{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:35:56Z","timestamp":1791020156672,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.bcmd.2006.03.002","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T07:52:48Z","timestamp":1146210768000},"page":"392-401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Thrombin-induced caspases 3 and 9 translocation to the cytoskeleton is independent of changes in cytosolic calcium in human platelets"],"prefix":"10.1016","volume":"36","author":[{"given":"Nidhal B.","family":"Amor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Pariente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin\u00e9s M.","family":"Salido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aghleb","family":"Bartegi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2006.03.002_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2006.03.002_bib2","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1101\/gad.12.11.1551","article-title":"Proteases to die for","volume":"12","author":"Cryns","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bcmd.2006.03.002_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1582-4934.2005.tb00360.x","article-title":"Pathways of apoptosis and importance in development","volume":"9","author":"Twomey","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bcmd.2006.03.002_bib4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/sj.cdd.4401378","article-title":"Coupling endoplasmic reticulum stress to the cell death program","volume":"11","author":"Rao","year":"2004","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.bcmd.2006.03.002_bib5","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1083\/jcb.150.4.887","article-title":"Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis","volume":"150","author":"Nakagawa","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcmd.2006.03.002_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2006.03.002_bib7","doi-asserted-by":"crossref","first-page":"33869","DOI":"10.1074\/jbc.M102225200","article-title":"Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation","volume":"276","author":"Rao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib8","doi-asserted-by":"crossref","first-page":"34287","DOI":"10.1074\/jbc.M204973200","article-title":"An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12","volume":"277","author":"Morishima","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1097-2765(00)80456-6","article-title":"The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex","volume":"3","author":"Puthalakath","year":"1999","journal-title":"Mol. Cell."},{"key":"10.1016\/j.bcmd.2006.03.002_bib10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0092-8674(00)00187-2","article-title":"BH3-only proteins\u2014Essential initiators of apoptotic cell death","volume":"103","author":"Huang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bcmd.2006.03.002_bib11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.femsyr.2005.08.001","article-title":"The actin cytoskeleton in ageing and apoptosis","volume":"5","author":"Gourlay","year":"2005","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.bcmd.2006.03.002_bib12","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1182\/blood.V94.5.1683","article-title":"Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation","volume":"94","author":"Wolf","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2006.03.002_bib13","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1046\/j.1537-2995.2003.00349.x","article-title":"Apoptotic activity in stored human platelets","volume":"43","author":"Perrotta","year":"2003","journal-title":"Transfusion"},{"key":"10.1016\/j.bcmd.2006.03.002_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1537-2995.2003.t01-4-00431.x","article-title":"Apoptotic markers are increased in platelets stored at 37 degrees C","volume":"43","author":"Bertino","year":"2003","journal-title":"Transfusion"},{"key":"10.1016\/j.bcmd.2006.03.002_bib15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1473-0502(03)00048-X","article-title":"Platelet apoptosis in stored platelet concentrates and other models","volume":"28","author":"Leytin","year":"2003","journal-title":"Transfus. Apheresis Sci."},{"key":"10.1016\/j.bcmd.2006.03.002_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2004.05.166","article-title":"Pathologic high shear stress induces apoptosis events in human platelets","volume":"320","author":"Leytin","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcmd.2006.03.002_bib17","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1074\/jbc.M307963200","article-title":"Hydrogen peroxide generation induces pp60src activation in human platelets: evidence for the involvement of this pathway in store-mediated calcium entry","volume":"279","author":"Rosado","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib18","doi-asserted-by":"crossref","first-page":"29231","DOI":"10.1074\/jbc.M403509200","article-title":"Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets","volume":"279","author":"Rosado","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib19","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1074\/jbc.275.11.7527","article-title":"A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets, Evidence for conformational coupling","volume":"275","author":"Rosado","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1042\/bj3510429","article-title":"Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton","volume":"351","author":"Rosado","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcmd.2006.03.002_bib21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2006.03.002_bib22","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/376037a0","article-title":"Identification and inhibition of the ICE\/CED-3 protease necessary for mammalian apoptosis","volume":"376","author":"Nicholson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2006.03.002_bib24","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1074\/jbc.274.17.11549","article-title":"An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9","volume":"274","author":"Zou","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.drup.2004.01.001","article-title":"Subcellular targeting regulates the function of caspase-activated protein kinases in apoptosis","volume":"7","author":"Jakobi","year":"2004","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bcmd.2006.03.002_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0143-4160(98)90108-7","article-title":"The role of Ca2+\/calmodulin-dependent protein kinases within the nucleus","volume":"23","author":"Heist","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcmd.2006.03.002_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/BJ20050168","article-title":"Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets","volume":"390","author":"Lopez","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcmd.2006.03.002_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cellsig.2005.05.006","article-title":"Two distinct Ca2+ compartments show differential sensitivity to thrombin, ADP and