the immune system","volume":"106","author":"Shoenfeld","year":"1982","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.bcmd.2005.12.029_bib5","first-page":"91","article-title":"Richter's transformation of lymphoma complicating Gaucher's disease","volume":"3","author":"Paulson","year":"1989","journal-title":"Hematol. Pathol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1600-0609.1985.tb02269.x","article-title":"Association of Gaucher's disease and lymphoid malignancy in 2 children","volume":"35","author":"Burstein","year":"1985","journal-title":"Scand. J. Haematol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib7","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1001\/archinte.1982.00340250195035","article-title":"Coexistence of Gaucher's disease and multiple myeloma","volume":"142","author":"Garfinkel","year":"1982","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bcmd.2005.12.029_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bcmd.2005.03.004","article-title":"Incidence of malignancies among patients with type I Gaucher disease from a single referral clinic","volume":"34","author":"Zimran","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2005.12.029_bib9","first-page":"149","article-title":"Abnormalities of cellular immunity and natural killer cells in Gaucher's disease","volume":"23","author":"Burstein","year":"1987","journal-title":"J. Clin. Lab. Immunol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/bcmd.1999.0237","article-title":"T cell numbers relate to bone involvement in Gaucher disease","volume":"25","author":"Lacerda","year":"1999","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bcmd.2005.12.029_bib11","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood.V90.9.3245","article-title":"Dendritic cells: unique leukocyte populations which control the primary immune response","volume":"90","author":"Hart","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.12.029_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/stem.150409","article-title":"Dendritic cell development: multiple pathways to nature's adjuvants","volume":"15","author":"Shortman","year":"1997","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcmd.2005.12.029_bib13","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2769::AID-IMMU2769>3.0.CO;2-2","article-title":"Human peripheral blood contains two distinct lineages of dendritic cells","volume":"29","author":"Robinson","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.gt.3300855","article-title":"Murine MHC class II locus control region drives expression of human b-glucocerebrosidase in antigen presenting cells of transgenic mice","volume":"6","author":"Guy","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.bcmd.2005.12.029_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00005792-199211000-00002","article-title":"Gaucher disease, clinical, laboratory, radiologic and genetic features of 53 patients","volume":"71","author":"Zimran","year":"1992","journal-title":"Medicine"},{"key":"10.1016\/j.bcmd.2005.12.029_bib16","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.clim.2004.08.007","article-title":"Defective tumor necrosis factor alpha-induced maturation of monocyte-derived dendritic cells in patients with myelodysplastic syndromes","volume":"113","author":"Micheva","year":"2004","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ajh.2830290403","article-title":"Polyclonal B-cell lymphocytosis and hypergammaglobulinemia in patients with Gaucher disease","volume":"29","author":"Marti","year":"1988","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib18","first-page":"129","article-title":"Gaucher's disease associated with monoclonal gammapathy of undetermined significance: a case report","volume":"78","author":"Airo","year":"1993","journal-title":"Haematologica"},{"key":"10.1016\/j.bcmd.2005.12.029_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2990.1991.tb00717.x","article-title":"B and T lymphocytes are affected in lysosomal disorders\u2014An immunoelectron microscopic study","volume":"17","author":"Bruck","year":"1991","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib20","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.4049\/jimmunol.163.6.3250","article-title":"Survival, maturation, and function of CD11c\u2212 and CD11c+ peripheral blood dendritic cells are differentially regulated by cytokines","volume":"163","author":"Kohrgruber","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.185.6.1101","article-title":"The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand","volume":"185","author":"Grouard","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcmd.2005.12.029_bib22","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.283.5405.1183","article-title":"Reciprocal control of T helper cell and dendritic cell differentiation","volume":"283","author":"Rissoan","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2005.12.029_bib23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/79747","article-title":"Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization","volume":"1","author":"Cella","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib24","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1084\/jem.192.2.219","article-title":"Natural interferon-\u03b1\/\u03b2-producing cells link innate and adaptive immunity","volume":"192","author":"Kadowaki","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcmd.2005.12.029_bib25","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3109\/10428190309178766","article-title":"Hemopoietic precursors and development of dendritic cell populations","volume":"44","author":"Dakic","year":"2003","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bcmd.2005.12.029_bib26","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.4049\/jimmunol.149.8.2681","article-title":"Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow","volume":"149","author":".Reid","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/jlb.52.3.274","article-title":"TNF-\u03b1 in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages","volume":"52","author":"Santiago-Schwarz","year":"1992","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.bcmd.2005.12.029_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S1074-7613(00)80149-1","article-title":"Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo","volume":"11","author":"Randolph","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.bcmd.2005.12.029_bib29","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1182\/blood.V98.10.2992","article-title":"Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10","volume":"98","author":"Brown","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.12.029_bib30","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0167-5699(97)01115-8","article-title":"The host\u2013tumor immune conflict: from immunosuppression to resistance and destruction","volume":"18","author":"Chouaib","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1016\/j.bcmd.2005.12.029_bib31","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1182\/blood.V92.12.4778","article-title":"Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor","volume":"92","author":"Menetrier-Caux","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2005.12.029_bib32","first-page":"205","article-title":"Cytokines in Gaucher's disease","volume":"10","author":"Barak","year":"1999","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.bcmd.2005.12.029_bib33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/bcmd.1997.0156","article-title":"Cytokine mRNA in Gaucher disease","volume":"23","author":"Lichtenstein","year":"1997","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bcmd.2005.12.029_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0925-4439(96)00056-7","article-title":"Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease","volume":"1317","author":"Michelakakis","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcmd.2005.12.029_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/bcmd.1997.0137","article-title":"Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease","volume":"23","author":"Hollak","year":"1997","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bcmd.2005.12.029_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/qjmed\/90.1.19","article-title":"Pro-inflammatory cytokines and the pathogenesis of Gaucher's disease: increased release of interleukin-6 and interleukin-10","volume":"90","author":"Allen","year":"1997","journal-title":"QJM"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979605002202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979605002202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:22:31Z","timestamp":1761049351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979605002202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1079979605002202"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2005.12.029","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendritic cells in patients with type I Gaucher disease are decreased in number but functionally normal","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2005.12.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}