{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:33:34Z","timestamp":1791275614679,"version":"4.1.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.bcmd.2008.06.007","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T17:42:15Z","timestamp":1218649335000},"page":"255-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":153,"title":["BCL11A is a major HbF quantitative trait locus in three different populations with \u03b2-hemoglobinopathies"],"prefix":"10.1016","volume":"41","author":[{"given":"Amanda E.","family":"Sedgewick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Timofeev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.C.","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond S.K.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Chong","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goonnapa","family":"Fucharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supan","family":"Fucharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynara G.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badri N.","family":"Vardarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton T.","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.K.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2008.06.007_bib1","series-title":"Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management","year":"2001"},{"key":"10.1016\/j.bcmd.2008.06.007_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood.V66.4.783.783","article-title":"DNA sequence variation associated with elevated fetal G\u03b3 globin production","volume":"66","author":"Gilman","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2008.06.007_bib3","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1073\/pnas.0611393104","article-title":"Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults","volume":"104","author":"Thein","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcmd.2008.06.007_bib4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1529-8817.2005.00188.x","article-title":"Interaction between two quantitative trait loci affects fetal haemoglobin expression","volume":"69","author":"Garner","year":"2005","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.bcmd.2008.06.007_bib5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1182\/blood.V80.3.816.816","article-title":"Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2","volume":"80","author":"Dover","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2008.06.007_bib6","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ng2108","article-title":"A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15","volume":"39","author":"Menzel","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2008.06.007_bib7","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.0711566105","article-title":"Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of \u03b2-thalassemia","volume":"105","author":"Uda","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcmd.2008.06.007_bib8","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM199505183322001","article-title":"Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia","volume":"332","author":"Charache","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcmd.2008.06.007_bib9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ajh.21150","article-title":"Variation and heritability of Hb F and F-cells among \u03b2-thalassemia heterozygotes in Hong Kong","volume":"83","author":"Gibney","year":"2008","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcmd.2008.06.007_bib10","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","author":"International HapMap Consortium","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bcmd.2008.06.007_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1182\/blood.V95.1.342","article-title":"Genetic influences on F cells and other hematologic variables: a twin heritability study","volume":"95","author":"Garner","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2008.06.007_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1476-4598-5-18","article-title":"Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells","volume":"5","author":"Liu","year":"2006","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcmd.2008.06.007_bib13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.abb.2004.10.028","article-title":"BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression","volume":"434","author":"Senawong","year":"2005","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979608001411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979608001411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:24:48Z","timestamp":1761049488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979608001411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1079979608001411"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2008.06.007","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BCL11A is a major HbF quantitative trait locus in three different populations with \u03b2-hemoglobinopathies","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2008.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}