vasopressin in human platelets","volume":"18","author":"Lopez","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bcmd.2006.03.002_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF02222186","article-title":"Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage","volume":"27","author":"Thastrup","year":"1989","journal-title":"Agents Actions"},{"key":"10.1016\/j.bcmd.2006.03.002_bib30","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1182\/blood.V93.12.4222","article-title":"Role of caspases in a subset of human platelet activation responses","volume":"93","author":"Shcherbina","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2006.03.002_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0049-3848(02)00338-9","article-title":"Weak platelet agonists and U46619 induce apoptosis-like events, in the absence of phosphatidylserine exposure","volume":"107","author":"Tonon","year":"2003","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bcmd.2006.03.002_bib32","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1046\/j.1365-2141.1997.4813284.x","article-title":"Alterations in Bcl-2\/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis","volume":"99","author":"Vanags","year":"1997","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcmd.2006.03.002_bib33","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1055\/s-0037-1613103","article-title":"Platelet aging in vivo is associated with activation of apoptotic pathways: studies in a model of suppressed thrombopoiesis in dogs","volume":"87","author":"Pereira","year":"2002","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bcmd.2006.03.002_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1014341611412","article-title":"Thrombocytopenia in an animal model of malaria is associated with an increased caspase-mediated death of thrombocytes","volume":"7","author":"Piquet","year":"2002","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcmd.2006.03.002_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrm1682","article-title":"The actin cytoskeleton: a key regulator of apoptosis and ageing?","volume":"6","author":"Gourlay","year":"2005","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bcmd.2006.03.002_bib36","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1002\/j.1460-2075.1995.tb00202.x","article-title":"Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases","volume":"14","author":"Brancolini","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.bcmd.2006.03.002_bib37","doi-asserted-by":"crossref","first-page":"31277","DOI":"10.1074\/jbc.271.49.31277","article-title":"Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme\/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease","volume":"271","author":"Cryns","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib38","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1006\/bbrc.1995.2894","article-title":"Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis","volume":"217","author":"Mashima","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcmd.2006.03.002_bib39","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.276.5318.1571","article-title":"Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2","volume":"276","author":"Rudel","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2006.03.002_bib40","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/27094","article-title":"Calcium\u2014A life and death signal","volume":"395","author":"Berridge","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2006.03.002_bib41","doi-asserted-by":"crossref","first-page":"28476","DOI":"10.1074\/jbc.274.40.28476","article-title":"The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca2+-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis","volume":"274","author":"Reddy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcmd.2006.03.002_bib42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0968-0004(97)01143-2","article-title":"The endoplasmic reticulum Ca2+ store: a view from the lumen","volume":"23","author":"Meldolesi","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bcmd.2006.03.002_bib43","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/PL00000765","article-title":"Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores","volume":"57","author":"Putney","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcmd.2006.03.002_bib44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ceca.2004.04.002","article-title":"Role of store-dependent influx of Ca2+ and efflux of K+ in apoptosis of CHO cells","volume":"36","author":"Pigozzi","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcmd.2006.03.002_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1535-6108(02)00034-X","article-title":"Bcl-2-dependent modulation of Ca2+ homeostasis and store-operated channels in prostate cancer cells","volume":"1","author":"Vanden Abeele","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcmd.2006.03.002_bib46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1160\/TH03-10-0631","article-title":"Apoptotic-like mitochondrial events associated to phosphatidylserine exposure in blood platelets induced by local anaesthetics","volume":"92","author":"Augereau","year":"2004","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bcmd.2006.03.002_bib47","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1152\/ajpcell.00139.2004","article-title":"Calcium, ATP, and ROS: a mitochondrial love\u2013hate triangle","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.bcmd.2006.03.002_bib48","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bcp.2004.05.042","article-title":"Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression","volume":"68","author":"Rahman","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcmd.2006.03.002_bib49","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1349-7006.2004.tb03323.x","article-title":"Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination","volume":"95","author":"Li","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcmd.2006.03.002_bib50","doi-asserted-by":"crossref","unstructured":"N. Ben Amor, J.A. Pariente, G.M. Salido, A. Bartegi, J.A. Rosado, Caspases 3 and 9 are translocated to the cytoskeleton and activated by thrombin in human platelets. Evidence for the involvement of PKC and the actin filament polymerization, Cell Signal, doi:10.1016\/j.cellsig.2005.10.002.","DOI":"10.1016\/j.cellsig.2005.10.002"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979606000854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979606000854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:23:34Z","timestamp":1761049414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979606000854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S1079979606000854"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2006.03.002","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombin-induced caspases 3 and 9 translocation to the cytoskeleton is independent of changes in cytosolic calcium in human platelets","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2006.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}