{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:48:29Z","timestamp":1788558509466,"version":"build-2803163510"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.bcmd.2011.12.003","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T12:22:18Z","timestamp":1327148538000},"page":"124-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Common TMPRSS6 mutations and iron, erythrocyte, and pica phenotypes in 48 women with iron deficiency or depletion"],"prefix":"10.1016","volume":"48","author":[{"given":"Pauline L.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Clayborn","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Khaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Y.","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcmd.2011.12.003_bb0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0002-9343(00)00396-X","article-title":"Intravenous iron dextran therapy in patients with iron deficiency and normal renal function who failed to respond to or did not tolerate oral iron supplementation","volume":"109","author":"Barton","year":"2000","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0010","first-page":"9","article-title":"Pica associated with iron deficiency or depletion: clinical and laboratory correlates in 262 non-pregnant adult outpatients","volume":"10","author":"Barton","year":"2010","journal-title":"BMC. Blood Disord."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0015","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1089\/thy.2008.0091","article-title":"Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS Study","volume":"18","author":"Barton","year":"2008","journal-title":"Thyroid"},{"key":"10.1016\/j.bcmd.2011.12.003_bb0020","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ng.456","article-title":"Common variants in TMPRSS6 are associated with iron status and erythrocyte volume","volume":"41","author":"Benyamin","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bcmd.2009.09.001","article-title":"Polymorphisms and mutations of human TMPRSS6 in iron deficiency anemia","volume":"44","author":"Beutler","year":"2010","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0030","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/ng.462","article-title":"Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels","volume":"41","author":"Chambers","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0035","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1001\/jama.1976.03260510055032","article-title":"Pica","volume":"235","author":"Crosby","year":"1976","journal-title":"JAMA"},{"key":"10.1016\/j.bcmd.2011.12.003_bb0040","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1126\/science.1157121","article-title":"The serine protease TMPRSS6 is required to sense iron deficiency","volume":"320","author":"Du","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bcmd.2011.12.003_bb0045","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ng.130","article-title":"Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)","volume":"40","author":"Finberg","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0050","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1042\/bj20030390","article-title":"Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues","volume":"373","author":"Hooper","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0055","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bcmd.2007.10.002","article-title":"Regulation of hepcidin: insights from biochemical analyses on human serum samples","volume":"40","author":"Kemna","year":"2008","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.amjmed.2004.07.050","article-title":"Pica and food craving in patients with iron-deficiency anemia: a case\u2013control study in France","volume":"118","author":"Kettaneh","year":"2005","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0065","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0002-9343(94)90309-3","article-title":"Pica, iron deficiency, and the medical history","volume":"97","author":"Moore","year":"1994","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0070","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1182\/blood-2011-06-364034","article-title":"TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals","volume":"118","author":"Nai","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bcmd.2011.12.003_bb0075","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3324\/haematol.2010.037960","article-title":"Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors","volume":"96","author":"Pasricha","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.bcmd.2011.12.003_bb0080","doi-asserted-by":"crossref","first-page":"435","DOI":"10.7326\/0003-4819-69-3-435","article-title":"Pagophagia and iron deficiency anemia","volume":"69","author":"Reynolds","year":"1968","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bcmd.2011.12.003_bb0085","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/jmedgenet-2011-100061","article-title":"Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations","volume":"48","author":"Traglia","year":"2011","journal-title":"J. Med. Genet."}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979611002385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979611002385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:28:16Z","timestamp":1761049696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979611002385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1079979611002385"],"URL":"https:\/\/doi.org\/10.1016\/j.bcmd.2011.12.003","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Common TMPRSS6 mutations and iron, erythrocyte, and pica phenotypes in 48 women with iron deficiency or depletion","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcmd.2011.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}